LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,844

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,837

A protein conjugation system essential for autophagy

Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M., & Ohsumi, Y. (1998) · Nature · doi:10.1038/26506 · Cited by 1,758

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.263 · Cited by 1,024

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881

GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

Wang, H.-B., Bedford, F., Brandon, N., Moss, S., & Olsen, R. (1999) · Nature · doi:10.1038/16264 · Cited by 754

Autophagy and related mechanisms of lysosome-mediated protein degradation

Dunn, W. A. (1994) · Trends in Cell Biology · doi:10.1016/0962-8924(94)90069-8 · Cited by 534

A New Protein Conjugation System in Human

Mizushima, N., Sugita, H., Yoshimori, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33889 · Cited by 521

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

Itakura, E., & Mizushima, N. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201009067 · Cited by 430

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

Parone, P. A., Da Cruz, S., Tondera, D., Mattenberger, Y., James, D. I., Maechler, P., Barja, F., & Martinou, J.-C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003257 · Cited by 415

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

Saiki, S., Sasazawa, Y., Imamichi, Y., Kawajiri, S., Fujimaki, T., Tanida, I., Kobayashi, H., Sato, F., Sato, S., Ishikawa, K.-I., et al. (2011) · Autophagy · doi:10.4161/auto.7.2.14074 · Cited by 419

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

Martins, I., Kepp, O., Schlemmer, F., Adjemian, S., Tailler, M., Shen, S., Michaud, M., Menger, L., Gdoura, A., Tajeddine, N., et al. (2010) · Oncogene · doi:10.1038/onc.2010.500 · Cited by 443

LC3-positive structures are prominent in autophagy-deficient cells

Runwal, G., Stamatakou, E., Siddiqi, F. H., Puri, C., Zhu, Y., & Rubinsztein, D. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-46657-z · Cited by 413

Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells

Daido, S., Kanzawa, T., Yamamoto, A., Takeuchi, H., Kondo, Y., & Kondo, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3084 · Cited by 416

Regulation and Function of Autophagy during Cell Survival and Cell DeathPreprint

Das, G., Shravage, B. V., & Baehrecke, E. H. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008813 · Cited by 422

PGC-1α-mediated regulation of mitochondrial function and physiological implications

Halling, J. F., & Pilegaard, H. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0005 · Cited by 430

How autophagy controls the intestinal epithelial barrier

Foerster, E. G., Mukherjee, T., Cabral-Fernandes, L., da Rocha, J. D. B., Girardin, S. E., & Philpott, D. J. (2021) · Autophagy · doi:10.1080/15548627.2021.1909406 · Cited by 427

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025416 · Cited by 365

Diverse Cellular Roles of Autophagy

Morishita, H., & Mizushima, N. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125300 · Cited by 376

The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia

Zhu, C., Wang, X., Xu, F., Bahr, B. A., Shibata, M., Uchiyama, Y., Hagberg, H., & Blomgren, K. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401545 · Cited by 403

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

Wong, Y., & Holzbaur, E. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1870-13.2014 · Cited by 380

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

Lee, Y., Lee, H.-Y., Hanna, R. A., & Gustafsson, Å. B. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2011 · Cited by 409

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

Hamacher‐Brady, A., & Brady, N. R. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2087-8 · Cited by 410

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

Shi, C.-S., & Kehrl, J. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804478200 · Cited by 395

Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae

Suzuki, K., & Ohsumi, Y. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.096 · Cited by 394

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

Chen, Z.-H., Lam, H. C., Jin, Y., Kim, H.-P., Cao, J., Lee, S.-J., Ifedigbo, E., Parameswaran, H., Ryter, S. W., & Choi, A. M. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005574107 · Cited by 380

Autophagy: A Critical Regulator of Cellular Metabolism and Homeostasis

Ryter, S. W., Cloonan, S. M., & Choi, A. M. K. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0140-8 · Cited by 391

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

Scarlatti, F., Maffei, R., Beau, I., Codogno, P., & Ghidoni, R. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.51 · Cited by 412

Autophagic control of listeria through intracellular innate immune recognition in drosophila

Yano, T., Mita, S., Ohmori, H., Oshima, Y., Fujimoto, Y., Ueda, R., Takada, H., Goldman, W. E., Fukase, K., Silverman, N. S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1634 · Cited by 401

