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Cited by 253Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsCardiac Valve Diseases and Treatments

Left ventricular volume measurement with echocardiography: a comparison of left ventricular opacification, three-dimensional echocardiography, or both with magnetic resonance imaging

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Jenkins, C., Moir, S., Chan, J., Rakhit, D., Haluska, B., Marwick, T. H.·2008·European Heart Journal
DOI 10.1093/eurheartj/ehn484
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Abstract

AIMS: Both contrast enhanced (CE) two-dimensional echocardiography (2DE) and three-dimensional echocardiography (3DE) have been proposed as techniques to improve the accuracy of left ventricular (LV) volume measurements. We sought to examine the accuracy of non-contrast (NC) and CE-2DE and 3DE for calculation of LV volumes and ejection fraction (EF), relative to cardiac magnetic resonance imaging (MRI). METHODS AND RESULTS: We studied 50 patients (46 men, age 63 +/- 10 year) with past myocardial infarction who underwent echocardiographic assessment of LV volume and function. All patients sequentially underwent NC-2DE followed by NC-3DE. CE-2DE and CE-3DE were acquired during contrast infusion. Resting echocardiographic image quality was evaluated on the basis of NC-2DE. The mean LV end-diastolic volume (LVEDV) of the group by MRI was 207 +/- 79 mL and was underestimated by 2DE (125 +/- 54 mL, P = 0.005), and less by CE-2DE (172 +/- 58 mL, P = 0.02) or 3DE (177 +/- 64 mL, P = 0.08), but EDV was comparable by CE-3DE (196 +/- 69 mL, P = 0.16). Limits of agreement with MRI were similar for NC-3DE and CE-2DE, with the best results for CE-3D. Results were similar for calculation of LVESV. Patients were categorized into groups of EF (< or =35, 35-50, >50%) by MRI. NC-2DE demonstrated a 68% agreement (kappa 0.45, P = 0.001), CE-2DE a 62% agreement (kappa 0.20, P = 136), NC-3DE a 74% agreement (kappa 0.39, P = 0.005) and CE-3DE an 80% agreement (kappa 0.56, P < 0.001). CONCLUSION: CE-2DE is analogous to NC-3DE in accurate categorization of LV function. However, CE-3DE is feasible and superior to other NC- and CE-techniques in patients with previous infarction.

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  • Echocardiography LVEF measurement is less precise relative to other approaches such as magnetic resonance imaging.

    “This might also be attributable to a lack of precision in LVEF measurement by echocardiography, which has shown to be less precise relative to other approaches, such as magnetic resonance imaging27,28.”

    From Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devices (2023) · cites this paper as [28]

    The Introduction and ‘Limitations of each technique’ sections (page not specified) describe poor reproducibility and observer variability for non-contrast 2D echocardiography, supporting the concern about its precision. But the Introduction also says contrast enhancement can bring inter-observer reproducibility to a level comparable with MRI, so the claim is too broad for echocardiography generally. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Authors
Jenkins, C., Moir, S., Chan, J., Rakhit, D., Haluska, B., & Marwick, T. H.
Affiliations
The University of Queensland (AU)
Corresponding author
Marwick, T. H.
ORCID
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2008-07-28
Volume
30
Issue
1
Pages
98-106
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehn484
OpenAlex
W2052900937
Cited by
253
References
0
Citations by year
2026: 6 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 12 · 2021: 8 · 2020: 6 · 2019: 18 · 2018: 10 · 2017: 20 · 2016: 16 · 2015: 15 · 2014: 24 · 2013: 12 · 2012: 26
FWCI
11.69
Type
journal article
Language
en
Open access
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Keywords
left ventricular volume, left ventricular ejection fraction, contrast echocardiography, three-dimensional echocardiography, left ventricular opacification, cardiac magnetic resonance imaging, end-diastolic volume, end-systolic volume, myocardial infarction, measurement accuracy, left ventricular function assessment, limits of agreement, myocardial perfusion imaging
MeSH terms
Aged, Analysis of Variance, Contrast Media, Echocardiography, Female, Heart Ventricles, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Sensitivity and Specificity, Stroke Volume, Observer Variation, Ventricular Dysfunction, Left, Echocardiography, Three-Dimensional

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