An anti-infective peptide that selectively modulates the innate immune response

A new mathematical model for relative quantification in real-time RT-PCR

Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works

Trends in antimicrobial drug development: Implications for the future

Spellberg, B., Powers, J. H., Brass, E. P., Miller, L. G., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/420937 · Cited by 867 · see citing works

Alarmins: chemotactic activators of immune responses

Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780 · see citing works

NLRs join TLRs as innate sensors of pathogens

Martinon, F., & Tschopp, J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.06.004 · Cited by 673 · see citing works

Toll-Like Receptors: Linking Innate and Adaptive Immunity

Pasare, C., & Medzhitov, R. M. (2005) · Advances in experimental medicine and biology · doi:10.1007/0-387-24180-9_2 · Cited by 661 · see citing works

How Toll-like receptors signal: what we know and what we don’t know

O'Neill, L. A. J. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.012 · Cited by 614 · see citing works

Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37

Mookherjee, N., Brown, K. L., Bowdish, D. M. E., Doria, S., Falsafi, R., Hokamp, K., Roche, F. M., Mu, R., Doho, G., Pistolic, J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2455 · Cited by 562 · see citing works

Innate immune responses to infection

Tosi, M. F. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.05.036 · Cited by 387 · see citing works

Impact of LL-37 on anti-infective immunity

Bowdish, D. M. E., Davidson, D. J., Lau, Y. E., Lee, K. C. L., Scott, M. G., & Hancock, R. E. W. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0704380 · Cited by 374 · see citing works

Cytokine Cascade in Sepsis

Cavaillon, J., Adib‐Conquy, M., Fitting, C., Adrie, C., & Payen, D. M. (2003) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540310015935 · Cited by 336 · see citing works

Immunomodulatory Activities of Small Host Defense Peptides

Bowdish, D. M. E., Davidson, D. J., Scott, M. G., & Hancock, R. E. W. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1727-1732.2005 · Cited by 317 · see citing works

Can innate immunity be enhanced to treat microbial infections?

Finlay, B. B., & Hancock, R. E. W. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro908 · Cited by 296 · see citing works

MCP-1 protects mice in lethal endotoxemia.

Zisman, D. A., Kunkel, S. L., Strieter, R. M., Tsai, W. C., Bucknell, K. A., Wilkowski, J., & Standiford, T. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119475 · Cited by 245 · see citing works

cAMP-induced Interleukin-10 Promoter Activation Depends on CCAAT/Enhancer-binding Protein Expression and Monocytic Differentiation

Brenner, S., Prösch, S., Schenke‐Layland, K., Riese, U., Gausmann, U., & Platzer, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207448200 · Cited by 147 · see citing works

Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches

Spahn, T. W., Fontana, A., Faria, A. M. C., Slavin, A., Eugster, H., Zhang, X., Koni, P. A., Ruddle, N. H., Flavell, R. A., Rennert, P. D., et al. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200104)31:4 · Cited by 143 · see citing works

Roles of Macrophages and Neutrophils in the Early Host Response toBacillus anthracisSpores in a Mouse Model of Infection

Cote, C. K., van Rooijen, N., & Welkos, S. L. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.469-480.2006 · Cited by 139 · see citing works

Release of tumor necrosis factor alpha and interleukin 6 during antibiotic killing of Escherichia coli in whole blood: influence of antibiotic class, antibiotic concentration, and presence of septic serum

Prins, J. M., Kuijper, E. J., Mevissen, M. L. C. M., Speelman, P., & van Deventer, S. J. H. (1995) · Infection and Immunity · doi:10.1128/iai.63.6.2236-2242.1995 · Cited by 112 · see citing works

Linking innate and adaptive immunity

Palucka, K., & Banchereau, J. (1999) · Nature Medicine · doi:10.1038/11303 · Cited by 94 · see citing works

Apoptosis of Airway Epithelial Cells

Lau, Y. E., Bowdish, D. M. E., Cosseau, C., Hancock, R. E. W., & Davidson, D. J. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0170oc · Cited by 93 · see citing works

