[Retracted] Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies

Stamerra, Cosimo Andrea; Di Giosia, Paolo; Giorgini, Paolo; Ferri, Claudio; Sukhorukov, Vasily N.; Sahebkar, Amirhossein

doi:10.1155/2022/9530007

Cited by 48Mitochondrial Function and PathologyCardiac Ischemia and ReperfusionAutophagy in Disease and Therapy

[Retracted] Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies

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Stamerra, Cosimo Andrea, Di Giosia, Paolo, Giorgini, Paolo, Ferri, Claudio, Sukhorukov, Vasily N., Sahebkar, Amirhossein·2022·Oxidative Medicine and Cellular Longevity

DOI 10.1155/2022/9530007PMC PMC9363184

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Abstract

Mitochondria ensure the supply of cellular energy through the production of ATP via oxidative phosphorylation. The alteration of this process, called mitochondrial dysfunction, leads to a reduction in ATP and an increase in the production of reactive oxygen species (ROS). Mitochondrial dysfunction can be caused by mitochondrial/nuclear DNA mutations, or it can be secondary to pathological conditions such as cardiovascular disease, aging, and environmental stress. The use of therapies aimed at the prevention/correction of mitochondrial dysfunction, in the context of the specific treatment of cardiovascular diseases, is a topic of growing interest. In this context, the data are conflicting since preclinical studies are numerous, but there are no large randomized studies.

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Mitochondrial function is widely recognized as a factor in the pathophysiology of several psychiatric disorders, including MDD, and a variety of physical conditions, such as metabolic diseases, cardiovascular diseases, and neurodegenerative disorders.
“Mitochondrial function is widely recognized as a factor in the pathophysiology of several psychiatric disorders, including MDD216, and a variety of physical conditions, such as metabolic diseases217, cardiovascular diseases218, and neurodegenerative disorders219.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [218]

