Cited by 203Psoriasis: Treatment and PathogenesisIL-33, ST2, and ILC PathwaysCytokine Signaling Pathways and Interactions

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Cytokines IL-17 and IL-22 in the host response to infection

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Valeri, Maria, Raffatellu, Manuela·2016·Pathogens and Disease

DOI 10.1093/femspd/ftw111PMC PMC5975231

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Abstract

Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and in the development of chronic inflammatory diseases. These cytokines are produced by cells that are often located in epithelial barriers, including subsets of T cells and innate lymphoid cells. In general, IL-17 and IL-22 can be characterized as important cytokines in the rapid response to infectious agents, both by recruiting neutrophils and by inducing the production of antimicrobial peptides. Although each cytokine induces an innate immune response in epithelial cells, their functional spectra are generally distinct: IL-17 mainly induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is largely protective and regenerative. In this review, we compare IL-17 and IL-22, describing overlaps and differences in their cellular sources as well as their regulation, signaling, biological functions and roles during disease, with a focus on the contribution of these cytokines to the gut mucosal barrier during bacterial infection.

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Authors: Valeri, M., & Raffatellu, M.
Affiliations: University of California, Irvine (US)
Corresponding author: Raffatellu, Manuela
ORCID: Raffatellu, Manuela
Venue: Pathogens and Disease
Publisher: Oxford University Press (OUP)
Published: 2016-12
Volume: 74
Issue: 9
Pages: ftw111
ISSN: 2049-632X (ISSN-L)
DOI: 10.1093/femspd/ftw111
PMC: PMC5975231
OpenAlex: W2557937803
Cited by: 202
References: 242
Citations by year: 2026: 16 · 2025: 34 · 2024: 22 · 2023: 20 · 2022: 19 · 2021: 29 · 2020: 26 · 2019: 26 · 2018: 4 · 2017: 6
FWCI: 1.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Pathogens and Disease (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Burroughs Wellcome Fund
National Institute of Allergy and Infectious Diseases (R01AI114625, R56AI114625, R21AI121928, R01AI126277, R21AI105374, R37AI126277)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058057)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: IL-17, IL-22, host defense against infection, innate immunity, epithelial barrier function, gut mucosal barrier, bacterial infection, neutrophil recruitment, antimicrobial peptides, innate lymphoid cells, T cells, cytokine signaling, autoimmune disease, chronic inflammation, tissue regeneration
MeSH terms: Interleukin-22, Animals, Enterocolitis, Humans, Infections, Interleukins, Cytokines, Interleukin-17, Host-Pathogen Interactions, Disease Resistance

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Cytokines IL-17 and IL-22 in the host response to infection

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