Subclinical atherosclerosis: how and when to treat it?
Open accessAbstract
Atherosclerosis is a condition characterized by a long, initial, asymptomatic phase. Progression of disease could lead to acute coronary events, such as acute myocardial infarction, unstable angina, or sudden cardiac death. However, there are imaging techniques, namely vascular echography and assessment of coronary calcium, capable to make the diagnosis of atherosclerosis at an early stage. There are several studies demonstrating the ability of statins to delay, and in some situation even revert the progression of this condition. Subclinical atherosclerosis is highly prevalent in people with optimal control of the risk factors, and the imaging techniques have been shown to provide an added value over the traditional risk factors: by identifying directly the condition, these techniques allow the reclassification of low-risk to intermediate- or high-risk subjects, thus directing the primary prevention therapeutic strategies, based on high efficacy statins, aimed at delaying or reversing the progression of the disease.
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The detection of subclinical atherosclerosis at a very early stage is critical to improving CV prevention and outcomes by allowing early implementation of primary prevention strategies.
“The detection of subclinical atherosclerosis at a very early stage is critical to improving CV prevention and outcomes by allowing early implementation of primary prevention strategies (22).”
From Triglycerides and residual atherosclerotic risk (2021) · cites this paper as [22]
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Subclinical atherosclerosis: what it is, what it means and what we can do about it
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Triglycerides and residual atherosclerotic risk
Raposeiras-Roubin, S., Rosselló, X., Oliva, B., Fernández-Friera, L., Mendiguren, J. M., Andrés, V., Bueno, H., Sanz, J., Martínez de Vega, V., Abu-Assi, E., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.04.059 · Cited by 254 · see citing works
- Authors
- Gatto, L., & Prati, F.
- Affiliations
- Azienda Ospedaliera San Giovanni Addolorata (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Corresponding author
- Gatto, Laura
- Venue
- European Heart Journal Supplements
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-24
- Volume
- 22
- Issue
- Supplement_E
- Pages
- E87-E90
- ISSN
- 1520-765X (ISSN-L)
- 1554-2815
- PMC
- PMC7270961
- OpenAlex
- W3033330650
- Cited by
- 61
- References
- 16
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 9
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Heart Journal Supplements (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- subclinical atherosclerosis, coronary artery calcification, statins, primary prevention, cardiovascular risk stratification, acute coronary events, atherosclerosis progression, risk factor control
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