The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

The language of covalent histone modifications

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The polycomb group protein EZH2 is involved in progression of prostate cancer

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Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

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Angiotensin II Induces Cardiomyocyte Hypertrophy Probably through Histone Deacetylases

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MEF-2 isoforms' (A-D) roles in development and tumorigenesis

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Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice

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Histone Deacetylase Inhibitor: Antineoplastic Agent and Radiation Modulator

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Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

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Transient receptor potential vanilloid 1 antagonism in neuroinflammation, neuroprotection and epigenetic regulation: potential therapeutic implications for severe psychiatric disorders treatment

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Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin

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Histone deacetylase‑2: A potential regulator and therapeutic target in liver disease (Review)

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Translational Regulation of NeuroD1 Expression by FMRP: Involvement in Glutamatergic Neuronal Differentiation of Cultured Rat Primary Neural Progenitor Cells

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HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo

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Fractal Characterization of Chromatin Decompaction in Live Cells

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The molecular hallmarks of epigenetic effects mediated by antiepileptic drugs

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Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines

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Histone Deacetylase 3 Modulates the Expansion of Human Hematopoietic Stem Cells

Elizalde, C., Fernández‐Rueda, J., Salcedo, J. M., Dorronsoro, A., Ferrin, I., Jakobsson, E., & Trigueros, C. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0698 · Cited by 23

Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth

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A combined approach for the study of histone deacetylase inhibitors

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Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

Takizawa, D., Kakizaki, S., Horiguchi, N., Tojima, H., Yamazaki, Y., Ichikawa, T., Sato, K., & Mori, M. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.032854 · Cited by 22

Valproic acid (VPA) reduces sensorimotor gating deficits and HDAC2 overexpression in the MAM animal model of schizophrenia

Bator, E., Latusz, J., Radaszkiewicz, A., Wędzony, K., & Maćkowiak, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.04.004 · Cited by 22

Chronic administration of valproic acid inhibits PC3 cell growth by suppressing tumor angiogenesis in vivo

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USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation.

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Photocarcinogenesis of topical tazarotene and isotretinoin alone and in combination with valproic acid in hairless mice

Lerche, C. M., Philipsen, P. A., Sehested, M., & Wulf, H. C. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00733.x · Cited by 22

Valproic acid synergistically enhances the cytotoxicity of gossypol in DU145 prostate cancer cells: An iTRTAQ-based quantitative proteomic analysis

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Molecular regulation of brain metabolism underlying circadian epilepsy

Chan, F., & Liu, J. S.-H. (2021) · Epilepsia · doi:10.1111/epi.16796 · Cited by 21

Valproic acid inhibits the proliferation of SHSY5Y neuroblastoma cancer cells by downregulating URG4/URGCP and CCND1 gene expression

Dodurga, Y., Gündoğdu, G., Tekin, V., Koc, T., Şatıroğlu-Tufan, N. L., Bağcı, G., & Küçükatay, V. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3330-3 · Cited by 21

Epigenetic modulation by inorganic metal complexes

Leung, C., Liu, L., Leung, K., & Ma, D. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.03.014 · Cited by 21

Rescue of altered HDAC activity recovers behavioural abnormalities in a mouse model of Angelman syndrome

Jamal, I., Kumar, V., Vatsa, N., Shekhar, S., Singh, B. K., Sharma, A., & Jana, N. R. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.05.010 · Cited by 22

Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention

Chowdhury, S. K., Liu, W., Zi, M., Li, Y., Wang, S., Tsui, H., Prehar, S., Castro, S. J., Zhang, H., Ji, Y. I., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.022941 · Cited by 21

Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs

Wang, F., McCannell, K. N., Bošković, A., Zhu, X., Shin, J., Yu, J., Gallant, J., Byron, M., Lawrence, J. B., Zhu, L. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.12.004 · Cited by 21

Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis

Zhou, J. J., Cho, J. S., Han, H., Blitz, I. L., Wang, W., & Cho, K. W. Y. (2023) · eLife · doi:10.7554/elife.79380 · Cited by 20

Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells

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Novel Interaction between Apc5p and Rsp5p in an Intracellular Signaling Pathway in Saccharomyces cerevisiae

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Valproic acid promotes the epithelial-to-mesenchymal transition of breast cancer cells through stabilization of Snail and transcriptional upregulation of Zeb1

Zhang, S., Tang, Z., Qing, B., Tang, R., Duan, Q., Ding, S., & Deng, D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172745 · Cited by 19

Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases

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Genome-Wide Screening for Genes Associated with Valproic Acid Sensitivity in Fission Yeast

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Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis

Kringel, D., Malkusch, S., & Lötsch, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147250 · Cited by 19

Chromatin Structure and Drug Resistance in Candida spp.

