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Cited by 159Antimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsImmune Response and Inflammation

Perspectives for clinical use of engineered human host defense antimicrobial peptides

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Pachón-Ibáñez, María Eugenia, Smani, Younes, Pachón, Jerónimo, Sánchez-Céspedes, Javier·2017·FEMS Microbiology Reviews
DOI 10.1093/femsre/fux012PMC PMC5435762
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Abstract

Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of death worldwide. The emergence of drug-resistance mechanisms, especially among bacteria, threatens the efficacy of all current antimicrobial agents, some of them already ineffective. As a result, there is an urgent need for new antimicrobial drugs. Host defense antimicrobial peptides (HDPs) are natural occurring and well-conserved peptides of innate immunity, broadly active against Gram-negative and Gram-positive bacteria, viruses and fungi. They also are able to exert immunomodulatory and adjuvant functions by acting as chemotactic for immune cells, and inducing cytokines and chemokines secretion. Moreover, they show low propensity to elicit microbial adaptation, probably because of their non-specific mechanism of action, and are able to neutralize exotoxins and endotoxins. HDPs have the potential to be a great source of novel antimicrobial agents. The goal of this review is to provide an overview of the advances made in the development of human defensins as well as the cathelicidin LL-37 and their derivatives as antimicrobial agents against bacteria, viruses and fungi for clinical use.

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Authors
Pachón-Ibáñez, M. E., Smani, Y., Pachón, J., & Sánchez-Céspedes, J.
Affiliations
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
  • Pachón-Ibáñez, María Eugenia
  • Smani, Younes
ORCID
Venue
FEMS Microbiology Reviews
Publisher
Oxford University Press (OUP)
Published
2017-05-01
Volume
41
Issue
3
Pages
323-342
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
DOI
10.1093/femsre/fux012
PMC
PMC5435762
OpenAlex
W2616486904
Cited by
159
References
5
Citations by year
2026: 10 · 2025: 15 · 2024: 15 · 2023: 15 · 2022: 23 · 2021: 17 · 2020: 24 · 2019: 24 · 2018: 13 · 2017: 3
FWCI
2.50
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • FEMS Microbiology Reviews (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by-nc-nd)
Funders
Spanish Network for Research in Infectious Diseases (REIPI RD12/0015/0001, REIPI RD16/0009)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
human defensins, cathelicidin LL-37, antimicrobial resistance, innate immunity, immunomodulation, antiviral activity, antifungal activity, clinical application, endotoxin neutralization
MeSH terms
Anti-Infective Agents, Bacteria, Bacterial Infections, Endotoxins, Exotoxins, Fungi, Humans, Microbial Sensitivity Tests, Mycoses, Virus Diseases, Viruses, Defensins, Antimicrobial Cationic Peptides, Cathelicidins

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