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Cited by 229Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth FactorsDietary Effects on Health

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Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

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Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., Khan, A. S.·1999·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/54.12.b521
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Abstract

Moderate caloric restriction (60% of ad libitum intake) is an important model to investigate potential mechanisms of biological aging. This regimen has been reported to decrease the number of pathologies and increase life span in all species tested to date. Although moderate caloric restriction induces a wide range of physiological changes within the organism, adaptive changes within the endocrine system are evident and serve to maintain blood levels of glucose. These alterations include an increase in growth hormone secretory dynamics and a decline in plasma levels of IGF-1. These endocrine compensatory mechanisms can be induced at any age, and we have proposed that these alterations mediate some of the beneficial aspects of moderate caloric restriction. Numerous studies indicate that growth hormone and IGF-1 decrease with age and that administration of these hormones ameliorates the deterioration of tissue function evident in aged ad libitum-fed animals, suggesting that the absence of these hormones contributes to the phenotype of aging. Nevertheless, IGF-1 is an important risk factor in age-related pathologies including lung, breast, and prostate cancer. From these studies, we propose that endocrine compensatory mechanisms induced by moderate caloric restriction (including increased growth hormone and decreased IGF-1) decrease the stimulus for cellular replication, resulting in a decline in pathologies and increased life span observed in these animals. These findings have important implications for potential mechanisms of moderate caloric restriction and suggest that neuroendocrine compensatory mechanisms exert a key role on the actions of moderate caloric restriction on life span.

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Metadata

Authors
Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., & Khan, A. S.
Affiliations
Wake Forest University Health Sciences (US)
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
1999-12-01
Volume
54
Issue
12
Pages
B521-B538
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/54.12.b521
OpenAlex
W2166656167
Cited by
229
References
131
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 12 · 2020: 10 · 2019: 14 · 2018: 3 · 2017: 7 · 2016: 12 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 9
FWCI
1.41
Type
journal article
Language
en
Open access
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
  • DigitalCommons-Cedarville (Cedarville University) (submittedVersion)
Funders
  • Wake Forest University
  • National Institutes of Health (5r01ag007752-07)
  • National Institute on Aging (AG-11370, P01AG011370, AG 07752)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords
biological aging, growth hormone, insulin-like growth factor I, lifespan extension, age-related diseases, cancer risk, neuroendocrine adaptation, glucose homeostasis
MeSH terms
Aging, Animals, Blood Glucose, Energy Intake, Cell Division, Disease Models, Animal, Female, Insulin-Like Growth Factor I, Longevity, Lung Neoplasms, Male, Mammary Neoplasms, Experimental, Neurosecretory Systems, Phenotype, Prostatic Neoplasms, Risk Factors, Growth Hormone

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