The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial
Open accessAbstract
AIMS: No drug has been proven efficacious to prevent the post-pericardiotomy syndrome (PPS), but colchicine seems safe and effective for the treatment and prevention of pericarditis. The aim of the COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS) trial is to test the efficacy and safety of colchicine for the primary prevention of the PPS. METHODS AND RESULTS: The COPPS study is a multicentre, double-blind, randomized trial. On the third post-operative day, 360 patients (mean age 65.7 ± 12.3 years, 66% males), 180 in each treatment arm, were randomized to receive placebo or colchicine (1.0 mg twice daily for the first day followed by a maintenance dose of 0.5 mg twice daily for 1 month in patients ≥70 kg, and halved doses for patients <70 kg or intolerant to the highest dose). The primary efficacy endpoint was the incidence of PPS at 12 months. Secondary endpoint was the combined rate of disease-related hospitalization, cardiac tamponade, constrictive pericarditis, and relapses. Baseline characteristics were well balanced between the study groups. Colchicine significantly reduced the incidence of the PPS at 12 months compared with placebo (respectively, 8.9 vs. 21.1%; P = 0.002; number needed to treat = 8). Colchicine also reduced the secondary endpoint (respectively, 0.6 vs. 5.0%; P = 0.024). The rate of side effects (mainly related to gastrointestinal intolerance) was similar in the colchicine and placebo groups (respectively, 8.9 vs. 5.0%; P = 0.212). CONCLUSION: Colchicine is safe and efficacious in the prevention of the PPS and its related complications and may halve the risk of developing the syndrome following cardiac surgery. ClinicalTrials.gov number, NCT00128427.
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Imazio, M., Bobbio, M., Cecchi, E., Demarie, D., Demichelis, B., Pomari, F., Moratti, M., Gaschino, G., Giammaria, M., Ghisio, A., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.542738 · Cited by 614
Self-citationEmmerson, B. T. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602153340707 · Cited by 516
Imazio, M., Bobbio, M., Cecchi, E., Demarie, D., Pomari, F., Moratti, M., Ghisio, A., Belli, R., & Trinchero, R. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.17.1987 · Cited by 424
Self-citationControversial Issues in the Management of Pericardial Diseases
Imazio, M., Spodick, D. H., Brucato, A., Trinchero, R., & Adler, Y. (2010) · Circulation · doi:10.1161/circulationaha.108.844753 · Cited by 414
Self-citationCleveland, J. C., Meldrum, D. R., Cain, B. S., Banerjee, A., & Harken, A. H. (1997) · Circulation · doi:10.1161/01.cir.96.1.29 · Cited by 294
Colchicine Treatment for Recurrent Pericarditis: A Decade of Experience
Adler, Y., Finkelstein, Y., Guindo, J., Rodriguez de la Serna, A., Shoenfeld, Y., Bayes-Genis, A., Sagie, A., Bayes de Luna, A., & Spodick, D. H. (1998) · Circulation · doi:10.1161/01.cir.97.21.2183 · Cited by 242
Self-citationUpdate on colchicine and its mechanism of action
Molad, Y. (2002) · Current Rheumatology Reports · doi:10.1007/s11926-002-0073-2 · Cited by 213
Artom, G., Koren‐Morag, N., Spodick, D. H., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi197 · Cited by 154
Self-citationColchicine for pericarditis: hype or hope?
Imazio, M., Brucato, A. L., Trinchero, R., Spodick, D. H., & Adler, Y. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehn608 · Cited by 147
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Klein, A. L., Abbara, S., Agler, D. A., Appleton, C. P., Asher, C. R., Hoit, B., Hung, J., Garcia, M. J., Kronzon, I., Oh, J. K., et al. (2013) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2013.06.023 · Cited by 773
Inflammatory processes in cardiovascular disease: a route to targeted therapies
Ruparelia, N., Chai, J. T., Fisher, E. A., & Choudhury, R. P. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.185 · Cited by 477
Erratum: Inflammatory processes in cardiovascular disease: a route to targeted therapies
Ruparelia, N., Chai, J. T., Fisher, E. A., & Choudhury, R. P. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.33 · Cited by 363
Imazio, M., Brucato, A., Ferrazzi, P., Rovere, M. E., Gandino, A., Cemin, R., Ferrua, S., Belli, R., Maestroni, S., Simon, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.026153 · Cited by 331
Self-citationOesterle, A., Singh, A., Balkhy, H., Husain, A. N., Moyer, D., Tung, R., & Nayak, H. M. (2016) · HeartRhythm Case Reports · doi:10.1016/j.hrcr.2016.07.003 · Cited by 11
Metadata
- Authors
- Imazio, M., Trinchero, R., Brucato, A., Rovere, M. E., Gandino, A., Cemin, R., Ferrua, S., Maestroni, S., Zingarelli, E., Barosi, A., Simon, C., Sansone, F., Patrini, D., Vitali, E., Ferrazzi, P., Spodick, D. H., Adler, Y., & on behalf of the COPPS Investigators
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08-30
- Volume
- 31
- Issue
- 22
- Pages
- 2749-2754
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2157786086
- Cited by
- 293
- References
- 21
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Imazio, M., Trinchero, R., Brucato, A., Rovere, M. E., Gandino, A., Cemin, R., Ferrua, S., Maestroni, S., Zingarelli, E., Barosi, A., Simon, C., Sansone, F., Patrini, D., Vitali, E., Ferrazzi, P., Spodick, D. H., Adler, Y., & on behalf of the COPPS Investigators. (2010). COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial. European Heart Journal. https://doi.org/10.1093/eurheartj/ehq319
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