Autophagosome Precursor Maturation Requires Homotypic Fusion

Moreau, K., Ravikumar, B., Renna, M., Puri, C., & Rubinsztein, D. C. (2011) · Cell · doi:10.1016/j.cell.2011.06.023 · Cited by 398

Complex Inhibitory Effects of Nitric Oxide on Autophagy

Sarkar, S., Korolchuk, V. I., Renna, M., Imarisio, S., Fleming, A., Williams, A. J., Garcı́a-Arencibia, M., Rose, C., Luo, S., Underwood, B. R., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.029 · Cited by 386

The intracellular sites of early replication and budding of SARS-coronavirus

Stertz, S., Reichelt, M., Spiegel, M., Kuri, T., Martínez‐Sobrido, L., García‐Sastre, A., Weber, F., & Kochs, G. (2007) · Virology · doi:10.1016/j.virol.2006.11.027 · Cited by 373

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

Satoo, K., Noda, N. N., Kumeta, H., Fujioka, Y., Mizushima, N., Ohsumi, Y., & Inagaki, F. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.80 · Cited by 384

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

Jiang, M., Liu, K., Luo, J., & Dong, Z. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090594 · Cited by 380

Distinct RolesIn Vivofor the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-Synuclein

Ebrahimi‐Fakhari, D., Cantuti‐Castelvetri, I., Fan, Z., Rockenstein, E. M., Masliah, E., Hyman, B. T., McLean, P. J., & Unni, V. K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1560-11.2011 · Cited by 387

Polyglutamine tracts regulate beclin 1-dependent autophagy

Ashkenazi, A., Bento, C. F., Ricketts, T., Vicinanza, M., Siddiqi, F., Pavel, M., Squitieri, F., Hardenberg, M. C., Imarisio, S., Menzies, F. M., et al. (2017) · Nature · doi:10.1038/nature22078 · Cited by 357

Autophagosome Supports Coxsackievirus B3 Replication in Host Cells

Wong, J. T., Zhang, J., Si, X., Gao, G., Mao, I., McManus, B. M., & Luo, H. (2008) · Journal of Virology · doi:10.1128/jvi.00641-08 · Cited by 388

Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy

Adhami, F., Liao, G., Morozov, Y. M., Schloemer, A., Schmithorst, V. J., Lorenz, J. N., Dunn, R. S., Vorhees, C. V., Wills-Karp, M., Degen, J. L., et al. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051066 · Cited by 326

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

Chino, H., Hatta, T., Natsume, T., & Mizushima, N. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.033 · Cited by 369

BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02246-06 · Cited by 369

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Sarkar, S. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130134 · Cited by 380

Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane

Ozeki, S., Cheng, J., Tauchi-Sato, K., Hatano, N., Taniguchi, H., & Fujimoto, T. (2005) · Journal of Cell Science · doi:10.1242/jcs.02401 · Cited by 369

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response†

Sir, D., Chen, W., Choi, J., Wakita, T., Yen, T. S. B., & Ou, J. J. (2008) · Hepatology · doi:10.1002/hep.22464 · Cited by 378

Autophagy: a barrier or an adaptive response to cancer

Ogier‐Denis, É., & Codogno, P. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00004-0 · Cited by 370

A current perspective of autophagosome biogenesis

Shibutani, S., & Yoshimori, T. (2013) · Cell Research · doi:10.1038/cr.2013.159 · Cited by 368

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

Crespo, J. L., & Hall, M. N. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.579-591.2002 · Cited by 371

HsAtg4B/HsApg4B/Autophagin-1 Cleaves the Carboxyl Termini of Three Human Atg8 Homologues and Delipidates Microtubule-associated Protein Light Chain 3- and GABAA Receptor-associated Protein-Phospholipid Conjugates

Tanida, I., Sou, Y.-S., Ezaki, J., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401461200 · Cited by 334

A Metal‐Organic Framework (MOF) Fenton Nanoagent‐Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition

Yang, B., Ding, L. S., Yao, H., Chen, Y., & Shi, J. (2020) · Advanced Materials · doi:10.1002/adma.201907152 · Cited by 363

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05254-w · Cited by 381

Autophagic machinery activated by dengue virus enhances virus replication

Lee, Y., Lei, H.-Y., Liu, M.-T., Wang, J., Chen, S., Jiang‐Shieh, Y., Lin, Y.-S., Yeh, T., Liu, C., & Liu, H. (2008) · Virology · doi:10.1016/j.virol.2008.02.016 · Cited by 372

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

Xu, Y., Zhou, P., Cheng, S., Lu, Q., Nowak, K., Hopp, A.-K., Li, L., Shi, X., Zhou, Z., Gao, W., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.007 · Cited by 379

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

Yamamoto, A., Cremona, M. L., & Rothman, J. E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510065 · Cited by 361

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.