ArrayPipe: a flexible processing pipeline for microarray data

Hokamp, K., Roche, F. M., Acab, M., Rousseau, M.-É., Kuo, B., Goode, D. L., Aeschliman, D., Bryan, J., Babiuk, L. A., Hancock, R. E. W., et al. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh446 · Cited by 79 · see citing works

Regulation of C/EBPβ isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3

Marcinkowska, E., Garay, E., Gocek, E., Chrobak, A., Wang, X., & Studzinski, G. P. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.003 · Cited by 67 · see citing works

C/EBPε Is a Myeloid-specific Activator of Cytokine, Chemokine, and Macrophage-Colony-stimulating Factor Receptor Genes

Williams, S. C., Du, Y., Schwartz, R. C., Weiler, S. R., Ortiz, M., Keller, J. R., & Johnson, P. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13493 · Cited by 64 · see citing works

ERK2- and p90Rsk2-dependent Pathways Regulate the CCAAT/Enhancer-binding Protein-β Interaction with Serum Response Factor

Hanlon, M., Sturgill, T. W., & Sealy, L. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102165200 · Cited by 62 · see citing works

C/EBPβ Blocks p65 Phosphorylation and Thereby NF-κB-Mediated Transcription in TNF-Tolerant Cells

Zwergal, A., Quirling, M., Saugel, B., Huth, K. C., Sydlik, C., Poli, V., Neumeier, D., Ziegler‐Heitbrock, H. W. L., & Brand, K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.665 · Cited by 60 · see citing works

Molecular and in silico characterization of a promoter module and C/EBP element that mediate LPS‐induced RANTES/CCL5 expression in monocytic cells

Fessele, S., Boehlk, S., Mojaat, A., Miyamoto, N. G., Werner, T., Nelson, E. L., Schloendorff, D., & Nelson, P. J. (2001) · The FASEB Journal · doi:10.1096/fj.00-0459fje · Cited by 58 · see citing works

Implications for the future

Herron, H., & Glasper, A. (1993) · Nursing Standard · doi:10.7748/ns.7.36.20.s28 · Cited by 57 · see citing works

Nature's clarion call of antibacterial resistance: are we listening?

Theuretzbacher, U., & Toney, J. H. (2006) · PubMed · Cited by 36 · see citing works

In Vivo Antibacterial Activity of S-3578, a New Broad-Spectrum Cephalosporin: Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Experimental Infection Models

Tsuji, M., Takema, M., Miwa, H., Shimada, J., & Kuwahara, S. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.8.2507-2512.2003 · Cited by 32 · see citing works

Representational difference analysis using myeloid cells from C/EBPε deletional mice

Kubota, T., Kawano, S., Chih, D. Y., Hisatake, Y., Chumakov, A. M., Taguchi, H., & Koeffler, H. P. (2000) · Blood · doi:10.1182/blood.v96.12.3953 · Cited by 25 · see citing works

Characterization of Modified Allergen Extracts by in vitro β-Hexosaminidase Release from Rat Basophils

Gehlhar, K., Peters, M., Brockmann, K., van Schijndel, H., & Bufe, A. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000083976 · Cited by 10 · see citing works

Antimicrobial host defence peptides: functions and clinical potential

Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502 · see citing works

Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo

Kumar, P., Kizhakkedathu, J. N., & Straus, S. K. (2018) · Biomolecules · doi:10.3390/biom8010004 · Cited by 1,233 · see citing works

Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works

The immunology of host defence peptides: beyond antimicrobial activity

Hancock, R. E. W., Haney, E. F., & Gill, E. E. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.29 · Cited by 947 · see citing works

Alternatives to antibiotics—a pipeline portfolio review

Czaplewski, L. G., Bax, R. P., Clokie, M. R. J., Dawson, M., Fairhead, H., Fischetti, V. A., Foster, S. J., Gilmore, B., Hancock, R. E. W., Harper, D. J., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00466-1 · Cited by 846 · see citing works

Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

Raphel, J., Holodniy, M., Goodman, S. B., & Heilshorn, S. C. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.016 · Cited by 678 · see citing works

The Roles of Antimicrobial Peptides in Innate Host Defense

Diamond, G., Beckloff, N., Weinberg, A., & Kisich, K. O. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682325 · Cited by 643 · see citing works

Multifunctional cationic host defence peptides and their clinical applications

Yeung, A. T. Y., Gellatly, S. L., & Hancock, R. E. W. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0710-x · Cited by 606 · see citing works

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

Hilchie, A. L., Wuerth, K. C., & Hancock, R. E. W. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1393 · Cited by 598 · see citing works

Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

Kalelkar, P. P., Riddick, M., & Garcı́a, A. J. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00362-4 · Cited by 555 · see citing works

Modulating immunity as a therapy for bacterial infections

Hancock, R. E. W., Nijnik, A., & Philpott, D. J. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2745 · Cited by 542 · see citing works

Host defense peptides: front-line immunomodulators

Mansour, S., Pena, O. M., & Hancock, R. E. W. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.004 · Cited by 493 · see citing works

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

Pfalzgraff, A., Brandenburg, K., & Weindl, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00281 · Cited by 488 · see citing works

Neutrophils: Cinderella of innate immune system

Kumar, V., & Sharma, A. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.012 · Cited by 442 · see citing works

Antibiotics in the clinical pipeline in 2013

Butler, M. S., Blaskovich, M. A. T., & Cooper, M. A. (2013) · The Journal of Antibiotics · doi:10.1038/ja.2013.86 · Cited by 432 · see citing works

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Jaynes, J. M., Sable, R. V., Ronzetti, M. H., Bautista, W., Knotts, Z., Abisoye-Ogunniyan, A., Li, D., Calvo, R., Dashnyam, M., Singh, A., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax6337 · Cited by 412 · see citing works

Reassessing the Host Defense Peptide Landscape

Haney, E. F., Straus, S. K., & Hancock, R. E. W. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00043 · Cited by 362 · see citing works

Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs

Cherkasov, A. R., Hilpert, K., Jenssen, H., Fjell, C. D., Waldbrook, M., Mullaly, S. C., Volkmer, R., & Hancock, R. E. W. (2008) · ACS Chemical Biology · doi:10.1021/cb800240j · Cited by 356 · see citing works

Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity

Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342 · see citing works

Anionic Antimicrobial Peptides from Eukaryotic Organisms

Harris, F., Dennison, S. R., & Phoenix, D. A. (2009) · Current Protein and Peptide Science · doi:10.2174/138920309789630589 · Cited by 333 · see citing works

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

Choi, S., Isaacs, A. K., Clements, D. J., Liu, D., Kim, H., Scott, R. W., Winkler, J. D., & DeGrado, W. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811818106 · Cited by 306 · see citing works

Antimicrobial Peptides: An Introduction

Haney, E. F., Mansour, S., & Hancock, R. E. W. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6737-7_1 · Cited by 303 · see citing works

Mechanisms underlying neutrophil-mediated monocyte recruitment

Soehnlein, O., Lindbom, L., & Weber, C. (2009) · Blood · doi:10.1182/blood-2009-06-221630 · Cited by 297 · see citing works

Peptide design for antimicrobial and immunomodulatory applications

Haney, E. F., & Hancock, R. E. W. (2013) · Biopolymers · doi:10.1002/bip.22250 · Cited by 289 · see citing works

The roles of cathelicidin LL-37 in immune defences and novel clinical applications

Nijnik, A., & Hancock, R. E. W. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32831ac517 · Cited by 287 · see citing works

Combating Implant Infections: Shifting Focus from Bacteria to Host

Yavari, S. A., Castenmiller, S. M., van Strijp, J. A. G., & Croes, M. (2020) · Advanced Materials · doi:10.1002/adma.202002962 · Cited by 257 · see citing works

Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics

Sang, Y., & Blecha, F. (2008) · Animal Health Research Reviews · doi:10.1017/s1466252308001497 · Cited by 253 · see citing works

Cationic Host Defence Peptides: Multifaceted Role in Immune Modulation and Inflammation

Choi, K.-Y. G., Chow, L. N. Y., & Mookherjee, N. (2012) · Journal of Innate Immunity · doi:10.1159/000336630 · Cited by 237 · see citing works

Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment

Nijnik, A., Madera, L., Ma, S., Waldbrook, M., Elliott, M. R., Easton, D. M., Mayer, M. L., Mullaly, S. C., Kindrachuk, J., Jenssen, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901813 · Cited by 218 · see citing works

Potential of immunomodulatory host defense peptides as novel anti-infectives

Easton, D. M., Nijnik, A., Mayer, M. L., & Hancock, R. E. W. (2009) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.07.004 · Cited by 215 · see citing works

Synthetic antibiofilm peptides

de la Fuente‐Núñez, C., Cardoso, M. H. E. S., Cândido, E. D. S., Franco, O. L., & Hancock, R. E. W. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.12.015 · Cited by 215 · see citing works

Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity

Auvynet, C., & Rosenstein, Y. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07360.x · Cited by 213 · see citing works

Peptide IDR‐1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic‐resistant bacterial infections

Mansour, S., de la Fuente‐Núñez, C., & Hancock, R. E. W. (2014) · Journal of Peptide Science · doi:10.1002/psc.2708 · Cited by 208 · see citing works

Gene-specific control of the TLR-induced inflammatory response

Foster, S. L., & Medzhitov, R. M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.015 · Cited by 205 · see citing works

Antimicrobial peptides´ immune modulation role in intracellular bacterial infection

Duarte-Mata, D. I., & Salinas-Carmona, M. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1119574 · Cited by 200 · see citing works

Fighting bacterial infections—Future treatment options

Fernebro, J. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.02.001 · Cited by 197 · see citing works

Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets

Nizet, V. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.06.005 · Cited by 192 · see citing works

Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections

Afacan, N. J., Yeung, A. T. Y., Pena, O. M., & Hancock, R. E. W. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799277617 · Cited by 192 · see citing works

The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

Qiu, H., Si, Z., Luo, Y. H., Feng, P., Wu, X., Hou, W., Zhu, Y., Chan‐Park, M. B. E., Xu, L., & Huang, D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00910 · Cited by 190 · see citing works

Neutrophil granule proteins tune monocytic cell function

Soehnlein, O., Weber, C., & Lindbom, L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.06.006 · Cited by 174 · see citing works

Biomolecule-functionalized polymer brushes

Jiang, H., & Xu, F. (2013) · Chemical Society Reviews · doi:10.1039/c2cs35453e · Cited by 170 · see citing works

Structural Studies of a Peptide with Immune Modulating and Direct Antimicrobial Activity

Wieczorek, M., Jenssen, H., Kindrachuk, J., Scott, W. R. P., Elliott, M. R., Hilpert, K., Cheng, J., Hancock, R. E. W., & Straus, S. K. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.07.007 · Cited by 165 · see citing works

Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections

Nijnik, A., & Hancock, R. E. W. (2009) · Emerging Health Threats Journal · doi:10.3134/ehtj.09.001 · Cited by 164 · see citing works

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

Brown, K. L., Poon, G. F. T., Birkenhead, D., Pena, O. M., Falsafi, R., Dahlgren, C., Karlsson, A., Bylund, J., Hancock, R. E. W., & Johnson, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002508 · Cited by 163 · see citing works

Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes

Mookherjee, N., Lippert, D. N. D., Hamill, P., Falsafi, R., Nijnik, A., Kindrachuk, J., Pistolic, J., Gardy, J. L., Miri, P., Naseer, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802586 · Cited by 162 · see citing works

