Personality traits and heart rate variability predict long-term cardiac mortality after myocardial infarction
Abstract
Aims To investigate personality traits and sympatho-vagal modulation of heart rate variability (HRV) during acute myocardial infarction (AMI), assessing their relationships and their long-term prognostic value. Methods and results Psychological traits and 24 h HRV were prospectively investigated in 246 patients at discharge of an AMI. Patients were followed-up to 8 years for the occurrence of cardiac death and non-fatal reinfarction. Low coping and anxiety traits associated with reduced HRV characterized the study population. At univariate analysis, low emotional sensitivity and insecurity, relative tachycardia, reduced high frequency (HF), and low frequency power and pNN50 were predictive of cardiac death at 8-year follow-up. At multivariable analysis, low emotional sensitivity and low HF power remained predictive, with a relative risk of 4.18 (P=0.003) and 2.76 (P=0.007), respectively; also the type of infarction (Q vs. non-Q) and hospital length of stay were independent predictive variables. Conclusion Anxiety and emotional sensitivity were significant predictors of 8-year cardiac mortality after AMI. Reduced HF power, a recognized marker of vagal withdrawal, increased the risk.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic persistent psychological distress can lead to increased sympathetic tone, decreased vagal tone, decreased heart rate variability, and increased arterial stiffness and endothelial dysfunction.
“Chronic persistent psychological distress can also lead to increased sympathetic tone, decreased vagal tone, decreased heart rate variability, and increased arterial stiffness and endothelial dysfunction. 120-123”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [123]
Cited by
Sorted by citations
Levine, G. N., Cohen, B. E., Commodore-Mensah, Y., Fleury, J., Huffman, J. C., Khalid, U., Labarthe, D. R., Lavretsky, H., Michos, E. D., Spatz, E. S., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000947 · Cited by 865 · see citing works
Anxiety disorders and comorbid medical illness
Roy-Byrne, P. P., Davidson, K. W., Kessler, R. C., Asmundson, G. J. G., Goodwin, R. D., Kubzansky, L., Lydiard, R. B., Massie, M. J., Katon, W., Laden, S. K., et al. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.12.006 · Cited by 668 · see citing works
Fang, S.-C., Wu, Y.-L., & Tsai, P.-S. (2020) · Biological Research For Nursing · doi:10.1177/1099800419877442 · Cited by 302 · see citing works
Kemp, A. H., Koenig, J., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.006 · Cited by 114 · see citing works
Cardiac autonomic dysregulation in acute schizophrenia
Chang, H.-A., Chang, C.-C., Tzeng, N.-S., Kuo, T. B. J., Lu, R.-B., & Huang, S.-Y. (2013) · Acta Neuropsychiatrica · doi:10.1111/acn.12014 · Cited by 30 · see citing works
- Authors
- Carpeggiani, C., Emdin, M., Bonaguidi, F., Landi, P., Michelassi, C., Trivella, M. G., Macerata, A., & L'Abbate, A.
- Affiliations
- Istituto di Fisiologia Clinica (IT)
- Corresponding author
- Carpeggiani, Clara
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-12
- Volume
- 26
- Issue
- 16
- Pages
- 1612-1617
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2018341004
- Cited by
- 70
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 2
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- personality traits, heart rate variability, myocardial infarction, cardiac mortality, anxiety, emotional sensitivity, vagal withdrawal, high-frequency power, reinfarction, prognostic factors, Q-wave myocardial infarction, length of hospital stay
- MeSH terms
- Affective Symptoms, Anxiety Disorders, Female, Follow-Up Studies, Heart Rate, Hospitalization, Humans, Length of Stay, Male, Middle Aged, Myocardial Infarction, Personality, Prognosis, Prospective Studies, Risk Factors, Sensitivity and Specificity, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