Raben, N., Hill, V., Shea, L., Takikita, S., Baum, R., Mizushima, N., Ralston, E., & Plotz, P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn292 · Cited by 352

Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1

Svenning, S., Lamark, T., Krause, K., & Johansen, T. (2011) · Autophagy · doi:10.4161/auto.7.9.16389 · Cited by 368

WIPI-1α (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy

Proikas-Cezanne, T., Waddell, S., Gaugel, A., Frickey, T., Lupas, A., & Nordheim, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208331 · Cited by 332

Autophagy Is Activated in Colorectal Cancer Cells and Contributes to the Tolerance to Nutrient Deprivation

Sato, K., Tsuchihara, K., Fujii, S., Sugiyama, M., Goya, T., Atomi, Y., Ueno, T., Ochiai, A., & Esumi, H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1462 · Cited by 362

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

Ni, H.-M., Bockus, A., Wozniak, A. L., Jones, K., Weinman, S., Yin, X.-M., & Ding, W.-X. (2011) · Autophagy · doi:10.4161/auto.7.2.14181 · Cited by 318

5-HT4Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice

Liu, M., Kuan, Y., Wang, J., Hen, R., & Gershon, M. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1145-09.2009 · Cited by 358

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

Spampanato, C., Feeney, E., Li, L., Cardone, M., Lim, J., Annunziata, F., Zare, H., Polishchuk, R., Puertollano, R., Parenti, G., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202176 · Cited by 341

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin

Sarkar, S., Krishna, G., Imarisio, S., Saiki, S., O’Kane, C. J., & Rubinsztein, D. C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm294 · Cited by 353

HspB8 Chaperone Activity toward Poly(Q)-containing Proteins Depends on Its Association with Bag3, a Stimulator of Macroautophagy

Carra, S., Seguin, S. J., Lambert, H., & Landry, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706304200 · Cited by 360

Identification of Aneuploidy-Selective Antiproliferation Compounds

Tang, Y.-C., Williams, B. R., Siegel, J. J., & Amon, A. (2011) · Cell · doi:10.1016/j.cell.2011.01.017 · Cited by 328

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

Balgi, A. D., Fonseca, B. D., Donohue, E., Tsang, T. C. F., Lajoie, P., Proud, C. G., Nabi, I. R., & Roberge, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007124 · Cited by 344

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

Strappazzon, F., Nazio, F., Corrado, M., Cianfanelli, V, Romagnoli, A., Fimia, G. M., Campello, S., Nardacci, R., Piacentini, M., Campanella, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.139 · Cited by 399

Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication

Checroun, C., Wehrly, T. D., Fischer, E. R., Hayes, S. F., & Celli, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601838103 · Cited by 356

The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3

Tanida, I., Tanida-Miyake, E., Ueno, T., & Kominami, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000752200 · Cited by 356

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

Sinha, R. A., Farah, B. L., Singh, B. K., Siddique, M. M., Li, Y., Wu, Y., Ilkayeva, O., Gooding, J. R., Ching, J., Zhou, J., et al. (2013) · Hepatology · doi:10.1002/hep.26667 · Cited by 348

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

Schaeffer, V., Lavenir, I., Ozcelik, S., Tolnay, M., Winkler, D. T., & Goedert, M. (2012) · Brain · doi:10.1093/brain/aws143 · Cited by 343

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

Shin, D.-M., Jeon, B., Lee, H., Jin, H. S., Yuk, J., Song, C., Lee, S. H., Lee, Z.-W., Cho, S.-N., Kim, J., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001230 · Cited by 345

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

Yang, Z., Fujii, H., Mohan, S. V., Goronzy, J. J., & Weyand, C. M. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130252 · Cited by 334

ESCRTs and Fab1 Regulate Distinct Steps of Autophagy

Rusten, T. E., Vaccari, T., Lindmo, K., Rodahl, L. M., Nezis, I. P., Sem-Jacobsen, C., Wendler, F., Vincent, J., Brech, A., Bilder, D. H., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.09.032 · Cited by 355

