Cited by 229Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth FactorsDietary Effects on Health

The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.

Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

Open access

Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., Khan, A. S.·1999·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/54.12.b521

Open this paper in CoChat — free account Open PDF

Abstract

Moderate caloric restriction (60% of ad libitum intake) is an important model to investigate potential mechanisms of biological aging. This regimen has been reported to decrease the number of pathologies and increase life span in all species tested to date. Although moderate caloric restriction induces a wide range of physiological changes within the organism, adaptive changes within the endocrine system are evident and serve to maintain blood levels of glucose. These alterations include an increase in growth hormone secretory dynamics and a decline in plasma levels of IGF-1. These endocrine compensatory mechanisms can be induced at any age, and we have proposed that these alterations mediate some of the beneficial aspects of moderate caloric restriction. Numerous studies indicate that growth hormone and IGF-1 decrease with age and that administration of these hormones ameliorates the deterioration of tissue function evident in aged ad libitum-fed animals, suggesting that the absence of these hormones contributes to the phenotype of aging. Nevertheless, IGF-1 is an important risk factor in age-related pathologies including lung, breast, and prostate cancer. From these studies, we propose that endocrine compensatory mechanisms induced by moderate caloric restriction (including increased growth hormone and decreased IGF-1) decrease the stimulus for cellular replication, resulting in a decline in pathologies and increased life span observed in these animals. These findings have important implications for potential mechanisms of moderate caloric restriction and suggest that neuroendocrine compensatory mechanisms exert a key role on the actions of moderate caloric restriction on life span.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/gerona/54.12.b521

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Part of this paper’s reference list could not be split into single entries.

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Brazeau, P., Vale, W., Burgus, R. C., LING, N. C., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,536
Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.
D’Ercole, A. J., Stiles, A. D., & Underwood, L. E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.3.935 · Cited by 1,179
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
Rivier, J., Spiess, J., Thorner, M. O., & Vale, W. (1982) · Nature · doi:10.1038/300276a0 · Cited by 1,102
The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake
Weindruch, R. H., Walford, R. L., Fligiel, S., & Guthrie, D. (1986) · Journal of Nutrition · doi:10.1093/jn/116.4.641 · Cited by 992
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
Argetsinger, L. S., Campbell, G. S., Yang, X.-J., Witthuhn, B. A., Silvennoinen, O., Ihle, J. N., & Carter‐Su, C. (1993) · Cell · doi:10.1016/0092-8674(93)90415-m · Cited by 974
Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary
Berelowitz, M., Szabó, M., Frohman, L. A., Firestone, S. L., Chu, L., & Hintz, R. L. (1981) · Science · doi:10.1126/science.6262917 · Cited by 829
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence
Weindruch, R. H., & Walford, R. L. (1982) · Science · doi:10.1126/science.7063854 · Cited by 766
Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat
Tannenbaum, G. S., & Martin, J. B. (1976) · Endocrinology · doi:10.1210/endo-98-3-562 · Cited by 744
Impaired growth hormone secretion in the adult population: relation to age and adiposity.
Rudman, D. R., Kutner, M., Rogers, C. M., Lubin, M., Fleming, G. A., & Bain, R. P. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110164 · Cited by 641

