The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction
Open accessAbstract
Aims: Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in rodents. Nevertheless, exosomes have not been studied in a translationally realistic large-animal model. We sought to optimize delivery and assess the efficacy of CDC-secreted exosomes in pig models of acute (AMI) and convalescent myocardial infarction (CMI). Methods and Results: In AMI, pigs received human CDC exosomes (or vehicle) by intracoronary (IC) or open-chest intramyocardial (IM) delivery 30 min after reperfusion. No-reflow area and infarct size (IS) were assessed histologically at 48 h. Intracoronary exosomes were ineffective, but IM exosomes decreased IS from 80 ± 5% to 61 ± 12% (P= 0.001) and preserved left ventricular ejection fraction (LVEF). In a randomized placebo-controlled study of CMI, pigs 4 weeks post-myocardial infarction (MI) underwent percutaneous IM delivery of vehicle (n = 6) or CDC exosomes (n = 6). Magnetic resonance imaging (MRI) performed before and 1 month after treatment revealed that exosomes (but not vehicle) preserved LV volumes and LVEF (−0.1 ± 2.2% vs. −5.4 ± 3.6%, P= 0.01) while decreasing scar size. Histologically, exosomes decreased LV collagen content and cardiomyocyte hypertrophy while increasing vessel density. Conclusion: Cardiosphere-derived cell exosomes delivered IM decrease scarring, halt adverse remodelling and improve LVEF in porcine AMI and CMI. While conceptually attractive as cell-free therapeutic agents for myocardial infarction, exosomes have the disadvantage that IM delivery is necessary.
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Cites
Exosomes: composition, biogenesis and function
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Self-citationExosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy
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Cited by
Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide
Vandergriff, A., Huang, K., Shen, D., Hu, S., Hensley, M. T., Caranasos, T. G., Qian, L., & Cheng, K. (2018) · Theranostics · doi:10.7150/thno.20524 · Cited by 406
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Circulating exosomes in cardiovascular disease: Novel carriers of biological information
Liu, Q., Piao, H., Wang, Y., Zheng, D., & Wang, W. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111148 · Cited by 70
Metadata
- Authors
- Gallet, R., Dawkins, J., Valle, J., Simsolo, E., de Couto, G., Middleton, R., Tseliou, E., Luthringer, D., Kreke, M., Smith, R. R., Marbán, L., Ghaleh, B., & Marbán, E.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-09-27
- Volume
- 38
- Issue
- 3
- Pages
- ehw240
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2525079554
- Cited by
- 567
- References
- 26
- FWCI
- 24.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Gallet, R., Dawkins, J., Valle, J., Simsolo, E., de Couto, G., Middleton, R., Tseliou, E., Luthringer, D., Kreke, M., Smith, R. R., Marbán, L., Ghaleh, B., & Marbán, E. (2016). Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. European Heart Journal. https://doi.org/10.1093/eurheartj/ehw240
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
