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EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention
Abstract
AIMS: Among patients with ST-elevation myocardial infarction (STEMI), reperfusion injury contributes to additional myocardial damage. MTP-131 is a cell-permeable peptide that preserves the integrity of cardiolipin, enhances mitochondrial energetics, and improves myocyte survival during reperfusion. METHODS AND RESULTS: EMBRACE STEMI is a multicentre, randomized, double-blind Phase 2a trial that evaluated the efficacy and safety of MTP-131 vs. placebo infused at a rate of 0.05 mg/kg/h for 1 h among first-time anterior STEMI subjects undergoing primary percutaneous coronary intervention (PCI) for a proximal or mid left anterior descending (LAD) artery occlusion. Administration of MTP-131 was not associated with a significant reduction in the primary endpoint, infarct size by creatine kinase-myocardial band (CK-MB) area under the curve (AUC) over 72 h (5785 ± 426 ng h/mL in placebo vs. 5570 ± 486 ng h/mL in MTP-131; ITALIC! P = NS). MTP-131 was not associated with an improvement in pre-specified magnetic resonance imaging, angiographic, electrocardiographic, or clinical outcomes. CONCLUSION: Among subjects with first-time anterior STEMI due to a proximal or mid LAD lesion who undergo successful PCI, administration of MTP-131 was safe and well tolerated. Treatment with MTP-131 was not associated with a decrease in myocardial infarct size as assessed by AUC0-72 of CK-MB.
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“Phase I clinical trials established that the molecule was safe and well tolerated (360).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [360]
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Yellon, D. M., & Hausenloy, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071667 · Cited by 3,797
Myocardial reperfusion: a double-edged sword?
D, E. B. M., & Kloner, R. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112160 · Cited by 1,368
Self-citationEffect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction
Piot, C. A., Croisille, P., Staat, P., Thibault, H., Rioufol, G., Mewton, N., Belghiti, R. E., Cung, T. T., Bonnefoy‐Cudraz, E., Angoulvant, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa071142 · Cited by 1,339
Halestrap, A. P. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00533-9 · Cited by 1,244
Zhao, K., Zhao, G.-M., Wu, D., Soong, Y., Birk, A. V., Schiller, P. W., & Szeto, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402999200 · Cited by 782
Ross, A. M., Gibbons, R. J., Stone, G. W., Kloner, R. A., & Alexander, R. W. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.061 · Cited by 608
Self-citationSzeto, H. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12461 · Cited by 561
Stone, G. W. (2012) · JAMA · doi:10.1001/jama.2012.421 · Cited by 542
The APEX AMI Investigators (2007) · JAMA · doi:10.1001/jama.297.1.43 · Cited by 447
Ibáñez, B., Macaya, C., Sánchez-Brunete, V., Pizarro, G., Fernández‐Friera, L., Rodríguez, A. A. M., Fernández‐Ortíz, A., García-Ruiz, J. M., García‐Álvarez, A., Íñiguez, A., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.003653 · Cited by 395
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Kim, H., Seo, J., Lee, Y.-H., Park, K., Perry, T. A., Arden, N., Mobasheri, A., & Choi, H. (2022) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x221085952 · Cited by 38
Benjanuwattra, J., Apaijai, N., Chunchai, T., Kerdphoo, S., Jaiwongkam, T., Arunsak, B., Wongsuchai, S., Chattipakorn, N., & Chattipakorn, S. C. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165893 · Cited by 44
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Fede, M. S., Daziani, G., Tavoletta, F., Montana, A., Compagnucci, P., Goteri, G., Neri, M., & Busardò, F. P. (2025) · Cells · doi:10.3390/cells14191509 · Cited by 41
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He, J., Bellenger, N. G., Ludman, A. J., Shore, A. C., & Strain, W. D. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2301023 · Cited by 33
Campo, G. C., Morciano, G., Pavasini, R., Bonora, M., Sbano, L., Biscaglia, S., Bovolenta, M., Pinotti, M., Punzetti, S., Rizzo, P., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.07.125 · Cited by 30
Kakavand, H., Aghakouchakzadeh, M., Coons, J. C., & Talasaz, A. H. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000980 · Cited by 31
Todisco, S., Musio, B., Pesce, V., Cavalluzzi, M. M., Petrosillo, G., Piana, G. L., Sgobba, M. N., Schlosserová, N., Beltrame, L. C., Lorenzo, R. D., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115405 · Cited by 31
Campo, G. C., Pavasini, R., Morciano, G., Lincoff, A. M., Gibson, C. M., Kitakaze, M., Lønborg, J., Ahluwalia, A., Ishii, H., Frenneaux, M. P., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.06.040 · Cited by 29
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Tschöpe, C., Linthout, S. V., & Kherad, B. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0874-6 · Cited by 27
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von Hardenberg, A., & Maack, C. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_123 · Cited by 26
Dai, W., Cheung, E., Alleman, R. J., Perry, J. B., Allen, M. E., Brown, D. A., & Kloner, R. A. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6695-9 · Cited by 25
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Paillard, M., Abdellatif, M., Andreadou, I., Bär, C., Bertrand, L., Brundel, B. J. J. M., Chiva‐Blanch, G., Davidson, S. M., Dawson, D. K., Lisa, F. D., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3674 · Cited by 29
Hortmann, M., Robinson, S., Mohr, M., Mauler, M., Stallmann, D., Reinöhl, J., Duerschmied, D., Peter, K., Carr, J., Gibson, C. M., et al. (2017) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872617710789 · Cited by 24
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Metadata
- Authors
- Gibson, C. M., Giugliano, R. P., Kloner, R. A., Bode, C., Tendera, M., Jánosi, A., Merkely, B., Godlewski, J., Halaby, R., Korjian, S., Daaboul, Y., Chakrabarti, A. K., Spielman, K., Neal, B. J., & Weaver, W. D.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- University of Southern California (US)
- University of Freiburg (DE)
- Gottsegen National Cardiovascular Center (HU)
- John Paul II Hospital (PL)
- Harvard University (US)
- Eastern Virginia Medical School (US)
- Henry Ford Hospital (US)
- Corresponding author
- Gibson, C. Michael
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-11-19
- Volume
- 37
- Issue
- 16
- Pages
- 1296.1-1303
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2176701303
- Cited by
- 162
- References
- 36
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 15 · 2023: 12 · 2022: 19 · 2021: 9 · 2020: 19 · 2019: 13 · 2018: 17 · 2017: 19 · 2016: 18
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Keywords
- ST-elevation myocardial infarction, ischemia-reperfusion injury, primary percutaneous coronary intervention, cell-permeable peptide, cardiolipin, mitochondrial bioenergetics, myocardial infarct size, CK-MB, left anterior descending artery occlusion, drug safety and tolerability
- MeSH terms
- ST Elevation Myocardial Infarction, Double-Blind Method, Humans, Oligopeptides, Percutaneous Coronary Intervention
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