Modifiers of epigenetic reprogramming show paternal effects in the mouse
Open accessAbstract
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.
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MommeD2 is a mutation in Dnmt1, encoding a DNA methyltransferase, and MommeD4 is a mutation in Smarca5, encoding Snf2h, a chromatin-remodeling enzyme.
“MommeD2 is a mutation in DNA methyltransferase 1, Dnmt1, encoding a DNA methyltransferase, and MommeD4 is a mutation in Smarca5, encoding Snf2h, a chromatin-remodeling enzyme [12].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [12]
MommeD2 and MommeD4 are homozygous lethal at 8.5 days post-coitus and 17.5 days post-coitus, respectively.
“MommeD2 and MommeD4 are homozygous lethal at 8.5 days post-coitus (dpc) and 17.5 dpc, respectively [10,12].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [12]
Examples of paternal effects resulting from haploinsufficiency of modifiers of epigenetic gene silencing in the mouse have been published previously.
“We have previously published examples of paternal effects resulting from haploinsufficiency of modifiers of epigenetic gene silencing in the mouse [12].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [12]
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- Authors
- Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H. S., de Kretser, D., O'Bryan, M., Blewitt, M., & Whitelaw, E.
- Affiliations
- QIMR Berghofer Medical Research Institute (AU)
- Monash Institute of Medical Research (AU)
- The University of Sydney (AU)
- Albert Einstein College of Medicine (US)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Corresponding author
- Whitelaw, Emma
- ORCID
- Venue
- Nature Genetics
- Published
- 2007-04-22
- Volume
- 39
- Issue
- 5
- Pages
- 614-622
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC3199608
- OpenAlex
- W1990669455
- Cited by
- 166
- References
- 51
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 15 · 2012: 18
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA079057)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Keywords
- epigenetic reprogramming, paternal effects, transgenerational inheritance, heterozygous mutation, chromosome ploidy, transcription, offspring phenotype, mice
- MeSH terms
- Adenosine Triphosphatases, Amino Acid Sequence, Animals, Base Sequence, Chromosomal Proteins, Non-Histone, Crosses, Genetic, DNA Mutational Analysis, Flow Cytometry, Immunohistochemistry, Male, Molecular Sequence Data, Phenotype, Spermatogenesis, Sequence Alignment, Point Mutation, Gene Expression Regulation, Developmental, DNA Methylation, Oligonucleotide Array Sequence Analysis, Gene Components, Inheritance Patterns, Epigenesis, Genetic, Mice, Agouti Signaling Protein
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