The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model
Open accessAbstract
Aging leads to several geriatric conditions including osteoporosis (OP) and associated frailty syndrome. Treatments for these conditions are limited and none target fundamental drivers of pathology, and thus identifying strategies to delay progressive loss of tissue homeostasis and functional reserve will significantly improve quality of life in elderly individuals. A fundamental property of aging is the accumulation of senescent cells. Senescence is a cell state defined by loss of proliferative capacity, resistance to apoptosis, and the release of a proinflammatory and anti-regenerative senescence-associated secretory phenotype (SASP). The accumulation of senescent cells and SASP factors is thought to significantly contribute to systemic aging. Senolytics—compounds which selectively target and kill senescent cells—have been characterized to target and inhibit anti-apoptotic pathways that are upregulated during senescence, which can elicit apoptosis in senescent cells and relieve SASP production. Senescent cells have been linked to several age-related pathologies including bone density loss and osteoarthritis in mice. Previous studies in murine models of OP have demonstrated that targeting senescent cells pharmacologically with senolytic drugs can reduce symptomology of the disease. Here, we demonstrate the efficacy of senolytic drugs (dasatinib, quercetin, and fisetin) to improve age-associated degeneration in bone using the Zmpste24−/− (Z24−/−) progeria murine system for Hutchinson–Gilford progeria syndrome (HGPS). We found that the combination of dasatinib plus quercetin could not significantly mitigate trabecular bone loss although fisetin administration could reduce bone density loss in the accelerated aging Z24−/− model. Furthermore, the overt bone density loss observed in the Z24−/− model reported herein highlights the Z24 model as a translational model to recapitulate alterations in bone density associated with advanced age. Consistent with the “geroscience hypothesis,” these data demonstrate the utility of targeting a fundamental driver of systemic aging (senescent cell accumulation) to alleviate a common condition with age, bone deterioration.
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1 retracted
RETRACTED: Quercetin: A flavonol with multifaceted therapeutic applications?
D’Andrea, G. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.09.018 · Cited by 729 · see citing works
RetractedLópez-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
Johnell, O., & Kanis, J. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0172-4 · Cited by 4,770 · see citing works
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works
Senescence in Health and Disease
He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works
Cellular senescence mediates fibrotic pulmonary disease
Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · see citing works
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Ageing and the pathogenesis of osteoarthritis
Loeser, R. F., Collins, J. A., & Diekman, B. O. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.65 · Cited by 1,309 · see citing works
Targeting cellular senescence prevents age-related bone loss in mice
Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4385 · Cited by 1,182 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
Fisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032 · see citing works
Cellular senescence: a translational perspective
Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works
Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · cited 1× · see citing works
“Senescent cells have also been linked to OP [23] and frailty [24, 25], and targeting SASP pharmacologically via JAK inhibition has been demonstrated to alleviate bone density loss in aged mice [12].”
BackgroundZhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017) · Aging · doi:10.18632/aging.101202 · Cited by 757 · see citing works
Identification of HSP90 inhibitors as a novel class of senolytics
Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00314-z · Cited by 701 · see citing works
Accumulation of senescent cells in Mitotic tissue of aging primates
Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works
Identification of senescent cells in the bone microenvironment
Farr, J. N., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M. M., Drake, M. T., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2892 · Cited by 562 · see citing works
Pendás, A. M., Zhou, Z., Cadiñanos, J., Freije, J. M. P., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., et al. (2002) · Nature Genetics · doi:10.1038/ng871 · Cited by 554 · see citing works
The Clinical potential of Senolytic Drugs
Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J., & Robbins, P. D. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14969 · Cited by 539 · see citing works
Osteoporosis: A Review of Treatment Options.
