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Cited by 305Atrial Fibrillation Management and OutcomesGenetic Associations and EpidemiologyCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Familial aggregation of atrial fibrillation in Iceland

Arnar, David O., Thorvaldsson, Sverrir, Manolio, Teri A., Thorgeirsson, Gudmundur, Kristjansson, Kristleifur, Hakonarson, Hakon, Stefansson, Kari·2006·European Heart Journal
DOI 10.1093/eurheartj/ehi727
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Abstract

AIMS: To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. METHODS AND RESULTS: The study population included 5269 patients diagnosed since 1987 and age-sex-matched controls randomly selected from the genealogy database. Kinship coefficients (KC), expressed as genealogical index of familiality (GIF = average KC x 100,000), were calculated before and after exclusion of relatives separated by one to five meiotic events. Risk ratios (RR) were calculated for first- to fifth-degree relatives. The average pairwise GIF among patients with AF was 15.9 (mean GIF for controls 13.9, 95%CI = 13.3, 14.4); this declined to 15.4 (mean GIF for controls 13.6, 95%CI = 13.1, 14.2) after exclusion of relatives separated by one meiosis and to 13.7 (mean GIF for controls 12.6, 95%CI = 12.1, 13.2), 12.7 (mean GIF for controls 11.9, 95%CI = 11.4, 12.4), and 11.3 (mean GIF for controls 10.6, 95%CI = 10.1, 11.1) after exclusion of relatives within two, three, and four meioses, respectively (all P<0.00001). RRs among relative pairs also declined incrementally, from 1.77 in first-degree relatives to 1.36, 1.18, 1.10, and 1.05 in second- through fifth-degree relatives (all P<0.001), consistent with the declining proportion of alleles shared identically by descent. When the analysis was limited to subjects diagnosed with AF before the age of 60, first-degree relatives of the AF cases were nearly five times more likely to have AF than the general population. CONCLUSION: AF shows strong evidence of heritability among unselected patients in Iceland, suggesting that there may be undiscovered genetic variants underlying the risk of the common form of AF.

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Metadata

Authors
Arnar, D. O., Thorvaldsson, S., Manolio, T. A., Thorgeirsson, G., Kristjansson, K., Hakonarson, H., & Stefansson, K.
ORCID
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2006-01-20
Volume
27
Issue
6
Pages
708-712
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehi727
OpenAlex
W2122436921
Cited by
305
References
32
Citations by year
2026: 5 · 2025: 1 · 2024: 13 · 2023: 10 · 2022: 2 · 2021: 7 · 2020: 15 · 2019: 13 · 2018: 7 · 2017: 26 · 2016: 28 · 2015: 12 · 2014: 24 · 2013: 21 · 2012: 25
FWCI
12.56
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • Hirsla (Landspítali University Hospital) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
familial aggregation, heritability, genealogical databases, kinship coefficient, relative risk, first-degree relatives, Icelanders
MeSH terms
Aged, Atrial Fibrillation, Family Health, Female, Humans, Iceland, Male, Middle Aged, Pedigree, Risk Factors, Cohort Studies, Case-Control Studies, Genetic Predisposition to Disease

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