The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease
Abstract
AIMS: To demonstrate that exposure to chronic inflammation results in coronary microvascular dysfunction (CMD). METHODS AND RESULTS: Using positron emission tomography, resting and hyperaemic (adenosine, 140 microg/kg/min) myocardial blood flow (MBF) was measured in 25 patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Coronary flow reserve (CFR) was calculated as adenosine/resting MBF. Patients had normal or minimally diseased (i.e. <or=20% luminal diameter) coronary arteries at angiography and no cardiovascular risk factors. Twenty five age- and gender-matched healthy volunteers served as controls. Resting MBF was similar in patients and controls (1.25 +/- 0.27 vs. 1.15 +/- 0.24 mL/min/g; P = 0.15) while patients had lower hyperaemic MBF (2.94 +/- 0.83 vs. 4.11 +/- 0.84 mL/min/g; P < 0.001) and CFR (2.44 +/- 0.78 vs. 3.81 +/- 1.07; P < 0.001). CFR was inversely related to disease duration (r = -0.65; P < 0.001) and SLE disease activity (r = -0.69; P = 0.01). Seven patients showed ischaemic electrocardiographic changes during adenosine. They had longer disease duration (21 +/- 7 vs. 14 +/- 5 years; P = 0.03) and lower CFR (1.76 +/- 0.81 vs. 2.49 +/- 0.54; P = 0.006) when compared with patients without changes. CONCLUSION: A reduced CFR in the absence of significant coronary disease is suggestive of CMD. We speculate that this is the consequence of prolonged systemic inflammation, which may precede and contribute to premature coronary artery disease in these patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Coronary microvascular dysfunction is an early marker of accelerated coronary atherosclerosis and may contribute to the increased cardiovascular morbidity and mortality in these patients.189”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [189]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310302 · Cited by 19,753
Prediction of Creatinine Clearance from Serum Creatinine
Cockcroft, D. W., & Gault, H. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000180580 · Cited by 15,291
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Derivation of the sledai. A disease activity index for lupus patients
Bombardier, C., Gladman, D. D., Urowitz, M. B., Caron, D., Chang, C. H., Austin, A., Bell, A., Bloch, D. A., Corey, P. N., Decker, J. L., et al. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350606 · Cited by 4,570
Analysis of probability as an aid in the clinical diagnosis of coronary artery disease.
Diamond, G. A., & Forrester, J. S. (1979) · New England Journal of Medicine · doi:10.1056/nejm197906143002402 · Cited by 2,664
Manzi, S., Meilahn, E. N., Rairie, J. E., Conte, C. G., Medsger, T. A., Jansen-McWilliams, L., D’Agostino, R. B., & Kuller, L. H. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009122 · Cited by 1,831
Coronary Microvascular Dysfunction
Camici, P. G., & Crea, F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra061889 · Cited by 1,680
Self-citationPrevalence and Correlates of Accelerated Atherosclerosis in Systemic Lupus Erythematosus
Roman, M. J., Shanker, B., Davis, A., Lockshin, M. D., Sammaritano, L. R., Simantov, R., Crow, M. K., Schwartz, J. E., Paget, S. A., Devereux, R. B., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035471 · Cited by 1,422
Inflammation as a Cardiovascular Risk Factor
Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304
Coronary Microvascular Dysfunction
Crea, F., Lanza, G. A., & Camici, P. G. (2013) · Springer eBooks · doi:10.1007/978-88-470-5367-0 · Cited by 1,295
Self-citationMethotrexate and mortality in patients with rheumatoid arthritis: a prospective study
Choi, H. K., Hernán, M. Á., Seeger, J. D., Robins, J. M., & Wolfe, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08213-2 · Cited by 1,133
Explaining How “High-Grade” Systemic Inflammation Accelerates Vascular Risk in Rheumatoid Arthritis
Sattar, N. A., McCarey, D. W., Capell, H. A., & McInnes, I. B. (2003) · Circulation · doi:10.1161/01.cir.0000099844.31524.05 · Cited by 932
Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus
Asanuma, Y., Oeser, A. M., Shintani, A., Turner, E. L., Olsen, N. J., Fazio, S., Linton, M. F., Raggi, P., & Stein, C. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035611 · Cited by 889
Relation between Myocardial Blood Flow and the Severity of Coronary-Artery Stenosis
Uren, N. G., Melin, J. A., Bruyne, B. D., Wijns, W. C., Baudhuin, T., & Camici, P. G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302503 · Cited by 881
Self-citationSchned, E. S., Glickstein, S. L., & Doyle, M. T. A. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360623 · Cited by 726
Hürlimann, D., Forster, A., Noll, G., Enseleit, F., Chenevard, R., Distler, O., Béchir, M., Spieker, L. E., Neidhart, M., Michel, B. A., et al. (2002) · Circulation · doi:10.1161/01.cir.0000037521.71373.44 · Cited by 577
Dixon, W. G., Watson, K. D., Lunt, M., Hyrich, K. L., Silman, A. J., & Symmons, D. P. M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22809 · Cited by 557
Risk Factors for Cardiovascular Disease in Systemic Lupus Erythematosus
Svenungsson, E., Jensen‐Urstad, K., Heimbürger, M., Silveira, A. M. V., Hamsten, A., Fairé, U. D., Witztum, J. L., & Frostegård, J. (2001) · Circulation · doi:10.1161/hc4101.097518 · Cited by 498
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482
Inoue, E., Yamanaka, H., Hara, M., Tomatsu, T., & Kamatani, N. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.054205 · Cited by 421
Kumeda, Y., Inaba, M., Goto, H., Nagata, M., Henmi, Y., Furumitsu, Y., Ishimura, E., Inui, K., Yutani, Y., Miki, T., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10269 · Cited by 307
Vascular Stiffness in Women With Systemic Lupus Erythematosus
Selzer, F., Sutton-Tyrrell, K., Fitzgerald, S. G., Tracy, R. P., Kuller, L. H., & Manzi, S. (2001) · Hypertension · doi:10.1161/01.hyp.37.4.1075 · Cited by 287
El-Magadmi, M., Bodill, H., Ahmad, Y. A., Durrington, P. N., Mackness, M., Walker, M. G., Bernstein, R. M., & Bruce, I. N. (2004) · Circulation · doi:10.1161/01.cir.0000136807.78534.50 · Cited by 276
Myocardial blood flow measurement by PET: technical aspects and clinical applications.