Tu, K. N., Lie, J. D., Wan, C. K. V., Cameron, M., Austel, A. G., Nguyen, J. K., Van, K., & Hyun, D. (2018) · PubMed Central · Cited by 534 · see citing works
Burden of high fracture probability worldwide: secular increases 2010–2040
Odén, A., McCloskey, E. V., Kanis, J. А., Harvey, N. C., & Johansson, H. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3154-6 · Cited by 533 · see citing works
Fisetin: A Dietary Antioxidant for Health Promotion
Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4901 · Cited by 512 · see citing works
The role of chondrocyte senescence in osteoarthritis
Price, J. S., Waters, J. G., Darrah, C., Pennington, C., Edwards, D. R., Donell, S. T., & Clark, I. M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00008.x · Cited by 386 · see citing works
Cellular senescence in osteoarthritis pathology
McCulloch, K., Litherland, G. J., & Rai, T. S. (2017) · Aging Cell · doi:10.1111/acel.12562 · Cited by 367 · see citing works
Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice
Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw154 · Cited by 352 · see citing works
Watanabe, S., Kawamoto, S., Ohtani, N., & Hara, E. (2017) · Cancer Science · doi:10.1111/cas.13184 · Cited by 321 · see citing works
The number of p16INK4a positive cells in human skin reflects biological age
Waaijer, M. E. C., Parish, W. E., Strongitharm, B. H., van Heemst, D., Slagboom, P. E., de Craen, A. J. M., Sedivy, J. M., Westendorp, R. G. J., Gunn, D. A., & Maier, A. B. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00837.x · Cited by 264 · see citing works
Farr, J. N., & Khosla, S. (2019) · Bone · doi:10.1016/j.bone.2019.01.015 · Cited by 263 · see citing works
Telomere Erosion and Senescence in Human Articular Cartilage Chondrocytes
Martin, J. A., & Buckwalter, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.4.b172 · Cited by 232 · see citing works
Senotherapeutics for healthy ageing
Niedernhofer, L. J., & Robbins, P. D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.44 · Cited by 190 · see citing works
Adhami, V. M., Syed, D. N., Khan, N., & Mukhtar, H. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.012 · Cited by 187 · see citing works
Zheng, W., Feng, Z., You, S., Zhang, H., Tao, Z., Wang, Q., Chen, H., & Wu, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.02.009 · Cited by 160 · see citing works
Cellular Senescence and the Biology of Aging, Disease, and Frailty
LeBrasseur, N. K., Tchkonia, T., & Kirkland, J. L. (2015) · Nestlé Nutrition Institute Workshop Series · doi:10.1159/000382054 · Cited by 147 · see citing works
Li, J., Cheng, Y., Qu, W., Sun, Y., Wang, Z., Wang, H., & Tian, B. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2010.00613.x · Cited by 119 · see citing works
Effect of Lamin A/C Knockdown on Osteoblast Differentiation and Function
Akter, R., Rivas, D., Geneau, G., Drissi, H., & Duque, G. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081010 · Cited by 118 · see citing works
Pal, H. C., Sharma, S., Elmets, C. A., Athar, M., & Afaq, F. (2013) · Experimental Dermatology · doi:10.1111/exd.12181 · Cited by 103 · see citing works
Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration
Nam, Y., Rim, Y. A., Lee, J. J., & Ju, J. H. (2018) · Stem Cells International · doi:10.1155/2018/8490489 · Cited by 103 · see citing works
Mu, X., Tseng, C., Hambright, W. S., Matre, P. R., Lin, C.-Y. G., Chanda, P. K., Chen, W., Gu, J., Ravuri, S. K., Cui, Y., et al. (2020) · Aging Cell · doi:10.1111/acel.13152 · Cited by 92 · see citing works
Self-citationFlavonoids induce HIF-1α but impair its nuclear accumulation and activity
Triantafyllou, A., Mylonis, I., Simos, G., Bonanou, S., & Tsakalof, A. K. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.10.050 · Cited by 87 · see citing works
Zhang, X., & Jia, S.-S. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.035 · Cited by 79 · see citing works
Translating the Science of Aging into Therapeutic Interventions
Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78 · see citing works
Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice
Li, W., Yeo, L. S., Vidal, C., McCorquodale, T., Herrmann, M., Fatkin, D., & Duque, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019313 · Cited by 74 · see citing works
Lamin A/C deficiency is associated with fat infiltration of muscle and bone
