The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
The controlling role of ATM in homologous recombinational repair of DNA damage
Open accessAbstract
The human genetic disorder ataxia telangiectasia (A-T), caused by mutation in the ATM gene, is characterized by chromosomal instability, radiosensitivity and defective cell cycle checkpoint activation. DNA double-strand breaks (dsbs) persist in A-T cells after irradiation, but the underlying defect is unclear. To investigate ATM's interactions with dsb repair pathways, we disrupted ATM along with other genes involved in the principal, complementary dsb repair pathways of homologous recombination (HR) or non-homologous end-joining (NHEJ) in chicken DT40 cells. ATM(-/-) cells show altered kinetics of radiation-induced Rad51 and Rad54 focus formation. Ku70-deficient (NHEJ(-)) ATM(-/-) chicken DT40 cells show radiosensitivity and high radiation-induced chromosomal aberration frequencies, while Rad54-defective (HR(-)) ATM(-/-) cells show only slightly elevated aberration levels after irradiation, placing ATM and HR on the same pathway. These results reveal that ATM defects impair HR-mediated dsb repair and may link cell cycle checkpoints to HR activation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both homologous recombination and nonhomologous end-joining pathways of double-strand break repair have been shown to be modulated by the ATM-and Chk2-dependent checkpoint (23)(24)(25).”
From Phosphorylation of Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A by Ataxia Telangiectasia Mutated and Rad3-Related–Dependent Checkpoint Pathway Promotes Cell Survival in Response to UV Irradiation (2006) · cites this paper as [24]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
International System for Human Cytogenetic Nomenclature
National Cancer Institute (2020) · Definitions · doi:10.32388/78qroa · Cited by 6,831
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
Transcriptional Activation by Tetracyclines in Mammalian Cells
Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., & Bujard, H. (1995) · Science · doi:10.1126/science.7792603 · Cited by 2,488 · cited 2×
“repressible (Gossen et al., 1995) RAD54 expression vector, a ScaI–MluI”
MethodCell Cycle Checkpoints: Preventing an Identity Crisis
Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,050
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322
Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi‐Iwai, Y., Shinohara, A., & Takeda, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5497 · Cited by 1,229
Self-citation
Cited by
Sorted by citations
Items 301–313 of 313
Schrauder, M. G., & Wiesmüller, L. (2006) · Wiley eBooks · doi:10.1002/9783527619665.ch32
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. E. (2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch21
G-Protein-Coupled Receptor (GPCR)-Dependent ADAM-17 Regulated Ectodomain Shedding
Georgakilas, A. G. (2012) · CRC Press eBooks · doi:10.1201/b14318-10
Vanderstichelen, G. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.68013
Functional Analysis of Two Novel DNA Repair Factors, Metnase and Pso4
Beck, B. D. (2008) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1776
Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks
Karlsson, K. H. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Han, D.-J., Kim, S., Lee, S.-Y., Moon, Y., Kang, S. J., Yoo, J., Jeong, H. Y., Cho, H. J., Jeon, J. Y., Sim, B. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26785991
Han, D.-J., Kim, S., Lee, S.-Y., Moon, Y., Kang, S. J., Yoo, J., Jeong, H. Y., Cho, H. J., Jeon, J. Y., Sim, B. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26786035
Targeting DNA damage response pathways in cancer
Torrado, C., Tan, H. N., & Yap, T. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00075-3
Rôle de la protéine ATM dans la régulation des gènes de latences du virus d’Epstein-Barr (EBV)
Tatfi, M. (2019) · theses.fr (ABES) · doi:10.70675/3b654584z65a5z4cbbzbbc2zde0a759cf1ab
Tripathi, U., & Singh, R. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11866-z
Zhang, Z., Zhao, J., Zhang, Z., Fu, Z., Li, X., Zhu, Z., Li, Q., Wang, X., Yuan, J., Gao, F., et al. (2026) · Reproductive Sciences · doi:10.1007/s43032-026-02082-y
Opportunities for biology-driven individualization of proton beam radiotherapy
Hessenow, R. K., Timmermann, B., & Jendrossek, V. (2026) · Trends Open · doi:10.1016/j.treopn.2026.08.012
Metadata
- Authors
- Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K., & Takeda, S.
- Affiliations
- Kyoto University (JP)
- Kanazawa University (JP)
- University of Chicago (US)
- Corresponding author
- Takeda, Shunichi
- ORCID
- Morrison, Ciaran
- Venue
- The EMBO Journal
- Published
- 2000-02-01
- Volume
- 19
- Issue
- 3
- Pages
- 463-471
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC305583
- OpenAlex
- W2017297714
- Cited by
- 312
- References
- 76
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 10 · 2023: 2 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 1 · 2015: 12 · 2014: 9 · 2013: 8 · 2012: 15
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Update notices
- erratum (2000-02-15)
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- QIMR Berghofer Medical Research Institute
- University of Cambridge
- University of Sussex
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Bayer Yakuhin
- Medical Research Council
- Japan Society for the Promotion of Science (CREST)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- ATM kinase, ataxia telangiectasia, homologous recombination, non-homologous end joining, DNA double-strand break repair, radiosensitivity, chromosomal instability, cell cycle checkpoints, RAD51, Rad54, Ku70, DT40 cells, chromosomal abnormalities
- MeSH terms
- Ku Autoantigen, Animals, Ataxia Telangiectasia, Cell Division, Cell Line, Chickens, Chromosome Aberrations, DNA Damage, DNA Repair, DNA Helicases, DNA-Binding Proteins, Fluorescent Antibody Technique, Fungal Proteins, Humans, Nuclear Proteins, Radiation Tolerance, Recombination, Genetic, Immunoblotting, Protein Serine-Threonine Kinases, Gene Targeting, Cell Cycle Proteins, Tumor Suppressor Proteins, Saccharomyces cerevisiae Proteins, Avian Proteins, Antigens, Nuclear, DNA Repair Enzymes, Rad51 Recombinase, Ataxia Telangiectasia Mutated Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