Show all 131 references

Research works printed but not linked: 30

Timiras PS. Neuroendocrinology of aging: retrospective, current, and prospective views. In: Meites J, ed. Neuroendocrinology ofAging. New York: Plenum Press; 1983:5-30.
Reichlin S. Neuroendocrinology. In: Williams RH, ed. Textbook of Endocrinology. 5th ed. Philadelphia:WB Saunders; 1974;774-831.
Weaver DR. The suprachiasmatic nucleus: a 25-year retrospective [Review; 248 refs]. J Biolog Rhythms. 1998;13:100-112.
Meites J. Neuroendocrinology ofAging. New York: Plenum Press; 1983.
McCay CM, Sperling G, Barnes LL. Growth, aging, chronic diseases and lifespan in rats. Arch Biochem Biophys. 1943;2:469-479.
Lipman 1M, Turturro A, Hart RW. The influence of dietary restriction on DNA repair in rodents: a preliminary study [Review; 31 refs). Mech Ageing Dev. 1989;48:135-143.
Turturro AT, Hart RW. DNA repair mechanisms in aging. In: Schiapelli D, Migaki G, eds. ComparativeBiology ofMajor Age-Related Diseases. New York:Alan Liss; 1984:351-361.
Hart RW, Leakey IE, Chou M, Duffy PH, Allaben WT, Feuers RI. Modulation of chemical toxicity by modification of caloric intake [Review; 36 refs}.Adv Exp Med Biol. 1992;322:73-81.
Sonntag WE, Lenham JE, Ingram RL. Effects of aging and dietary re- striction on tissue protein synthesis: relationship to plasma insulin-like growth factor-I. J GerontolBiol Sci. 1992;47:B159-B 163.
Verdery RB, Ingram DK, Roth GS, Lane MA. Caloric restriction in- creases HDL2 levels in rhesus monkeys (Macaca mulatta). Am J Physiol. I997;273:E714-E719.
McCarter RI. Role of caloric restriction in the prolongation of life [Review; 53 refs}.Clin GeriatrMed. 1995;11:553-565.
Weindruch R. The retardation of aging by caloric restriction: studies in ro- dents and primates [Review; 26 refs}.ToxicolPathol. 1996;24:742-745.
Richardson A, Cheung HT. Current concepts: I. The relationship between age-related changes in gene expression, protein turnover, and the respon- siveness of an organism to stimuli [Review; 42 refs]. Life Sci. 1982;31: 605--613.
Walter CA, Grabowski DT, Street KA, Conrad CC, Richardson A. Analysis and modulation of DNA repair in aging [Review; 84 refs]. MechAgeing Dev. 1997;98:203-222.
Rudman D, Feller AG, Cohn L, Shetty KR, Rudman IW, Draper MW. Effects of human growth hormone on body composition in elderly men [Review]. Honn Res. 1991;36(Suppll ):73-81.
Haley-Zitlin V, Richardson A. Effect of dietary restriction on DNA repair and DNA damage [Review; 32 refs]. Mutat Res. 1993;295:237-245.
Li CH, Evans HM, Simpson ME. Isolation and properties of the anterior pituitary hypophyseal growth hormone. J Bioi Chern. 1945;159:353-356.
Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging [Review]. Endocr Rev. 1993;14:20-39.
Cohick WS, Clemmons DR. The insulin-like growth factors [Review; 137 refs]. Annu Rev Physiol. 1993;55: 131-153.
Yamamoto H, Murphy U. Enzymatic conversion of IGF-I to des(l- 3)IGF-I in rat serum and tissues: a further potential site of growth hor- mone regulation ofIGF-I action. J Endocrinol. 1995;146:141-148.
Isaksson OG, Lindahl A, Nilsson A, Isgaard 1. Action of growth hor- mone: current views [Review; 45 refs]. Acta Paediatr Scand [Supplj. 1988;343: 12-18.
Tannenbaum GS, Ling N. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm ofGH secretion. Endocrinology. 1984;115:1952-1957.
Sonntag WE, Steger RW, Forman U, Meites 1. Decreased pulsatile re- lease of growth hormone in old male rats. Endocrinology. 1980; 107: 1875-1879.
Florini JR, Harned JA, Richman RA, Weiss JP. Effect of rat age on serum levels of growth hormone and somatomedins. Mech Ageing Dev. 1981; 15:165-176.
Sonntag WE, Hylka VW, Meites J. Growth hormone restores protein syn- thesis in skeletal muscle of old male rats. J Gerontol. 1985;40:689--694.
Sonntag WE, Boyd RL. Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-I. Life Sci. 1988;43:1325-1330.
Sonntag WE, Hylka VW, Meites 1. Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF( 1- 44). Endocrinology. 1983;113:2305-2307.
Sotiropoulos A, Perrot-Applanat M, Dinerstein H, et al. Distinct cyto- plasmic regions of the growth hormone receptor are required for activa- tion of JAK2, mitogen-activated protein kinase, and transcription [see comments]. Endocrinology. 1994;135:1292-1298.
Carvalho CR, Brenelli SL, Silva AC, Nunes AL, Velloso LA, Saad MJ. Effect of aging on insulin receptor, insulin receptor substrate-I, and phos- phatidylinositol 3-kinase in liver and muscle of rats. Endocrinology. 1996;137:151-159.
Werther GA, Abate M, Hogg A, et al. Localization of insulin-like growth factor-I mRNA in rat brain by in situ hybridization-relationship to IGF- I receptors. Mol Endocrinol. 1990;4:773-778.

