Fluoxetine vs. propranolol in the treatment of vasovagal syncope: a prospective, randomized, placebo-controlled study
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AIMS: To compare the therapeutic efficacy of placebo, propranolol, and fluoxetine in patients with vasovagal syncope (VVS). METHODS AND RESULTS: Ninety-six consecutive patients with VVS were randomized to treatment with placebo, propranolol, or fluoxetine and followed-up for 6 months. Before and during treatment, they reported their syncopal and presyncopal episodes and graded their well-being, expressed as the general evaluation of life, general activities, and everyday activities (each scaled from 1 = very good to 5 = very bad). Two patients refused follow-up. Among the remaining 94, no difference between groups was observed regarding the distribution of time of vasovagal events (syncopes or presyncopes) during follow-up (log-rank test). No difference was also observed when syncopes and presyncopes were assessed separately. Eighteen patients discontinued therapy. Among the remaining 76 ('on-treatment' analysis), the mean time to a vasovagal episode (syncope or presyncope) was significantly longer in the fluoxetine group when compared with the two other groups (log-rank test, P < 0.05). A significant difference in favour of fluoxetine was also observed regarding presyncopes. The difference between groups regarding the syncope-free period was not significant. During therapy, patients' well-being was improved (decreased) only in the fluoxetine-group (13.4 +/- 0.7 vs. 15.4 +/- 0.9 before treatment, P < 0.01). CONCLUSION: Fluoxetine seems to be equivalent to propranolol and placebo in the treatment of VVS. However, it improves patients' well-being and might be more effective in reducing presyncopes and total vasovagal events in some patients with recurrent VVS.
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Based on this evidence, there have been several observational studies and three small randomized trials of serotonin transport inhibitors for prevention of vasovagal syncope.
“Based on this evidence, there have been several observational studies and 3 small, randomized trials on serotonin transport inhibitors for the prevention of vasovagal syncope.130–132”
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- Authors
- Theodorakis, G. N., Leftheriotis, D., Livanis, E. G., Flevari, P., Karabela, G., Aggelopoulou, N., & Kremastinos, D. T.
- Affiliations
- Onassis Cardiac Surgery Center (GR)
- Corresponding author
- Theodorakis, George N.
- Venue
- EP Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02-13
- Volume
- 8
- Issue
- 3
- Pages
- 193-198
- ISSN
- 1099-5129 (ISSN-L)
- 1532-2092
- OpenAlex
- W2161502613
- Semantic Scholar
- 371d2f5f04f2b780e3d79040424dceb590b043df
- Cited by
- 81
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 8
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EP Europace (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- vasovagal syncope, fluoxetine, propranolol, presyncope, syncope, treatment efficacy, well-being, recurrent syncope, beta-blockers, antidepressants
- MeSH terms
- Adrenergic beta-Antagonists, Adult, Attitude to Health, Double-Blind Method, Female, Fluoxetine, Humans, Male, Propranolol, Quality of Life, Recurrence, Selective Serotonin Reuptake Inhibitors, Syncope, Vasovagal
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