Perspectives for clinical use of engineered human host defense antimicrobial peptides

Pachón-Ibáñez, M. E., Smani, Y., Pachón, J., & Sánchez-Céspedes, J. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux012 · Cited by 159 · see citing works

Cost-effective expression and purification of antimicrobial and host defense peptides in Escherichia coli

Bommarius, B., Jenssen, H., Elliott, M. R., Kindrachuk, J., Pasupuleti, M., Gieren, H., Jaeger, K., Hancock, R. E. W., & Kalman, D. (2010) · Peptides · doi:10.1016/j.peptides.2010.08.008 · Cited by 158 · see citing works

Antibacterial Surfaces Based on Polymer Brushes: Investigation on the Influence of Brush Properties on Antimicrobial Peptide Immobilization and Antimicrobial Activity

Gao, G., Yu, K., Kindrachuk, J., Brooks, D. E., Hancock, R. E. W., & Kizhakkedathu, J. N. (2011) · Biomacromolecules · doi:10.1021/bm2009697 · Cited by 154 · see citing works

Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide‐Induced Inflammation

Sun, Y., & Shang, D. (2015) · Mediators of Inflammation · doi:10.1155/2015/167572 · Cited by 150 · see citing works

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

Wu, X., Li, Z., Li, X., Tian, Y., Fan, Y., Yu, C., Zhou, B., Liu, Y., Xiang, R., & Yang, L. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s107195 · Cited by 147 · see citing works

Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection

Steinstraesser, L., Hirsch, T., Schulte, M., Kueckelhaus, M., Jacobsen, F., Mersch, E., Stricker, I., Afacan, N. J., Jenssen, H., Hancock, R. E. W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039373 · Cited by 147 · see citing works

Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity and Special Mechanism

Wei, L., Gao, J., Zhang, S., Wu, S., Xie, Z., Ling, G., Kuang, Y., Yang, Y., Yu, H., & Wang, Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.642645 · Cited by 138 · see citing works

Novel peptide therapeutics for treatment of infections

Oyston, P. C. F., Fox, M. A., Richards, S. J., & Clark, G. C. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.011122-0 · Cited by 138 · see citing works

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

Boto, A., Pérez de la Lastra, J., & González, C. (2018) · Molecules · doi:10.3390/molecules23020311 · Cited by 136 · see citing works

Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs

Yang, X., Lee, W., & Zhang, Y. (2011) · Journal of Proteome Research · doi:10.1021/pr200782u · Cited by 132 · see citing works

Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications

Zhang, G., & Sunkara, L. T. (2014) · Pharmaceuticals · doi:10.3390/ph7030220 · Cited by 128 · see citing works

Future Antibacterial Strategies: From Basic Concepts to Clinical Challenges

Cattoir, V., & Felden, B. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz134 · Cited by 128 · see citing works

Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action

Drayton, M., Deisinger, J. P., Ludwig, K. C., Raheem, N., Müller, A., Schneider, T., & Straus, S. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011172 · Cited by 127 · see citing works

Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models

Rivas-Santiago, B. T., Castañeda‐Delgado, J. E., Rivas-Santiago, C., Waldbrook, M., Gonzalez-Curiel, I. E., León‐Contreras, J. C., Enciso‐Moreno, J. A., del Villar, V., Mendez-Ramos, J., Hancock, R. E. W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059119 · Cited by 124 · see citing works

Eosinophil Cationic Protein High-Affinity Binding to Bacteria-Wall Lipopolysaccharides and Peptidoglycans

Torrent, M., Navarro, S., Moussaoui, M., Nogués, M. V., & Boix, E. (2008) · Biochemistry · doi:10.1021/bi702065b · Cited by 122 · see citing works

pH‐Triggered Size‐Transformable and Bioactivity‐Switchable Self‐Assembling Chimeric Peptide Nanoassemblies for Combating Drug‐Resistant Bacteria and Biofilms

