The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension?
Abstract
Pregnancy in women with pulmonary arterial hypertension (PAH) is considered to be associated with prohibitive maternal mortality. During the past decade, new advanced therapies for PAH have emerged and progress in high-risk pregnancy management has been made. We examined whether these changes have improved outcomes in parturients with PAH. A systematic review of all cases of parturients with idiopathic pulmonary hypertension (iPAH), congenital heart disease associated with PAH (CHD-PAH), or PAH of other aetiology (oPH) published in the past decade (1997-2007) was performed. Outcome data from this study were then compared with relevant data published between 1978 and 1996. Forty-eight case reports or case series met the inclusion criteria, totalling 73 parturients with PAH. Seventy-two per cent of patients with iPAH were receiving advanced therapies, compared with 52% of CHD-PAH and 47% of oPH. Although a publication bias cannot be excluded, overall maternal mortality was significantly lower compared with previous era (25 vs. 38%, P = 0.047) and was 17% in iPAH, 28% in CHD-PAH, and 33% in oPH. Seventy-eight per cent of deaths occurred within the first month after delivery. Primigravidae and parturients who received general anaesthesia were at higher risk of death (OR 3.70, 95% CI 1.15-12.5, P = 0.03 and OR 4.37, 95% CI 1.28-16.50, P = 0.02, respectively). Maternal mortality in parturients with PAH remains prohibitively high, despite lower death rates than previous decades. Early advice on pregnancy risks, including contraception, remains paramount. Women with PAH who become pregnant warrant a multidisciplinary approach with consideration of advanced therapies.
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Cites
THE JOURNAL OF REPRODUCTIVE MEDICINE: PATIENT ANXIETY DURING GYNECOLOGIC EXAMINATIONS
Reddy, D. M., & Wasserman, S. A. (1999) · American Journal of Nursing · doi:10.1097/00000446-199901000-00024 · Cited by 2,483
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Levine, J. S., Branch, D. W., & Rauch, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra002974 · Cited by 1,543
Prospective Multicenter Study of Pregnancy Outcomes in Women With Heart Disease
Siu, S. C., Sermer, M., Colman, J. M., Alvarez, A. N., Mercier, L.-A., Morton, B. C., Kells, C. M., Bergin, M. L., Kiess, M. C., Marcotte, F., et al. (2001) · Circulation · doi:10.1161/hc3001.093437 · Cited by 1,402
Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension
Sitbon, O., Humbert, M., Jaïs, X., Ioos, V., Hamid, A. M., Provencher, S., Garcia, G., Parent, F., Hervé, P., & Simonneau, G. (2005) · Circulation · doi:10.1161/circulationaha.104.488486 · Cited by 1,255
D'Cruz, D. P., Khamashta, M. A., & Hughes, G. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60279-7 · Cited by 992
Galiè, N., Beghetti, M., Gatzoulis, M. A., Granton, J., Berger, R. M. F., Lauer, A., Chiossi, E., & Landzberg, M. (2006) · Circulation · doi:10.1161/circulationaha.106.630715 · Cited by 843
Self-citationOutcome of Pulmonary Vascular Disease in Pregnancy: A Systematic Overview From 1978 Through 1996
Weiss, B. M., Zemp, L., Seifert, B., & Hess, O. M. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00162-4 · Cited by 672
Pulmonary Arterial Hypertension
McLaughlin, V. V., & McGoon, M. D. (2006) · Circulation · doi:10.1161/circulationaha.104.503540 · Cited by 664
Cardiovascular Function Before, During, and After the First and Subsequent Pregnancies
Clapp, J. F., & Capeless, E. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00738-8 · Cited by 521
Cited by
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292
ESC Guidelines on the management of cardiovascular diseases during pregnancy
Endorsed by the European Society of Gynecology (ESG), T. A. F. E. P. C. (., Authors/Task Force Members, Regitz-Zagrosek, V., Blomstrom Lundqvist, C., Borghi, C., Cifkova, R., Ferreira, R., Foidart, J.-M., Gibbs, J. S. R., Gohlke-Baerwolf, C., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr218 · Cited by 1,924
Impact of having a high-risk pregnancy on future postpartum contraceptive method choice
Kiykac Altinbas, S., Bayoglu Tekin, Y., Dilbaz, B., Kilic, S., Khalil, S. S., & Kandemir, O. (2014) · Women and Birth · doi:10.1016/j.wombi.2014.06.006 · Cited by 14
Metadata
- Authors
- Bedard, E., Dimopoulos, K., & Gatzoulis, M. A.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09-10
- Volume
- 30
- Issue
- 3
- Pages
- 256-265
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2135608965
- Cited by
- 632
- References
- 42
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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