The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Detecting a Local Signature of Genetic Hitchhiking Along a Recombining Chromosome
Abstract
The theory of genetic hitchhiking predicts that the level of genetic variation is greatly reduced at the site of strong directional selection and increases as the recombinational distance from the site of selection increases. This characteristic pattern can be used to detect recent directional selection on the basis of DNA polymorphism data. However, the large variance of nucleotide diversity in samples of moderate size imposes difficulties in detecting such patterns. We investigated the patterns of genetic variation along a recombining chromosome by constructing ancestral recombination graphs that are modified to incorporate the effect of genetic hitchhiking. A statistical method is proposed to test the significance of a local reduction of variation and a skew of the frequency spectrum caused by a hitchhiking event. This method also allows us to estimate the strength and the location of directional selection from DNA sequence data.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Press, W. H., Teukolsky, S. A., Vetterling, W. T., & Flannery, B. P. (1994) · Cited by 15,411
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
Tajima, F. (1989) · Genetics · doi:10.1093/genetics/123.3.585 · Cited by 13,941
Fu, Y.-X. (1997) · Genetics · doi:10.1093/genetics/147.2.915 · Cited by 7,164
On the number of segregating sites in genetical models without recombination
Watterson, G. A. (1975) · Theoretical Population Biology · doi:10.1016/0040-5809(75)90020-9 · Cited by 3,915
The hitch-hiking effect of a favourable gene
Smith, J. M., & Haigh, J. (1974) · Genetical Research · doi:10.1017/s0016672300014634 · Cited by 3,415
EVOLUTIONARY RELATIONSHIP OF DNA SEQUENCES IN FINITE POPULATIONS
Tajima, F. (1983) · Genetics · doi:10.1093/genetics/105.2.437 · Cited by 3,092
The hitch-hiking effect of a favourable gene
MAYNARD, J., & HAIGH, J. (2007) · Genetics Research · doi:10.1017/s0016672308009579 · Cited by 2,643
Linkage disequilibrium in finite populations
Hill, W. G., & Robertson, A. (1968) · Theoretical and Applied Genetics · doi:10.1007/bf01245622 · Cited by 2,035
Hitchhiking Under Positive Darwinian Selection
Fay, J. C., & Wu, C.-I. (2000) · Genetics · doi:10.1093/genetics/155.3.1405 · Cited by 1,819
The effect of deleterious mutations on neutral molecular variation.
Charlesworth, B., Morgan, M. T., & Charlesworth, D. (1993) · Genetics · doi:10.1093/genetics/134.4.1289 · Cited by 1,803
Cited by
Adaptation from standing genetic variation
BARRETT, R., & SCHLUTER, D. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2007.09.008 · Cited by 2,091
Linkage disequilibrium--understanding the evolutionary past and mapping the medical future.
Slatkin, M. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2361 · Cited by 1,614
Molecular Signatures of Natural Selection
Nielsen, R. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.112420 · Cited by 1,641
Hermisson (2005) · doi:10.1534/genetics.104.036947 · Cited by 1,009
Genome sequencing and population genomics in non-model organisms
Ellegren, H. (2014) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2013.09.008 · Cited by 759
Metadata
- Authors
- Kim, Y., & Stephan, W.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-02-01
- Volume
- 160
- Issue
- 2
- Pages
- 765-777
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2109183238
- Cited by
- 631
- References
- 31
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Detecting a Local Signature of Genetic Hitchhiking Along a Recombining Chromosome. https://app.cochat.ai/papers/10.1093/genetics/160.2.765
- The paper
- Kim, Y., & Stephan, W. (2002). Detecting a Local Signature of Genetic Hitchhiking Along a Recombining Chromosome. Genetics. https://doi.org/10.1093/genetics/160.2.765
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