Tan, P., Wu, C., Tang, Q., Wang, T., Zhou, C., Ding, Y., Fu, H., Xu, S., Feng, Y., Zhang, Y., et al. (2023) · Advanced Materials · doi:10.1002/adma.202210766 · Cited by 121 · see citing works

Manipulation of innate immunity by a bacterial secreted peptide: Lantibiotic nisin Z is selectively immunomodulatory

Kindrachuk, J., Jenssen, H., Elliott, M. R., Nijnik, A., Janot, L., Pasupuleti, M., Thorson, L., Ma, S., Easton, D. M., Bains, M., et al. (2012) · Innate Immunity · doi:10.1177/1753425912461456 · Cited by 117 · see citing works

The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

Barlow, P. G., Beaumont, P. E., Cosseau, C., Mackellar, A., Wilkinson, T. S., Hancock, R. E. W., Haslett, C., Govan, J. R. W., Simpson, A. J., & Davidson, D. J. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0250oc · Cited by 117 · see citing works

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

Dong, J., Wang, W., Zhou, W., Zhang, S., Li, M., Li, N., Pan, G., Zhang, X., Bai, J., & Zhu, C. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00326-x · Cited by 116 · see citing works

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

Lai, Y. Y., Adhikarakunnathu, S., Bhardwaj, K., Ranjith-Kumar, C. T., Wen, Y., Jordan, J. L., Wu, L. H., Dragnea, B. G., Mateo, L. S., & Kao, C. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026632 · Cited by 115 · see citing works

The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches

Bednarska, N. G., Wren, B. W., & Willcocks, S. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.02.001 · Cited by 112 · see citing works

Immunomodulators as adjuvants for vaccines and antimicrobial therapy

Nicholls, E. F., Madera, L., & Hancock, R. E. W. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05787.x · Cited by 111 · see citing works

Synthetic Mimics of Antimicrobial Peptides with Immunomodulatory Responses

Thaker, H. D., Som, A., Ayaz, F., Lui, D., Pan, W., Scott, R. W., Anguíta, J., & Tew, G. N. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303304j · Cited by 110 · see citing works

Cathelicidins and functional analogues as antisepsis molecules

Mookherjee, N., Rehaume, L. M., & Hancock, R. E. W. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.8.993 · Cited by 109 · see citing works

Monocyte Chemoattractant Protein 1 Regulates Pulmonary Host Defense via Neutrophil Recruitment during Escherichia coli Infection

Balamayooran, G., Batra, S., Theivanthiran, B., Cai, S., & Jeyaseelan, S. (2011) · Infection and Immunity · doi:10.1128/iai.00067-11 · Cited by 104 · see citing works

Functions of Cationic Host Defense Peptides in Immunity

Hemshekhar, M., Anaparti, V., & Mookherjee, N. (2016) · Pharmaceuticals · doi:10.3390/ph9030040 · Cited by 103 · see citing works

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells

Mookherjee, N., Hamill, P., Gardy, J. L., Blimkie, D., Falsafi, R., Chikatamarla, A., Arenillas, D. J., Doria, S., Kollmann, T. R., & Hancock, R. E. W. (2009) · Molecular BioSystems · doi:10.1039/b813787k · Cited by 103 · see citing works

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents

Czyzewski, A. M., Jenssen, H., Fjell, C. D., Waldbrook, M., Chongsiriwatana, N. P., Yuen, E., Hancock, R. E. W., & Barron, A. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0135961 · Cited by 102 · see citing works

Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects

van der Does, A. M., Hiemstra, P. S., & Mookherjee, N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3588-4_10 · Cited by 101 · see citing works

IFN-γ Regulated Chemokine Production Determines the Outcome of Staphylococcus aureus Infection

McLoughlin, R. M., Lee, J. C., Kasper, D. L., & Tzianabos, A. O. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1323 · Cited by 101 · see citing works

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions

Niyonsaba, F., Madera, L., Afacan, N. J., Okumura, K., Ogawa, H., & Hancock, R. E. W. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012497 · Cited by 100 · see citing works

