From psychological moments to mortality: a multidisciplinary synthesis on heart rate variability spanning the continuum of time

Kemp, Andrew H.; Koenig, Julian; Thayer, Julian F.

doi:10.1016/j.neubiorev.2017.09.006

Cited by 114Heart Rate Variability and Autonomic ControlVagus Nerve Stimulation ResearchCardiac Health and Mental Health

From psychological moments to mortality: a multidisciplinary synthesis on heart rate variability spanning the continuum of time

Kemp, Andrew H., Koenig, Julian, Thayer, Julian F.·2017·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2017.09.006

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Abstract

Heart rate variability (HRV) indexes functioning of the vagus nerve, arguably the most important nerve in the human body. The Neurovisceral Integration Model has provided a structural framework for understanding brain-body integration, highlighting the role of the vagus in adaptation to the environment. In the present paper, we emphasise a temporal framework in which HRV may be considered a missing, structural link between psychological moments and mortality, a proposal we label as Neurovisceral Integration Across a Continuum of Time (or NIACT). This new framework places neurovisceral integration on a dimension of time, highlighting implications for lifespan development and healthy aging, and helping to bridge the gap between clearly demarcated disciplines such as psychology and epidemiology. The NIACT provides a novel framework, which conceptualizes how everyday psychological moments both affect and are affected by the vagus in ways that have long-term effects on mortality risk. We further emphasize that a longitudinal approach to understanding change in vagal function over time may yield novel scientific insights and important public health outcomes.

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Cardioventilatory Coupling in Resting Human Subjects
Tzeng, Y., Larsen, P., & Galletly, D. C. (2003) · Experimental Physiology · doi:10.1113/eph8802606 · Cited by 82 · see citing works
Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?
Harrison, N. A., Cooper, E., Voon, V., Miles, K., & Critchley, H. D. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.001 · Cited by 76 · see citing works
Lower heart rate variability predicts increased level of C‐reactive protein 4 years later in healthy, nonsmoking adults
Jarczok, M. N., Koenig, J., Mauss, D., Fischer, J. E., & Thayer, J. F. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12295 · Cited by 75 · see citing works
Aristotle on the Brain
Gross, C. G. (1995) · The Neuroscientist · doi:10.1177/107385849500100408 · Cited by 75 · see citing works
Short-term effects of fish-oil supplementation on heart rate variability in humans: a meta-analysis of randomized controlled trials
Xin, W., Wei, W., & Li, X.-Y. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.049833 · Cited by 74 · see citing works
Do People With Psychosis Have Specific Difficulties Regulating Emotions?
Lincoln, T. M., Hartmann, M. M., Köther, U., & Moritz, S. (2014) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.1923 · Cited by 74 · see citing works
Individual Differences in Heart Rate Variability Predict the Degree of Slowing during Response Inhibition and Initiation in the Presence of Emotional Stimuli
Krypotos, A., Jahfari, S., van Ast, V. A., Kindt, M., & Forstmann, B. U. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00278 · Cited by 73 · see citing works
Heavy alcohol use, rather than alcohol dependence, is associated with dysregulation of the hypothalamic–pituitary–adrenal axis and the autonomic nervous system
