Myocardial Reperfusion Injury

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280 · see citing works

Effects of Glucagon-Like Peptide-1 in Patients With Acute Myocardial Infarction and Left Ventricular Dysfunction After Successful Reperfusion

Nikolaidis, L. A., Mankad, S., Sokos, G. G., Miske, G., Shah, A., Elahi, D., & Shannon, R. P. (2004) · Circulation · doi:10.1161/01.cir.0000120505.91348.58 · Cited by 901 · see citing works

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature · doi:10.1038/nature13909 · Cited by 2,907 · see citing works

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Hausenloy, D. J., & Yellon, D. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62874 · Cited by 2,357 · see citing works

Can Animal Models of Disease Reliably Inform Human Studies?

van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V., & Macleod, M. R. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000245 · Cited by 1,354 · see citing works

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Chen, W., Zhao, H., & Li, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01547-9 · Cited by 1,306 · see citing works

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

Kawaguchi, M., Takahashi, M., Hata, T., Kashima, Y., Usui, F., Morimoto, H., Izawa, A., Takahashi, Y., Masumoto, J., Koyama, J., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.982777 · Cited by 884 · see citing works

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., & Murphy, M. P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.009 · Cited by 752 · see citing works

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

Cung, T.-T., Morel, O., Cayla, G., Rioufol, G., Garcia-Dorado, D., Angoulvant, D., Bonnefoy-Cudraz, E., Guérin, P., Elbaz, M., Delarche, N., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1505489 · Cited by 713 · see citing works

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Chouchani, E. T., Methner, C., Nadtochiy, S. M., Logan, A., Pell, V. R., Ding, S., James, A. M., Cochemé, H. M., Reinhold, J., Lilley, K. S., et al. (2013) · Nature Medicine · doi:10.1038/nm.3212 · Cited by 619 · see citing works

Guidelines for experimental models of myocardial ischemia and infarction

Lindsey, M. L., Bolli, R., Canty, J. M., Du, X.-J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2017 · Cited by 526 · see citing works

Cardiac troponins: from myocardial infarction to chronic disease

Park, K. C., Gaze, D. C., Collinson, P. O., & Marber, M. S. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx183 · Cited by 510 · see citing works

Arginase: A Multifaceted Enzyme Important in Health and Disease

Caldwell, R. W., Rodriguez, P. C., Toque, H. A., Narayanan, S. P., & Caldwell, R. B. (2018) · Physiological Reviews · doi:10.1152/physrev.00037.2016 · Cited by 495 · see citing works

The role of the mitochondrial permeability transition pore in heart disease

Halestrap, A. P., & Pasdois, P. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.017 · Cited by 362 · see citing works

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

Yamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098972 · Cited by 305 · see citing works

Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning

Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.01.004 · Cited by 201 · see citing works

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion

Rudolph, V., Rudolph, T. K., Schopfer, F. J., Bonacci, G., Woodcock, S. R., Cole, M. P., Baker, P. R. S., Ramani, R., & Freeman, B. A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvp275 · Cited by 188 · see citing works

Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models

Ogura, Y., Ouchi, N., Ohashi, K., Shibata, R., Kataoka, Y., Kambara, T., Kito, T., Maruyama, S., Yuasa, D., Matsuo, K., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.115089 · Cited by 183 · see citing works

Vagus nerve stimulation: From pre-clinical to clinical application: Challenges and future directions

De Ferrari, G. M., & Schwartz, P. J. (2011) · Heart Failure Reviews · doi:10.1007/s10741-010-9216-0 · Cited by 169 · see citing works

EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention

Gibson, C. M., Giugliano, R. P., Kloner, R. A., Bode, C., Tendera, M., Jánosi, A., Merkely, B., Godlewski, J., Halaby, R., Korjian, S., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv597 · Cited by 162 · see citing works

A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement

Rodrigo, R., Korantzopoulos, P., Cereceda, M., Asenjo, R., Zamorano, J., Villalabeitia, E., Baeza, C., Aguayo, R., Castillo, R., Carrasco, R., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.014 · Cited by 154 · see citing works

Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care

Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145 · see citing works

Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia–Reperfusion

Jang, S., Lewis, T. S., Powers, C., Khuchua, Z., Baines, C. P., Wipf, P., & Javadov, S. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6635 · Cited by 103 · see citing works

Nanoparticle-Mediated Drug Delivery System for Cardiovascular Disease

Matoba, T., & Egashira, K. (2014) · International Heart Journal · doi:10.1536/ihj.14-150 · Cited by 83 · see citing works

The Oxygen Paradox, the French Paradox, and age-related diseases

Davies, J. M. S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L., Derbré, F., et al. (2017) · GeroScience · doi:10.1007/s11357-017-0002-y · Cited by 82 · see citing works

Effect of Arginase Inhibition on Ischemia-Reperfusion Injury in Patients with Coronary Artery Disease with and without Diabetes Mellitus

Kövamees, O., Shemyakin, A., & Pernow, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103260 · Cited by 57 · see citing works

Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure

Gong, Y., Lin, J., Ma, Z., Yu, M., Wang, M., Lai, D., & Fu, G. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119511 · Cited by 58 · see citing works

Tissue Engineering and Targeted Drug Delivery in Cardiovascular Disease: The Role of Polymer Nanocarrier for Statin Therapy

Montelione, N., Loreni, F., Nenna, A., Catanese, V., Scurto, L., Ferrisi, C., Jawabra, M., Gabellini, T., Codispoti, F. A., Spinelli, F., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11030798 · Cited by 30 · see citing works

Novel protective effects of pulsed electromagnetic field ischemia/reperfusion injury rats

Ma, F., Li, W., Li, X., Tran, B. H., Suguro, R., Guan, R., Hou, C., Wang, H., Zhang, A., Zhu, Y., et al. (2016) · Bioscience Reports · doi:10.1042/bsr20160082 · Cited by 26 · see citing works

Integration of machine learning to identify diagnostic genes in leukocytes for acute myocardial infarction patients

Zhang, L., Liu, Y., Wang, K., Ou, X., Zhou, J., Zhang, H., Huang, M., Du, Z., & Qiang, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04573-x · Cited by 18 · see citing works

Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway

Li, C., Ma, Z., Wei, X., Wang, Y., Wu, J., Li, X., Sun, X., Ding, Z., Yang, C., & Zou, Y. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10577-9 · Cited by 13 · see citing works

Can glucagon-like peptide-1 (GLP-1) analogues make neuroprotection a reality?

Basalay, M. V., Davidson, S. M., & Yellon, D. M. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.280313 · Cited by 4 · see citing works

Inhibition of transient receptor potential vanilloid 4: A promising novel strategy for myocardial ischemia/reperfusion injury treatment

Dong, Q., Wang, Z., Wu, Q., & Du, Y. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118765 · Cited by 4 · see citing works