Tong, J. Y., Li, W., Vidal, C., Yeo, L. S., Fatkin, D., & Duque, G. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.09.004 · Cited by 55 · see citing works
Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
Kawakami, Y., Hambright, W. S., Takayama, K., Mu, X., Lu, A., Cummins, J. H., Matsumoto, T., Yurube, T., Kuroda, R., Kurosaka, M., et al. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.05.011 · Cited by 48 · see citing works
Self-citationHarbo, M., Delaissé, J., Kjærsgaard‐Andersen, P., Soerensen, F. B., Kølvraa, S., & Bendix, L. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.07.002 · Cited by 42 · see citing works
Odanacatib: Location and timing are everything
Khosla, S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1541 · Cited by 37 · see citing works
Safety of drugs used in the treatment of osteoporosis
McGreevy, C., & Williams, D. J. (2011) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098611411012 · Cited by 37 · see citing works
Improving Outcomes in Chronic Myeloid Leukemia Over Time in the Era of Tyrosine Kinase Inhibitors
Chopade, P., & Akard, L. P. (2018) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2018.06.029 · Cited by 33 · see citing works
Deng, Z., Gao, X., Sun, X., Amra, S., Lu, A., Cui, Y., Eltzschig, H. K., Lei, G., & Huard, J. (2019) · The FASEB Journal · doi:10.1096/fj.201802132rr · Cited by 32 · see citing works
Self-citationGao, X., Cheng, H., Awada, H. K., Tang, Y. M., Amra, S., Lu, A., Sun, X., Lv, G., Huard, C., Wang, B., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1434-3 · Cited by 32 · see citing works
Self-citationGunawardene, P., Bermeo, S., Vidal, C., Saedi, A. A., Chung, P., Boersma, D., Phu, S., Pokorski, I., Suriyaarachchi, P., Demontiero, O., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv190 · Cited by 31 · see citing works
Saedi, A. A., Gunawardene, P., Bermeo, S., Vogrin, S., Boersma, D., Phu, S., Singh, L., Suriyaarachchi, P., & Duque, G. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.015 · Cited by 22 · see citing works
Gao, X.-Q., Tang, Y., Amra, S., Sun, X., Cui, Y., Cheng, H.-Z., Wang, B., & Huard, J. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz012 · Cited by 19 · see citing works
Self-citationGender differences in tibial fractures healing in normal and muscular dystrophic mice.
Deng, Z., Gao, X., Sun, X., Cui, Y., Amra, S., & Huard, J. (2020) · PubMed Central · Cited by 15 · see citing works
Self-citationImproved Bone Quality and Bone Healing of Dystrophic Mice by Parabiosis
Li, H., Lu, A., Gao, X., Tang, Y. M., Ravuri, S. K., Wang, B., & Huard, J. (2021) · Metabolites · doi:10.3390/metabo11040247 · Cited by 8 · see citing works
Self-citationSun, X., Gao, X., Deng, Z., Zhang, L., McGilvray, K. C., Gadomski, B. C., Amra, S., Bao, G., & Huard, J. (2019) · The FASEB Journal · doi:10.1096/fj.201901229rr · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
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Sorted by citations
Mi, B.-B., Xiong, Y., Knoedler, S. A., Alfertshofer, M. G., Panayi, A. C., Wang, H., Lin, S.-E., Li, G., & Liu, G. (2024) · Bone Research · doi:10.1038/s41413-024-00346-4 · Cited by 138 · see citing works
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases
Tavenier, J., Nehlin, J. O., Houlind, M. B., Rasmussen, L. J., Tchkonia, T., Kirkland, J. L., Andersen, O., & Rasmussen, L. J. H. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111995 · Cited by 97 · see citing works
Osteoimmunology of Fracture Healing.
Molitoris, K. H., Huang, M., & Baht, G. S. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00869-z · Cited by 84 · see citing works
The role of cellular senescence in ovarian aging
Hense, J. D., Isola, J. V. V., Garcia, D. N., Magalhães, L. S., Masternak, M. M., Stout, M. B., & Schneider, A. (2024) · npj Aging · doi:10.1038/s41514-024-00157-1 · Cited by 59 · see citing works
Lee, E., Carreras-Gallo, N., Lopez, L., Turner, L., Lin, A., Mendez, T. L., Went, H., Tomusiak, A., Verdin, E. M., Corley, M. J., et al. (2024) · Aging · doi:10.18632/aging.205581 · Cited by 51 · see citing works
Rizzo, M. G., Best, T. M., Huard, J., Philippon, M. J., Hornicek, F. J., Duan, Z., Griswold, A. J., Kaplan, L. D., Hare, J. M., & Kouroupis, D. (2023) · Cells · doi:10.3390/cells12101421 · Cited by 46 · see citing works
Self-citationSenolytic therapeutics: An emerging treatment modality for osteoarthritis
