Cited by 203Psoriasis: Treatment and PathogenesisIL-33, ST2, and ILC PathwaysCytokine Signaling Pathways and Interactions

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Cytokines IL-17 and IL-22 in the host response to infection

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Valeri, Maria, Raffatellu, Manuela·2016·Pathogens and Disease

DOI 10.1093/femspd/ftw111PMC PMC5975231

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Abstract

Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and in the development of chronic inflammatory diseases. These cytokines are produced by cells that are often located in epithelial barriers, including subsets of T cells and innate lymphoid cells. In general, IL-17 and IL-22 can be characterized as important cytokines in the rapid response to infectious agents, both by recruiting neutrophils and by inducing the production of antimicrobial peptides. Although each cytokine induces an innate immune response in epithelial cells, their functional spectra are generally distinct: IL-17 mainly induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is largely protective and regenerative. In this review, we compare IL-17 and IL-22, describing overlaps and differences in their cellular sources as well as their regulation, signaling, biological functions and roles during disease, with a focus on the contribution of these cytokines to the gut mucosal barrier during bacterial infection.

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An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
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Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
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Interleukin-22: Immunobiology and Pathology
Dudakov, J. A., Hanash, A. M., & van den Brink, M. R. M. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112123 · Cited by 939
Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis
Papp, K. A., Leonardi, C. L., Menter, A., Ortonne, J. P., Krueger, J. G., Kricorian, G., Aras, G. A., Li, J., Russell, C. B., Thompson, E. H. Z., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109017 · Cited by 932
RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells
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Origin of the Lamina Propria Dendritic Cell Network
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Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
Hunter, C. A. (2005) · Nature reviews. Immunology · doi:10.1038/nri1648 · Cited by 857
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
Miao, E. A., Mao, D. P., Yudkovsky, N., Bonneau, R., Lorang, C. G., Warren, S. E., Leaf, I. A., & Aderem, A. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913087107 · Cited by 838
Assembly and localization of Toll-like receptor signalling complexes
Gay, N. J., Symmons, M. F., Gangloff, M., & Bryant, C. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3713 · Cited by 832
Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals
Martin, B., Hirota, K., Cua, D. J., Stockinger, B., & Veldhoen, M. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.020 · Cited by 822
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
Nograles, K. E., Zaba, L. C., Guttman‐Yassky, E., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Cardinale, I. R., Khatcherian, A., Gonzalez, J., Pierson, K. C., White, T. R., et al. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08769.x · Cited by 816
Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer
Kang, J. Y., Nan, X., Jin, M. S., Youn, S.-J., Ryu, Y. H., Mah, S., Han, S. H., Lee, H., Paik, S., & Lee, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.018 · Cited by 800
TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice
McKinley, L., Alcorn, J. F., Peterson, A., DuPont, R., Kapadia, S. B., Logar, A., Henry, A. C., Irvin, C. G., Piganelli, J. D., Ray, A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4089 · Cited by 783
A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease
Sandborn, W. J., Feagan, B. G., Fedorak, R. N., Scherl, E., Fleisher, M. R., Katz, S., Johanns, J., BLANK, M. A., & Rutgeerts, P. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.014 · Cited by 772
Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22
Takatori, H., Kanno, Y., Watford, W. T., Tato, C. M., Weiss, G. E., Ivanov, I. I., Littman, D. R., & O’Shea, J. J. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072713 · Cited by 769
Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria
Sonnenberg, G. F., Monticelli, L. A., Alenghat, T., Fung, T. C., Hutnick, N. A., Kunisawa, J., Shibata, N., Grunberg, S., Sinha, R., Zahm, A. M., et al. (2012) · Science · doi:10.1126/science.1222551 · Cited by 764
Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S.-H., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.001 · Cited by 760
Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
Cosmi, L., Palma, R. D., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., Rodolico, G., Querci, V., Abbate, G., Angeli, R., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080397 · Cited by 733
Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function
Spits, H., & Cupedo, T. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075053 · Cited by 722
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
Schulz, O., Gyllenbäck, E. J., Persson, E. K., Liu, X., Worbs, T., Agace, W. W., & Pabst, O. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091925 · Cited by 702
The light and dark sides of intestinal intraepithelial lymphocytes
Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693 · cited 1×
“In contrast, specific subsets of cells called intraepithelial lymphocytes (IELs) are found associated with the epithelial layer, in particular at the basement membrane between enterocytes (Cheroutre, Lambolez and Mucida 2011) .”
Background
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
Chan, J. R., Blumenschein, W. M., Murphy, E., Diveu, C., Wiekowski, M., Abbondanzo, S. J., Lucian, L., Geissler, R. H., Brodie, S. J., Kimball, A. B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060244 · Cited by 691
Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells
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Control of TH17 cells occurs in the small intestine
Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O’Connor, W., Rongvaux, A., van Rooijen, N., Haberman, A. M., et al. (2011) · Nature · doi:10.1038/nature10228 · Cited by 660
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
Cho, J. S., Pietras, E. M., Garcia, N. C., Ramos, R. I., Farzam, D. M., Monroe, H. R., Magorien, J. E., Blauvelt, A., Kolls, J. K., Cheung, A. L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40891 · Cited by 658
Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.
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Nutritional immunity beyond iron: a role for manganese and zinc
Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
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CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets
Ribot, J. C., deBarros, A., Pang, D. J., Neves, J. F., Peperzak, V., Roberts, S. J., Girardi, M., Borst, J., Hayday, A. C., Pennington, D. J., et al. (2009) · Nature Immunology · doi:10.1038/ni.1717 · Cited by 628
IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.041 · Cited by 627 · cited 4×
“CD4+, CCR4+, CCR6+, CCR10+ Human Eyerich et al. (2009); Trifari et al. (2009) Tc22 IL-22 Unknown CD4+, CD8+, IL-21R+ Human Nograles et al. (2009) Tc17 IL-17 Unknown CD8+, CD45RB+, CD38+, CD103+, CCR6+ Mouse Yen et al. (2009) γ δ cells IL-17, IL-22 AP1 CD27−, CD28−, NKP80+, CD45RA+, CD158+ Human and mouse Peng et al. (…”
BackgroundInfluential
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R., Shellito, J. E., Bagby, G. J., Nelson, S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050193 · Cited by 625
DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
Fu, Y., & Chaplin, D. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.399 · Cited by 615
IL-17: prototype member of an emerging cytokine family
Aggarwal, S., & Gurney, A. L. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.1.1 · Cited by 598
Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity
Harris, T. J., Grosso, J. F., Yen, H., Xin, H., Kortylewski, M., Albesiano, E., Hipkiss, E. L., Getnet, D., Goldberg, M. V., Maris, C. H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4313 · Cited by 592
CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut
Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A., & Artis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.009 · Cited by 591
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
Nowarski, R., Jackson, R. P., Gagliani, N., de Zoete, M. R., Palm, N. W., Bailis, W., Low, J. S., Harman, C. C. D., Graham, M. M., Elinav, E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.072 · Cited by 582
Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?
Wolk, K., Kunz, S., Asadullah, K., & Sabat, R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5397 · Cited by 581
Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
Raffatellu, M., Santos, R. L., Verhoeven, D. E., George, M. D., Wilson, R. P., Winter, S., Godinez, I., Sankaran, S., da Paixão, T. A., Gordon, M. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1743 · Cited by 574
Self-citation
Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex
Toy, D., Kugler, D., Wolfson, M., Bos, T. V., Gurgel, J., Derry, J., Tocker, J., & Peschon, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.36 · Cited by 570
Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R
Xie, M.-H., Aggarwal, S., Ho, W.-H., Foster, J., Zhang, Z., Stinson, J., Wood, W. I., Goddard, A. D., & Gurney, A. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005304200 · Cited by 570
Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine
Lewis, K. L. T., Caton, M. L., Bogunovic, M., Greter, M., Grajkowska, L. T., Ng, D., Klinakis, A., Charo, I. F., Jung, S., Gommerman, J. L., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.013 · Cited by 557
IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation
Ma, H., Liang, S. C., Li, J., Napierata, L., Brown, T., Benoit, S., Senices, M., Gill, D. S., Dunussi‐Joannopoulos, K., Collins, M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33263 · Cited by 555
Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
Luci, C., Reynders, A., Ivanov, I. I., Cognet, C., Chiche, L., Chasson, L., Hardwigsen, J., Anguiano, E., Banchereau, J., Chaussabel, D., et al. (2008) · Nature Immunology · doi:10.1038/ni.1681 · Cited by 551
IL-22 is increased in active Crohn’s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
Brand, S., Beigel, F., Olszak, T., Zitzmann, K., Eichhorst, S. T., Otte, J., Diepolder, H. M., Marquardt, A., Jagla, W., Popp, A., et al. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00513.2005 · Cited by 548
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses
Sano, T., Huang, W., Hall, J. A., Yang, Y., Chen, A., Gavzy, S. J., Lee, J.-Y., Ziel, J. W., Miraldi, E. R., Domingos, A. I., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.061 · Cited by 547
Lipocalin-2 Resistance Confers an Advantage to Salmonella enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine
Raffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.011 · Cited by 525
Self-citation
IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guerin Infection
Umemura, M., Yahagi, A., Hamada, S., Begum, M. D., Watanabe, H., Kawakami, K., Suda, T., Sudo, K., Nakae, S., Iwakura, Y., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3786 · Cited by 516
Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses
Hall, J. A., Bouladoux, N. J., Sun, C., Wohlfert, E. A., Blank, R. B., Zhu, Q., Grigg, M. E., Berzofsky, J. A., & Belkaid, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.009 · Cited by 500
Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9
Dumoutier, L., Louahed, J., & Renauld, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1814 · Cited by 500
Resident Vδ1+ γδ T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production
Shibata, K., Yamada, H., Hara, H., Kishihara, K., & Yoshikai, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4466 · Cited by 498
Interleukin 23 production by intestinal CD103+CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
Kinnebrew, M. A., Buffie, C. G., Diehl, G. E., Zenewicz, L. A., Leiner, I., Hohl, T. M., Flavell, R. A., Littman, D. R., & Pamer, E. G. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.011 · Cited by 491
Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ
Jensen, K. D. C., Su, X., Shin, S., Li, L., Youssef, S., Yamasaki, S., Steinman, L., Saito, T., Locksley, R. M., Davis, M. M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.022 · Cited by 480
Interleukin-22, a Member of the IL-10 Subfamily, Induces Inflammatory Responses in Colonic Subepithelial Myofibroblasts
Andoh, A., Zhang, Z., Inatomi, O., Fujino, S., Deguchi, Y., Araki, Y., Tsujikawa, T., Kitoh, K., Kim‐Mitsuyama, S., Takayanagi, A., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.071 · Cited by 480
Clinical targeting of the TNF and TNFR superfamilies
Croft, M., Benedict, C. A., & Ware, C. F. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3930 · Cited by 465
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
Kleinschek, M. A., Boniface, K., Sadekova, S., Grein, J., Murphy, E. E., Turner, S. P., Raskin, L., Desai, B., Faubion, W. A., de Waal Malefyt, R., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081712 · Cited by 460
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury
Berger, T., Togawa, A., Duncan, G. S., Elia, A. J., You-Ten, A., Wakeham, A., Fong, H. E. H., Cheung, C. C., & Mak, T. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510847103 · Cited by 460
Interleukin-17 and Lung Host Defense against Klebsiella pneumoniae Infection
Ye, P., Garvey, P. B., Zhang, P., Nelson, S., Bagby, G. J., Summer, W. R., Schwarzenberger, P. O., Shellito, J. E., & Kolls, J. K. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.3.4424 · Cited by 459
NETWORK COMMUNICATIONS: Lymphotoxins, LIGHT, and TNF
Ware, C. F. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115719 · Cited by 452
Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to Klebsiella pneumoniae Infection
