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E‐cadherin controls adherens junctions in the epidermis and the renewal of hair follicles
Open accessAbstract
E-cadherin is thought to mediate intercellular adhesion in the mammalian epidermis and in hair follicles as the adhesive component of adherens junctions. We have tested this role of E-cadherin directly by conditional gene ablation in the mouse. We show that postnatal loss of E-cadherin in keratinocytes leads to a loss of adherens junctions and altered epidermal differentiation without accompanying signs of inflammation. Overall tissue integrity and desmosomal structures were maintained, but skin hair follicles were progressively lost. Tumors were not observed and beta-catenin levels were not strongly altered in the mutant skin. We conclude that E-cadherin is required for maintaining the adhesive properties of adherens junctions in keratinocytes and proper skin differentiation. Furthermore, continuous hair follicle cycling is dependent on E-cadherin.
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“As described previously (Young et al, 2003;Tinkle et al, 2004), no difference in localization of desmosomal markers like plakoglobin, desmocollin 2 and desmoglein 1/2 was observed (Figure 3A).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Young et al, 2003
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“Both phenotypes are not observed in K14-Cre/Ecad Fl/À mice (Young et al, 2003;Tinkle et al, 2004;this paper).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Young et al, 2003
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“This paper, and another study, in which E-cadherin was inactivated in the epidermis after birth, showed a gradual loss of hair in the E-cadherin mutant mice (Young et al, 2003;Tinkle et al, 2004).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Young et al, 2003
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Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,543
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512
Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting
Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995
van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 972
E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8263 · Cited by 930
Self-citationMOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS
Yap, A. S., Brieher, W. M., & Gumbiner, B. M. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.119 · Cited by 818
Cadherin-catenin complex: Protein interactions and their implications for cadherin function
Aberle, H., Schwartz, H. T., & Kemler, R. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960616)61:4 · Cited by 806
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Items 101–157 of 157
Wang, X., Steinberg, T., Dieterle, M. P., Ramminger, I., Husari, A., & Tomakidi, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189774 · Cited by 9
HIV-associated penile anaerobes disrupt epithelial barrier integrity
Buchanan, L. B., Shao, Z., Galiwango, R. M., Constable, S., Zuanazzi, D., Biribawa, V. M., Ssemunywa, H., Namuniina, A., Okech, B. A., Edfeldt, G., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013094 · Cited by 8
Bezděková, M., Brychtová, S., Sedlákova, E., Steigerová, J., Hlobílková, A., Bienová, M., Kučerová, R., Brychta, T., Krejci, V., & Kolář, Z. (2007) · Biomedical Papers · doi:10.5507/bp.2007.042 · Cited by 8
Lewis, N. S., Chouhan, G., Belapurkar, V., Arora, P., Satyanarayan, Ainavarapu, S. R. K., & Sonawane, M. S. (2020) · The International Journal of Developmental Biology · doi:10.1387/ijdb.190219ms · Cited by 6
Dissecting the role of cadherin–catenin proteins in mammalian epidermis
Lien, W., Stępniak-Konieczna, E., & Vasioukhin, V. I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808458105 · Cited by 6
Kim, H. J., Yang, D., & Hong, J. H. (2025) · Antioxidants · doi:10.3390/antiox14040426 · Cited by 7
Zayas, G. A., Rojas, C. S., Rodriguez, E. E., Hernandez, A. S., Beard, A., Rafiq, F., Davila, K. M. S., & Mateescu, R. G. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1576966 · Cited by 6
Prunskaite‐Hyyryläinen, R. (2014) · Cited by 5
Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis
Seidel, P., Remus, M., Delacher, M., Grigaravičius, P., Reuß, D., Frappart, L., von Deimling, A., Feuerer, M., Abdollahi, A., & Frappart, P. (2016) · Oncotarget · doi:10.18632/oncotarget.8470 · Cited by 5
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Rebey, H. S. E., Maree, A. H., Tahmody, M. E., & Naby, H. A. (2014) · Egyptian Journal of Pathology · doi:10.1097/01.xej.0000455929.33903.19 · Cited by 5
UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia
Pacella, G., Kuprasertkul, N., Bao, L., Huang, S., D’souza, C. A., Prouty, S. M., Anderson, A., López, A. M. M., Sinkfield, M., Olingou, C., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422971122 · Cited by 4
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Polak, J., Sachs, D., Scherrer, N., Süess, A., Liu, H., Levesque, M. P., Werner, S., Mazza, E., Restivo, G., Meboldt, M., et al. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213702 · Cited by 2
An E-cadherin endocytic mutant rescues the severe epidermal p120-catenin null phenotype