Ferroptosis and cell death mechanisms in Parkinson's disease

Guiney, S. J., Adlard, P. A., Bush, A. I., Finkelstein, D. I., & Ayton, S. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.01.004 · Cited by 353

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

Crippa, V., Sau, D., Rusmini, P., Boncoraglio, A., Onesto, E., Bolzoni, E., Galbiati, M., Fontana, E., Marino, M., Carra, S., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq257 · Cited by 330

Autophagy-monitoring and autophagy-deficient mice

Kuma, A., Komatsu, M., & Mizushima, N. (2017) · Autophagy · doi:10.1080/15548627.2017.1343770 · Cited by 336

FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis

Sanchez, A. M. J., Candau, R. B., & Bernardi, H. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1513-z · Cited by 349

Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

Ke, P., & Chen, S. S.-L. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41474 · Cited by 347

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

Disatnik, M., Ferreira, J. C. B., Campos, J. C., Gomes, M. K., Dourado, P. M. M., Qi, X., & Mochly‐Rosen, D. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000461 · Cited by 340

Inhibition of Mammalian Target of Rapamycin or Apoptotic Pathway Induces Autophagy and Radiosensitizes PTEN Null Prostate Cancer Cells

Cao, C., Subhawong, T. K., Albert, J. M., Kim, K. W., Geng, L., Sekhar, K. R., Gi, Y. J., & Lu, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0802 · Cited by 332

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury

Sarkar, C., Zhao, Z., Aungst, S. L., Sabirzhanov, B. E., Faden, A. I., & Lipinski, M. M. (2014) · Autophagy · doi:10.4161/15548627.2014.981787 · Cited by 329

Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

Zeng, X., Overmeyer, J. H., & Maltese, W. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02735 · Cited by 339

Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)

Koike, M., Shibata, M., Waguri, S., Yoshimura, K., Tanida, I., Kominami, E., Gotow, T., Peters, C., von Figura, K., Mizushima, N., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61253-9 · Cited by 330

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

Kimura, T., Jia, J., Kumar, S. G., Choi, S. W., Gu, Y., Mudd, M. H., Dupont, N., Jiang, S., Peters, R. S., Farzam, F., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201695081 · Cited by 340

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

Birmingham, C. L., Canadien, V., Kaniuk, N. A., Steinberg, B. E., Higgins, D. E., & Brumell, J. H. (2008) · Nature · doi:10.1038/nature06479 · Cited by 330

ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

Darshi, M., Mendiola, V. L., Mackey, M. R., Murphy, A. N., Koller, A. A., Perkins, G. A., Ellisman, M. H., & Taylor, S. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.171975 · Cited by 338

AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1

Sanchez, A. M., Csibi, A., Raibon, A., Cornille, K., Gay, S., Bernardi, H., & Candau, R. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23399 · Cited by 306

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

Kuballa, P., Huett, A. S., Rioux, J. D., Daly, M. J., & Xavier, R. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003391 · Cited by 346

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

Mandell, M. A., Jain, A., Arko‐Mensah, J., Chauhan, S., Kimura, T., Dinkins, C., Silvestri, G., Münch, J., Kirchhoff, F., Simonsen, A., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.013 · Cited by 331

Autophagy and the Immune System

Kuballa, P., Nolte, W. M., Castoreno, A. B., & Xavier, R. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074948 · Cited by 335

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

Tanik, S. A., Schultheiss, C. E., Volpicelli-Daley, L. A., Brunden, K. R., & Lee, V. M. Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457408 · Cited by 326

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

Kimura, T., Jain, A., Choi, S. W., Mandell, M. A., Schroder, K., Johansen, T., & Deretic, V. P. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201503023 · Cited by 331

Insufficient autophagy in idiopathic pulmonary fibrosis

Araya, J., Kojima, J., Takasaka, N., Ito, S., Fujii, S., Hara, H., Yanagisawa, H., Kobayashi, K., Tsurushige, C., Kawaishi, M., et al. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00213.2012 · Cited by 329

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

Periyasamy‐Thandavan, S., Jiang, M., Wei, Q., Smith, R., Yin, X., & Dong, Z. (2008) · Kidney International · doi:10.1038/ki.2008.214 · Cited by 321

Targeting autophagy using natural compounds for cancer prevention and therapy

Deng, S., Shanmugam, M. K., Kumar, A. P., Yap, C. T., Sethi, G., & Bishayee, A. (2019) · Cancer · doi:10.1002/cncr.31978 · Cited by 324

Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo

Gills, J. J., LoPiccolo, J., Tsurutani, J., Shoemaker, R. H., Best, C. J. M., Abu-Asab, M. S., Borojerdi, J. P., Warfel, N. A., Gardner, E. R., Danish, M., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0161 · Cited by 322

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

Wang, J., Whiteman, M. W., Lian, H., Wang, G., Singh, A. K., Huang, D., & Denmark, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026013 · Cited by 323

Autolysosomal β‐catenin degradation regulates Wnt‐autophagy‐p62 crosstalk

Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez‐Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J. M., Batson, J., Malik, K. T. A., Paraskeva, C., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.123 · Cited by 327

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

Iwata, A., Christianson, J. C., Bucci, M., Ellerby, L., Nukina, N., Forno, L. S., & Kopito, R. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505801102 · Cited by 318

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

Li, J., Hou, N., Faried, A., Tsutsumi, S., & Kuwano, H. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.021 · Cited by 318

CD40 induces macrophage anti–Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes

Andrade, R. M., Wessendarp, M., Gubbels, M., Striepen, B., & Subauste, C. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28796 · Cited by 322

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

Bodemann, B. O., Orvedahl, A., Cheng, T., Ram, R. R., Ou, Y.-H., Formstecher, É., Maiti, M., Hazelett, C. C., Wauson, E., Balakireva, M., et al. (2011) · Cell · doi:10.1016/j.cell.2010.12.018 · Cited by 325

Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation

Parihar, S. P., Guler, R., Khutlang, R., Lang, D. M., Hurdayal, R., Mhlanga, M. M., Suzuki, H., Marais, A. D., & Brombacher, F. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit550 · Cited by 320

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

Kim, R. H., Coates, J. M., Bowles, T. L., McNerney, G. P., Sutcliffe-Goulden, J., Jung, J. U., Gandour‐Edwards, R. F., Chuang, F. Y. S., Bold, R. J., & Kung, H.-J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3157 · Cited by 321

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

Nakatogawa, H. (2013) · Essays in Biochemistry · doi:10.1042/bse0550039 · Cited by 322

Chemical Inhibition of Acetyl-CoA Carboxylase Induces Growth Arrest and Cytotoxicity Selectively in Cancer Cells

Beckers, A., Organe, S., Timmermans, L., Scheys, K., Peeters, A., Brusselmans, K., Verhoeven, G., & Swinnen, J. V. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0389 · Cited by 315

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

Renna, M., Schaffner, C., Brown, K., Shang, S., Henao-Tamayo, M. I., Hegyi, K., Grimsey, N. J., Cusens, D., Coulter, S., Cooper, J. F., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46095 · Cited by 318

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

Lampert, M. A., Orogo, A. M., Najor, R. H., Hammerling, B. C., Leon, L. J., Wang, B. J., Kim, T.-Y., Sussman, M. A., & Gustafsson, Å. B. (2019) · Autophagy · doi:10.1080/15548627.2019.1580095 · Cited by 316

Posttranslational modification of autophagy-related proteins in macroautophagy

Xie, Y., Kang, R., Sun, X., Zhong, M., Huang, J., Klionsky, D. J., & Tang, D. (2015) · Autophagy · doi:10.4161/15548627.2014.984267 · Cited by 302

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., & Yoshimori, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01131 · Cited by 1,394

Molecular cloning and characterization of rat LC3A and LC3B—Two novel markers of autophagosome

Wu, J., Dang, Y., Su, W., Liu, C., Ma, H., Shan, Y., Pei, Y., Wan, B., Guo, J., & Yu, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.211 · Cited by 180

LC3 and Autophagy

Tanida, I., Ueno, T., & Kominami, E. (2008) · Methods in Molecular Biology™ · doi:10.1007/978-1-59745-157-4_4 · Cited by 1,785

Molecular Dynamics Simulations of Microtubule-associated protein 1A/1B-light chain 3 (LC3) and its membrane associated form(LC3-II)

Mathew, S. (2017) · doi:10.7916/d8z60w0j

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes

Ballesteros, U., Etxaniz, A., Iriondo, M. N., Varela, Y. R., Lázaro, M., Viguera, A. R., Montes, L. R., Valle, M., Goñi, F. M., & Alonso, A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.05.129 · Cited by 10