Bacterial secretion chaperones: the mycobacterial type VII case
Open accessAbstract
Chaperones are central players in maintaining the proteostasis in all living cells. Besides highly conserved generic chaperones that assist protein folding and assembly in the cytosol, additional more specific chaperones have evolved to ensure the successful trafficking of proteins with extra-cytoplasmic locations. Associated with the distinctive secretion systems present in bacteria, different dedicated chaperones have been described that not only keep secretory proteins in a translocation competent state, but often are also involved in substrate targeting to the specific translocation channel. Recently, a new class of such chaperones has been identified that are involved in the specific recognition of substrates transported via the type VII secretion pathway in mycobacteria. In this minireview, we provide an overview of the different bacterial chaperones with a focus on their roles in protein secretion and will discuss in detail the roles of mycobacterial type VII secretion chaperones in substrate recognition and targeting.
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Some conserved ESX components could potentially exhibit chaperone-like activity (e.g., EspG or EccA).
“Recently, it has become clear that some of the conserved ESX components could potentially exhibit chaperone-like activity (e.g., EspG or EccA) (48).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [48]
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ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins
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- Authors
- Phan, T. H., & Houben, E. N. G.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Houben, Edith N G
- Venue
- FEMS Microbiology Letters
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- Oxford University Press (OUP)
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- 2018-08-06
- Volume
- 365
- Issue
- 18
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- PMC
- PMC6109436
- OpenAlex
- W2887297977
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- References
- 83
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- VIDI (864.12.006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Keywords
- type VII secretion system, mycobacteria, substrate recognition, substrate targeting, protein secretion, protein translocation, proteostasis, mycobacterial virulence factors
- MeSH terms
- Bacterial Proteins, Mycobacterium, Protein Folding, Molecular Chaperones, Protein Transport, Bacterial Secretion Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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