Sorted by citations

Items 101–200 of 228

Growth hormone secretagogues: prospects and potential pitfalls
Smith, R. G., Sun, Y., Betancourt, L., & Asnicar, M. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.04.001 · Cited by 30
Role of sirtuin proteins in life extension by caloric restriction
Masoro, E. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.011 · Cited by 30
Effects of mild calorie restriction on reproduction, plasma parameters and hepatic gene expression in mice with altered GH/IGF-I axis
Rocha, J. S., Bonkowski, M. S., França, L. R., & Bartke, A. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.02.001 · Cited by 29
Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.
Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., & Kirkland, J. L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw112 · Cited by 28
Obesity and endometrial cancer: biological mechanisms, nutritional strategies, and clinical perspectives
Simancas‐Racines, D., Campuzano-Donoso, M., Román-Galeano, N. M., Zambrano-Villacres, R., Memoli, P., Verde, L., Reytor-González, C., & Carbone, L. (2025) · Food and Agricultural Immunology · doi:10.1080/09540105.2025.2510961 · Cited by 29
Caloric restriction promotes the reproductive capacity of female rats via modulating the level of insulin-like growth factor-1 (IGF-1)
Li, L., Fu, Y., Xu, J.-J., Chen, X., Lin, X.-H., & Luo, L.-L. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.09.005 · Cited by 26
The effects of physiological adaptations to calorie restriction on global cell proliferation rates
Bruss, M. D., Thompson, A. C. S., Aggarwal, I., Khambatta, C. F., & Hellerstein, M. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00661.2010 · Cited by 28
Short-term fasting accompanying chemotherapy as a supportive therapy in gynecological cancer: protocol for a multicenter randomized controlled clinical trial
Koppold, D. A., Keßler, C. S., Steckhan, N., Bähr, V., Kempter, C., Wischnewsky, M. B., Hübner, M., Kunz, B., Paul, M., Zorn, S., et al. (2020) · Trials · doi:10.1186/s13063-020-04700-9 · Cited by 25
Growth Hormone Receptor/Binding Protein (GHR/BP) Knockout Mice: A 3-Year Update
List, E. O., Coschigano, K. T., & Kopchick, J. J. (2001) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3164 · Cited by 25
The tumor suppression theory of aging
Wolf, A. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111583 · Cited by 27
Dietary restriction: Current status
Masoro, E. J. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03353421 · Cited by 24
Effects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue
Bozkaya, F., Atlı, M. O., Güzeloğlu, A., Kayış, S. A., Yildirim, M. E., Kurar, E., Yilmaz, R., & Aydilek, N. (2016) · Andrologia · doi:10.1111/and.12668 · Cited by 23
Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice
Ashpole, N. M., Herron, J. C., Estep, P. N., Logan, S., Hodges, E. L., Yabluchanskiy, A., Humphrey, M. B., & Sonntag, W. E. (2016) · AGE · doi:10.1007/s11357-016-9902-5 · Cited by 22
Self-citation
Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient Restriction
Li, N., Liu, Q., Xiong, Y., & Yu, J. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.086 · Cited by 22
Insulin-like growth factor 1 signaling in motor neuron and polyglutamine diseases: From molecular pathogenesis to therapeutic perspectives
Pennuto, M., Pandey, U. B., & Polanco, M. J. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100821 · Cited by 22
Calorie Restriction Influences Cell Cycle Protein Expression and DNA Synthesis during Liver Regeneration
Cuenca, A. G., Cress, W. D., Good, R. A., Marikar, Y., & Engelman, R. W. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122601114 · Cited by 22
Effects of caloric restriction on gene expression along the epididymis of the Brown Norway rat during aging
Jervis, K. M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00034-2 · Cited by 21