Happel, K. I., Zheng, M., Young, E. A., Quinton, L. J., Lockhart, E., Ramsay, A. J., Shellito, J. E., Schurr, J. R., Bagby, G. J., Nelson, S., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4432 · Cited by 448
Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2
Taylor, P. R., Roy, S., Leal, S. M., Sun, Y., Howell, S. J., Cobb, B. A., Li, X., & Pearlman, E. M. (2013) · Nature Immunology · doi:10.1038/ni.2797 · Cited by 422
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
Sander, L. E., Davis, M. J., Boekschoten, M. V., Amsen, D., Dascher, C. C., Ryffel, B., Swanson, J. A., Müller, M. M., & Blander, J. M. (2011) · Nature · doi:10.1038/nature10072 · Cited by 412
Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and RORγt and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion
Rachitskaya, A. V., Hansen, A. M., Horai, R., Li, Z., Villasmil, R., Luger, D., Nussenblatt, R. B., & Caspi, R. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5167 · Cited by 409
Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen
Mombaerts, P., Arnoldi, J., Russ, F., Tonegawa, S., & Kaufmann, S. H. E. (1993) · Nature · doi:10.1038/365053a0 · Cited by 406
Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor
Dumoutier, L., Roost, E. V., Colau, D., & Renauld, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170291697 · Cited by 376
IL-22–producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
Zindl, C. L., Lai, J.-F., Lee, Y. K., Maynard, C. L., Harbour, S. N., Ouyang, W., Chaplin, D., & Weaver, C. T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300318110 · Cited by 365
IL-17A Produced by γδ T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver
Hamada, S., Umemura, M., Shiono, T., Tanaka, K., Yahagi, A., Begum, M. D., Oshiro, K., Okamoto, Y., Watanabe, H., Kawakami, K., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3456 · Cited by 364
TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis : Role of IL-17-Producing T Cells
Higgins, S. C., Jarnicki, A., Lavelle, E. C., & Mills, K. H. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7980 · Cited by 364
Hematopoietic cytokines, transcription factors and lineage commitment
Zhu, J., & Emerson, S. G. (2002) · Oncogene · doi:10.1038/sj.onc.1205318 · Cited by 349
Antibacterial membrane attack by a pore-forming intestinal C-type lectin
Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo, J., Grabe, M., Jiang, Q., et al. (2013) · Nature · doi:10.1038/nature12729 · Cited by 337
Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed Gut
Liu, J. Z., Jellbauer, S., Poe, A. J., Ton, V., Pesciaroli, M., Kehl-Fie, T. E., Restrepo, N. A., Hosking, M. P., Edwards, R. A., Battistoni, A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.017 · Cited by 328
Self-citation
Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities
Rickel, E., Siegel, L. A., Yoon, B. P., Rottman, J. B., Kugler, D. G., Swart, D., Anders, P., Tocker, J. E., Comeau, M. R., & Budelsky, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4299 · Cited by 326
Wound repair: role of immune–epithelial interactions
Leoni, G., Neumann, P.-A., Sumagin, R., Denning, T. L., & Nusrat, A. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.63 · Cited by 320
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Authors: Valeri, M., & Raffatellu, M.
Affiliations: University of California, Irvine (US)
Corresponding author: Raffatellu, Manuela
ORCID: Raffatellu, Manuela
Venue: Pathogens and Disease
Publisher: Oxford University Press (OUP)
Published: 2016-12
Volume: 74
Issue: 9
Pages: ftw111
ISSN: 2049-632X (ISSN-L)
DOI: 10.1093/femspd/ftw111
PMC: PMC5975231
OpenAlex: W2557937803
Cited by: 202
References: 242
Citations by year: 2026: 16 · 2025: 34 · 2024: 22 · 2023: 20 · 2022: 19 · 2021: 29 · 2020: 26 · 2019: 26 · 2018: 4 · 2017: 6
FWCI: 1.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Pathogens and Disease (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Burroughs Wellcome Fund
National Institute of Allergy and Infectious Diseases (R01AI114625, R56AI114625, R21AI121928, R01AI126277, R21AI105374, R37AI126277)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058057)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: IL-17, IL-22, host defense against infection, innate immunity, epithelial barrier function, gut mucosal barrier, bacterial infection, neutrophil recruitment, antimicrobial peptides, innate lymphoid cells, T cells, cytokine signaling, autoimmune disease, chronic inflammation, tissue regeneration
MeSH terms: Interleukin-22, Animals, Enterocolitis, Humans, Infections, Interleukins, Cytokines, Interleukin-17, Host-Pathogen Interactions, Disease Resistance

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Cytokines IL-17 and IL-22 in the host response to infection

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