Boschloo, L., Vogelzangs, N., Licht, C. M. M., Vreeburg, S. A., Smit, J. H., van den Brink, W., Veltman, D. J., de Geus, E. J. C., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.12.006 · Cited by 73 · see citing works
Respiratory sinus arrhythmia is associated with trait positive affect and positive emotional expressivity
Wang, Z., Lu, W. D., & Qin, R. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.12.006 · Cited by 72 · see citing works
Personality traits and heart rate variability predict long-term cardiac mortality after myocardial infarction
Carpeggiani, C., Emdin, M., Bonaguidi, F., Landi, P., Michelassi, C., Trivella, M. G., Macerata, A., & L'Abbate, A. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi252 · Cited by 70 · see citing works
Respiratory sinus arrhythmia responses to induced emotional states: Effects of RSA indices, emotion induction method, age, and sex
Overbeek, T. J. M., Boxtel, A. V., & Westerink, J. H. D. M. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.05.011 · Cited by 62 · see citing works
A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
Quintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 61 · see citing works
Effects of Smoking Cessation on Heart Rate Variability Among Long-Term Male Smokers
Harte, C. B., & Meston, C. M. (2013) · International Journal of Behavioral Medicine · doi:10.1007/s12529-013-9295-0 · Cited by 61 · see citing works
Moderate alcohol intake is related to increased heart rate variability in young adults: Implications for health and well‐being
Quintana, D. S., Guastella, A. J., McGregor, I. S., Hickie, I. B., & Kemp, A. H. (2013) · Psychophysiology · doi:10.1111/psyp.12134 · Cited by 56 · see citing works
Cardiac Arrhythmias and Risk Stratification After Myocardial Infarction:
Huikuri, H. V., Mahaux, V., Bloch-Thomsen, P.-E., & CARISMA Investigators (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.00061.x · Cited by 55 · see citing works
Ultra-Short-Term Heart Rate Variability for Early Risk Stratification following Acute ST-Elevation Myocardial Infarction
Karp, E., Shiyovich, A., Zahger, D., Gilutz, H., Grosbard, A., & Katz, A. (2009) · Cardiology · doi:10.1159/000235568 · Cited by 45 · see citing works
The wonders of the Wanderer
Clancy, J. A., Deuchars, S. A., & Deuchars, J. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.064543 · Cited by 44 · see citing works
A systematic review on heart rate variability in Bulimia Nervosa
Peschel, S. K. V., Feeling, N. R., Vögele, C., Kaess, M., Thayer, J. F., & Koenig, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.012 · Cited by 43 · see citing works
Pregnant Mothers with Resolved Anxiety Disorders and Their Offspring Have Reduced Heart Rate Variability: Implications for the Health of Children
Braeken, M. A. K. A., Kemp, A. H., Outhred, T., Otte, R. A., Monsieur, G. J. Y. J., Jones, A., & den Bergh, B. R. H. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083186 · Cited by 42 · see citing works
Race and Resting-State Heart Rate Variability in Brazilian Civil Servants and the Mediating Effects of Discrimination: An ELSA-Brasil Cohort Study
Kemp, A. H., Koenig, J., Thayer, J. F., Bittencourt, M. S., Pereira, A. C., Santos, I. S., Dantas, E. M., Mill, J. G., Chor, D., Ribeiro, A. L. P., et al. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000359 · Cited by 41 · see citing works
Heart rate variability in patients with fully remitted major depressive disorder
Chang, H., Chang, C.-C., Chen, C.-L., Kuo, T. B. J., Lu, R., & Huang, S. (2012) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2012.00658.x · Cited by 39 · see citing works
Sympathovagal balance from heart rate variability: time for a second round?
Pagani, M., Lucini, D., & Porta, A. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.066977 · Cited by 37 · see citing works

