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Gender-related differences in catheter ablation of atrial fibrillation
Open accessAbstract
AIMS: Women have an increased risk for atrial fibrillation (AF)-related complications and there is evidence towards a reduced efficacy of the rhythm control strategy than men. A catheter-based strategy is therefore widely attractive, but the impact of gender on catheter ablation (CA) of AF remains undefined. METHODS AND RESULTS: We included 221 consecutive patients (150 men) who underwent CA of drug-refractory AF. Gender differences in clinical presentation and outcomes were compared. Women were older (P = 0.002), had a longer history of AF (P = 0.04), and were more likely to have hypertension (P = 0.04). Moreover, a concomitant valvular heart disease tended to be more common in women (32.4 vs. 23.3%; P = 0.28) and left atrium dimensions were significantly larger (P = 0.003). However, acute success rate and complications rate were similar between genders. After 22.5 +/- 11.8 months of follow-up, the overall freedom from arrhythmia recurrences was similar (83.1 vs. 82.7% in men), and a similar improvement in SF-36 quality of life scores was achieved in both groups. CONCLUSION: Women are referred for AF ablation later with a more complex clinical pre-operative presentation. Despite this higher risk profile in women, no differences were detected in clinical outcomes. Our findings indicate that CA of AF appears to be safe and effective in women as in men.
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“Bleeding risk on anticoagulation is similar in both sexes, 49,50,53 but women appear less likely to receive specialist care and rhythm control therapy, 54 while the outcomes of catheter ablation or AF surgery are comparable to those in men.55,56”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [55]
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Metadata
- Authors
- Forleo, G. B., Tondo, C., De Luca, L., Russo, A. D., Casella, M., De Sanctis, V., Clementi, F., Fagundes, R. L., Leo, R., Romeo, F., & Mantica, M.
- Affiliations
- Istituto Clinico Sant'Ambrogio (IT)
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Forleo, Giovanni B.
- Venue
- EP Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-07-18
- Volume
- 9
- Issue
- 8
- Pages
- 613-620
- ISSN
- 1099-5129 (ISSN-L)
- 1532-2092
- OpenAlex
- W2001923192
- Cited by
- 189
- References
- 42
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 17 · 2023: 11 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 13 · 2018: 16 · 2017: 16 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 10 · 2012: 6
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EP Europace (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- atrial fibrillation, catheter ablation, sex differences, women, drug-refractory atrial fibrillation, arrhythmia recurrence, valvular heart disease, left atrium size, quality of life, hypertension, clinical features
- MeSH terms
- Atrial Fibrillation, Female, Humans, Italy, Male, Middle Aged, Quality of Life, Recurrence, Risk Factors, Sex Factors, Prevalence, Treatment Outcome, Catheter Ablation, Sex Distribution, Risk Assessment, Disease-Free Survival
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