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Novel Mitochondria-Targeting Peptide in Heart Failure Treatment
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MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation
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Background
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Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts
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Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability
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Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice.
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Phase 2a Clinical Trial of Mitochondrial Protection (Elamipretide) During Stent Revascularization in Patients With Atherosclerotic Renal Artery Stenosis
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Impaired Autophagy Contributes to Adverse Cardiac Remodeling in Acute Myocardial Infarction
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Aspirin Recapitulates Features of Caloric Restriction
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Cardioprotective Effects of 17β-Estradiol Produced by Activation of Mitochondrial ATP-Sensitive K+Channels in Canine Hearts
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A Deletion of Mitochondrial DNA in Murine Doxorubicin-Induced Cardiotoxicity
Adachi, K., Fujiura, Y., Mayumi, F., Nozuhara, A., Sugiu, Y., Sakanashi, T., Hidaka, T., & Toshima, H. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2135 · Cited by 103 · see citing works
The effect of fasting or calorie restriction on mitophagy induction: A literature review
Mehrabani, S., Bagherniya, M., Askari, G., Read, M. I., & Sahebkar, A. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12611 · Cited by 103 · see citing works
DNA Damage as a New Emerging Risk Factor in Atherosclerosis
Andreassi, M. G., & Botto, N. (2003) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(03)00109-9 · Cited by 102 · see citing works
Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart
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Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials
Li, L., & Liu, Y. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0628-9 · Cited by 93 · see citing works
Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition
Javadov, S. A., Rajapurohitam, V., Kilić, A., Hunter, J. C., Zeidan, A., Faruq, N. S., Escobales, N., & Karmazyn, M. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0122-3 · Cited by 92 · see citing works
17β-Estradiol as a Receptor-Mediated Cardioprotective Agent
Booth, E. A., Marchesi, M., Kilbourne, E. J., & Lucchesi, B. R. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054205 · Cited by 90 · see citing works
Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle
Swenson, A. M., Tang, W., Blair, C. A., Fetrow, C., Unrath, W. C. T., Previs, M. J., Campbell, K. S., & Yengo, C. M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.748780 · Cited by 89 · see citing works
Neuroprotective effects of curcumin through autophagy modulation
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Dietary spermidine for lowering high blood pressure
Eisenberg, T., Abdellatif, M., Zimmermann, A., Schroeder, S., Pendl, T., Harger, A., Stekovic, S., Schipke, J., Magnes, C., Schmidt, A. G., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1280225 · Cited by 87 · see citing works
Lack of Glutathione Peroxidase 1 Accelerates Cardiac-Specific Hypertrophy and Dysfunction in Angiotensin II Hypertension
Ardanaz, N., Yang, X.-P., Cifuentes-Pagano, E., Haurani, M. J., Jackson, K. W., Liao, T., Carretero, O. A., & Pagano, P. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.135715 · Cited by 85 · see citing works
Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure
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The cardioprotective actions of statins in targeting mitochondrial dysfunction associated with myocardial ischaemia-reperfusion injury
Bland, A. R., Payne, F. M., Ashton, J. C., Jamialahmadi, T., & Sahebkar, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105986 · Cited by 82 · see citing works
Multiple Levels of PGC-1α Dysregulation in Heart Failure
Oka, S., Sabry, A. D., Cawley, K. M., & Warren, J. S. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00002 · Cited by 81 · see citing works
Mitochondrial toxicity–new adverse drug effects
Swartz, M. N. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510263331710 · Cited by 80 · see citing works
Is there a role for supplemented antioxidants in the prevention of atherosclerosis?
Katsiki, N., & Manes, C. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.10.011 · Cited by 79 · see citing works
Non-histone lysine acetylated proteins in heart failure
Grillon, J. M., Johnson, K. R., Kumar, K. U., & Danziger, R. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.016 · Cited by 77 · see citing works
Gender differences in cardiovascular prophylaxis: Focus on antiplatelet treatment
Giosia, P. D., Passacquale, G., Petrarca, M., Giorgini, P., Marra, A. M., & Ferro, A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.025 · Cited by 76 · see citing works
Impact of curcumin on sirtuins: A review
