A molecular explanation of the bobbed mutants of drosophila as partial deficiencies of “ribosomal” DNA

Ritossa, F M; Atwood, K C; Spiegelman, S

doi:10.1093/genetics/54.3.819

Cited by 296RNA and protein synthesis mechanismsChromosomal and Genetic VariationsGenomics and Chromatin Dynamics

A molecular explanation of the bobbed mutants of drosophila as partial deficiencies of “ribosomal” DNA

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Ritossa, F M, Atwood, K C, Spiegelman, S·1966·Genetics

DOI 10.1093/genetics/54.3.819

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Abstract

F M Ritossa, K C Atwood, S Spiegelman; A MOLECULAR EXPLANATION OF THE BOBBED MUTANTS OF DROSOPHILA AS PARTIAL DEFICIENCIES OF 'RIBOSOMAL' DNA, Genetics, Vo

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In D. melanogaster, rDNA clusters on the X and Y chromosomes usually consist of 200-250 rDNA units, more than half of which contain insertions.
“In D. melanogaster, rDNA clusters located in the X and Y chromosomes usually consist of 200–250 rDNA units (32), more than half of which contain insertions.”
From Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon (2022) · cites this paper as [32]
The citation is attached to the claim that X- and Y-chromosome rDNA clusters contain 200–250 units, not to the subsequent statement about insertions. The paper’s opening section instead calculates enough rDNA for about 130 templates for each ribosomal RNA type per haploid genome; it does not give 200–250 units per cluster. Page numbers are unavailable in our copy. (LLM, conf=0.78)
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Nonoperative DNA complementary to ribosomal RNA.
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Self-citation
Magnification of rRNA gene number in a Neurospora crassa strain with a partial deletion of the nucleolus organizer
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Authors: Ritossa, F. M., Atwood, K. C., & Spiegelman, S.
Affiliations: University of Illinois Urbana-Champaign (US)
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1966-09-23
Volume: 54
Issue: 3
Pages: 819-834
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/54.3.819
OpenAlex: W1778910066
Cited by: 296
References: 16
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 4 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 2
FWCI: 4.03
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: ribosomal DNA, Drosophila, ribosome biogenesis
MeSH terms: Animals, Chromosomes, DNA, Drosophila, Molecular Biology, Mutation, Ribosomes, RNA

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A molecular explanation of the bobbed mutants of drosophila as partial deficiencies of “ribosomal” DNA

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