The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Liver Function Abnormalities and Outcome in Patients with Chronic Heart Failure: Data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program
Open accessAbstract
Aims: The prevalence and importance of liver function test (LFT) abnormalities in a large contemporary cohort of heart failure patients have not been systematically evaluated. Methods and results: We characterized the LFTs of 2679 patients with symptomatic chronic heart failure from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity program (CHARM). We used multivariable modelling to assess the relationships between baseline LFT values and long-term outcomes. Liver function test abnormalities were common in patients with chronic heart failure, ranging from alanine aminotransferase elevation in 3.1% of patients to low albumin in 18.3% of patients; total bilirubin was elevated in 13.0% of patients. In multivariable analysis, elevated total bilirubin was the strongest LFT predictor of adverse outcome for both the composite outcome of cardiovascular death or heart failure hospitalization (HR 1.21 per 1 SD increase, P < 0.0001) and all-cause mortality (HR 1.19 per 1 SD increase, P < 0.0001). Even after adjustment for other variables, elevated total bilirubin was one of the strongest independent predictors of poor prognosis (by global chi-square). Conclusion: Bilirubin is independently associated with morbidity and mortality. Changes in total bilirubin may offer insight into the underlying pathophysiology of chronic heart failure.
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Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14285-7 · Cited by 2,994
Self-citationMcMurray, J. J., Östergren, J., Swedberg, K., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer, M. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14283-3 · Cited by 2,604
Self-citationThe Seattle Heart Failure Model: Prediction of Survival in Heart Failure
Levy, W. C., Mozaffarian, D., Linker, D. T., Sutradhar, S. C., Anker, S. D., Cropp, A. B., Anand, I., Maggioni, A., Burton, P., Sullivan, M. D., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.584102 · Cited by 2,021
Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., Östergren, J., & Yusuf, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14282-1 · Cited by 1,889
Self-citationGranger, C. B., McMurray, J. J., Yusuf, S., Held, P., Michelson, E. L., Olofsson, B., Östergren, J., Pfeffer, M. A., & Swedberg, K. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14284-5 · Cited by 1,686
Self-citationAaronson, K. D., Schwartz, J. S., Chen, T.-M., Wong, K.-L., Goin, J. E., & Mancini, D. M. (1997) · Circulation · doi:10.1161/01.cir.95.12.2660 · Cited by 1,188
McMurray, J. J. V., Östergren, J., Swedberg, K. B., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer (2003) · The Lancet · Cited by 1,043
Self-citationPredictors of mortality and morbidity in patients with chronic heart failure
Pocock, S. J., Wang, D., Pfeffer, M. A., Yusuf, S., McMurray, J. J. V., Swedberg, K. B., Östergren, J., Michelson, E. L., Pieper, K. S., & Granger, C. B. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi555 · Cited by 973
Self-citationRed Cell Distribution Width as a Novel Prognostic Marker in Heart Failure
Felker, G. M., Allen, L. A., Pocock, S. J., Shaw, L. K., McMurray, J. J. V., Pfeffer, M. A., Swedberg, K., Wang, D., Yusuf, S., Michelson, E. L., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.067 · Cited by 947
Self-citationDrazner, M. H., Rame, J. E., Stevenson, L. W., & Dries, D. L. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010641 · Cited by 655
Cited by
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879
Self-citationESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs105 · Cited by 2,644
Self-citationBiomarkers for the diagnosis and management of heart failure
Castiglione, V., Aimo, A., Vergaro, G., Saccaro, L., Passino, C., & Emdin, M. (2022) · Heart Failure Reviews · doi:10.1007/s10741-021-10105-w · Cited by 512
Interactions of the heart and the liver
Møller, S., & Bernardi, M. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht246 · Cited by 490
Heart Failure and Liver Disease
Xanthopoulos, A., Starling, R. C., Kitai, T., & Triposkiadis, F. (2019) · JACC: Heart Failure · doi:10.1016/j.jchf.2018.10.007 · Cited by 341
Metadata
- Authors
- Allen, L. A., Felker, G. M., Pocock, S., McMurray, J. J. V., Pfeffer, M. A., Swedberg, K., Wang, D., Yusuf, S., Michelson, E. L., Granger, C. B., & for the CHARM Investigators
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-28
- Volume
- 11
- Issue
- 2
- Pages
- 170-177
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W2081438731
- Cited by
- 425
- References
- 19
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Allen, L. A., Felker, G. M., Pocock, S., McMurray, J. J. V., Pfeffer, M. A., Swedberg, K., Wang, D., Yusuf, S., Michelson, E. L., Granger, C. B., & for the CHARM Investigators. (2009). Liver Function Abnormalities and Outcome in Patients with Chronic Heart Failure: Data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program. European Journal of Heart Failure. https://doi.org/10.1093/eurjhf/hfn031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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