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A meta-analysis of heart rate variability in major depression
Koch, C., Wilhelm, M., Salzmann, S., Rief, W., & Euteneuer, F. (2019) · Psychological Medicine · doi:10.1017/s0033291719001351 · Cited by 489 · see citing works
Heart-rate variability: A biomarker to study the influence of nutrition on physiological and psychological health?
Young, H. A., & Benton, D. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000383 · Cited by 249 · see citing works
Stress and cardiovascular disease: an update
Vaccarino, V., & Bremner, J. D. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01024-y · Cited by 268 · see citing works
The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
Arias-López, J. A., Williams, C., Raghvani, R., Aghajani, M., Báez, S., Belzung, C., Booij, L., Busatto, G. F., Chiarella, J., Fu, C. H. Y., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.006 · Cited by 132 · see citing works
A Systematic Review and Meta-Analysis of Within-Person Changes in Cardiac Vagal Activity across the Menstrual Cycle: Implications for Female Health and Future Studies
Schmalenberger, K., Eisenlohr-Moul, T., Würth, L., Schneider, E., Thayer, J., Ditzen, B., & Jarczok, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111946 · Cited by 104 · see citing works
Metacognition, Hardiness, and Grit as Resilience Factors in Unmanned Aerial Systems (UAS) Operations: A Simulation Study
Matthews, G., Panganiban, A. R., Wells, A., Wohleber, R. W., & Reinerman-Jones, L. E. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00640 · Cited by 85 · see citing works
Psychophysiological Markers of Fear and Anxiety
Hyde, J., Ryan, K. M., & Waters, A. M. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1036-x · Cited by 83 · see citing works
Emotional Response and Changes in Heart Rate Variability Following Art-Making With Three Different Art Materials
Haiblum-Itskovitch, S., Czamanski‐Cohen, J., & Galili, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00968 · Cited by 78 · see citing works
Toward a social psychophysiology of vagally mediated heart rate variability: Concepts and methods in self‐regulation, emotion, and interpersonal processes
Smith, T. W., Deits‐Lebehn, C., Williams, P. G., Baucom, B. R. W., & Uchino, B. N. (2020) · Social and Personality Psychology Compass · doi:10.1111/spc3.12516 · Cited by 88 · see citing works
Association of Depressive Symptoms and Heart Rate Variability in Vietnam War–Era Twins
Huang, M., Shah, A. J., Su, S., Goldberg, J. H., Lampert, R. J., Levantsevych, O. M., Shallenberger, L. H., Pimple, P. M., Bremner, J. D., & Vaccarino, V. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.0747 · Cited by 72 · see citing works
Reference values for short‐term resting‐state heart rate variability in healthy adults: Results from the Brazilian Longitudinal Study of Adult Health—ELSA‐Brasil study
Dantas, E. M., Kemp, A. H., Andreão, R. V., da Silva, V. J. D., Brunoni, A. R., Hoshi, R. A., Benseñor, I. M., Lotufo, P. A., Ribeiro, A. L. P., & Mill, J. G. (2018) · Psychophysiology · doi:10.1111/psyp.13052 · Cited by 72 · see citing works
Allostatic interoceptive overload in frontotemporal dementia
Birba, A., Santamaría-García, H., Prado, P., Cruzat, J., Ballesteros, A. S., Legaz, A., Fittipaldi, S., Duran-Aniotz, C., Slachevsky, A., Santibañez, R., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.02.955 · Cited by 70 · see citing works
Moving beyond disciplinary silos towards a transdisciplinary model of wellbeing: an invited review
Mead, J., Fisher, Z., & Kemp, A. H. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.642093 · Cited by 71 · see citing works
The age-dependent relationship between resting heart rate variability and functional brain connectivity
Kumral, D., Schaare, H. L., Beyer, F., Reinelt, J., Uhlig, M., Liem, F., Lampe, L., Babayan, A., Reiter, A., Erbey, M., et al. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.027 · Cited by 64 · see citing works
Heart rate variability: Evaluating a potential biomarker of anxiety disorders
Tomasi, J., Zai, C. C. H., Pouget, J. G., Tiwari, A. K., & Kennedy, J. L. (2023) · Psychophysiology · doi:10.1111/psyp.14481 · Cited by 66 · see citing works
Integrating Biosignals Measurement in Virtual Reality Environments for Anxiety Detection
Petrescu, L., Petrescu, C., Mitruț, O., Moise, G., Moldoveanu, A. D. B., Moldoveanu, F., & Leordeanu, M. (2020) · Sensors · doi:10.3390/s20247088 · Cited by 62 · see citing works
Early life maltreatment and resting-state heart rate variability: A systematic review and meta-analysis
Sigrist, C., Mürner-Lavanchy, I. M., Peschel, S. K. V., Schmidt, S. J., Kaess, M., & Koenig, J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.026 · Cited by 57 · see citing works