Zendedel, E., Butler, A. E., Atkin, S. L., & Sahebkar, A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27371 · Cited by 76 · see citing works
Mitochondrion as a Selective Target for the Treatment of Atherosclerosis: Role of Mitochondrial DNA Mutations and Defective Mitophagy in the Pathogenesis of Atherosclerosis and Chronic Inflammation
Orekhov, A. N., Poznyak, A. V., Sobenin, I. A., Nikifirov, N. N., & Ivanova, E. A. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191118125018 · Cited by 76 · see citing works
Epigenetic Control of Mitochondrial Function in the Vasculature
Mohammed, S. A., Ambrosini, S., Lüscher, T. F., Paneni, F., & Costantino, S. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00028 · Cited by 76 · see citing works
Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
Singh, R. B., Neki, N. S., Kartikey, K., Pella, D., Kumar, A., Niaz, M. A., & Thakur, A. S. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0298-2_11 · Cited by 74 · see citing works
Mitochondrial Function Is Involved in LDL Oxidation Mediated by Human Cultured Endothelial Cells
Mabile, L., Meilhac, O., Escargueil‐Blanc, I., Troly, M., Pieraggi, M., Salvayre, R., & Nègre‐Salvayre, A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1575 · Cited by 74 · see citing works
Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice
Vendrov, A. E., Stevenson, M., Alahari, S., Pan, H., Wickline, S. A., Madamanchi, N. R., & Runge, M. S. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006775 · Cited by 73 · see citing works
DNA-adducts and atherosclerosis: a study of accidental and sudden death males in the Czech Republic
Binková, B., Šmerhovský, Z., Strejc, P., Boubelík, O., Stávková, Z., Chvátalová, I., & Šrám, R. J. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00019-2 · Cited by 72 · see citing works
Cardiac Involvement in Adults With m.3243A>G MELAS Gene Mutation
Vydt, T., de Coo, I. F. M., Soliman, O. I. I., ten Cate, F. J., van Geuns, R., Vletter, W. B., Schoonderwoerd, K. C., van den Bosch, B. J. C., Smeets, H. J. M., & Geleijnse, M. L. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.07.089 · Cited by 72 · see citing works
Decreased Superoxide Dismutase Activity and Increased Superoxide Anion Production in Cardiac Hypertrophy of Spontaneously Hypertensive Rats
Ito, H., Torii, M., & Suzuki, T. (1995) · Clinical and Experimental Hypertension · doi:10.3109/10641969509033636 · Cited by 72 · see citing works
Smoke cardiomyopathy: disturbance of oxidative processes in myocardial mitochondria
Gvozdjáková, A., Bada, V., Sány, L., Kucharská, J., Krutý, F., Božek, P., TRSTANSKY, L., & Gvozdják, J. (1984) · Cardiovascular Research · doi:10.1093/cvr/18.4.229 · Cited by 71 · see citing works
Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection
Carraro, M., Carrer, A., Urbani, A., & Bernardi, P. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.05.014 · Cited by 71 · see citing works
Opening of Ca2+-activated K+ channels is involved in ischemic preconditioning in canine hearts
Shintani, Y. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.09.012 · Cited by 69 · see citing works
Melatonin, mitochondria and hypertension
Baltatu, O. C., do Amaral, F. G., Campos, L. A., & Cipolla‐Neto, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2613-y · Cited by 66 · see citing works
Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
Singh, R. B., Neki, N. S., Kartikey, K., Pella, D., Kumar, A., Niaz, M. A., & Thakur, A. S. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1023408031111 · Cited by 66 · see citing works
Oxidative Stress and Antioxidant Supplementation in the Management of Diabetic Cardiovascular Disease
Vega‐López, S., Devaraj, S., & Jialal, I. (2004) · Journal of Investigative Medicine · doi:10.1136/jim-52-01-23 · Cited by 65 · see citing works
Functional Role of Mitochondria in Arrhythmogenesis
Gambardella, J., Sorriento, D., Ciccarelli, M., Giudice, C. D., Fiordelisi, A., Napolitano, L., Trimarco, B., Iaccarino, G., & Santulli, G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_10 · Cited by 65 · see citing works
The Aging Heart: Mitophagy at the Center of Rejuvenation
Liang, W., & Gustafsson, Å. B. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00018 · Cited by 62 · see citing works
Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart
Shi, J., Dai, W., Hale, S. L., Brown, D. A., Wang, M., Han, X., & Kloner, R. A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.09.022 · Cited by 61 · see citing works
Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model
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Mitochondrial ion channels as targets for cardioprotection
Hausenloy, D. J., Schulz, R., Girão, H., Kwak, B. R., Stefani, D. D., Rizzuto, R., Bernardi, P., & Lisa, F. D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15341 · Cited by 59 · see citing works
Physiology and relevance of human adaptive thermogenesis response
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Oxidized low-density lipoprotein and 15-deoxy-Δ12,14-PGJ2increase mitochondrial complex I activity in endothelial cells
CEASER, E. K., Ramachandran, A., Levonen, A., & Darley-Usmar, V. M. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00508.2003 · Cited by 55 · see citing works