Caloric restriction versus drug therapy to delay the onset of aging diseases and extend life
Everitt, A. V., Roth, G. S., Couteur, D. G. L., & Hilmer, S. N. (2005) · AGE · doi:10.1007/s11357-005-3284-4 · Cited by 21
Biological Effects of Calorie Restriction: Implications for Modification of Human Aging
Spindler, S. R. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_12 · Cited by 20
Mechanisms of Prolonged Longevity: Mutants, Knock-Outs, and Caloric Restriction
Bartke, A., & Turyn, D. (2001) · Rejuvenation Research · doi:10.1089/109454501753249966 · Cited by 20
Development of an UPLC/MS–MS Method for Quantification of Intact IGF-I from Human Serum
Tanna, N., Lame, M. E., & Wrona, M. D. (2019) · Bioanalysis · doi:10.4155/bio-2019-0234 · Cited by 20
Risk Factors for Prostate Cancer
Shepherd, D. L. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-099-5_9 · Cited by 18
Pharmacological Approaches to Decelerate Aging: A Promising Path
Hassani, B., Goshtasbi, G., Nooraddini, S., & Firouzabadi, N. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4201533 · Cited by 19
Molecular and cellular biology
Masoro, E. J. (2002) · Elsevier eBooks · doi:10.1016/b978-044451162-1/50003-5 · Cited by 18
Interactions of long-term food ration variation and short-term fasting on insulin-like growth factor-1 (IGF-1) pathways in copper rockfish (Sebastes caurinus)
Hack, N. L., Cordova, K. L., Glaser, F. L., Journey, M. L., Resner, E. J., Hardy, K. M., Beckman, B. R., & Lema, S. C. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.04.025 · Cited by 18
Age, diet and injury affect the survival of facial motoneurons
Aperghis, M., Johnson, I., Patel, N., Khadir, A., Cannon, J., & Goldspink, G. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00762-5 · Cited by 18
Mild Calorie Restriction Does Not Affect Testosterone Levels and Testicular Gene Expression in Mutant Mice
Rocha, J. S., Bonkowski, M. S., França, L. R., & Bartke, A. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-rm-52 · Cited by 18
A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process
McCarty, M. F. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00235-9 · Cited by 19
Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice
Thompson, A. C. S., Bruss, M. D., Nag, N., Kharitonenkov, A., Adams, A. C., & Hellerstein, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111418 · Cited by 17
Effects of food deprivation on plasma insulin-like growth factor-1 (Igf1) and Igf binding protein (Igfbp) gene transcription in juvenile cabezon (Scorpaenichthys marmoratus)
Strobel, J. S., Hack, N. L., Label, K. T., Cordova, K. L., Bersin, T. V., Journey, M. L., Beckman, B. R., & Lema, S. C. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113319 · Cited by 17
Modulation by dietary restriction in gene expression related to insulin-like growth factor-1 in rat muscle
Tomita, M., Shimokawa, I., Higami, Y., Yanagihara‐Outa, K., Kawahara, T., Tanaka, K., Ikeda, T., & Shindo, H. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03353423 · Cited by 17
Rodent diet aids and the fallacy of caloric restriction
Wolf, A. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111584 · Cited by 15
Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex
Shi, L., Poe, B., Linville, M. C., Sonntag, W. E., & Brunso‐Bechtold, J. K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02249-7 · Cited by 15
Self-citation
Growth hormone plus high protein diet promotes adaptation after massive bowel resection in aged rats
Fadrique, B., Lopez, J. D. M., Bermudez, R., de Segura, I. Á. G., Vazquez, I., & de Miguel, E. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00119-x · Cited by 15
The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats
Molon-Noblot, S., Laroque, P., Coleman, J. B., Hoe, C., & Keenan, K. P. (2003) · Toxicologic Pathology · doi:10.1080/01926230390204351 · Cited by 14
