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Cited by 287

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure

Opasich, Cristina, Cazzola, Mario, Scelsi, Laura, De Feo, Stefania, Bosimini, Enzo, Lagioia, Rocco, Febo, Oreste, Ferrari, Roberto, Fucili, Alessandro, Moratti, Remigio, Tramarin, Roberto, Tavazzi, Luigi·2005·European Heart Journal
DOI 10.1093/eurheartj/ehi388
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Abstract

AIMS: Anaemia is often observed in patients with chronic heart failure (CHF), and it may be associated with a worse prognosis. Aim of this study was to identify the individual mechanisms of anaemia in CHF patients. METHODS AND RESULTS: One hundred and forty-eight consecutive patients with haemoglobin concentration <13 g/dL (if males) or <12 g/dL (if females) were enrolled. Factors responsible for anaemia were investigated by evaluating endogenous erythropoietin (Epo) production, serum cytokines levels, body iron status, and iron supply for erythropoiesis. Most patients (57%) presented anaemia of chronic disease and among them, 92% showed evidence of a defective endogenous Epo production. This was indicated by an observed/predicted log(serum Epo) ratio less than 0.8 and/or a defective iron supply for erythropoiesis diagnosed by low transferrin saturation and/or increased value of soluble transferrin receptor. According to regression analysis sex, renal failure, and serum Epo were correlated with anaemia. CONCLUSION: According to our study, about half of anaemic CHF patients showed anaemia of chronic disease with blunted endogenous Epo production and/or a defective iron supply for erythropoiesis. Determination of the individual mechanisms of anaemia in CHF could justify a rational therapeutic approach to anaemia.

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Research works printed but not linked: 33

