INFLUENCE OF MATERNAL PHENOTYPE ON METABOLIC DIFFERENTIATION OF AGOUTI LOCUS MUTANTS IN THE MOUSE
Abstract
The results of extensive breeding experiments indicate that the phenotypic differentiation of embryos carrying the viable yellow, Avy, or mottled, am, mutations is influenced to a major extent by the agouti locus genotype and the strain genome of the dam. The Avy/a and am/a genotypes are each expressed in a spectrum of coat color phenotypes. These can be grouped into two classes, mottled and pseudoagouti.—In a reciprocal cross of C57BL/6JNIcrWf and AM/Wf-am/am mice, 29.5% of the offspring of C57BL/6 dams were of the pseudoagouti phenotype, whereas no pseudoagouti offspring were produced by AM strain dams.—Mottled yellow Avy/a mice become obese and tumor formation is enhanced in these mice in comparison with the lean pseudoagouti Avy/a siblings.—In two different reciprocal crosses using four different inbred strains, the proportion of pseudoagouti Avy/a offspring differed according to the strain of the dam. Regardless of strain, mottled yellow Avy/a dams produced significantly fewer pseudoagouti Avy/a offspring than did black a/a dams.—The data suggest that metabolic differentiation of Avy/a zygotes into phenotypic classes with different susceptibilities to obesity and tumor formation is influenced to a considerable degree by the metabolic characteristics of the oviductal and uterine environment of the dam.
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The best characterized example of variegation in mammals is the coat color of mice carrying the Avy allele.
“The best characterized example of variegation in mammals is the coat color of mice carrying the Avy allele [3,4].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [3]
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- Authors
- Wolff, G. L.
- Affiliations
- National Center for Toxicological Research (US)
- Corresponding author
- Wolff, George L
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1978-03-01
- Volume
- 88
- Issue
- 3
- Pages
- 529-539
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1887697591
- Cited by
- 95
- References
- 6
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 4 · 2019: 2 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- agouti locus, maternal phenotype, maternal effects, obesity, cancer susceptibility, reciprocal crosses, inbred mouse strains, uterine environment
- MeSH terms
- Animals, Cell Differentiation, Crosses, Genetic, Extrachromosomal Inheritance, Female, Hair, Male, Maternal-Fetal Exchange, Mice, Inbred C57BL, Mice, Inbred Strains, Mutation, Phenotype, Pigmentation, Pigments, Biological, Pregnancy, Mice
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