Reduced Insulin-Like Growth Factor-I Serum Levels in Formerly Obese Women Subjected to Laparoscopic-Adjustable Gastric Banding or Diet-Induced Long-term Caloric Restriction
Mitterberger, M. C., Mattesich, M., Klaver, E., Piza‐Katzer, H., & Zwerschke, W. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr149 · Cited by 13
The historical context and scientific legacy of John O. Holloszy
Hagberg, J. M., Coyle, E. F., Baldwin, K. M., Cartee, G. D., Fontana, L., Joyner, M. J., Kirwan, J. P., Seals, D. R., & Weiss, E. P. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00669.2018 · Cited by 11
Sexual dimorphic impact of adult‐onset somatopause on life span and age‐induced osteoarthritis
Poudel, S. B., Dixit, M., Yildirim, G., Córdoba‐Chacón, J., Gahete, M. D., Ikeno, Y., Kirsch, T., Kineman, R. D., & Yakar, S. (2021) · Aging Cell · doi:10.1111/acel.13427 · Cited by 13
Effect of feed restriction and subsequent re-alimentation on hormones and genes of the somatotropic axis in cattle
Keogh, K. A., Waters, S. M., Kelly, A. K., Wylie, A. R. G., & Kenny, D. A. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00134.2014 · Cited by 14
Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?
Kim, S. E., Mori, R., & Shimokawa, I. (2020) · Nutrients · doi:10.3390/nu12071959 · Cited by 14
A meta-analysis of the effects of energy intake on risk of digestive cancers
Yu, X. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i48.7362 · Cited by 12
Influence of diet and metabolism on hematopoietic stem cells and leukemia development following ionizing radiation exposure
Karabulutoglu, M., Finnon, R., Imaoka, T., Friedl, A. A., & Badie, C. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1490042 · Cited by 11
Metformin slows down ageing processes at the cellular level in SHR mice
Arkadieva, A. V., Mamonov, A. A., Popovich, I. G., Anisimov, V. N., Mikhelson, V. M., & Im, S. (2011) · Cell and Tissue Biology · doi:10.1134/s1990519x11020027 · Cited by 10
Life extension versus improving quality of life
Nass, R. M., & Thorner, M. O. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.02.003 · Cited by 10
Annual Fasting; the Early Calories Restriction for Cancer Prevention
Eslami, S., Barzgari, Z., Saliani, N., Saeedi, N., & Barzgari, A. (2012) · Europe PMC (PubMed Central) · doi:10.5681/bi.2012.028 · Cited by 8
Effects of caloric restriction on monoaminergic neurotransmission, peripheral hormones, and olfactory memory in aged rats
Rojic-Becker, D., Tresserra, M. P., Martí‐Nicolovius, M., Vale-Martı́nez, A., & Guillazo‐Blanch, G. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113328 · Cited by 8
Exploring the Effects of Energy Constraints on Performance, Body Composition, Endocrinological/Hematological Biomarkers, and Immune System among Athletes: An Overview of the Fasting State
Nobarı, H., Saedmocheshi, S., Murawska‐Ciałowicz, E., Clemente, F. M., Suzuki, K., & Silva, A. F. (2022) · Nutrients · doi:10.3390/nu14153197 · Cited by 9
Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: Evidence supported by structural equation modeling (SEM) parameter estimates
Braverman, E. R., Chen, T. J. H., Prihoda, T. J., Sonntag, W. E., Meshkin, B., Downs, B. W., Mengucci, J. F., Blum, S. H., Notaro, A., Arcuri, V., et al. (2007) · AGE · doi:10.1007/s11357-007-9030-3 · Cited by 7
Self-citation
Litter expansion alters metabolic homeostasis in a sex specific manner
Kurup, K., Mann, S. N., Jackson, J. A., Matyi, S., Ranjo‐Bishop, M., Freeman, W. M., Stout, M. B., Richardson, A. G., & Unnikrishnan, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0237199 · Cited by 7
Age-Related Decreases in Growth Hormone and Insulin-Like Growth Factor (IGF)–1: Implications for Brain Aging
Sonntag, W. E., Brunso‐Bechtold, J. K., & Riddle, D. R. (2001) · Rejuvenation Research · doi:10.1089/10945450152850641 · Cited by 7
Self-citation