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Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336 · see citing works
Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases
Liu, Y., Huang, Y., Xu, C. B., An, P., Luo, Y., Jiao, L., Luo, J., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416053 · Cited by 149 · see citing works
Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease
Camacho-Encina, M., Booth, L. K., Redgrave, R. E., Folaranmi, O., Spyridopoulos, I., & Richardson, G. D. (2024) · Cells · doi:10.3390/cells13040353 · Cited by 101 · see citing works
“Therefore, restoring their ATP-producing capacity and counteracting the damaging effects of ROS to reduce oxidative stress and chronic inflammation have been suggested as primary therapeutic targets to improve mitochondrial dysfunction [31].”
Background
Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
Rocca, C., Soda, T., Francesco, E. D. D., Fiorillo, M., Moccia, F., Viglietto, G., Angelone, T., & Amodio, N. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04498-5 · Cited by 82 · see citing works
“A crucial determinant of CVDs may also be represented by mtDNA mutations leading to OXPHOS impairment [96].”
BackgroundInfluential
Subcellular Visualization: Organelle-Specific Targeted Drug Delivery and Discovery.
Shao, X.-T., Meng, C.-C., Song, W., Zhang, T., & Chen, Q. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114977 · Cited by 58 · see citing works
Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
Sun, M., Jiang, W., Mu, N., Zhang, Z., Yu, L., & Ma, H. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04203-6 · Cited by 67 · see citing works
“Ultrastructural analysis shows a significant increase in the number and size of mitochondria, resulting in the enlargement of cardiomyocytes and sarcomere disorders hinder contractile activity in mitochondrial heart disease [17].”
Background
The impact of oxidative stress on abnormal lipid metabolism-mediated disease development
Li, L., Guo, Z., Zhao, Y., Liang, C., Zheng, W., Tian, W., Chen, Y., Cheng, Y. H., Zhu, F.-G., & Xiang, X. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110348 · Cited by 53 · see citing works
Therapeutic approaches targeting aging and cellular senescence in Huntington's disease
Bhat, A. A., Moglad, E. H. O., Afzal, M., Thapa, R., Almalki, W. H., Kazmi, I. A., Alzarea, S. I., Ali, H., Pant, K., Singh, T. G., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70053 · Cited by 32 · see citing works
Targeting mitochondrial transporters and metabolic reprogramming for disease treatment
Anselme, M., He, H., Lai, C., Luo, W., & Zhong, S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06976-4 · Cited by 31 · see citing works
Resveratrol combats chronic diseases through enhancing mitochondrial quality
Tao, W., Zhang, H., Jiang, X., & Chen, N. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250140 · Cited by 29 · see citing works
Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells
Kulovic‐Sissawo, A., Tocantins, C., Diniz, M. S., Weiß, E., Steiner, A. J., Tokic, S., Madreiter‐Sokolowski, C. T., Pereira, S. P., & Hiden, U. (2024) · Biology · doi:10.3390/biology13020070 · Cited by 25 · see citing works
“Consequently, this recognition bears significant new implications for the understanding One of the major driving forces of the inflammatory response in ECs is low-density lipoprotein (LDL) in its oxidized form (oxLDL), promoting plaque formation [161–163]. of CVD development [20,73,168].”
Background
Atmospheric fine particulate matter (PM2.5) induces pulmonary fibrosis by regulating different cell fates via autophagy
Liu, B., Han, Y., Ye, Y., Wei, X., Li, G., & Jiang, W. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171396 · Cited by 23 · see citing works
Oxidative Stress Biomarkers in Coronary Artery Disease
Simantiris, S., Papastamos, C., Antonopoulos, A. S., Theofilis, P., Sagris, Μ., Bounta, M., Konisti, G., Galiatsatos, N., Xanthaki, A., Tsioufis, K. P., et al. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230502140614 · Cited by 21 · see citing works
On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson’s Disease
García‐Beltrán, O., Urrutia, P. J., & Núñez, M. T. (2023) · Antioxidants · doi:10.3390/antiox12020214 · Cited by 19 · see citing works
“In addition, mitochondria are the major intracellular source of ROS and are the site of the Krebs cycle that translate the products of the catabolism of carbohydrates, lipids, and proteins into reduced nicotinamide adenine dinucleotide and flavin adenine dinucleotide, which are substrates of the electron transport cha…”
Background
Dysfunctional mitochondria elicit bioenergetic decline in the aged heart
Mone, P., Agyapong, E. D., Morciano, G., Jankauskas, S. S., Luca, A. D., Varzideh, F., Pinton, P., & Santulli, G. (2024) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.50 · Cited by 19 · see citing works