Schell, S. L., Seo, T., Xu, H., Sennett, M. L., Ding, K., Helm, M. F., Lanza, M. R., Nelson, A. M., & Kowalczyk, A. P. (2026) · Molecular Biology of the Cell · doi:10.1091/mbc.e26-01-0040 · Cited by 2
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Rashwan, A. M., El‐Gendy, S. A. A., Elarab, S. M. E., Seif, M. A., El‐Mansi, A. A., Eldesoqui, M. B., & Alsafy, M. (2025) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.70014 · Cited by 2
Expression profiling of adhesion proteins during prenatal and postnatal liver development in rats
Yousaf, M., Tayyeb, A., & Ali, G. (2017) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s139497 · Cited by 2
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Izaguirre, M. F., Galetto, C. D., Baró, L., & Casco, V. H. (2019) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2019.78004 · Cited by 3
Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells
Lien, W., & Vasioukhin, V. I. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0711-0_3 · Cited by 2
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Broussard, J. A., Koetsier, J. L., Hegazy, M., & Green, K. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.21.914176 · Cited by 2
Zorlu, Ö., Karabağ, S., Erdoğan, K. E., Aksın, M., & Üstün, B. (2024) · American Journal of Dermatopathology · doi:10.1097/dad.0000000000002741 · Cited by 1
Chaturvedi, D., Gore, M., Yadav, S., Majumder, A., Jain, R. D., & Dandekar, P. P. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.117187 · Cited by 3
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Joseph, L. B., Ozkuyumcu, K., Weinstock, D., Zhou, P., Croutch, C. R., & Laskin, J. D. (2026) · Cutaneous and Ocular Toxicology · doi:10.1080/15569527.2026.2718949 · Cited by 1
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Bikle, D. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809965-0.00031-8 · Cited by 1
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Connelly, J. T. (2019) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2019.04.001 · Cited by 1
Alibardi, L., & Noecker, B. (2021) · Biocell · doi:10.32604/biocell.2021.013913 · Cited by 1
The role of E-cadherin in colon cancer drug resistance.
Murray, L. J. (2010) · Enlighten: Theses (The University of Glasgow) · Cited by 1
Yu, Y., Su, Y., Opalenik, S. R., Sobolik-Delmaire, T., Neel, N. F., Zaja‐Milatovic, S., Short, S. P., Sai, J., & Richmond, A. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0807544 · Cited by 1
Becker, K., & Luber, B. (2010) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a003905.01 · Cited by 1
The role of E-cadherin in mediating epidermal stem cell differentiation
Pham, M. T. (2011) · eScholarship (California Digital Library)
Karaköse, E. (2012) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.16817
Garcia, C. M., & Gutmann, D. H. (2014) · Scientifica · doi:10.1155/2014/915725
Kaur, H. (2013) · Sycamore Scholars (Indiana State University)
Apoptotic markers in spongiotic dermatitis
Monib, K. M. E.-D., Sabry, H. H., Abdelsalam, O. H., Andl, T., Elaziz, H. A., & Elaziz, T. A. (2014) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.1097/01.ewx.0000444375.38016.90
Tight Junctions/Adherens Junctions: Basic Structure and
Niessen, F. M. (2007)
Bago, R., & Bosnar, M. H. (2007)
Rempel, G. J. (2021) · Scholarship@Western (Western University)
Yao, D., Alexander, C. L., Quinn, J. A., Porter, M. J., Wu, H., & Greenhalgh, D. A. (2023) · doi:10.1158/0008-5472.c.6495200.v1
Yao, D., Alexander, C. L., Quinn, J. A., Porter, M., Wu, H., & Greenhalgh, D. A. (2023) · doi:10.1158/0008-5472.c.6495200
Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation
Kanemaru, K., Nagasawa, K., Kunugi, Y., Tanaka, A., Ikeoku, S., Tai, Y., Harada, Y., & Nakamura, Y. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149745
Holtorf, S. M., & Morris, R. J. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.10.603
Balasubramaniam, L. (2021) · theses.fr (ABES) · doi:10.70675/1099cf72zaa1bz4f7azbfc0z3067478b32d6
Ozkuyumcu, K., Weinstock, D., Zhou, P., Croutch, C. R., Joseph, L. B., & Laskin, J. D. (2026) · Journal of Dermatology Research · doi:10.46889/jdr.2026.7301
Metadata
- Authors
- Young, P., Boussadia, O., Halfter, H., Grose, R., Berger, P., Leone, D. P., Robenek, H., Charnay, P., Kemler, R., & Suter, U.
- Affiliations
- University of Münster (DE)
- Cancer Research UK (GB)
- ETH Zurich (CH)
- Inserm (FR)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- Corresponding author
- Suter, Ueli
- Venue
- The EMBO Journal
- Published
- 2003-11-03
- Volume
- 22
- Issue
- 21
- Pages
- 5723-5733
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC275417
- OpenAlex
- W2097736136
- Cited by
- 156
- References
- 50
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 8
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- E-cadherin, adherens junctions, epidermis, keratinocytes, epidermal differentiation, conditional gene deletion, β-catenin, desmosomes, hair cycle, cell-cell adhesion
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, DNA-Binding Proteins, Epidermis, Mice, Inbred C57BL, Transcription Factors, Keratinocytes, Cadherins, Mice, Knockout, Gene Expression Regulation, Developmental, Hair Follicle, Adherens Junctions, Mice, Early Growth Response Protein 2
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