Validity of the Polar H7 Heart Rate Sensor for Heart Rate Variability Analysis during Exercise in Different Age, Body Composition and Fitness Level Groups
Hernández‐Vicente, A., Hernando, D., Marín-Puyalto, J., Vicente‐Rodríguez, G., Garatachea, N., Pueyo, E., & Bailón, R. (2021) · Sensors · doi:10.3390/s21030902 · Cited by 57 · see citing works
Sex Differences in the Impact of Racial Discrimination on Mental Health Among Black Americans
Brownlow, B. N., Sosoo, E. E., Long, R. N., Hoggard, L. S., Burford, T. I., & Hill, L. K. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1098-9 · Cited by 58 · see citing works
Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease
Whittaker, D. S., Loh, D. H., Wang, H. B., Tahara, Y., Kuljis, D. A., Cutler, T., Ghiani, C. A., Shibata, S., Block, G. D., & Colwell, C. S. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418790401 · Cited by 55 · see citing works
Family nurture intervention in the NICU increases autonomic regulation in mothers and children at 4-5 years of age: Follow-up results from a randomized controlled trial
Welch, M. G., Barone, J. L., Porges, S. W., Hane, A. A., Kwon, K. Y., Ludwig, R. J., Stark, R. I., Surman, A. L., Kołacz, J., & Myers, M. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236930 · Cited by 56 · see citing works
Heart rate variability status at rest in adult depressed patients: a systematic review and meta-analysis
Wu, Q., Miao, X.-Y., Cao, Y.-Y., Chi, A.-P., & Xiao, T. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1243213 · Cited by 46 · see citing works
Heart Rate Variability and Exceptional Longevity
Hernández‐Vicente, A., Hernando, D., Santos‐Lozano, A., Rodríguez‐Romo, G., Vicente‐Rodríguez, G., Pueyo, E., Bailón, R., & Garatachea, N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.566399 · Cited by 49 · see citing works
Heart Rate Variability Mainly Relates to Cognitive Executive Functions and Improves Through Exergame Training in Older Adults: A Secondary Analysis of a 6-Month Randomized Controlled Trial
Eggenberger, P., Annaheim, S., Kündig, K. A., Rossi, R. M., Münzer, T., & de Bruin, E. D. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00197 · Cited by 45 · see citing works
Cardiac interoception in patients accessing secondary mental health services: A transdiagnostic study
Critchley, H., Sherrill, S. P., Ewing, D. L., van Praag, C. G., Habash‐Bailey, H., Quadt, L., Eccles, J., Meeten, F., Bibby-Jones, A.-M., & Garfinkel, S. N. (2023) · Autonomic Neuroscience · doi:10.1016/j.autneu.2023.103072 · Cited by 42 · see citing works
Reduced heart rate variability and lower cerebral blood flow associated with poor cognition during recovery following concussion
Purkayastha, S., Williams, B., Murphy, M. N., Lyng, S. H., Sabo, T., & Bell, K. R. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.04.004 · Cited by 42 · see citing works
The Movesense Medical Sensor Chest Belt Device as Single Channel ECG for RR Interval Detection and HRV Analysis during Resting State and Incremental Exercise: A Cross-Sectional Validation Study
Rogers, B., Schaffarczyk, M., Clauß, M., Mourot, L., & Gronwald, T. (2022) · Sensors · doi:10.3390/s22052032 · Cited by 41 · see citing works
Circadian Rhythms of the Autonomic Nervous System: Scientific Implication and Practical Implementation
Jarczok, M. N., Guendel, H. O., McGrath, J. J., & Balint, E. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86822 · Cited by 35 · see citing works
Health, pre-disease and critical transition to disease in the psycho-immune-neuroendocrine network: Are there distinct states in the progression from health to major depressive disorder?
Stapelberg, N. J. C., Neumann, D. L., Shum, D., & Headrick, J. P. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.10.014 · Cited by 35 · see citing works
Heart rate variability in children and adolescents with major depressive disorder: A systematic review and meta-analysis
Chen, W., Zhong, Q., Chen, H., & Chen, S. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.05.022 · Cited by 36 · see citing works
Non-linear Heart Rate Variability as a Discriminator of Internalizing Psychopathology and Negative Affect in Children With Internalizing Problems and Healthy Controls
Fiskum, C., Andersen, T. G., Bornas, X., Aslaksen, P. M., Flaten, M. A., & Jacobsen, K. H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00561 · Cited by 34 · see citing works
Association between Micronutrients and Heart Rate Variability: A Review of Human Studies
Lopresti, A. L. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz136 · Cited by 33 · see citing works
Transdiagnostic Expression of Interoceptive Abnormalities in Psychiatric ConditionsPreprint