Ansari, M. M., Ghosh, M., Lee, D., & Son, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102275 · Cited by 48 · see citing works
A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment
Saleh, T., Greenberg, E. F., Faber, A. C., Harada, H., & Gewirtz, D. A. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2219 · Cited by 26 · see citing works
Cellular senescence and frailty: a comprehensive insight into the causal links
Marcozzi, S., Bigossi, G., Giuliani, M. E., Giacconi, R., Piacenza, F., Cardelli, M., Brunetti, D., Segala, A., Valerio, A., Nisoli, E., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00960-w · Cited by 24 · see citing works
A new clinical age of aging research
Zhang, Z., Yang, R., Zi, Z., & Liu, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.08.004 · Cited by 25 · see citing works
Premature aging in genetic diseases: what conclusions can be drawn for physiological aging
Milosic, F., Hengstschläger, M., & Osmanagic‐Myers, S. (2024) · Frontiers in Aging · doi:10.3389/fragi.2023.1327833 · Cited by 19 · see citing works
ÖZDEMİR, K., & Demir, Y. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103406 · Cited by 17 · see citing works
Cellular Models of Aging and Senescence
Kim, B., Lee, D. I., Basisty, N., & Dai, D.-F. (2025) · Cells · doi:10.3390/cells14161278 · Cited by 16 · see citing works
Jha, L. A., Imran, M., Shrestha, J., Devkota, H. P., Bhattacharya, K., Alsayari, A., Wahab, S., Jha, S. K., Paudel, K. R., & Kesharwani, P. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113243 · Cited by 17 · see citing works
Mavrogonatou, E., & Kletsas, D. (2024) · Metabolites · doi:10.3390/metabo14030146 · Cited by 15 · see citing works
Jacob, J., Aggarwal, A., Bhattacharyya, S., Sahni, D., Sharma, V., & Aggarwal, A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177573 · Cited by 12 · see citing works
Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy
Delrue, C., Speeckaert, R., & Speeckaert, M. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199372 · Cited by 11 · see citing works
Skeletal phenotypes and molecular mechanisms in aging mice
Guan, Q., 上海体育大学运动健康学院, 上. 2., Zhang, Y., Wang, Z., Liu, X.-H., Zou, J., & Zhang, L.-L. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.397 · Cited by 11 · see citing works
Falvino, A., Bonanni, R., Tarantino, U., Tancredi, V., & Cariati, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157573 · Cited by 11 · see citing works
Kontoghiorghes, G. J. (2025) · Nutrients · doi:10.3390/nu17203270 · Cited by 9 · see citing works
Senolytic treatment attenuates immune cell infiltration without improving IAV outcomes in aged mice
Luna, A. J., Chou, K., Wragg, K. M., Worley, M. J., Paruchuri, N., Zhou, X., Blin, M. G., Moore, B. B., Salmon, M., Goldstein, D. R., et al. (2025) · Aging Cell · doi:10.1111/acel.14437 · Cited by 6 · see citing works
Nishimura, H., Murata, Y., Mullen, M. T., Yamaura, K., Singer, J., Huard, C., Lind, D. R. G., Hambright, W. S., Bahney, C. S., Philippon, M. J., et al. (2025) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1155/term/9187855 · Cited by 6 · see citing works
Self-citationPharmacological frontiers in senescence: Transforming senescence with drug repurposing
Shahzadi, A., Özyazgan, S., & Çakatay, U. (2025) · Advances in pharmacology · doi:10.1016/bs.apha.2025.02.010 · Cited by 5 · see citing works
Cross-talk between aging resilience pathways and autoimmunity onset
Mittal, R., Saavedra, D., Mittal, M., & Hirani, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1712575 · Cited by 5 · see citing works
Sayed, S. E., Saiyed, D., Macri, V. I., Asamoah‐Mensah, A., Segars, J. H., & Islam, M. S. (2026) · Nutrients · doi:10.3390/nu18030393 · Cited by 6 · see citing works
The flavonoid fisetin reduces multiple physiological risk factors for dementia
Maher, P. A. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105805 · Cited by 5 · see citing works
Sokal, A., Stocerz, K., Olczyk, P., & Kadela-Tomanek, M. (2024) · Annales Academiae Medicae Silesiensis · doi:10.18794/aams/175007 · Cited by 5 · see citing works
The potential for senotherapy as a novel approach to extend life quality in veterinary medicine
Williams, Z. J., Chow, L., Dow, S., & Pezzanite, L. M. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1369153 · Cited by 5 · see citing works