Environmental Enrichment Mitigates Age-Related Metabolic Decline and Lewis Lung Carcinoma Growth in Aged Female Mice
Queen, N. J., Hong, D., Huang, W., Mo, X. M., Wilkins, R. K., Zhu, T., Wu, X., & Cao, L. (2021) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-21-0085 · Cited by 7
Voluntary exercise and mild food restriction effectively retard the collagen biomarker of aging
Viidik, A., & Skalicky, M. (2003) · Aging Clinical and Experimental Research · doi:10.1007/bf03327370 · Cited by 7
Insulin-Like Growth Factor 1 and Mammalian Aging
Bartke, A. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.16.vp4 · Cited by 7
The effects of short-term calorie restriction on mutations in the spleen cells of infant-irradiated mice
Kakomi, S., Nakayama, T., Shang, Y., Tsuruoka, C., Sunaoshi, M., Morioka, T., Shimada, Y., Kakinuma, S., & Tachibana, A. (2019) · Journal of Radiation Research · doi:10.1093/jrr/rrz078 · Cited by 6
Efeitos do envelhecimento sobre o encéfalo
Aversi‐Ferreira, T. A., Rodrigues, H. G., & Paiva, L. R. (2009) · Americanae (AECID Library) · doi:10.5335/rbceh.2012.128 · Cited by 6
Treating glucosphingolipid disorders by chemotherapy: Use of approved drugs and over‐the‐counter remedies
Radin, N. S. (2000) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1026796200760 · Cited by 6
Trophic Status of the Small Intestine in Young and Aged Rats: Modulation by a Yogurt-Supplemented Diet
Foligné, B., Senegas‐Balas, F., Antoine, J., Cayuela, C., Rolf-Pedersen, N., & Balas, D. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000037826.94345.f8 · Cited by 6
Growth Hormone Effects in Intestinal Adaptation After Massive Bowel Resection in the Suckling Rat
Tellez, L. G., de Segura, I. Á. G., Vazquez, I., Miguel, E. D., & Garcia-Sancho, L. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2001.tb07506.x · Cited by 6
Bone Aging
Lau, A. N., & Adachi, J. D. (2011) · Springer eBooks · doi:10.1007/978-1-4419-5792-4_2 · Cited by 6
Energy restriction at young age, genetic variants in the insulin‐like growth factor pathway and colorectal cancer risk in the Netherlands Cohort Study
Simons, C. C. J. M., Schouten, L. J., Godschalk, R., van Engeland, M., van den Brandt, P. A., van Schooten, F., & Weijenberg, M. P. (2016) · International Journal of Cancer · doi:10.1002/ijc.30439 · Cited by 5
Calorie restriction alters the mechanisms of radiation-induced mouse thymic lymphomagenesis
Nakayama, T., Sunaoshi, M., Shang, Y., Takahashi, M., Saito, T., Blyth, B. J., Amasaki, Y., Daino, K., Shimada, Y., Tachibana, A., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280560 · Cited by 5
Beneficial influences of systemic cooperation and sociological behavior on longevity
Mountz, J. D., Zant, G. E. V., Allison, D. B., Zhang, H., & Hsu, H. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00034-9 · Cited by 5
Editorial: Citations, Impact Factor, and the Journal
Morley, J. E. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.12.m765 · Cited by 5
Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylationPreprint
Hadad, N., Unnikrishnan, A., Jackson, J. A., Masser, D. R., Otalora, L., Stanford, D. R., Richardson, A. G., & Freeman, W. M. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/175810 · Cited by 5
Calorie Restriction in Nonhuman and Human Primates
Fontana, L., Colman, R. J., Holloszy, J. O., & Weindruch, R. H. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00021-x · Cited by 4
Relationships between endogenous circadian period, physiological and cognitive parameters and sex in aged gray mouse lemurs ( Microcebus murinus )
Hozer, C., & Pifferi, F. (2021) · Chronobiology International · doi:10.1080/07420528.2021.2001478 · Cited by 5
Ano Europeu da Educação pelo Desporto
Bento, J. (2004) · Revista Portuguesa de Ciências do Desporto · doi:10.5628/rpcd.04.01.03 · Cited by 4
HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
