The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Aerobic fitness reduces brain tissue loss in aging humans.
Abstract
BACKGROUND: The human brain gradually loses tissue from the third decade of life onward, with concomitant declines in cognitive performance. Given the projected rapid growth in aged populations, and the staggering costs associated with geriatric care, identifying mechanisms that may reduce or reverse cerebral deterioration is rapidly emerging as an important public health goal. Previous research has demonstrated that aerobic fitness training improves cognitive function in older adults and can improve brain health in aging laboratory animals, suggesting that aerobic fitness may provide a mechanism to improve cerebral health in aging humans. We examined the relationship between aerobic fitness and in vivo brain tissue density in an older adult population, using voxel-based morphometric techniques. METHODS: We acquired high-resolution magnetic resonance imaging scans from 55 older adults. These images were segmented into gray and white matter maps, registered into stereotaxic space, and examined for systematic variation in tissue density as a function of age, aerobic fitness, and a number of other health markers. RESULTS: Consistent with previous studies of aging and brain volume, we found robust declines in tissue densities as a function of age in the frontal, parietal, and temporal cortices. More importantly, we found that losses in these areas were substantially reduced as a function of cardiovascular fitness, even when we statistically controlled for other moderator variables. CONCLUSIONS: These findings extend the scope of beneficial effects of aerobic exercise beyond cardiovascular health, and they suggest a strong solid biological basis for the benefits of exercise on the brain health of older adults.
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“(iii) favorable structural brain changes in older adults (Colcombe et al., 2003; Erickson et al., 2009; Szabo et al., 2011; Bugg et al., 2012) and individuals with Alzheimer’s disease (Burns et al., 2008; Honea et al., 2009; Vidoni et al., 2012).”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Colcombe et al., 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation (Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“The clinical benefits of aerobic exercise on preventing brain tissue loss have been reported in older adults via crosssectional and longitudinal studies (Colcombe et al, 2003;Colcombe et al, 2006).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Zhang, Y., Brady, M., & Smith, S. M. (2001) · IEEE Transactions on Medical Imaging · doi:10.1109/42.906424 · Cited by 7,628
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study
Colcombe, S., & Kramer, A. F. (2003) · Psychological Science · doi:10.1111/1467-9280.t01-1-01430 · Cited by 3,782
Self-citationExercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739
An application of prefrontal cortex function theory to cognitive aging.
West, R. L. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.120.2.272 · Cited by 2,157
The handbook of aging and cognition
Craik, F. I. M., & Salthouse, T. A. (1992) · doi:10.4324/9781410601988 · Cited by 2,064
Research works printed but not linked: 4
- 1995, Psychological bulletin, 120, 272
- 1987, Medicine and Science in Sports and Exercise, 19, 353
- 1995, Human brain mapping, 2, 198
- 1994, Human brain mapping, 1, 214
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Study protocol: EXERcise and Cognition In Sedentary adults with Early-ONset dementia (EXERCISE-ON)
Hooghiemstra, A. M., Eggermont, L. H. P., Scheltens, P., van der Flier, W. M., Bakker, J., de Greef, M. H., Koppe, P. A., & Scherder, E. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-75 · Cited by 20
Shephard, R. J. (2008) · Yearbook of Sports Medicine · doi:10.1016/s0162-0908(08)79169-4 · Cited by 20
La condición física es un componente importante de la salud para los adultes de hoy y del mañana
Garzón, M. J. C. (2007) · Cited by 20
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Guillamón, A. R. (2019) · Ciencias de la actividad física · doi:10.29035/rcaf.20.1.1 · Cited by 20
Exercise and Early-Onset Alzheimer’s Disease: Theoretical Considerations
Hooghiemstra, A. M., Eggermont, L. H. P., Scheltens, P., van der Flier, W. M., & Scherder, E. (2012) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000335493 · Cited by 20
Ho, A., Raji, C., Parikshak, N., Becker, J. T., Lopez, O., Kuller, L. H., Hua, X., Leow, A. D., Toga, A. W., & Thompson, P. M. (2009) · NeuroImage · doi:10.1016/s1053-8119(09)70976-0 · Cited by 20
NASCIDOS PARA CORRER: A IMPORTÂNCIA DO EXERCÍCIO PARA A SAÚDE DO CÉREBRO
Vorkapic, C. F., Góis, R. S., Gomes, L. P. D. S., Britto, A., Afrânio, B., & Dantas, E. H. M. (2017) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-869220172306175209 · Cited by 22
Chen, H., Wang, Y., Zhang, M., Wang, N., Song, G., & Liu, Y. (2023) · Aging & Mental Health · doi:10.1080/13607863.2023.2253183 · Cited by 23
Cognitive function and heart rate variability in open and closed skill sports
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Agha, A., Liu-Ambrose, T. Y. L., Backman, C. L., Leese, J., & LI, L. C. (2015) · Interactive Journal of Medical Research · doi:10.2196/ijmr.4257 · Cited by 19
The LIFE Cognition Study: design and baseline characteristics
Sink, K. M., Williamson, J. D., Espeland, M. A., Rushing, J., Castro, C. M., Church, T. R., Cohen, R., Gill, T. M., Henkin, L. F., Jennings, J., et al. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s65381 · Cited by 19