QSAR modeling and computer‐aided design of antimicrobial peptides

Jenssen, H., Fjell, C. D., Cherkasov, A. R., & Hancock, R. E. W. (2007) · Journal of Peptide Science · doi:10.1002/psc.908 · Cited by 99 · see citing works

Synthetic Cationic Peptide IDR-1018 Modulates Human Macrophage Differentiation

Pena, O. M., Afacan, N. J., Pistolic, J., Chen, C. C. L., Madera, L., Falsafi, R., Fjell, C. D., & Hancock, R. E. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052449 · Cited by 97 · see citing works

The global need for effective antibiotics—Moving towards concerted action

Cars, O., Hedin, A., & Heddini, A. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.02.006 · Cited by 97 · see citing works

Effect of Immunomodulation and Immunomodulatory Agents on Health with some Bioactive Principles, Modes of Action and Potent Biomedical Applications

Dhama, K., Saminathan, M., Jacob, S. S., Singh, M. K., Karthik, K., AMARPAL, A., Tiwari, R., Sunkara, L. T., Malik, Y. S., & Singh, R. K. (2015) · International Journal of Pharmacology · doi:10.3923/ijp.2015.253.290 · Cited by 96 · see citing works

Complexities of targeting innate immunity to treat infection

Brown, K. L., Cosseau, C., Gardy, J. L., & Hancock, R. E. W. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.04.005 · Cited by 95 · see citing works

Effective Adjunctive Therapy by an Innate Defense Regulatory Peptide in a Preclinical Model of Severe Malaria

Achtman, A. H., Pilat, S., Law, C. W., Lynn, D. J., Janot, L., Mayer, M. L., Ma, S., Kindrachuk, J., Finlay, B. B., Brinkman, F. S. L., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003515 · Cited by 94 · see citing works

Mechanisms of avoidance of host immunity by Neisseria meningitidis and its effect on vaccine development

Lo, H., Tang, C. M., & Exley, R. M. (2009) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(09)70132-x · Cited by 94 · see citing works

Treatment of Oral Multispecies Biofilms by an Anti-Biofilm Peptide

Wang, Z., de la Fuente‐Núñez, C., Shen, Y., Haapasalo, M., & Hancock, R. E. W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132512 · Cited by 94 · see citing works

THE ROLE OF EPITHELIAL β -DEFENSINS AND CATHELICIDINS IN HOST DEFENSE OF THE LUNG

Hiemstra, P. S. (2007) · Experimental Lung Research · doi:10.1080/01902140701756687 · Cited by 93 · see citing works

A helminth cathelicidin‐like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase

Robinson, M. W., Alvarado, R., To, J., Hutchinson, A. T., Dowdell, S., Lund, M. E., Turnbull, L., Whitchurch, C. B., O’Brien, B. A., Dalton, J. P., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-213876 · Cited by 92 · see citing works

Novel anti-infectives: is host defence the answer?

Hamill, P., Brown, K. L., Jenssen, H., & Hancock, R. E. W. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.10.006 · Cited by 87 · see citing works

In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical applications

Thakur, A., Sharma, A., Alajangi, H. K., Jaiswal, P. K., Lim, Y., Singh, G., & Barnwal, R. P. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.103 · Cited by 86 · see citing works

Antiviral Potential of Cathelicidins

Barlow, P. G., Findlay, E. G., Currie, S. M., & Davidson, D. J. (2013) · Future Microbiology · doi:10.2217/fmb.13.135 · Cited by 84 · see citing works

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

Beaumont, P. E., McHugh, B. J., Findlay, E. G., Mackellar, A., Mackenzie, K. J., Gallo, R. L., Govan, J. R. W., Simpson, A. J., & Davidson, D. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099029 · Cited by 83 · see citing works

Odorranalectin Is a Small Peptide Lectin with Potential for Drug Delivery and Targeting