Critchley, H., Ewing, D. L., van Praag, C. G., Habash‐Bailey, H., Eccles, J., Meeten, F., & Garfinkel, S. N. (2019) · SSRN Electronic Journal · doi:10.1101/19012393 · Cited by 30 · see citing works
Accountability
Witvliet, C. V., & Peteet, J. R. (2021) · doi:10.1093/med/9780197524480.003.0002 · Cited by 27 · see citing works
Contributing factors predicting nightmares in children: Trauma, anxiety, dissociation, and emotion regulation.
Secrist, M. E., Dalenberg, C. J., & Gevirtz, R. (2018) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000387 · Cited by 23 · see citing works
Resting heart rate variability as a possible marker of cognitive decline
Grässler, B., Hökelmann, A., & Cabral, R. H. (2020) · Kinesiology · doi:10.26582/k.52.1.9 · Cited by 23 · see citing works
Predicting the severity of mood and neuropsychiatric symptoms from digital biomarkers using wearable physiological data and deep learning
Rykov, Y. G., Ng, K. P., Patterson, M. D., Gangwar, B. A., & Kandiah, N. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108959 · Cited by 22 · see citing works
Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial
Stauffer, C. S., Moschetto, J. M., McKernan, S. M., Meinzer, N. K., Chiang, C., Rapier, R., Hsiang, E., Norona, J. C., Borsari, B. E., & Woolley, J. D. (2020) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2020.108059 · Cited by 21 · see citing works
Does psychological treatment of major depression reduce cardiac risk biomarkers? An exploratory randomized controlled trial
Euteneuer, F., Neuert, M., Salzmann, S., Fischer, S., Ehlert, U., & Rief, W. (2022) · Psychological Medicine · doi:10.1017/s0033291722000447 · Cited by 21 · see citing works
Where is the love? A double-blind, randomized study of the effects of intranasal oxytocin on stress regulation and aggression
Romney, C. E., Hahn‐Holbrook, J., Norman, G. J., Moore, A., & Holt‐Lunstad, J. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.08.010 · Cited by 20 · see citing works
The “Managed” or Damaged Heart? Emotional Labor, Gender, and Posttraumatic Stressors Predict Workplace Event-Related Acute Changes in Cortisol, Oxytocin, and Heart Rate Variability
Birze, A., LeBlanc, V. R., Regehr, C., Paradis, E., & Einstein, G. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00604 · Cited by 19 · see citing works
Heart–brain interactions during social and cognitive stress in hypertensive disease: A multidimensional approach
Legaz, A., Yoris, A., Sedeño, L., Abrevaya, S., Martorell, M., Alifano, F., García, A. M., & Ibáñez, A. M. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14979 · Cited by 19 · see citing works
Approach motivation and loneliness: Individual differences and parasympathetic activity
Smith, K. E., & Pollak, S. D. (2022) · Psychophysiology · doi:10.1111/psyp.14036 · Cited by 18 · see citing works
Determining the direction of prediction of the association between parasympathetic dysregulation and exhaustion symptoms
Wekenborg, M., Schwerdtfeger, A. R., Rothe, N., Penz, M. S., Walther, A., Kirschbaum, C., Thayer, J. F., Wittling, R. A., & Hill, L. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-14743-4 · Cited by 18 · see citing works
Heart rate variability to track autonomic nervous system health in young children: Effects of physical activity and cardiometabolic risk factors
Speer, K. E., Naumovski, N., & McKune, A. J. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114576 · Cited by 17 · see citing works
The ‘Rippling’ Waves of Wellbeing: A Mixed Methods Evaluation of a Surf-Therapy Intervention on Patients with Acquired Brain Injury
Wilkie, L., Fisher, Z., & Kemp, A. H. (2022) · Sustainability · doi:10.3390/su14159605 · Cited by 17 · see citing works
Relaxation or Regulation: The Acute Effect of Mind-Body Exercise on Heart Rate Variability and Subjective State in Experienced Qi Gong Practitioners
Goldbeck, F., Xie, Y.-L., Hautzinger, M., Fallgatter, A., Sudeck, G., & Ehlis, A. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/6673190 · Cited by 18 · see citing works
Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept
Trumpff, C., Marsland, A. L., Sloan, R. P., Kaufman, B. A., & Picard, M. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.001 · Cited by 16 · see citing works
Editorial: Improving Wellbeing in Patients With Chronic Conditions: Theory, Evidence, and Opportunities
Kemp, A. H., Tree, J. J., Gracey, F., & Fisher, Z. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.868810 · Cited by 16 · see citing works
Vagally-mediated heart rate variability and depression in children and adolescents - A meta-analytic update
Baumeister-Lingens, L., Rothe, R., Wolff, L., Gerlach, A. L., Koenig, J., & Sigrist, C. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.027 · Cited by 15 · see citing works