“Hence arises the necessity for the cell to eliminate these dysfunctional organelles in order to preserve cellular homeostasis [165,166] .”
Background
Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis
Liu, W., Zhao, X., & Wu, X. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03669-w · Cited by 17 · see citing works
Epigenetic crossroads in metabolic and cardiovascular health: the role of DNA methylation in type 2 diabetes and cardiovascular diseases
Kaimala, S., Yassin, L. K., Hamad, M. I. K., Allouh, M. Z., Sampath, P., Alkaabi, J., Leow, M. K., Shehab, S. A. S., Ansari, S. A., & Emerald, B. S. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02800-x · Cited by 14 · see citing works
“Aberrations in mitochondrial function can lead to metabolic disorders and CVDs. Impaired mitochondrial function can cause defective oxidative phosphorylation and abnormally high levels of ROS generation [86, 87].”
The mitochondrial link: Phthalate exposure and cardiovascular disease
Kabekkodu, S. P., Gladwell, L. R., & Choudhury, M. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119708 · Cited by 14 · see citing works
Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model
Pereira, S. P., Diniz, M. S., Tavares, L. C., Cunha‐Oliveira, T., Li, C., Cox, L. A., Nijland, M. J., Nathanielsz, P. W., & Oliveira, P. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015192 · Cited by 12 · see citing works
“However, we cannot underestimate the impact of mitochondrial dysfunction and signaling dysregulation in driving proper cardiomyocyte maturation, cardiac differentiation, and heart organogenesis that may only be perceivable in advanced postnatal life stages [49,62,63].”
Background
Cardioprotective potential of compound 3K, a selective PKM2 inhibitor in isoproterenol-induced acute myocardial infarction: A mechanistic study
Rihan, M., & Sharma, S. S. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116905 · Cited by 12 · see citing works
Building the case for mitochondrial transplantation as an anti-aging cardiovascular therapy
Headley, C. A., & Tsao, P. S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1141124 · Cited by 11 · see citing works
Mitochondrial biomarkers for airborne particulate matter–associated cardiovascular diseases
Mishra, P. K., & Kaur, P. (2023) · Current Opinion in Environmental Science & Health · doi:10.1016/j.coesh.2023.100494 · Cited by 11 · see citing works
Atherosclerosis: From the Disruption of Mitochondrial Membrane Potential to the Potential Interventional Strategies
Xia, D., Chen, Y., Luo, G., & Wei, D. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867330666221201120405 · Cited by 6 · see citing works
Cardiac damage following renal ischemia reperfusion injury increased with excessive consumption of high fat diet but enhanced the cardiac resistance to reperfusion stress in rat
Prem, P. N., & Kurian, G. A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22273 · Cited by 6 · see citing works
“Many studies demonstrated the direct relationship between inflammation and mitochondrial dysfunction in developing cardiovascular abnormalities [50 – 52].”
Background
Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions
Chaurembo, A. I., Xing, N., Chanda, F., Li, Y., Zhang, H., Fu, L.-D., Huang, J.-Y., Xu, Y.-J., Deng, W., Cui, H., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107164 · Cited by 6 · see citing works
Monoamine Oxidase Contributes to Valvular Oxidative Stress: A Prospective Observational Pilot Study in Patients with Severe Mitral Regurgitation
Șoșdean, R., Dănilă, M. D., Ionică, L. N., Pescariu, S. A., Mircea, M., Ionac, A., Mornoş, C., Luca, C. T., Feier, H. B., Muntean, D. M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910307 · Cited by 6 · see citing works
“…in aging populations [4], and the main four sources widely acknowledged as being responsible for the increased generation of reactive oxygen species (ROS) are NADPH oxidases, a dysfunctional mitochondrial electron transport system, uncoupled endothelial NO synthase and xanthine oxidase [5–9].”
Background
Analyses of mitochondrial metabolism in diseases: a review on 13 C magnetic resonance tracers
Sharma, G., Duarte, S., Shen, Q., & Khemtong, C. (2024) · RSC Advances · doi:10.1039/d4ra03605k · Cited by 4 · see citing works
“18 As a highly energy-demanding organ, the heart can be greatly a ﬀ ected by reduced ATP production and impaired cardiac function caused by mitochondrial dysfunction.”
PM2.5 Exposure-Linked Mitochondrial Dysfunction Negates SB216763-Mediated Cardio-Protection against Myocardial Ischemia–Reperfusion Injury
Sivakumar, B., Nadeem, A., Dar, M. A., & Kurian, G. A. (2023) · Life · doi:10.3390/life13112234 · Cited by 4 · see citing works