Chen, B., Li, G., Fang, Q., Ding, P., & Gao, Y. (2026) · Inflammation and Regeneration · doi:10.1186/s41232-026-00416-6 · Cited by 5 · see citing works
Yang, G., Bi, S., Zhang, X., Zhong, J., & Wu, L. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116612 · Cited by 4 · see citing works
Research Progress of Senolytic Drugs in the Treatment of Orthopedic Diseases
Zhang, M., Lou, P., Shou, D., Tong, P., & Zhang, Y. (2025) · Gerontology · doi:10.1159/000543386 · Cited by 4 · see citing works
Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials
Zhu, Q., Hu, M., Wu, L., Wei, E., Pan, X., Liu, H., & Liu, Y. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70350 · Cited by 4 · see citing works
Nakamichi, S., Yamada, L., Roselle, C., Horikawa, I., June, C. H., & Harris, C. C. (2025) · GeroScience · doi:10.1007/s11357-025-01819-y · Cited by 2 · see citing works
Senotherapy: Implications for Transplantation
Jaros, M., & Melk, A. (2025) · Transplantation · doi:10.1097/tp.0000000000005291 · Cited by 2 · see citing works
Murine Progeria Model Exhibits Delayed Fracture Healing with Dysregulated Local Immune ResponsePreprint
Duke, V. R., Philippon, M. J., Lind, D. R. G., Kasler, H. G., Yamaura, K., Huard, M., Czachor, M. E., Hollenbeck, J. F. M., Brown, J., Garcia, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.596277 · Cited by 2 · see citing works
Self-citationFisetin enhances osteoblast differentiation and bone formation under simulated microgravity
Wu, Z., Hu, L., Zhang, W., Ru, K., Xu, X., Liu, S., Liu, H., Jia, Y., Chen, Z., & Qian, A. (2024) · Acta Astronautica · doi:10.1016/j.actaastro.2024.12.045 · Cited by 1 · see citing works
Duke, V. R., Philippon, M. J., Lind, D. R. G., Kasler, H. G., Yamaura, K., Huard, M., Czachor, M. E., Hollenbeck, J. F. M., Brown, J., Garcia, A., et al. (2026) · Journal of Orthopaedic Research® · doi:10.1002/jor.70193 · Cited by 3 · see citing works
Self-citationCellular senescence and aging: molecular mechanisms and convergent pathways
Piritore, F. C., Braggio, M., Minoia, A., Bolognin, S., Cominacini, M., Trabetti, E., Bombieri, C., Romanelli, M. G., Carbonare, L. D., & Valenti, M. T. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06317-8 · Cited by 1 · see citing works
Heinrichs, D. P., & Samsonraj, R. M. (2026) · Current Osteoporosis Reports · doi:10.1007/s11914-026-00977-y · Cited by 1 · see citing works
Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortalityPreprint
Yamada, L., Liu, H., von Muhlinen, N., Harris, C. C., & Horikawa, I. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.31.697195
Lim, S. H., Seo, H. S., Kang, H., & Hong, S.-P. (2026) · Journal of Ginseng Research · doi:10.1016/j.jgr.2026.101018 · Cited by 1 · see citing works
Tamimi, R., Tafazzoli‐Shadpour, M., & Vosough, M. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189626
Wilson, D. V., Acharjee, A., Duggal, N. A., Hombrebueno, J. R., Jones, S. W., Lewis, J. W., de Magalhães, J. P., Martínez-Serrato, Y., Mazaheri, A., McGettrick, H. M., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0346347
Miola, V. F. B., Marzola, G. P., Abuna, R. P. F., & Miglino, M. A. (2026) · Translational Research in Anatomy · doi:10.1016/j.tria.2026.100522
- Authors
- Hambright, W. S., Mu, X., Gao, X., Guo, P., Kawakami, Y., Mitchell, J., Mullen, M., Nelson, A.-L., Bahney, C., Nishimura, H., Hellwinkel, J., Eck, A., & Huard, J.
- Affiliations
- Steadman Philippon Research Institute (US)
- Kobe University (JP)
- University of California, San Francisco (US)
- NewYork–Presbyterian Hospital (US)
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Huard, Johnny
- ORCID
- Venue
- Journal of Osteoporosis
- Publisher
- Wiley
- Published
- 2023-02-22
- Volume
- 2023
- Pages
- 1-12
- ISSN
- 2042-0064 (ISSN-L)
- 2090-8059
- PMC
- PMC9977556
- OpenAlex
- W4321502148
- Cited by
- 44
- References
- 57
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 16 · 2023: 2
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Osteoporosis (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (NIAP01AG043376)
- Hart Family Foundation (NIAP01AG043376)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- fisetin, senolytics, cellular senescence, Hutchinson-Gilford progeria syndrome, osteoporosis, bone mineral loss, senescence-associated secretory phenotype, dasatinib, quercetin, trabecular bone, aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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