The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome
Open accessAbstract
Although health disparities in women presenting with acute coronary syndrome (ACS) have received growing attention in recent years, clinical outcomes from ACS are still worse for women than for men. Women continue to experience higher patient and system delays and receive less aggressive invasive treatment and pharmacotherapies. Gender- and sex-specific variables that contribute to ACS vulnerability remain largely unknown. Notwithstanding the sex differences in baseline coronary anatomy and function, women and men are treated the same based on guidelines that were established from experimental and clinical trial data over-representing the male population. Importantly, younger women have a particularly unfavourable prognosis and a plethora of unanswered questions remains in this younger population. The present review summarizes contemporary evidence for gender and sex differences in vascular biology, clinical presentation, and outcomes of ACS. We further discuss potential mechanisms and non-traditional risk conditions modulating the course of disease in women and men, such as unrecognized psychosocial factors, sex-specific vascular and neural stress responses, and the potential impact of epigenetic modifications.
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Cited by
Impact of sex and gender on COVID-19 outcomes in Europe
Gebhard, C., Regitz-Zagrosek, V., Neuhauser, H. K., Morgan, R., & Klein, S. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00304-9 · Cited by 1,306
Self-citationGender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes
Regitz-Zagrosek, V., & Gebhard, C. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00797-4 · Cited by 386
Self-citationEUROASPIRE IV & V Investigators, Ferrannini, G., De Bacquer, D., Vynckier, P., De Backer, G., Gyberg, V., Kotseva, K., Mellbin, L., Norhammar, A., Tuomilehto, J., et al. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01233-6 · Cited by 54
LeBlanc, E. S., Brooks, N., Davies, M., & Chatterjee, R. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae655 · Cited by 11
Metadata
- Authors
- Haider, A., Bengs, S., Luu, J., Osto, E., Siller-Matula, J. M., Muka, T., & Gebhard, C.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-12-26
- Volume
- 41
- Issue
- 13
- Pages
- 1328-1336
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2996943854
- Cited by
- 305
- References
- 185
- FWCI
- 26.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Haider, A., Bengs, S., Luu, J., Osto, E., Siller-Matula, J. M., Muka, T., & Gebhard, C. (2020). Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome. European Heart Journal. https://doi.org/10.1093/eurheartj/ehz898
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
