Sonntag, William E.

Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis

Lichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 428

Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1

Sonntag, W. E., Lynch, C. D., Cooney, P. T., & Hutchins, P. M. (1997) · Endocrinology

Growth Hormone and Insulin-like Growth FactorsBarrier Structure and Function Studies

Cited by 307

Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., & Khan, A. S. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 229

Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

Mangold, C. A., Wronowski, B., Du, M., Masser, D. R., Hadad, N., Bixler, G. V., Brucklacher, R. M., Ford, M. M., Sonntag, W. E., & Freeman, W. M. (2017) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 203

Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

Tucsek, Z., Toth, P., Tarantini, S., Sosnowska, D., Gautam, T., Warrington, J. P., Giles, C. B., Wren, J. D., Koller, A., Ballabh, P., et al. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Barrier Structure and Function StudiesNeurological Disease Mechanisms and Treatments

Cited by 191

Ionizing Radiation Promotes the Acquisition of a Senescence-Associated Secretory Phenotype and Impairs Angiogenic Capacity in Cerebromicrovascular Endothelial Cells: Role of Increased DNA Damage and Decreased DNA Repair Capacity in Microvascular Radiosensitivity

Ungvari, Z., Podlutsky, A., Sosnowska, D., Tucsek, Z., Toth, P., Deak, F., Gautam, T., Csiszar, A., & Sonntag, W. E. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Effects of Radiation ExposureTelomeres, Telomerase, and Senescence

Cited by 179

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection

Toth, P., Tarantini, S., Springo, Z., Tucsek, Z., Gautam, T., Giles, C. B., Wren, J. D., Koller, A., Sonntag, W. E., Csiszar, A., et al. (2015) · Aging Cell

Intracerebral and Subarachnoid Hemorrhage ResearchNeurological Disease Mechanisms and Treatments

Cited by 163

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

VanGuilder, H. D., Bixler, G. V., Brucklacher, R. M., Farley, J. A., Yan, H., Warrington, J. P., Sonntag, W. E., & Freeman, W. M. (2011) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 132

Measuring behavior in the home cage: study design, applications, challenges, and perspectives

Grieco, F., Bernstein, B. J., Biemans, B., Bikovski, L., Burnett, C. J., Cushman, J. D., van Dam, E. A., Fry, S. A., Richmond-Hacham, B., Homberg, J. R., et al. (2021) · Frontiers in Behavioral Neuroscience

Animal Behavior and Welfare StudiesNeuroscience and Neuropharmacology Research

Cited by 109

Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression

Mitschelen, M., Yan, H., Farley, J. A., Warrington, J. P., Han, S., Hereñú, C. B., Csiszar, A., Ungvari, Z., Bailey-Downs, L. C., Bass, C. E., et al. (2011) · Neuroscience

Growth Hormone and Insulin-like Growth FactorsTreatment of Major Depression

Cited by 103

Mitochondria and aging in the vascular system

Ungvari, Z., Sonntag, W. E., & Csiszar, A. (2010) · Journal of Molecular Medicine

Mitochondrial Function and PathologyNitric Oxide and Endothelin Effects

Cited by 103

Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning

Ramsey, M. M., Weiner, J. L., Moore, T. P., Carter, C. S., & Sonntag, W. E. (2004) · Neuroscience

Growth Hormone and Insulin-like Growth FactorsNeuroscience and Neuropharmacology Research

Cited by 101

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini, S., Tucsek, Z., Valcarcel-Ares, M. N., Toth, P., Gautam, T., Giles, C. B., Ballabh, P., Wei, J. Y., Wren, J. D., Ashpole, N. M., et al. (2016) · AGE

Neurological Disease Mechanisms and TreatmentsBarrier Structure and Function Studies

Cited by 98

Physical performance and longevity in aged rats

Carter, C. S., Sonntag, W. E., Onder, G., & Pahor, M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsFrailty in Older Adults

Cited by 68

Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum

Hua, K., Forbes, M. E., Lichtenwalner, R. J., Sonntag, W. E., & Riddle, D. R. (2009) · Glia

Neurogenesis and neuroplasticity mechanismsGrowth Hormone and Insulin-like Growth Factors

Cited by 36

The ependymal route for insulin-like growth factor-1 gene therapy in the brain

Hereñú, C. B., Sonntag, W. E., Morel, G. R., Portiansky, E. L., & Goya, R. G. (2009) · Neuroscience

Virus-based gene therapy researchBarrier Structure and Function Studies

Cited by 36

Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats

Molina, D. P., Ariwodola, O. J., Linville, C., Sonntag, W. E., Weiner, J. L., Brunso-Bechtold, J. K., & Adams, M. M. (2012) · Neurobiology of Aging

Neuroscience and Neuropharmacology ResearchGrowth Hormone and Insulin-like Growth Factors

Cited by 35