The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
E‐cadherin controls adherens junctions in the epidermis and the renewal of hair follicles
Open accessAbstract
E-cadherin is thought to mediate intercellular adhesion in the mammalian epidermis and in hair follicles as the adhesive component of adherens junctions. We have tested this role of E-cadherin directly by conditional gene ablation in the mouse. We show that postnatal loss of E-cadherin in keratinocytes leads to a loss of adherens junctions and altered epidermal differentiation without accompanying signs of inflammation. Overall tissue integrity and desmosomal structures were maintained, but skin hair follicles were progressively lost. Tumors were not observed and beta-catenin levels were not strongly altered in the mutant skin. We conclude that E-cadherin is required for maintaining the adhesive properties of adherens junctions in keratinocytes and proper skin differentiation. Furthermore, continuous hair follicle cycling is dependent on E-cadherin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As described previously (Young et al, 2003;Tinkle et al, 2004), no difference in localization of desmosomal markers like plakoglobin, desmocollin 2 and desmoglein 1/2 was observed (Figure 3A).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Young et al, 2003
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both phenotypes are not observed in K14-Cre/Ecad Fl/À mice (Young et al, 2003;Tinkle et al, 2004;this paper).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Young et al, 2003
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“This paper, and another study, in which E-cadherin was inactivated in the epidermis after birth, showed a gradual loss of hair in the E-cadherin mutant mice (Young et al, 2003;Tinkle et al, 2004).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Young et al, 2003
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,543
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512
Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting
Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995
van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 972
E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8263 · Cited by 930
Self-citationMOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS
Yap, A. S., Brieher, W. M., & Gumbiner, B. M. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.119 · Cited by 818
Cadherin-catenin complex: Protein interactions and their implications for cadherin function
Aberle, H., Schwartz, H. T., & Kemler, R. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960616)61:4 · Cited by 806
Self-citation
Cited by
Sorted by citations
The cell-cell adhesion molecule E-cadherin
Roy, F. M. V., & Berx, G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8281-1 · Cited by 1,392
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
Schmalhofer, O., Brabletz, S., & Brabletz, T. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9179-y · Cited by 771
Tight junctions/adherens junctions: basic structure and function
Niessen, C. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700865 · Cited by 756
Derksen, P. W. B., Liu, X., Saridin, F., van der Gulden, H., Zevenhoven, J., Evers, B., van Beijnum, J. R., Griffioen, A. W., Vink, J., Krimpenfort, P., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.09.013 · Cited by 591
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
Simpson, C. L., Patel, D. M., & Green, K. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3175 · Cited by 516
E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
Tunggal, J. A., Helfrich, I., Schmitz, A., Schwarz, H., Günzel, D., Fromm, M., Kemler, R., Krieg, T., & Niessen, C. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600605 · Cited by 491
Self-citationNiessen, C. M., Leckband, D., & Yap, A. S. (2011) · Physiological Reviews · doi:10.1152/physrev.00004.2010 · Cited by 427
Calcium regulation of keratinocyte differentiation
Bikle, D. D., Xie, Z., & Tu, C. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.34 · Cited by 345
Battle, M. A., Konopka, G., Parviz, F., Gaggl, A. L., Yang, C., Sladek, F. M., & Duncan, S. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600246103 · Cited by 246
Maternal β-catenin and E-cadherin in mouse development
de Vries, W. N., Evsikov, A. V., Haac, B. E., Fancher, K. S., Holbrook, A. E., Kemler, R., Solter, D., & Knowles, B. B. (2004) · Development · doi:10.1242/dev.01316 · Cited by 217