Kaufmann, P. A., & Camici, P. G. (2005) · PubMed · Cited by 275
Self-citationCD4+CD28− T Lymphocytes Contribute to Early Atherosclerotic Damage in Rheumatoid Arthritis Patients
Gerli, R., Schillaci, G., Giordano, A., Bartoloni, E., Bistoni, O., Vaudo, G., Marchesi, S., Pirro, M., Ragni, F., Shoenfeld, Y., et al. (2004) · Circulation · doi:10.1161/01.cir.0000131450.66017.b3 · Cited by 254
Coronary Heart Disease in Smokers: Vitamin C Restores Coronary Microcirculatory Function
Kaufmann, P. A., Gnecchi-Ruscone, T., di Terlizzi, M., Schäfers, K. P., Lüscher, T. F., & Camici, P. G. (2000) · Circulation · doi:10.1161/01.cir.102.11.1233 · Cited by 246
Self-citationMaki-Petaja, K. M., Booth, A. D., Hall, F. C., Wallace, S. M. L., Brown, J., McEniery, C. M., & Wilkinson, I. B. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.076 · Cited by 241
González‐Juanatey, C., Llorca, J., Testa, A., Revuelta, J., Garcı́a-Porrúa, C., & González-Gay, M. Á. (2003) · Medicine · doi:10.1097/01.md.0000101572.76273.60 · Cited by 238
Selzer, F., Sutton‐Tyrrell, K., Fitzgerald, S. G., Pratt, J. E., Tracy, R. P., Kuller, L. H., & Manzi, S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11418 · Cited by 228
González‐Juanatey, C., Testa, A., García‐Castelo, A., Garcı́a-Porrúa, C., Llorca, J., & González-Gay, M. Á. (2004) · Arthritis Care & Research · doi:10.1002/art.20407 · Cited by 227
Wong, M., Toh, L., Wilson, A., Rowley, K., Karschimkus, C. S., Prior, D., Romas, E., Clemens, L., Dragicevic, G., Harianto, H., et al. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10748 · Cited by 189
Progression of carotid intima‐media thickness and plaque in women with systemic lupus erythematosus
Thompson, T., Sutton‐Tyrrell, K., Wildman, R. P., Kao, A. H., Fitzgerald, S. G., Shook, B., Tracy, R. P., Kuller, L. H., Brockwell, S. E., & Manzi, S. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23196 · Cited by 157
Raza, K., Thambyrajah, J., Townend, J., Exley, A., Hortas, C., Filer, A. D., Carruthers, D. M., & BACON, P. A. (2000) · Circulation · doi:10.1161/01.cir.102.13.1470 · Cited by 152
Angiotensin-Converting Enzyme Inhibition Improves Vascular Function in Rheumatoid Arthritis
Flammer, A. J., Sudano, I., Hermann, F., Gay, S., Forster, A., Neidhart, M., Künzler, P., Enseleit, F., Périat, D., Hermann, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.734384 · Cited by 130
Series of Monographs on Venous Thromboembolic Disease
Jaff, M. R., & Halperin, J. L. (2004) · Circulation · doi:10.1161/01.cir.0000122867.89751.59 · Cited by 126
Simvastatin improves endothelial function in patients with rheumatoid arthritis
Hermann, F., Forster, A., Chenevard, R., Enseleit, F., Hürlimann, D., Corti, R., Spieker, L. E., Frey, D., Hermann, M., Riesen, W., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.11.006 · Cited by 105
Çiftçi, Ö., Yılmaz, S., Topçu, S., Çalışkan, M., Güllü, H., Erdoğan, D., Pamuk, B. Ö., Yı́ldı́rı́r, A., & Müderrisoğlu, H. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.013 · Cited by 91
Coronary hemodynamics and myocardial metabolism during and after pacing stress in normal humans
Camici, P. G., Marraccini, P., Marzilli, M., Lorenzoni, R., Buzzigoli, G., Puntoni, R., Boni, C. D., Bellina, C. R., Klassen, G. A., L’Abbate, A., et al. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.3.e309 · Cited by 80
Self-citationBøttcher, M., Madsen, M. M., Refsgaard, J. C., Buus, N. H., Dørup, I., Nielsen, T. T., & Sørensen, K. E. (2001) · Circulation · doi:10.1161/01.cir.103.8.1109 · Cited by 72
Disease modification and cardiovascular risk reduction: two sides of the same coin?