Quinn, J., Astemborski, J. A., Mehta, S. H., Kirk, G. D., Thomas, D. L., & Balagopal, A. (2017) · Pathogens and Immunity · doi:10.20411/pai.v2i1.183 · Cited by 4
The Effects of Ad Libitum Feeding and Marked Dietary Restriction on Spontaneous Skeletal Muscle Pathology in Sprague–Dawley Rats
Molon-Noblot, S., Hubert, M.-F., Hoe, C., Keenan, K., & Laroque, P. (2005) · Toxicologic Pathology · doi:10.1080/01926230500251428 · Cited by 5
The Insulin Growth Factor System and Nutrition in Adulthood and Aging
LEWITT, M. S., & Hall, K. E. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-795-6_9 · Cited by 4
Dietary Energy Intake, Hormesis, and Health
Martin, B., Ji, S., White, C. M., Maudsley, S. R., & Mattson, M. P. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-495-1_7 · Cited by 4
Decline of life’s energy theory of ageing 2. Restoration of anabolic and regulatory processes
Grant, G., & Parr, T. B. (2000) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.10.12.1885 · Cited by 4
Hormones and Oxidative Stress
Brown‐Borg, H. M., & Harman, S. M. (2002) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812775733_0061 · Cited by 4
Impact of 16/8 time-restricted eating on body composition and lipolytic hormone regulation in female DanceSport dancers
Li, X., Guo, X., Zhou, Y., Cao, G., Chen, M., & Mu, J. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2513943 · Cited by 3
The consequences of a high-calorie diet background before calorie restriction on skeletal muscles in a mouse model
Maldonado, M., Chen, J., Lujun, Y., Duan, H., Raja, M. A., Qu, T., Huang, T., Gu, J., & Zhong, Y. (2021) · Aging · doi:10.18632/aging.203237 · Cited by 3
Human Aging and the Growth Hormone/Insulin-like Growth Factor-I Axis: The Impact of Growth Factors on Dementia
Arvat, E., Giordano, R., Pellegrino, M., Lanfranco, F., Baldi, M., PICU, A., Bonelli, L., & Ghigo, E. (2006) · Elsevier eBooks · doi:10.1016/b978-012088484-1/50024-0 · Cited by 3
Impaired joint mobility
Christiansen, C. L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-02948-3.00022-5 · Cited by 4
Fasting and engineered diets as powerful tool in the medical practice: an old approach in the new era
Panebianco, C., Potenza, A., & Pazienza, V. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.08.34 · Cited by 4
Nutrition and Exercise in Cardiovascular Aging: Metabolic and Pharmacological Interventions
Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_15 · Cited by 3
Issues Regarding the Routine and Long-Term Use of Growth Hormone in Anti-Aging Medicine
Walker, R. F., & Bercu, B. B. (2001) · Rejuvenation Research · doi:10.1089/10945450152850623 · Cited by 3
The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of agingPreprint
Wolf, A. M. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/a2689 · Cited by 2
The Differential Effects of APOE ɛ4 on Cerebral Volumetric Structures in Different Lifespan in Community-Dwelling Populations
Tang, M., Su, N., Zhang, D., Dai, Y., Yao, M., Zhou, L., Cui, L., Zhang, S., Zhu, Y., & Ni, J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220834 · Cited by 2
«Ageingfeatures» analysis of IGF-1 and PGC-1 genes polymorphism
Владимировна, П. С., Glotov, O. S., & Баранов, В. С. (2009) · Ecological genetics · doi:10.17816/ecogen7112-18 · Cited by 2
Mechanisms of the anti-aging action of caloric restriction
Masoro, E. J. (2002) · Elsevier eBooks · doi:10.1016/b978-044451162-1/50006-0 · Cited by 2
Hormones and adult neurogenesis in mammals
Richardson, S. J., Almeida, O. F. X., & DEMENEIX, B. A. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2.2.261 · Cited by 2
Growth Hormone, Insulin-Like Growth Factor-1, and the Biology of Aging
Carter, C. S., & Sonntag, W. E. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50023-6 · Cited by 2
Self-citation
Updated results on the karyology of the WI-38, MRC-5 and MRC-9 cell strains.
Jacobs, J. P. (1976) · PubMed · Cited by 2