Does psychological treatment of major depression reduce cardiac risk biomarkers? An exploratory randomized controlled trial
Euteneuer, F., Neuert, M., Salzmann, S., Fischer, S., Ehlert, U., & Rief, W. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-218437 · Cited by 15 · see citing works
Heart rate variability in patients with bipolar disorder: From mania to euthymia
Wazen, G. L. L., Gregório, M. L., Kemp, A. H., & de Godoy, M. F. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.01.008 · Cited by 15 · see citing works
A shy heart may benefit from everyday life social interactions with close others: An ecological momentary assessment trial using Bayesian multilevel modeling
Schwerdtfeger, A. R., Rominger, C., & Obser, P. D. (2020) · Biological Psychology · doi:10.1016/j.biopsycho.2020.107864 · Cited by 15 · see citing works
The effect of ambient sounds on decision-making and heart rate variability in autism
Bellamy, R., RING, H. A., Watson, P., Kemp, A. H., Munn, G., & Clare, I. C. H. (2021) · Autism · doi:10.1177/13623613211014993 · Cited by 15 · see citing works
Autonomic nervous system flexibility for understanding brain aging
Lin, F. V., & Heffner, K. L. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102016 · Cited by 14 · see citing works
Vagal control of the heart decreases during increasing imminence of interoceptive threat in patients with panic disorder and agoraphobia
Richter, J., Pietzner, A., Koenig, J., Thayer, J. F., Pané‐Farré, C. A., Gerlach, A. L., Gloster, A. T., Wïttchen, H., Lang�, T., Alpers, G. W., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-86867-y · Cited by 16 · see citing works
Emotion, Wellbeing and the Neurological Disorders
Fisher, Z., Galloghly, E., Boglo, E., Gracey, F., & Kemp, A. H. (2022) · Encyclopedia of Behavioral Neuroscience, 2nd edition · doi:10.1016/b978-0-12-819641-0.00013-x · Cited by 20 · see citing works
Brief induction of loneliness decreases vagal regulation during social information processing
Piejka, A., Wiśniewska, M., Thayer, J. F., & Okruszek, Ł. (2021) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2021.03.002 · Cited by 12 · see citing works
Stress Management Intervention for Leaders Increases Nighttime SDANN: Results from a Randomized Controlled Trial
Balint, E. M., Angerer, P., Guendel, H. O., Marten‐Mittag, B., & Jarczok, M. N. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19073841 · Cited by 13 · see citing works
Herzfrequenzvariabilität – Stand der Forschung und klinische Anwendbarkeit
Fouradoulas, M., von Känel, R., & Schmid, J. (2019) · Praxis · doi:10.1024/1661-8157/a003206 · Cited by 12 · see citing works
A novel ACT-based video game to support mental health through embedded learning: A mixed-methods feasibility study protocol
Edwards, D. J., & Kemp, A. H. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-041667 · Cited by 11 · see citing works
Incorporating Internal and External Training Load Measurements in Clinical Decision Making After ACL Reconstruction: A Clinical Commentary
Taylor, J. B., Ford, K. R., Queen, R. M., Owen, E. C., & Gisselman, A. S. (2021) · International Journal of Sports Physical Therapy · doi:10.26603/001c.21152 · Cited by 11 · see citing works
Heart Rate Variability
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Novel ACT-based eHealth psychoeducational intervention for students with mental distress: A study protocol for a mixed-methodology pilot trial
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Authors: Kemp, A. H., Koenig, J., & Thayer, J. F.
Affiliations: The University of Sydney (AU)
Heidelberg University (DE)
The Ohio State University (US)
Corresponding author: Kemp, Andrew H.
Thayer, Julian F.
ORCID: Kemp, Andrew H.
Koenig, Julian
Thayer, Julian F.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2017-12
Volume: 83
Pages: 547-567
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2017.09.006
OpenAlex: W2752326235
Cited by: 114
References: 225
Citations by year: 2026: 8 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 15 · 2020: 19 · 2019: 17 · 2018: 13
FWCI: 1.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: FAPESP (#2013/50327-6)
Brazilian research funding institution
Medical School of Heidelberg University
Post-Doctoral Fellowship provided by the Daimler and Benz Foundation
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: heart rate variability, vagus nerve, neurovisceral integration, mortality risk, lifespan development, healthy aging, temporal framework
MeSH terms: Aging, Animals, Heart Rate, Humans, Psychophysiology, Vagus Nerve, Health Behavior, Visceral Afferents

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From psychological moments to mortality: a multidisciplinary synthesis on heart rate variability spanning the continuum of time

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