The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial
Abstract
AIMS: To examine the extent of platelet inhibition by prasugrel vs. clopidogrel in a TRITON-TIMI 38 substudy. METHODS AND RESULTS: TRITON-TIMI 38 randomized acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) to prasugrel or standard dose clopidogrel. Selected sites prospectively enrolled TRITON-TIMI 38 patients to evaluate adenosine diphosphate (ADP)-attenuated phosphorylation of platelet vasodilator-stimulated phosphoprotein (VASP) (n = 125 patients) and, in a subset (n = 31 patients), ADP-stimulated platelet aggregation. VASP platelet reactivity index (PRI) was lower in prasugrel-treated patients than in clopidogrel-treated patients at 1-2 h post-PCI (>or=1 h after loading dose) (P < 0.001) and at 30 days (P < 0.001). Maximal platelet aggregation to 20 microM ADP was lower in prasugrel-treated patients than in clopidogrel-treated patients at 1-2 h (P = 0.004) and 30 days (P = 0.03). Results were similar with 5 microM ADP. Thienopyridine hyporesponsiveness, prespecified as VASP PRI >50%, was more frequent in clopidogrel-treated patients than in prasugrel-treated patients at 1-2 h (P < 0.001) and 30 days (P = 0.03). CONCLUSIONS: The TRITON-TIMI 38 platelet substudy shows that prasugrel results in greater inhibition of ADP-mediated platelet function in ACS patients than clopidogrel, supporting the hypothesis that greater platelet inhibition leads to a lower incidence of ischaemic events and more bleeding both early and late following PCI.
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Citations
Cites
Prasugrel versus clopidogrel in patients with acute coronary syndromes
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“The results of the TRITON-TIMI 38 platelet substudy support the hypothesis that greater inhibition of ADP-mediated platelet function, both early and late following PCI in ACS patients, led to the lower incidence of ischaemic events, both early and late, and the increase in bleeding, observed in the TRITON-TIMI 38 stud…”
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Variability in Individual Responsiveness to Clopidogrel
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Self-citationPlatelet Reactivity in Patients and Recurrent Events Post-Stenting
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Kushner, F. G., Hand, M., Smith, S. C., King, S. B., Anderson, J. L., Antman, E. M., Bailey, S. R., Bates, E. R., Blankenship, J. C., Casey, D. E., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.015 · Cited by 1,911
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Self-citationRao, S. V., O’Donoghue, M. L., Ruel, M., Rab, T., Tamis-Holland, J. E., Alexander, J. H., Baber, U., Baker, H., Cohen, M. G., Cruz-Ruiz, M., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001309 · Cited by 625
Gurbel, P. A., Bliden, K. P., Butler, K., Antonino, M. J., Wei, C., Teng, R., Rasmussen, L., Storey, R. F., Nielsen, T., Eikelboom, J. W., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.919456 · Cited by 447
Alexopoulos, D., Xanthopoulou, I., Gkizas, V., Kassimis, G., Theodoropoulos, K. C., Makris, G., Koutsogiannis, N., Damelou, A., Tsigkas, G., Davlouros, P., et al. (2012) · Circulation: Cardiovascular Interventions · doi:10.1161/circinterventions.112.972323 · Cited by 396
Metadata
- Authors
- Michelson, A. D., Frelinger, A. L., Braunwald, E., Downey, W. E., Angiolillo, D. J., Xenopoulos, N. P., Jakubowski, J. A., Li, Y., Murphy, S. A., Qin, J., McCabe, C. H., Antman, E. M., & Wiviott, S. D.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05-12
- Volume
- 30
- Issue
- 14
- Pages
- 1753-1763
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2140776066
- Cited by
- 257
- References
- 23
- FWCI
- 19.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Michelson, A. D., Frelinger, A. L., Braunwald, E., Downey, W. E., Angiolillo, D. J., Xenopoulos, N. P., Jakubowski, J. A., Li, Y., Murphy, S. A., Qin, J., McCabe, C. H., Antman, E. M., & Wiviott, S. D. (2009). Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial. European Heart Journal. https://doi.org/10.1093/eurheartj/ehp159
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