Consequences of adrenalectomy on small intestine trophic parameters in aged and young rats: evidence of defective adaptation by aging and lack of corticoids.
Foligné, B. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1023733216568 · Cited by 2
The role of oxidative stress in C. elegans aging
Thamsen, M. (2011) · Gutenberg Open Science · doi:10.25358/openscience-4772 · Cited by 2
Calorie restriction in radiation-exposed mice affects the expression of autophagy-related protein p62
Nakayama, T., Suzuki, K., & Mitsutake, N. (2025) · BMC Cancer · doi:10.1186/s12885-025-14771-z · Cited by 1
Global Food Restriction
Matzko, M. E., McCarter, R., & Masoro, E. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-507-1_6 · Cited by 1
Telomeres, Senescence and Longevity: The Role of Oxidative Stress and Antioxidants
Saretzki, G. C. (2005) · Current Pharmacogenomics · doi:10.2174/1570160054022926 · Cited by 1
Oxidative Stress, Gene Expression, and Lifespan
Honda, S., & Honda, Y. (2005) · Oxidative stress and disease · doi:10.1201/9781420028096.ch4 · Cited by 1
Is There A Way to Prevent Aging? A Study Using Metformin in Blood Sugar Levels and Serum Levels of IGF-1
Gama, A. W., Santoso, A., Yustisia, I., Taslim, N. A., Idris, I., & Wahid, I. (2021) · Al-sihah The Public Health Science Journal · doi:10.24252/al-sihah.v13i1.21694 · Cited by 3
Platelet Factor 4 and Longevity of Patients with Essential Thromobocythemia: An Example of Antagonistic Pathogenic Pleiotropy
Bains, W. (2024) · Rejuvenation Research · doi:10.1089/rej.2023.0066 · Cited by 1
Diabetes Mellitus and the Risk of Carcinogenesis: An Interdisciplinary Approach
Tkaczenko, H., Kamiński, P., & Kurhaluk, N. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_426 · Cited by 1
From weight loss to cancer treatment: Fasting as an adjuvant anticancer therapy
Talib, W. H., Ali, A. J., Baban, M. M., Salman, J. A. S., Junaidi, H. S. A., Jumah, L. A., Radhi, R. H., Fleifel, R. E., Abuarab, S. F., Al-Yasari, A. H., et al. (2024) · Pharmacia · doi:10.3897/pharmacia.71.e122170 · Cited by 1
Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory
Miller, G. S. (2010) · Human Biology · Cited by 1
Evolución de la condición física y parámetros de referencia entre las poblaciones de mayores de la provincia de León-España y Minas Gerais-Brasil
Rocha, C. C. D. (2012) · Buleria (Universidad de León) · doi:10.18002/10612/2313 · Cited by 1
Insulin and Insulin‐Like Growth Factor
Levine, T., & Levine, A. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch5 · Cited by 1

Authors: Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., & Khan, A. S.
Affiliations: Wake Forest University Health Sciences (US)
ORCID: Sonntag, W. E.
Cefalu, W. T.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 1999-12-01
Volume: 54
Issue: 12
Pages: B521-B538
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/54.12.b521
OpenAlex: W2166656167
Cited by: 229
References: 131
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 12 · 2020: 10 · 2019: 14 · 2018: 3 · 2017: 7 · 2016: 12 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 9
FWCI: 1.41
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
DigitalCommons-Cedarville (Cedarville University) (submittedVersion)
Funders: Wake Forest University
National Institutes of Health (5r01ag007752-07)
National Institute on Aging (AG-11370, P01AG011370, AG 07752)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: biological aging, growth hormone, insulin-like growth factor I, lifespan extension, age-related diseases, cancer risk, neuroendocrine adaptation, glucose homeostasis
MeSH terms: Aging, Animals, Blood Glucose, Energy Intake, Cell Division, Disease Models, Animal, Female, Insulin-Like Growth Factor I, Longevity, Lung Neoplasms, Male, Mammary Neoplasms, Experimental, Neurosecretory Systems, Phenotype, Prostatic Neoplasms, Risk Factors, Growth Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks