The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Telomere Erosion and Senescence in Human Articular Cartilage Chondrocytes
Open accessAbstract
Aging and the degeneration of articular cartilage in osteoarthritis are distinct processes, but a strong association exists between age and the incidence and prevalence of osteoarthritis. We hypothesized that this association is due to in vivo replicative senescence, which causes age-related declines in the ability of chondrocytes to maintain articular cartilage. For this hypothesis to be tested, senescence-associated markers were measured in human articular chondrocytes from donors ranging in age from 1 to 87 years. These measures included in situ staining for senescence-associated β-galactosidase activity, 3H-thymidine incorporation assays for mitotic activity, and Southern blots for telomere length determinations. We found that senescence-associated β-galactosidase activity increased with age, whereas both mitotic activity and mean telomere length declined. These findings indicate that chondrocyte replicative senescence occurs in vivo and support the hypothesis that the association between osteoarthritis and aging is due in part to replicative senescence. The data also imply that transplantation procedures performed to restore damaged articular surfaces could be limited by the inability of older chondrocytes to form new cartilage after transplantation.
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Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1×
“In contrast, germ cell lines and cancer cell lines, in which the “telomerase” enzyme is active, are virtually immortal (18,24,25).”
BackgroundTelomere end-replication problem and cell aging
Levy, M. Z., Allsopp, R. C., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90096-3 · Cited by 1,069
Vaziri, H., & Benchimol, S. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70109-5 · Cited by 1,003 · cited 1×
“Furthermore, transfection with the telomerase gene is sufficient to greatly extend the replicative life span of normal somatic cells (26,27).”
BackgroundTelomere Shortening Is Associated with Cell Division in Vitro and in Vivo
Allsopp, R. C., Chang, E., Kashefi-Aazam, M., Rogaev, E. I., Piatyszek, M. A., Shay, J. W., & Harley, C. B. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1306 · Cited by 533
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370
Cited by
Loeser, R. F. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.03.002 · Cited by 726
Senescent cell clearance by the immune system: Emerging therapeutic opportunities
Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T., & Kirkland, J. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2019.04.003 · Cited by 497
Le Maitre, C. L., Freemont, A. J., & Hoyland, J. A. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2198 · Cited by 457
“The attrition rate seen in disc cells in vivo is higher than the 30 bp/year attrition rate seen in articular chondrocytes [27] but is similar to the attrition rate of 102 bp/ year seen in iliac artery cells [28].”
The role of chondrocyte senescence in osteoarthritis
Price, J. S., Waters, J. G., Darrah, C., Pennington, C., Edwards, D. R., Donell, S. T., & Clark, I. M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00008.x · Cited by 386
Cellular senescence in osteoarthritis pathology
McCulloch, K., Litherland, G. J., & Rai, T. S. (2017) · Aging Cell · doi:10.1111/acel.12562 · Cited by 367
Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice
Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw154 · Cited by 352
Post‐traumatic osteoarthritis: The role of accelerated chondrocyte senescence
Martin, J. A., Brown, T., Heiner, A., & Buckwalter, J. A. (2004) · Biorheology: The Official Journal of the International Society of Biorheology · doi:10.1177/0006355x2004041003004017 · Cited by 168
Self-citationExpression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis
Diekman, B. O., Sessions, G. A., Collins, J. A., Knecht, A. K., Strum, S. L., Mitin, N. K., Carlson, C. S., Loeser, R. F., & Sharpless, N. E. (2018) · Aging Cell · doi:10.1111/acel.12771 · Cited by 158
Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis
Mavrogonatou, E., Pratsinis, H., Papadopoulou, A., Karamanos, N. K., & Kletsas, D. (2019) · Matrix Biology · doi:10.1016/j.matbio.2017.10.004 · Cited by 153
Role of the inflammation-autophagy-senescence integrative network in osteoarthritis
Vinatier, C., Domínguez, E., Guicheux, J., & Caramés, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00706 · Cited by 135
Buckwalter, J. A., & Martin, J. A. (2004) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000132647.55056.a9 · Cited by 113
Self-citationCaveolin-1, cellular senescence and age-related diseases
Zou, H., Stoppani, E., Volonte, D., & Galbiati, F. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.11.001 · Cited by 112
Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro
Zhou, H. W. (2004) · Rheumatology · doi:10.1093/rheumatology/keh127 · Cited by 108
Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
Zhai, G., Aviv, A., Hunter, D. J., Hart, D. J., Gardner, J. P., Kimura, M., Lu, X., Valdes, A. M., & Spector, T. D. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.056903 · Cited by 72
The role of cellular senescence in aging through the prism of Koch-like criteria
Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45
The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model
Hambright, W. S., Mu, X., Gao, X., Guo, P., Kawakami, Y., Mitchell, J., Mullen, M., Nelson, A.-L., Bahney, C., Nishimura, H., et al. (2023) · Journal of Osteoporosis · doi:10.1155/2023/5572754 · Cited by 44
Metadata
- Authors
- Martin, J. A., & Buckwalter, J. A.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-04-01
- Volume
- 56
- Issue
- 4
- Pages
- B172-B179
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2109142422
- Cited by
- 234
- References
- 11
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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