Hall, F. C., & Dalbeth, N. (2005) · Rheumatology · doi:10.1093/rheumatology/kei012 · Cited by 71
Mycophenolate mofetil treatment reduces cholesterol-induced atherosclerosis in the rabbit
Romero, F., Rodríguez‐Iturbe, B., Pons, H., Parra, G., Quiroz, Y., Rincon, J. C., & González, L. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00458-x · Cited by 60
Microcirculatory Hemodynamics and Endothelial Dysfunction in Systemic Lupus Erythematosus
Wright, S., O’Prey, F. M., Rea, D. J., Plumb, R., Gamble, A., Leahey, W. J., Devine, A. B., McGivern, R. C., Johnston, D., Finch, M. B., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000238351.82900.7f · Cited by 58
Altered coronary vasomotor function in young patients with systemic lupus erythematosus
Hirata, K., Kadirvelu, A., Kinjo, M., Sciacca, R. R., Sugioka, K., Otsuka, R., Choy, A. M., Chow, S. K., Yoshiyama, M., Yoshikawa, J., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22702 · Cited by 57
Naoumova, R. P., Kindler, H. E., Leccisotti, L., Mongillo, M., Khan, M. T., Neuwirth, C. K. Y., Seed, M., Holvoet, P., Betteridge, J. D., & Camici, P. G. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.070 · Cited by 43
Self-citationChronic Inflammatory Autoimmune Disorders and Atherosclerosis
ABOURAYA, S., Abou‐Raya, A., Naim, A., & Abuelkheir, H. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.007 · Cited by 36
Ho (2001) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200110)44:10 · Cited by 3
Komuro (2001) · doi:10.1002/1529-0131(200112)44:12
Research works printed but not linked: 4
- Kaufmann, 2005, Journal of Nuclear Medicine, 46, 75
- 2008, 198, 332
- 1989, American Journal of Physiology -- Legacy Content, 257, E309
- 2000, 152, 127
Cited by
Sorted by citations
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
European guidelines on cardiovascular disease prevention in clinical practice: executive summary
Graham, I., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm316 · Cited by 3,865
2024 ESC Guidelines for the management of chronic coronary syndromes
Vrints, C. J., Andreotti, F., Koskinas, K. C., Rosselló, X., Adamo, M., Ainslie, J., BANNING, A. P., Budaj, A., Buechel, R. R., Chiariello, G. A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae177 · Cited by 3,521
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Authors/Task Force Members, Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corrà, U., Cosyns, B., et al. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316653709 · Cited by 1,435
Kunadian, V., Chieffo, A., Camici, P. G., Berry, C., Escaned, J., Maas, A. H. E. M., Prescott, E., Karam, N., Appelman, Y., Fraccaro, C., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa503 · Cited by 867
Self-citation
Metadata
- Authors
- Recio-Mayoral, A., Mason, J. C., Kaski, J. C., Rubens, M. B., Harari, O. A., & Camici, P. G.
- Affiliations
- Imperial College London (GB)
- St George's, University of London (GB)
- Royal Brompton Hospital (GB)
- Corresponding author
- Camici, P. G.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06-05
- Volume
- 30
- Issue
- 15
- Pages
- 1837-1843
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2021794274
- Cited by
- 235
- References
- 50
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 15 · 2023: 11 · 2022: 14 · 2021: 28 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 20 · 2014: 12 · 2013: 11 · 2012: 17
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Sociedad Española de Cardiología
- Cardiovascular Research Foundation
- National Institute for Health and Care Research
- British Heart Foundation (PG/08001)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- chronic inflammation, coronary microvascular dysfunction, coronary flow reserve, systemic lupus erythematosus, rheumatoid arthritis, myocardial blood flow, disease duration, disease activity, myocardial ischemia, premature coronary artery disease
- MeSH terms
- Adenosine, Adult, Arthritis, Rheumatoid, Coronary Artery Disease, Coronary Circulation, Endothelium, Vascular, Female, Humans, Inflammation, Lupus Erythematosus, Systemic, Male, Microcirculation, Prospective Studies, Vasodilator Agents, Case-Control Studies, Risk Assessment, Positron-Emission Tomography, Fractional Flow Reserve, Myocardial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
