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Cited by 650

The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.

Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus

Open access
Raman, Betty, Bluemke, David A., Lüscher, Thomas F., Neubauer, Stefan·2022·European Heart Journal

Abstract

Emerging as a new epidemic, long COVID or post-acute sequelae of coronavirus disease 2019 (COVID-19), a condition characterized by the persistence of COVID-19 symptoms beyond 3 months, is anticipated to substantially alter the lives of millions of people globally. Cardiopulmonary symptoms including chest pain, shortness of breath, fatigue, and autonomic manifestations such as postural orthostatic tachycardia are common and associated with significant disability, heightened anxiety, and public awareness. A range of cardiovascular (CV) abnormalities has been reported among patients beyond the acute phase and include myocardial inflammation, myocardial infarction, right ventricular dysfunction, and arrhythmias. Pathophysiological mechanisms for delayed complications are still poorly understood, with a dissociation seen between ongoing symptoms and objective measures of cardiopulmonary health. COVID-19 is anticipated to alter the long-term trajectory of many chronic cardiac diseases which are abundant in those at risk of severe disease. In this review, we discuss the definition of long COVID and its epidemiology, with an emphasis on cardiopulmonary symptoms. We further review the pathophysiological mechanisms underlying acute and chronic CV injury, the range of post-acute CV sequelae, and impact of COVID-19 on multiorgan health. We propose a possible model for referral of post-COVID-19 patients to cardiac services and discuss future directions including research priorities and clinical trials that are currently underway to evaluate the efficacy of treatment strategies for long COVID and associated CV sequelae.

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Crossref · 10.1093/eurheartj/ehac031

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Metadata

Authors
Raman, B., Bluemke, D. A., Lüscher, T. F., & Neubauer, S.
Venue
European Heart Journal
Published
2022-02-18
Volume
43
Issue
11
Pages
1157-1172
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W4210657012
Cited by
650
References
251
FWCI
69.95
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus. https://app.cochat.ai/papers/10.1093/eurheartj/ehac031
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Raman, B., Bluemke, D. A., Lüscher, T. F., & Neubauer, S. (2022). Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus. European Heart Journal. https://doi.org/10.1093/eurheartj/ehac031

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.