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Colchicine Reduces Postoperative Atrial Fibrillation: Results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) Atrial Fibrillation Substudy
Open accessAbstract
Background—: Inflammation and pericarditis may be contributing factors for postoperative atrial fibrillation (POAF), and both are potentially affected by antiinflammatory drugs and colchicine, which has been shown to be safe and efficacious for the prevention of pericarditis and the postpericardiotomy syndrome (PPS). The aim of the Colchicine for the Prevention of the Post-Pericardiotomy Syndrome (COPPS) POAF substudy was to test the efficacy and safety of colchicine for the prevention of POAF after cardiac surgery. Methods and Results—: The COPPS POAF substudy included 336 patients (mean age, 65.7±12.3 years; 69% male) of the COPPS trial, a multicenter, double-blind, randomized trial. Substudy patients were in sinus rhythm before starting the intervention (placebo/colchicine 1.0 mg twice daily starting on postoperative day 3 followed by a maintenance dose of 0.5 mg twice daily for 1 month in patients ≥70 kg, halved doses for patients <70 kg or intolerant to the highest dose). The substudy primary end point was the incidence of POAF on intervention at 1 month. Despite well-balanced baseline characteristics, patients on colchicine had a reduced incidence of POAF (12.0% versus 22.0%, respectively; P =0.021; relative risk reduction, 45%; number needed to treat, 11) with a shorter in-hospital stay (9.4±3.7 versus 10.3±4.3 days; P =0.040) and rehabilitation stay (12.1±6.1 versus 13.9±6.5 days; P =0.009). Side effects were similar in the study groups. Conclusion—: Colchicine seems safe and efficacious in the reduction of POAF with the potentiality of halving the complication and reducing the hospital stay. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00128427.
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Developed with the special contribution of the European Heart Rhythm Association (EHRA), Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), Authors/Task Force Members, Camm, A. J., Kirchhof, P., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Van Gelder, I. C., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,864
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Atrial Fibrillation after Cardiac Surgery
Maisel, W. H., Rawn, J. D., & Stevenson, W. G. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-12-200112180-00010 · Cited by 797
Imazio, M., Bobbio, M., Cecchi, E., Demarie, D., Demichelis, B., Pomari, F., Moratti, M., Gaschino, G., Giammaria, M., Ghisio, A., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.542738 · Cited by 614
Self-citationImazio, M., Bobbio, M., Cecchi, E., Demarie, D., Pomari, F., Moratti, M., Ghisio, A., Belli, R., & Trinchero, R. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.17.1987 · Cited by 424
Self-citationControversial Issues in the Management of Pericardial Diseases
Imazio, M., Spodick, D. H., Brucato, A., Trinchero, R., & Adler, Y. (2010) · Circulation · doi:10.1161/circulationaha.108.844753 · Cited by 414
Self-citationHalonen, J., Halonen, P., Järvinen, O., Taskinen, P., Auvinen, T., Tarkka, M., Hippeläinen, M., Juvonen, T., Hartikainen, J., & Hakala, T. (2007) · JAMA · doi:10.1001/jama.297.14.1562 · Cited by 331
Ishii, Y., Schuessler, R. B., Gaynor, S. L., Yamada, K., Fu, A. S., Boineau, J. P., & Damiano, R. J. (2005) · Circulation · doi:10.1161/circulationaha.104.475194 · Cited by 319
Imazio, M., Trinchero, R., Brucato, A., Rovere, M. E., Gandino, A., Cemin, R., Ferrua, S., Maestroni, S., Zingarelli, E., Barosi, A., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq319 · Cited by 293
Self-citationEpidemiology, Mechanisms, and Risks
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Cited by
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001193 · Cited by 2,765
Calkins, H., Hindricks, G., Cappato, R., Kim, Y.-H., Saad, E. B., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,755
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000040 · Cited by 2,056
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.017 · Cited by 933
Metadata
- Authors
- Imazio, M., Brucato, A., Ferrazzi, P., Rovere, M. E., Gandino, A., Cemin, R., Ferrua, S., Belli, R., Maestroni, S., Simon, C., Zingarelli, E., Barosi, A., Sansone, F., Patrini, D., Vitali, E., Trinchero, R., Spodick, D. H., Adler, Y., & for the COPPS Investigators
- Venue
- Circulation
- Published
- 2011-11-22
- Volume
- 124
- Issue
- 21
- Pages
- 2290-2295
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2151995209
- Cited by
- 331
- References
- 20
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Imazio, M., Brucato, A., Ferrazzi, P., Rovere, M. E., Gandino, A., Cemin, R., Ferrua, S., Belli, R., Maestroni, S., Simon, C., Zingarelli, E., Barosi, A., Sansone, F., Patrini, D., Vitali, E., Trinchero, R., Spodick, D. H., Adler, Y., & for the COPPS Investigators. (2011). Colchicine Reduces Postoperative Atrial Fibrillation: Results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) Atrial Fibrillation Substudy. Circulation. https://doi.org/10.1161/circulationaha.111.026153
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