  1. Cohn JN. The management of chronic heart failure. N Engl J Med1996;335:490–498. · DOI · Paper page
  2. Komajda M. Prevalence of anaemia in patients with chronic heart failure and their clinical characteristics. J Card Fail2004;10(Suppl. 1):S1–S4. · DOI
  3. Anand I, McMurray JJ, Whitmore J, Warren M, Pham A, McCamish MA, Burton PB. Anaemia and its relationship to clinical outcome in heart failure. Circulation2004;110:149–154. · DOI · Paper page
  4. McClellan WM, Flanders WD, Langston RD, Jurkovitz C, Presley R. Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: a population-based study. J Am Soc Nephrol2002;13:1928–1936. · DOI · Paper page
  5. Kosiborod M, Smith GL, Radford MJ, Foody JM, Krumholz HM. The prognostic importance of anemia in patients with heart failure. Am J Med2003;114:112–119. · DOI · Paper page
  6. Sharma R, Francis DP, Pitt B, Poole-Wilson PA, Coats AJ, Anker SD. Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial. Eur Heart J2004;25:1021–1028. · DOI · Paper page
  7. Felker GM, Gattis WA, Leimberger JD, Adams KF, Cuffe MS, Gheorghiade M, O'Connor CM. Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. Am J Cardiol2003;92:625–628. · DOI · Paper page
  8. Al-Ahmad A, Rand WM, Manjunath G, Konstam MA, Salem DN, Levey AS, Sarnak MJ. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol2001;38:955–962. · DOI · Paper page
  9. Silverberg DS, Wexler D, Laina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Fail2002;4:681–686. · DOI · Paper page
  10. Silverberg DS, Wexler D, Blum M, Keren G, Sheps D, Leibovitch E, Brosh D, Laniado S, Schwartz D, Yachnin T, Shapira I, Gavish D, Baruch R, Koifman B, Kaplan C, Steinbruch S, Iaina A. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol2000;35:1737–1744. · DOI · Paper page
  11. Silverberg DS, Wexler D, Sheps D, Blum M, Keren G, Baruch R, Schwartz D, Yachnin T, Steinbruch S, Shapira I, Laniado S, Iaina A. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study. J Am Coll Cardiol2001;37:1775–1780. · DOI · Paper page
  12. Mancini DM, Katz SD, Lang CC, LaManca J, Hudaihed A, Androne AS. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation2003;107:294–299. · DOI · Paper page
  13. Cromie N, Lee C, Struthers AD. Anemia in chronic heart failure: what is the frequency in the UK and its underlying causes? Heart2002;87:377–378. · doi:10.1136/heart.87.4.377
  14. Okonko D, Ankers S. Anemia in chronic heart failure: pathogenetic mechanisms. J Card Fail2004;10:S5–S9. · DOI
  15. Kalra PR, Collier T, Cowie MR, Fox KF, Wood DA, Poole-Wilson PA, Coats AJ, Sutton GC. Haemoglobin concentration and prognosis in new cases of heart failure. Lancet2003;362:211–212. · DOI
  16. Remme WJ, Swedberg K. Task force of the diagnosis and treatment of chronic heart failure, European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J2001;22:1527–1560. · DOI · Paper page
  17. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron1976;16:31–41. · DOI · Paper page
  18. Beguin Y, Clemons GK, Pootrakul P, Fillet G. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood1993;81:1067–1076. · DOI · Paper page
  19. Cazzola M, Beguin Y. New tools for clinical evaluation of erythron function in man. Br J Haematol1992;80:278–284. · DOI
  20. Cazzola M, Guarnone R, Cerani P, Centenara E, Rovati A, Beguin Y. Red blood cell precursor mass as an independent determinant of serum erythropoietin level. Blood1998;91:2139–2145. · doi:10.1182/blood.v91.6.2139
  21. Cerutti A, Custodi P, Duranti M, Cazzola M, Balduini CL. Circulating thrombopoietin in reactive conditions behaves like an acute phase reactant. Clin Lab Haematol1999;21:271–275. · DOI
  22. Valgimigli M, Agnoletti L, Curello S, Comini L, Francolini G, Mastrorilli F, Merli E, Pirani R, Guardigli G, Grigolato PG, Ferrari R. Serum from patients with acute coronary syndromes displays a proapoptotic effect on human endothelial cells: a possible link to pan-coronary syndromes. Circulation2003;107:264–270. · DOI
  23. Androne AS, Katz SD, Lund L, LaManca J, Hudaihed A, Hryniewicz K, Mancini DM. Hemodilution is common in patients with advanced heart failure. Circulation2003;107:226–229. · DOI · Paper page
  24. Witte KK, Desilva R, Chattopadhyay S, Ghosh J, Cleland JG, Clark AL. Are hematinic deficiencies the cause of anemia in chronic heart failure? Am Heart J2004;147:924–930. · DOI
  25. Tefferi A. Anemia in adults: a contemporary approach to diagnosis. Mayo Clin Proc2003;78:1274–1280. · DOI · Paper page
  26. Cazzola M, Mercuriali F, Brugnara C. Use of recombinant human erythropoietin outside the setting of uremia. Blood1997;89:4248–4267. · DOI · Paper page
  27. Faquin WC, Schneider TJ, Goldberg MA. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood1992;79:1987–1994. · doi:10.1182/blood.v79.8.1987.bloodjournal7981987
  28. van der Meer P, Voors AA, Lipsic E, Smilde TD, van Gilst WH, van Veldhuisen DJ. Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure. J Am Coll Cardiol2004;44:63–67. · DOI · Paper page
  29. Martini A, Ravelli A, Di Fuccia G, Rosti V, Cazzola M, Barosi G. Intravenous iron therapy for severe anaemia in systemic-onset juvenile chronic arthritis. Lancet1994;344:1052–1054. · DOI
  30. Thomas C, Thomas L. Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clin Chem2002;48:1066–1076. · DOI · Paper page
  31. Plata R, Cornejo A, Arratia C, Anabaya A, Perna A, Dimitrov BD, Remuzzi G, Ruggenenti P. Commission on Global Advancement of Nephrology (COMGAN), Research Subcommittee of the International Society of Nephrology. Angiotensin-converting-enzyme inhibition therapy in altitude polycythaemia: a prospective randomised trial. Lancet2002;359:663–666. · DOI
  32. Chatterjee B, Nydegger UE, Mohacsi P. Serum erythropoietin in heart failure patients treated with ACE-inhibitors or AT1 antagonists. Eur J Heart Fail2000;2:393–398. · DOI
  33. Cazzola M. Erythropoietin therapy: need for rationality and active surveillance. Haematologica2003;88:601–605.

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Metadata

Authors
Opasich, C., Cazzola, M., Scelsi, L., De Feo, S., Bosimini, E., Lagioia, R., Febo, O., Ferrari, R., Fucili, A., Moratti, R., Tramarin, R., & Tavazzi, L.
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2005-06-29
Volume
26
Issue
21
Pages
2232-2237
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehi388
OpenAlex
W2124839834
Cited by
287
References
7
FWCI
9.10
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure. https://app.cochat.ai/papers/10.1093/eurheartj/ehi388
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Opasich, C., Cazzola, M., Scelsi, L., De Feo, S., Bosimini, E., Lagioia, R., Febo, O., Ferrari, R., Fucili, A., Moratti, R., Tramarin, R., & Tavazzi, L. (2005). Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure. European Heart Journal. https://doi.org/10.1093/eurheartj/ehi388

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