Self-citationPhosphoinositide 3-Kinase Signaling to Akt Promotes Keratinocyte Differentiation Versus Death
Calautti, E., Li, J., Saoncella, S., Brissette, J. L., & Goetinck, P. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506119200 · Cited by 216
Cadherins in development and cancer
Stemmler, M. P. (2008) · Molecular BioSystems · doi:10.1039/b719215k · Cited by 219
A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation
Schneider, M. R., Dahlhoff, M., Horst, D. A., Hirschi, B., Trülzsch, K., Müller‐Höcker, J., Vogelmann, R., Allgäuer, M., Gerhard, M., Steininger, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014325 · Cited by 206
Tinkle, C. L., Lechler, T., Pasolli, H. A., & Fuchs, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307437100 · Cited by 193
Cdc42 controls progenitor cell differentiation and β-catenin turnover in skinPreprint
Wu, X., Quondamatteo, F., Lefever, T., Czuchra, A., Meyer, H., Chrostek, A., Paus, R., Langbein, L., & Brakebusch, C. (2006) · Genes & Development · doi:10.1101/gad.361406 · Cited by 172
Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate DevelopmentPreprint
Stępniak-Konieczna, E., Radice, G. L., & Vasioukhin, V. I. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002949 · Cited by 175
Müller, E. J., Williamson, L., Kolly, C., & Suter, M. M. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701248 · Cited by 166
Miyashita, Y., & Ozawa, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608351200 · Cited by 143
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity
Tinkle, C. L., Pasolli, H. A., Stokes, N., & Fuchs, E. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807374105 · Cited by 138
ALX4 dysfunction disrupts craniofacial and epidermal development
Kayserili, H., Uz, E., Niessen, C. M., Vargel, İ., Alanay, Y., Tunçbi̇lek, G., Yigit, G., Uyguner, Z. O., Candan, Ş., Okur, H., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp391 · Cited by 132
Tu, C., Chang, W., Xie, Z., & Bikle, D. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708318200 · Cited by 130
Cell Adhesion in Epidermal Development and Barrier Formation
Sumigray, K., & Lechler, T. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.027 · Cited by 116
ATP‐dependent nucleosome remodeling complexes: Enzymes tailored to deal with chromatin
Sif, S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20005 · Cited by 107
Xie, Z., & Bikle, D. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609135200 · Cited by 103
Wahlsten, A., Rütsche, D., Nanni, M., Giampietro, C., Biedermann, T., Ernst Reichmann, A., & Mazza, E. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120779 · Cited by 99
E-cadherin is required for intestinal morphogenesis in the mouse
Bondow, B. J., Faber, M. L., Wojta, K. J., Walker, E. M., & Battle, M. A. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.005 · Cited by 98
Rezza, A., Sennett, R., & Rendl, M. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00012-3 · Cited by 99
Jin, Y., Shenoy, A. K., Doernberg, S. N., Chen, H., Luo, H., Shen, H., Lin, T., Tarrash, M., Cai, Q., Hu, X., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.03.037 · Cited by 87
Cadherin–catenin proteins in vertebrate development
Lien, W., Klezovitch, O., & Vasioukhin, V. I. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.07.001 · Cited by 80
Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b
Lüdtke, T. H., Farin, H. F., Rudat, C., Schuster-Gossler, K., Petry, M., Barnett, P., Christoffels, V. M., & Kispert, A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003189 · Cited by 81
A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis
Tominaga, M., Ozawa, S., Ogawa, H., & Takamori, K. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2007.02.002 · Cited by 76
Kuphal, F., & Behrens, J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.007 · Cited by 80
Giangreco, A., Lu, L., Vickers, C., TEIXEIRA, V. H., Groot, K. R., Butler, C. R., Ilieva, E. V., George, P. J., Nicholson, A. G., Sage, E. K., et al. (2011) · The Journal of Pathology · doi:10.1002/path.3962 · Cited by 73
Carlomagno, G., van Bragt, M. P. A., Korver, C. M., Repping, S., de Rooij, D. G., & van Pelt, A. M. M. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.085456 · Cited by 70
Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function
Tu, C., & Bikle, D. D. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.03.002 · Cited by 69
Vasioukhin, V. I. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4186-7_16 · Cited by 67