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Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19

Aminpour, M., Miranda, W. E., Wacker, S., Noskov, S., Houghton, M., Tyrrell, D. L., & Tuszyński, J. A. (2021) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-021-00519-5 · Cited by 17

The Class I HDAC Inhibitor Valproic Acid Strongly Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Immune System Activation

Blaauboer, A., van Koetsveld, P. M., Mustafa, D. A. M., Dumas, J., Dogan, F., van Zwienen, S., van Eijck, C. H. J., & Hofland, L. J. (2022) · Biomedicines · doi:10.3390/biomedicines10030517 · Cited by 17

Fatty acids and epigenetics in health and diseases

Chung, M.-Y., & Kim, B. H. (2024) · Food Science and Biotechnology · doi:10.1007/s10068-024-01664-3 · Cited by 21

Role of Histone Deacetylase Inhibitors in the Treatment of Lymphomas and Multiple Myeloma

Zain, J. M. (2012) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2012.01.006 · Cited by 17

Building up and knocking down: An emerging role for epigenetics and proteasomal degradation in systems consolidation

Walters, B. J., & Zovkic, I. B. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.005 · Cited by 19

Deficient spermiogenesis in mice lacking Rlim

Wang, F., Gervasi, M. G., Bošković, A., Sun, F., Rinaldi, V. D., Yu, J., Wallingford, M. C., Tourzani, D. A., Mager, J., Zhu, L. J., et al. (2021) · eLife · doi:10.7554/elife.63556 · Cited by 18

The use of catechins in Chinese hamster ovary cell media for the improvement of monoclonal antibody yields and a reduction of acidic species

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Effects of histone deacetylase inhibitor valproic acid on skeletal myocyte development

Li, Q., Foote, M., & Chen, J. (2014) · Scientific Reports · doi:10.1038/srep07207 · Cited by 17

Valproate and copper accelerate TRH-like peptide synthesis in male rat pancreas and reproductive tissues

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The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil

Kiweler, N., Schwarz, H., Nguyen, A., Matschos, S., Mullins, C. S., Piée‐Staffa, A., Brachetti, C., Roos, W. P., Schneider, G., Linnebacher, M., et al. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09731-3 · Cited by 16

Combined therapy of colon carcinomas with an oncolytic adenovirus and valproic acid

Bressy, C., Majhen, D., Raddi, N., Jdey, W., Cornilleau, G., Zig, L., Guirouilh‐Barbat, J., López, B. S., Bawa, O., Opolon, P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22107 · Cited by 16

The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines

Duan, H., Wang, C., Zhou, K., Wang, T., Li, Y., Qiu, D., Li, Q., Zhang, Y., & Hua, Y. (2016) · Placenta · doi:10.1016/j.placenta.2016.11.011 · Cited by 16

Histone deacetylase inhibitors differentially regulate c‑Myc expression in retinoblastoma cells

Yu, N. H., Chen, P., Wang, Q., Liang, M., Qiu, J., Zhou, P., Yang, M., Yang, P., Wu, Y., Han, X., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.11111 · Cited by 16

Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites

Moreno‐Torres, M., Guzmán, C., Petrov, P., & Jover, R. (2022) · Nutrients · doi:10.3390/nu14132673 · Cited by 15

The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat

Hoffend, N. C., Magner, W. J., & Tomasi, T. B. (2016) · Epigenetics · doi:10.1080/15592294.2016.1267886 · Cited by 15

Paediatric patients with acute leukaemia and KMT 2A ( MLL ) rearrangement show a distinctive expression pattern of histone deacetylases

Vega‐García, N., Malatesta, R., Estella, C., Pérez‐Jaume, S., Esperanza‐Cebollada, E., Torrebadell, M., Català, A., Gassiot, S., Berrueco, R., Ruiz‐Llobet, A., et al. (2018) · British Journal of Haematology · doi:10.1111/bjh.15436 · Cited by 15

Trichostatin A promotes GLI1 degradation and P21 expression in multiple myeloma cells

Geng, Y., Liu, J., Xie, Y., Jiang, H., Zuo, K., Li, T., & Liu, Z. (2018) · Cancer Management and Research · doi:10.2147/cmar.s167330 · Cited by 15

Rlim/Rnf12, Rex1, and X Chromosome Inactivation

Wang, F., & Bach, I. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00258 · Cited by 15

Dysregulation of the chromatin environment leads to differential alternative splicing as a mechanism of disease in a human model of autism spectrum disorder

Leung, C. S., Rosenzweig, S. J., Yoon, B., Marinelli, N. A., Hollingsworth, E. W., Maguire, A. M., Cowen, M. H., Schmidt, M., Imitola, J., Uzun, E. D. G., et al. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad002 · Cited by 16

Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells

Licht, V., Noack, K., Schlott, B., Förster, M., Schlenker, Y., Licht, A., Krämer, O. H., & Heinzel, T. (2014) · Oncotarget · doi:10.18632/oncotarget.1911 · Cited by 15

Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma

Bhattacharya, S., Reddy, D., Ingle, A., Khade, B., & Gupta, S. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216649262 · Cited by 15

HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers

Vulcano, F., Ciccarelli, C., Mattia, G., Marampon, F., Macioce, G., Milazzo, L., Pascuccio, M., ZANI, B. M., Giampaolo, A., & Hassan, H. J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.01.017 · Cited by 15

Chemopreventive Effects of an HDAC2-Selective Inhibitor on Rat Colon Carcinogenesis and APCmin/+ Mouse Intestinal Tumorigenesis

Ravillah, D., Mohammed, A., Li, Q., Brewer, M. F., Zhang, Y., Biddick, L., Steele, V. E., & Rao, C. V. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.208645 · Cited by 14

Histone deacetylase 2 inhibitor valproic acid attenuates bisphenol A-induced liver pathology in male mice

Al-Griw, M. A., Alshibani, Z. O., Alghazeer, R. O., Elhensheri, M., Tabagh, R. M., Eskandrani, A. A., Alansari, W. S., Habibulla, M. M., & Shamlan, G. H. (2022) · Scientific Reports · doi:10.1038/s41598-022-12937-4 · Cited by 14

Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro

Jin, Y.-X., Zhao, M., Zheng, Z., Kwon, J.-S., Lee, S., Cui, X., & Kim, N. (2013) · Reproduction Fertility and Development · doi:10.1071/rd13013 · Cited by 14

Pharmacokinetics and tissue distribution of N-(2-hydroxyphenyl)-2-propylpentanamide in Wistar Rats and its binding properties to human serum albumin

Correa-Basurto, A. M., Romero‐Castro, A., Correa‐Basurto, J., Rodríguez, M. H., Soriano-Ursua, M. A., García‐Machorro, J., Tolentino-López, L. E., Rosales‐Hernández, M. C., & Mendieta‐Wejebe, J. E. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.09.010 · Cited by 14

E3 ligase RCHY1 negatively regulates HDAC2

Choi, M., Choi, Y. M., An, I., Bae, S., Jung, J. H., & An, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.10.049 · Cited by 14

Interferon-γ regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells

Ren, W.-B., Xia, X., Huang, J., Guo, W., Che, Y., Huang, T.-H., & Lei, L. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1800211 · Cited by 13

Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion

Nguyen, A., Dzulko, M., Murr, J., Yun, Y., Schneider, G., & Krämer, O. (2021) · Cells · doi:10.3390/cells10102520 · Cited by 10

c‐Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity‐dependent manner

Aoyama, K., Yamaguchi, N., Yuki, R., Morii, M., Kubota, S., Hirata, K., Abe, K., Honda, T., Kuga, T., Hashimoto, Y., et al. (2015) · Cell Biology International · doi:10.1002/cbin.10413 · Cited by 14

Crosstalk between Epigenetic Modulations in Valproic Acid Deactivated Hepatic Stellate Cells: An Integrated Protein and miRNA Profiling Study

Lü, P., Yan, M., He, L., Li, J., Ji, Y., & Ji, J. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.28642 · Cited by 13

Regulation of somatostatin expression by vitamin D3 and valproic acid in human adipose-derived mesenchymal stem cells

Doering, L., Khatri, R., Petry, S. F., Sauer, H., Howaldt, H., & Linn, T. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1330-x · Cited by 13

Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition

青华, Aono, J., Findeisen, H. M., Jones, K. L., Heywood, E. B., & Bruemmer, D. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25226 · Cited by 13

The Effect of Sodium Valproate on the Glioblastoma U87 Cell Line Tumor Development on the Chicken Embryo Chorioallantoic Membrane and on EZH2 and p53 Expression

Kavaliauskaitė, D., Stakišaitis, D., Martinkutė, J., Šlekienė, L., Kazlauskas, A., Balnytė, I., Lesauskaitė, V., & Valančiūtė, A. (2017) · BioMed Research International · doi:10.1155/2017/6326053 · Cited by 13

SARS-CoV-2 Infection, Sex-Related Differences, and a Possible Personalized Treatment Approach with Valproic Acid: A Review

Stakišaitis, D., Kapočius, L., Valančiūtė, A., Balnytė, I., Tamošuitis, T., Vaitkevičius, A., Sužiedėlis, K., Urbonienė, D., Tatarūnas, V., Kilimaitė, E., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10050962 · Cited by 12

Histone deacetylase inhibitors in multiple myeloma

Deleu, S., Menu, E., Valckenborgh, E. V., Camp, B. V., Fraczek, J., Broek, I. V., Rogiers, V., & Vanderkerken, K. (2009) · Hematology Reports · doi:10.4081/hr.2009.e9 · Cited by 12

Histone deacetylase inhibitors: can we consider potent anti-neoplastic agents for the treatment of asthma?

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Histone Deacetylase Inhibitors Increase p27Kip1 by Affecting Its Ubiquitin‐Dependent Degradation through Skp2 Downregulation

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