The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
Open accessAbstract
Emerging as a new epidemic, long COVID or post-acute sequelae of coronavirus disease 2019 (COVID-19), a condition characterized by the persistence of COVID-19 symptoms beyond 3 months, is anticipated to substantially alter the lives of millions of people globally. Cardiopulmonary symptoms including chest pain, shortness of breath, fatigue, and autonomic manifestations such as postural orthostatic tachycardia are common and associated with significant disability, heightened anxiety, and public awareness. A range of cardiovascular (CV) abnormalities has been reported among patients beyond the acute phase and include myocardial inflammation, myocardial infarction, right ventricular dysfunction, and arrhythmias. Pathophysiological mechanisms for delayed complications are still poorly understood, with a dissociation seen between ongoing symptoms and objective measures of cardiopulmonary health. COVID-19 is anticipated to alter the long-term trajectory of many chronic cardiac diseases which are abundant in those at risk of severe disease. In this review, we discuss the definition of long COVID and its epidemiology, with an emphasis on cardiopulmonary symptoms. We further review the pathophysiological mechanisms underlying acute and chronic CV injury, the range of post-acute CV sequelae, and impact of COVID-19 on multiorgan health. We propose a possible model for referral of post-COVID-19 patients to cardiac services and discuss future directions including research priorities and clinical trials that are currently underway to evaluate the efficacy of treatment strategies for long COVID and associated CV sequelae.
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Cites
1 retracted
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“Given the strong association between obesity and long COVID, measures to reduce weight through caloric restriction, diet, tailored graded exercise, stress reduction, and good sleep hygiene could be beneficial in the long run,(223) with growing evidence indicating its favourable effects on systemic inflammation,(224) v…”
BackgroundLa certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463
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Cited by
Heidecker, B., Dagan, N., Balicer, R., Eriksson, U., Rosano, G., Coats, A., Tschöpe, C., Kelle, S., Poland, G. A., Frustaci, A., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2669 · Cited by 159
Self-citationSelf, W. H., Shotwell, M. S., Gibbs, K. W., de Wit, M., Files, D. C., Harkins, M., Hudock, K. M., Merck, L. H., Moskowitz, A., Apodaca, K. D., et al. (2023) · JAMA · doi:10.1001/jama.2023.3546 · Cited by 52
Cell-Specific Mechanisms in the Heart of COVID-19 Patients
Tsai, E. J., Čiháková, D., & Tucker, N. R. (2023) · Circulation Research · doi:10.1161/circresaha.123.321876 · Cited by 37
Chen, H., Peng, J., Wang, T., Wen, J., Chen, S., Huang, Y., & Zhang, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115370 · Cited by 19
Metadata
- Authors
- Raman, B., Bluemke, D. A., Lüscher, T. F., & Neubauer, S.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-02-18
- Volume
- 43
- Issue
- 11
- Pages
- 1157-1172
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W4210657012
- Cited by
- 650
- References
- 251
- FWCI
- 69.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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