Choi, J., Nam, S., Song, Y.-S., Lee, H.-W., Lee, H. J., Song, K., Hong, J. W., & Kim, G. (2014) · Archives of Dermatological Research · doi:10.1007/s00403-014-1463-9 · Cited by 65
Prolactin delays hair regrowth in mice
Craven, A. J., Nixon, A. J., Ashby, M. G., Ormandy, C. J., Blazek, K. D., Wilkins, R. J., & Pearson, A. J. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06685 · Cited by 63
Cadherin-Mediated Cell–Cell Contact Regulates Keratinocyte Differentiation
Charest, J. L., Jennings, J. M., King, W. P., Kowalczyk, A. P., & Garcı́a, A. J. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.265 · Cited by 62
Kimball, A. B., Alora-Palli, M. B., Tamura, M., Mullins, L. A., Soh, C., Binder, R. L., Houston, N. A., Conley, E. D., Tung, J. Y., Annunziata, N. E., et al. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.09.012 · Cited by 62
Amphiregulin Causes Functional Downregulation of Adherens Junctions in Psoriasis
Chung, E., Cook, P. W., Parkos, C. A., Park, Y., Pittelkow, M. R., & Coffey, R. J. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23762.x · Cited by 62
Tu, C., Chang, W., & Bikle, D. D. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.414 · Cited by 61
Role of TGFβ in skin inflammation and carcinogenesis
Li, A. G., Lu, S., Han, G., Hoot, K. E., & Wang, X. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20229 · Cited by 61
E‐cadherin's role in development, tissue homeostasis and disease: Insights from mouse models
Schneider, M. R., & Kolligs, F. T. (2014) · BioEssays · doi:10.1002/bies.201400141 · Cited by 60
Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function
Rivard, N. (2009) · Frontiers in bioscience · doi:10.2741/3259 · Cited by 55
Nakai, K., Yoneda, K., Hosokawa, Y., Moriue, T., Presland, R. B., Fallon, P. G., Kabashima, K., Kosaka, H., & Kubota, Y. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.005 · Cited by 51
Apoptosis may underlie the pathology of zinc‐deficient skin
Wilson, D., Varigos, G., & Ackland, M. L. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01391.x · Cited by 51
Broussard, J. A., Koetsier, J. L., Hegazy, M., & Green, K. J. (2021) · Current Biology · doi:10.1016/j.cub.2021.05.021 · Cited by 42
E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis
Brand, A., Diener, N., Zahner, S. P., Tripp, C. H., Backer, R. A., Karram, K., Jiang, A., Mellman, I., Stoitzner, P., & Clausen, B. E. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.06.132 · Cited by 42
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients
Chung, S., Low, S., Zembutsu, H., Takahashi, A., Kubo, M., Sasa, M., & Nakamura, Y. (2013) · Breast Cancer Research · doi:10.1186/bcr3475 · Cited by 44
Cirillo, N., Femiano, F., Gombos, F., & Lanza, A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.089 · Cited by 44
Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function
Brandner, J. M., Haftek, M., & Niessen, C. M. (2010) · The Open Dermatology Journal · doi:10.2174/1874372201004010014 · Cited by 43
Calı̀, G., Zannini, M., Rubini, P., Tacchetti, C., D’Andrea, B., Affuso, A., Wintermantel, T. M., Boussadia, O., Terracciano, D., Silberschmidt, D., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1344 · Cited by 41
Self-citationAhn, M., Cho, W., Lee, H., Park, W., Lee, S. H., Back, J. W., Gao, Q., Gao, G., Cho, D., & Kim, B. S. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301015 · Cited by 41
E-cadherin dynamics is regulated by galectin-7 at epithelial cell surface
Advedissian, T., Proux‐Gillardeaux, V., Nkosi, R., Peyret, G., Nguyen, T., Poirier, F., Viguier, M., & Deshayes, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-17332-y · Cited by 41
A Novel Role for Integrin-linked Kinase in Epithelial Sheet Morphogenesis
Vespa, A., D’Souza, S. J. A., & Dagnino, L. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0087 · Cited by 38
E-cadherin Controls Bronchiolar Progenitor Cells and Onset of Preneoplastic Lesions in Mice
Ceteci, F., Ceteci, S., Zanucco, E., Thakur, C., Becker, M., El-Nikhely, N. A., Fink, L., Seeger, W., Savai, R., & Rapp, U. R. (2012) · Neoplasia · doi:10.1593/neo.121088 · Cited by 36
DNA methylation of E-cadherin is a priming mechanism for prostate development
Keil, K. P., Abler, L. L., Mehta, V., Altmann, H. M., Laporta, J., Plisch, E. H., Suresh, M., Hernandez, L. L., & Vezina, C. M. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.01.020 · Cited by 35
Necl2 regulates epidermal adhesion and wound repair
Giangreco, A., Jensen, K. B., Takai, Y., Miyoshi, J., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038232 · Cited by 36