“The majority of cardiac anomalies are linked to mitochondrial dysfunction that deprives energy and promotes the accumulation of ROS and dysregulation of ionic and metabolic balance [35].”
Background
Metabolic and Mitochondrial Myopathies
Canda, E. E., Köse, M., & Dınız, G. (2023) · Springer eBooks · doi:10.1007/978-3-031-33924-0_14 · Cited by 3 · see citing works
Associations between mitochondrial copy number, exercise capacity, physiologic cost of walking, and cardiac strain in young adult survivors of childhood cancer
Berkman, A. M., Goodenough, C. G., Durakiewicz, P., Howell, C. R., Wang, Z., Easton, J. B., Mulder, H. L., Armstrong, G. T., Hudson, M. M., Kundu, M., et al. (2024) · Journal of Cancer Survivorship · doi:10.1007/s11764-024-01590-7 · Cited by 3 · see citing works
“…mitochondrial dysfunction are associated with the development of several age-related chronic conditions, most notably cardiovascular disease (CVD), as the pathophysiology of CVD may be particularly sensitive to oxidative damage and mitochondrial dysfunction impacting calcium homeostasis [11, 12].”
Pathophysiological mechanisms of post-exertional malaise: an integrative analysis based on the metabolism-immune-neuro interaction model
Jin, H.-J., An, Y., Huang, J., Luo, T., & Wu, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1774310 · Cited by 2 · see citing works
“Thus, the ATP de ﬁ ciency observed in the traditional view may (68, 69, 75), to a signi ﬁ cant extent, be a downstream consequence of upstream ion pump failure and subsequent calcium overload.”
Acyl-CoA thioesterase 13 (ACOT13) attenuates the progression of autosomal dominant polycystic kidney disease in vitro via triggering mitochondrial-related cell apoptosis
Wang, B., Yang, Q., Che, L., Sun, L., & Du, N. (2024) · Aging · doi:10.18632/aging.206054 · Cited by 2 · see citing works
“Mitochondria could provide cellular energy for cell growth through the generation of ATP [24, 25].”
Mitochondria: A source of potential biomarkers for non-communicable diseases
Ichegiri, A., Kodolikar, K., Bagade, V., Selukar, M., & Dey, T. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.04.007 · Cited by 1 · see citing works
Is salsolinol a friend or foe? Revisiting its roles in neurotoxicity and cellular protection
Park, C.-M., & Na, H. (2025) · Toxicological Research · doi:10.1007/s43188-025-00306-y · Cited by 1 · see citing works
Retracted: Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies
Longevity, O. M. A. C. (2024) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2024/9785792 · Cited by 1 · see citing works
Retracted
Mitochondrial Energy Metabolism in Carcinogenesis
Kurhaluk, N., & Tkaczenko, H. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_226 · Cited by 1 · see citing works
Evaluation of the Level of Sirtuin7 and Some Biochemical Parameters in Patients with Cardiovascular Disease
Lazem, H., & Hassin, M. B. (2024) · International Journal for Scientific Research · doi:10.59992/ijsr.2024.v3n5p11 · Cited by 1 · see citing works
Mitochondrial transplantation, methods and mitochondrial dysfunction related diseases
Ülger, Ö., & Kubat, G. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18858-9.00001-9
The Biological Effects of Soy Isoflavones against Myocardial Ischemia-reperfusion Injuries: A Systematic Review
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Authors: Stamerra, C. A., Di Giosia, P., Giorgini, P., Ferri, C., Sukhorukov, V. N., & Sahebkar, A.
Affiliations: University of L'Aquila (IT)
Institute for Atherosclerosis Research (RU)
Mashhad University of Medical Sciences (IR)
Corresponding author: Sahebkar, Amirhossein
ORCID: Giorgini, Paolo
Ferri, Claudio
Sukhorukov, Vasily N.
Sahebkar, Amirhossein
Venue: Oxidative Medicine and Cellular Longevity
Publisher: Wiley
Published: 2022-01
Volume: 2022
Issue: 1
Pages: 9530007-9530007
ISSN: 1942-0994 (ISSN-L)
1942-0900
DOI: 10.1155/2022/9530007
PMC: PMC9363184
OpenAlex: W4289519687
Cited by: 48
References: 238
Citations by year: 2026: 5 · 2025: 7 · 2024: 20 · 2023: 14 · 2022: 2
FWCI: 3.51
Type: journal article
Language: en
Status: Retracted
Update notices: retraction (2024-01-09)
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 213 d)
Locations: Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
Funders: Russian Science Foundation (22-15-00064)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: mitochondrial dysfunction, cardiovascular disease, oxidative phosphorylation, ATP production, reactive oxygen species, mitochondrial DNA mutations, nuclear DNA mutations, aging, environmental stress, mitochondrial-targeted therapy
MeSH terms: Adenosine Triphosphate, Cardiovascular Diseases, DNA, Mitochondrial, Humans, Mitochondria, Oxidative Phosphorylation, Reactive Oxygen Species, Oxidative Stress

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[Retracted] Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies

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