Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies

Malavazos, Alexis Elias; Iacobellis, Gianluca; Dozio, Elena; Basilico, Sara; Di Vincenzo, Angelica; Dubini, Carola; Menicanti, Lorenzo; Vianello, Elena; Meregalli, Chiara; Ruocco, Chiara; Ragni, Maurizio; Secchi, Francesco; Spagnolo, Pietro; Castelvecchio, Serenella; Morricone, Lelio; Buscemi, Silvio; Giordano, Antonio; Goldberger, Jeffrey J; Carruba, Michele; Cinti, Saverio; Corsi Romanelli, Massimiliano Marco; Nisoli, Enzo

doi:10.1093/eurjpc/zwad050

Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies

Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and progression of coronary artery disease, atrial fibrillation, and heart failure. Microscopically, EAT is composed of adipocytes, nerve tissues, inflammatory, stromovascular, and immune cells. Epicardial adipose …