Choi, S., Park, J., Kim, J., Lee, K., Kim, E., Jeong, K., & Jeon, W. B. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.006 · Cited by 34
Espada, J., Galaz, S., Sanz-Rodrı́guez, F., Blázquez‐Castro, A., STOCKERT, J. C., Bagazgoitia, L., Jaén, P., González, S., Cano, A., & Juarranz, Á. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21652 · Cited by 34
Xiao, P., Zhong, T., Liu, Z., Ding, Y., Guan, W., He, X., Pu, Y., Jiang, L., Ma, Y., & Zhao, Q. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2019.01263 · Cited by 34
Effects of IGF-Binding Protein 5 in Dysregulating the Shape of Human Hair
Sriwiriyanont, P., Hachiya, A., Pickens, W. L., Moriwaki, S., Kitahara, T., Visscher, M. O., Kitzmiller, W. J., Bello, A., Takema, Y., & Kobinger, G. P. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.309 · Cited by 32
Cadherin expression in the developing mouse olfactory system
Akins, M. R., Benson, D. L., & Greer, C. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21270 · Cited by 31
Wang, T., Sun, J., Huang, Y., Wu, H., Chen, L.-T., & Lin, F. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.05.004 · Cited by 30
Simon, D., Lindberg, R. L. P., Kozlowski, E., Braathen, L. R., & Simon, H. (2006) · Experimental Dermatology · doi:10.1111/j.0906-6705.2006.00428.x · Cited by 30
Yao, D., Alexander, C. L., Quinn, J. A., Porter, M., Wu, H., & Greenhalgh, D. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2341 · Cited by 29
CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading
Huang, X., Xiao, L., Zhou, Y., Li, H., Du, H., Suo, Y., Liu, W., Jin, R., Chai, B., Duan, R., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.51309 · Cited by 28
Compliance-induced adherens junction formation in epithelial cells and tissues is regulated by JNK
You, H., Padmashali, R. M., Ranganathan, A., Lei, P., Girnius, N., Davis, R. J., & Andreadis, S. T. (2013) · Journal of Cell Science · doi:10.1242/jcs.122903 · Cited by 30
Gendronneau, G., Sanii, S., Dang, T., Deshayes, F., Delacour, D., Pichard, E., Advedissian, T., Sidhu, S., Viguier, M., Magnaldo, T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119031 · Cited by 27
Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin
Wu, X., Quondamatteo, F., & Brakebusch, C. (2006) · Matrix Biology · doi:10.1016/j.matbio.2006.09.001 · Cited by 27
Tuning the Kinetics of Cadherin Adhesion
Sivasankar, S. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.229 · Cited by 27
Multifaceted Roles of Connexin 43 in Stem Cell Niches
Genet, N., Bhatt, N., Bourdieu, A., & Hirschi, K. K. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0110-3 · Cited by 26
Sayedyahossein, S., Rudkouskaya, A., Leclerc, V., & Dagnino, L. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.10.056 · Cited by 24
Ly6C+ monocytes in the skin promote systemic alphavirus dissemination
Holmes, A. C., Lucas, C. J., Brisse, M. E., Ware, B. C., Hickman, H. D., Morrison, T. E., & Diamond, M. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113876 · Cited by 23
van der Werf, C. S., Hsiao, N., Conroy, S., Paredes, J., Ribeiro, A. S., Sribudiani, Y., Seruca, R., Hofstra, R. M. W., Westers, H., & van IJzendoorn, S. C. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054649 · Cited by 24
JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia
Strobl, K., Klufa, J., Jin, R., Artner-Gent, L., Krauß, D., Novoszel, P., Strobl, J., Stary, G., Vujic, I., Griss, J., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00166-3 · Cited by 25
Bao, Q., Ma, X., Jia, C., Wu, X., Wu, Y., Meng, G., Bao, P., Chu, M., Guo, X., Liang, C., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.798076 · Cited by 22
Degen, M., Wiederkehr, A., Scala, G. C. L., Carmann, C., Schnyder, I., & Katsaros, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01703 · Cited by 23
The Misregulation of Cell Adhesion Components during Tumorigenesis: Overview and Commentary
Andl, C. D. (2010) · Journal of Oncology · doi:10.1155/2010/174715 · Cited by 25
SPC24 is critical for anaplastic thyroid cancer progression
Yin, H., Meng, T., Zhou, L., Chen, H., & Song, D. (2017) · Oncotarget · doi:10.18632/oncotarget.15670 · Cited by 22
Identification of novel cell-adhesion molecules in peripheral nerves using a signal-sequence trap
Spiegel, I., Adamsky, K., Eisenbach, M., Eshed‐Eisenbach, Y., Spiegel, A., Mirsky, R., Scherer, S. S., & Peles, E. (2005) · Neuron Glia Biology · doi:10.1017/s1740925x0600007x · Cited by 21
Cadherin‐Mediated Regulation of Tight Junctions in Stratifying Epithelia