Li, J., Wu, H., Hong, J., Xu, X., Yang, H., Wu, B., Wang, Y., Zhu, J., Lai, R., Jiang, X., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002381 · Cited by 83 · see citing works

Ligand Recognition Specificity of Leukocyte Integrin αMβ2 (Mac-1, CD11b/CD18) and Its Functional Consequences

Podolnikova, N. P., Podolnikov, A. V., Haas, T. A., Lishko, V. K., & Ugarova, T. P. (2015) · Biochemistry · doi:10.1021/bi5013782 · Cited by 83 · see citing works

Sequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide

Yu, H. B., Kielczewska, A., Rozek, A., Takenaka, S., Li, Y., Thorson, L., Hancock, R. E. W., Guarna, M. M., North, J. R., Foster, L. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.073627 · Cited by 81 · see citing works

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease

Brown, K. L., Bylund, J., MacDonald, K. L., Song-Zhao, G. X., Elliott, M. R., Falsafi, R., Hancock, R. E. W., & Speert, D. P. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.06.005 · Cited by 80 · see citing works

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

Kindrachuk, J., Jenssen, H., Elliott, M. R., Townsend, R., Nijnik, A., Lee, S. F., Gerdts, V., Babiuk, L. A., Halperin, S. A., & Hancock, R. E. W. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.05.094 · Cited by 80 · see citing works

Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an α-helical ‘sequence template’

Pag, U., Oedenkoven, M., Sass, V., Shai, Y., Валерьевна, Ш. О., Antcheva, N., Tossi, A., & Sahl, H. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm479 · Cited by 79 · see citing works

Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes

Andreev, K., Bianchi, C., Laursen, J. S., Citterio, L., Hein-Kristensen, L., Gram, L., Kuzmenko, I., Olsen, C. A., & Gidalevitz, D. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.05.022 · Cited by 78 · see citing works

Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities

van Dijk, A. I. J. M., Molhoek, E. M., Veldhuizen, E. J. A., Bokhoven, J. L. M. T.-V., Wagendorp, E., Bikker, F. J., & Haagsman, H. P. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.05.019 · Cited by 78 · see citing works

Antimicrobial Peptide hLF1-11 Directs Granulocyte-Macrophage Colony-Stimulating Factor-Driven Monocyte Differentiation toward Macrophages with Enhanced Recognition and Clearance of Pathogens

van der Does, A. M., Bogaards, S. J. P., Ravensbergen, B., Beekhuizen, H., van Dissel, J. T., & Nibbering, P. H. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00652-09 · Cited by 78 · see citing works

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

Mayer, M. L., Blohmke, C. J., Falsafi, R., Fjell, C. D., Madera, L., Turvey, S. E., & Hancock, R. E. W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201404 · Cited by 77 · see citing works

Mechanisms of immune response regulation by innate defense regulator peptides

Madera, L. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0073068

Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment

Nijnik, A., Madera, L., Ma, S., Waldbrook, M., Elliott, M. R., Easton, D. M., Mayer, M. L., Mullaly, S. C., Kindrachuk, J., Jenssen, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901813 · Cited by 218 · see citing works

Innate Defence Regulator Peptides as a Novel Anti-infective Strategy (94.2)

Ma, S., Nijnik, A., Madera, L., Elliott, M. R., Easton, D. M., Mayer, M. L., Kindrachuk, J., Jenssen, H., Mok, K. Y., Yang, T., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.94.2

The role of PI3-Kinase signalling in immunomodulation by a protective innate defence regulator peptide (135.6)

Madera, L., Nijnik, A., Waldbrook, M., Mookherjee, N., Gardy, J. L., Falsafi, R., Elliott, M. R., & Hancock, R. E. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.supp.135.6

Innate defence regulator peptide 1018 protects mice in the Pseudomonas aeruginosa acute lung infection model (P4045)

Hilchie, A. L., Janot, L., Wuerth, K. C., & Hancock, R. E. W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.131.23 · Cited by 1 · see citing works