Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk
Abstract
Metabolic syndrome is related to multiple cardiovascular risk factors. Visceral adipose tissue (VAT) plays a key role in metabolic syndrome. Easy detection of VAT could be an important tool to increase knowledge of metabolic syndrome. The objective of this study was to study the relationship of echocardiographic epicardial adipose tissue to anthropometric and clinical parameters of metabolic syndrome. We selected 72 consecutive subjects, 46.5 +/- 17.4 yr of age, with a body mass index between 22 and 47 kg/m(2). Each subject underwent transthoracic echocardiogram to measure epicardial fat thickness on right ventricle and magnetic resonance imaging to calculate visceral adipose tissue. Anthropometric, metabolic, and cardiac parameters were also evaluated. Echocardiographic epicardial adipose tissue showed a very good correlation with magnetic resonance imaging abdominal VAT and epicardial fat measurement (Bland-Altman plot and linear regression). Multiple regression analysis showed that waist circumference (r(2) = 0.428; P = 0.01), diastolic blood pressure (r(2) = 0. 387; P = 0.02), and fasting insulin (r(2) = 0.387; P = 0.03) were the strongest independent variables correlated with epicardial adipose tissue. Echocardiographic epicardial adipose tissue could be applied as an easy and reliable imaging indicator of VAT and cardiovascular risk.
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EAT can be easily measured with standard ultrasound and independently reflects intra-abdominal visceral fat and myocardial triglyceride content.
“Epicardial adipose tissue can be easily measured with standard ultrasound and independently reflects intra-abdominal visceral fat and myocardial triglyceride content [7–10].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [7]
EAT is higher in subjects with T2DM and metabolic syndrome, independently of traditional body fat indicators.
“Epicardial adipose tissue is higher in subjects with T2DM and metabolic syndrome, independently of traditional body fat indicators [5–7].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [7]
EAT is a modifiable and measurable cardiovascular risk factor that is thicker in subjects with diabetes, owing to its strong correlation with visceral adiposity and insulin resistance.
“EAT has shown to be a modifiable and measurable cardiovascular risk factor that is thicker in subjects with diabetes, owing to its strong correlation with visceral adiposity and insulin resistance [7–9].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [7]
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- Authors
- Iacobellis, G., Ribaudo, M. C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., Di Mario, U., & Leonetti, F.
- Affiliations
- Sapienza University of Rome (IT)
- Endocrinology, Department of Clinical Sciences, La Sapienza University, 00161 Rome, Italy; and Radiology Department, Ospedale G. Vannini, Istituto Figlie di S. Camillo (F.A.), 00100 Rome, Italy
- Corresponding author
- Iacobellis, Gianluca
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-11-01
- Volume
- 88
- Issue
- 11
- Pages
- 5163-5168
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2132513629
- Cited by
- 842
- References
- 37
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 29 · 2023: 30 · 2022: 38 · 2021: 35 · 2020: 50 · 2019: 52 · 2018: 46 · 2017: 40 · 2016: 48 · 2015: 71 · 2014: 55 · 2013: 68 · 2012: 50
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- epicardial adipose tissue, metabolic syndrome, visceral adipose tissue, cardiovascular risk, waist circumference, diastolic blood pressure, fasting insulin, right ventricle, echocardiography, anthropometric parameters
- MeSH terms
- Adipose Tissue, Adult, Cardiovascular Diseases, Echocardiography, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pericardium, Risk Factors, Body Mass Index, Metabolic Syndrome
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