Michels, C., Aghdam, S. Y., & Niessen, C. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04443.x · Cited by 20
Zhao, R., Liu, N., Han, F., Li, H., Liu, J., Li, L., Wang, G., & He, J. (2020) · BMC Genomics · doi:10.1186/s12864-020-6599-8 · Cited by 19
Obligatory roles of filamin A in E-cadherin-mediated cell–cell adhesion in epidermal keratinocytes
Tu, C., & You, M. S. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.09.007 · Cited by 19
Jiang, X., Teng, M., Ji, R., Zhang, D., Zhang, Z., Lv, Y., Zhang, Q., Zhang, J., & Huang, Y. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.118574 · Cited by 18
E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions
Nelson, A. M., Cong, Z., Gettle, S. L., Longenecker, A. L., Kidacki, M., Kirby, J. S., Adams, D. R., Stairs, D. B., & Danby, F. W. (2019) · Experimental Dermatology · doi:10.1111/exd.13973 · Cited by 18
Wongwanakul, R., Jianmongkol, S., Gonil, P., Sajomsang, W., Maniratanachote, R., & Aueviriyavit, S. (2016) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911516658780 · Cited by 18
Abud, H. E., Lock, P., & Heath, J. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.006 · Cited by 17
Adherens Junctions and Stem Cells
Lechler, T. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4186-7_15 · Cited by 14
Cytoskeletal anchorage of different Dsg3 pools revealed by combination of hybrid STED/SMFS-AFM
Fuchs, M. T., Radeva, M. Y., Spindler, V., Vielmuth, F., Kugelmann, D., & Waschke, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04681-9 · Cited by 13
Honey Extracted Polyphenolics Reduce Experimental Hypoxia in Human Keratinocytes Culture
Chaudhary, A., Bag, S., Banerjee, P., & Chatterjee, J. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00366 · Cited by 13
Michalczyk‐Wetula, D., Popik, M., Salwiński, A., & Plonka, P. M. (2009) · Acta Biochimica Polonica · doi:10.18388/abp.2009_2467 · Cited by 12
Interplay between EGFR, E-cadherin, and PTP1B in epidermal homeostasis
Arnaud, T., Rodrigues‐Lima, F., Viguier, M., & Deshayes, F. (2022) · Tissue Barriers · doi:10.1080/21688370.2022.2104085 · Cited by 12
Alibardi, L., & Noecker, B. (2013) · Acta Histochemica · doi:10.1016/j.acthis.2012.11.011 · Cited by 11
Epidermal cell junctions and their regulation by p63 in health and disease
Ferone, G., Mollo, M. R., & Missero, C. (2015) · Cell and Tissue Research · doi:10.1007/s00441-014-2108-1 · Cited by 11
Culturing Keratinocytes on Biomimetic Substrates Facilitates Improved Epidermal Assembly In Vitro
Hunter-Featherstone, E., Young, N., Chamberlain, K. L., Cubillas, P., Hulette, B. C., Wei, X., Tiesman, J. P., Bascom, C. C., Benham, A. M., Goldberg, M. W., et al. (2021) · Cells · doi:10.3390/cells10051177 · Cited by 11
Adherens Junctions in Mammalian Development, Homeostasis and Disease: Lessons from Mice
Boggetti, B., & Niessen, C. M. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4186-7_14 · Cited by 11
Skin remodeling and wound healing in the Gottingen minipig following exposure to sulfur mustard
Laskin, J. D., Wahler, G., Croutch, C. R., Sinko, P. J., Laskin, D. L., Heck, D. E., & Joseph, L. B. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104470 · Cited by 10
CtBP1 Overexpression in Keratinocytes Perturbs Skin Homeostasis
Deng, H., Li, F., Li, H., Deng, Y., Liu, J., Wang, D., Han, G., Wang, X., & Zhang, Q. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.504 · Cited by 10
Metadata
- Authors
- Young, P., Boussadia, O., Halfter, H., Grose, R., Berger, P., Leone, D. P., Robenek, H., Charnay, P., Kemler, R., & Suter, U.
- Affiliations
- University of Münster (DE)
- Cancer Research UK (GB)
- ETH Zurich (CH)
- Inserm (FR)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- Corresponding author
- Suter, Ueli
- Venue
- The EMBO Journal
- Published
- 2003-11-03
- Volume
- 22
- Issue
- 21
- Pages
- 5723-5733
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC275417
- OpenAlex
- W2097736136
- Cited by
- 156
- References
- 50
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 8
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- E-cadherin, adherens junctions, epidermis, keratinocytes, epidermal differentiation, conditional gene deletion, β-catenin, desmosomes, hair cycle, cell-cell adhesion
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, DNA-Binding Proteins, Epidermis, Mice, Inbred C57BL, Transcription Factors, Keratinocytes, Cadherins, Mice, Knockout, Gene Expression Regulation, Developmental, Hair Follicle, Adherens Junctions, Mice, Early Growth Response Protein 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