Fitness, insulin sensitivity, and frontal lobe integrity in adults with overweight and obesity
Castro, M. G., Venutolo, C., Yau, P. L., & Convit, A. J. (2016) · Obesity · doi:10.1002/oby.21500 · Cited by 19
Building your best day for healthy brain aging—The neuroprotective effects of optimal time use
Mellow, M. L., Dumuid, D., Thacker, J. S., Dorrian, J., & Smith, A. E. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.04.204 · Cited by 19
Reifegerste, J., Meyer, A. S., Zwitserlood, P., & Ullman, M. T. (2021) · Brain and Language · doi:10.1016/j.bandl.2021.104941 · Cited by 21
Dotson, V. M., Gradone, A. M., Bogoian, H. R., Minto, L. R., Taiwo, Z., & Salling, Z. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617721000710 · Cited by 19
Beydoun, M. A., Weiss, J., Beydoun, H. A., Kuczmarski, M. F., Hossain, S. A., El‐Hajj, Z. W., Evans, M. K., & Zonderman, A. B. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12275 · Cited by 19
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Hillman, C. H., & Drobes, D. J. (2012) · Child Development Perspectives · doi:10.1111/cdep.12000 · Cited by 21
Elias, J. W., & Wagster, M. V. (2007) · The Journals of Gerontology Series B · doi:10.1093/geronb/62.special_issue_1.5 · Cited by 19
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Vance, D. E., McDougall, G. J., Wilson, N., Debiasi, M. O., & Cody, S. L. (2014) · Topics in Geriatric Rehabilitation · doi:10.1097/tgr.0000000000000002 · Cited by 19
Guan, J., Sun, Y., Fan, Y., Liang, J., Liu, C., Yu, H., & Liu, J. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1406670 · Cited by 18
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Wood, K. N., Badrov, M. B., Speechley, M. R., & Shoemaker, J. K. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.05.012 · Cited by 18
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Martin, B. G. (2022) · Research Online (University of Wollongong) · doi:10.5281/zenodo.5851398 · Cited by 18
Zlatar, Z. Z., McGregor, K., Towler, S., Nocera, J. R., Dzierzewski, J. M., & Crosson, B. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00005 · Cited by 20
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Simone, P. M., & Scuilli, M. (2006) · Scholar Commons (Santa Clara University) · Cited by 18
Biundo, R., Fiorenzato, E., & Antonini, A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.031 · Cited by 18
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Catalano, A., Sardella, A., Bellone, F., Lasco, C. G., Martino, G., & Morabito, N. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01426-w · Cited by 18
Shu, Y., He, Q., Xie, Y., Zhang, W., Zhai, S., & Wu, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.582380 · Cited by 19
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Boecker, H. (2011) · The EPMA Journal · doi:10.1007/s13167-011-0093-y · Cited by 20
Smith, A. E., Goldsworthy, M. R., Wood, F. M., Olds, T., Garside, T., & Ridding, M. C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.034 · Cited by 17
Robison, L. S., Popescu, D. L., Anderson, M. E., Beigelman, S. I., Fitzgerald, S. M., Kuzmina, A. E., Lituma, D. A., Subzwari, S., Michaelos, M., Anderson, B. J., et al. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.06.002 · Cited by 18
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Eymundsdóttir, H., Ramel, A., Geirsdóttir, Ó. G., Skúladóttir, S. S., Gudmundsson, L. S., Jónsson, P. V., Gudnason, V. G., Launer, L. J., Jónsdóttir, M. K., & Chang, M. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12163 · Cited by 16
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Marson, F., Fano, A. D., PELLEGRINO, M. A., Pesce, C., Glicksohn, J., & Ben‐Soussan, T. D. (2021) · Children · doi:10.3390/children8070583 · Cited by 15
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Esmaeilzadeh, S., Kalantari, H.-A., & Nakhostin-Roohi, B. (2013) · Biology of Sport · doi:10.5604/20831862.1029825 · Cited by 16
Alosco, M. L., Spitznagel, M. B., van Dulmen, M. H. M., Raz, N., Cohen, R. A., Sweet, L. H., Colbert, L. H., Josephson, R., Hughes, J. W., Rosneck, J., et al. (2013) · Journal of Aging and Health · doi:10.1177/0898264312474039 · Cited by 15
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Sogaard, I., & Ni, R. (2018) · Acta Psychopathologica · doi:10.4172/2469-6676.100178 · Cited by 15
Langeskov‐Christensen, M., Eskildsen, S., Stenager, E., Jensen, H. B., Nielsen, H. H., Petersen, T., Hvid, L. G., Hämäläinen, P. I., Marstrand, L., & Dalgas, U. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090272 · Cited by 15
Predovan, D., Gazes, Y., Lee, S., Li, P., Sloan, R. P., & Stern, Y. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.681634 · Cited by 16
Clark, U. S., & Williams, D. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6373-4_16 · Cited by 15
Young, J. C., Dowell, N. G., Watt, P., Tabet, N., & Rusted, J. M. (2016) · Journal of Aging and Physical Activity · doi:10.1123/japa.2015-0039 · Cited by 16
Voelcker‐Rehage, C., Niemann, C., Hübner, L. A., Godde, B., & Winneke, A. H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803634-1.00003-0 · Cited by 16
Stavestrand, S. H., Sirevåg, K., Nordhus, I. H., Sjøbø, T., Endal, T. B., Nordahl, H. M., Specht, K., Hammar, Å., Halmøy, A., Martinsen, E. W., et al. (2019) · Trials · doi:10.1186/s13063-019-3268-9 · Cited by 15
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Yu, C.-C., Muggleton, N. G., Chen, C.-Y., Ko, C.-H., & Liu, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256272 · Cited by 14
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de Almeida, M. F., Chaves, R. S., Silva, C. M., Chaves, J. C. S., de Melo, K. P., & Ferrari, M. (2016) · IBRO Reports · doi:10.1016/j.ibror.2016.08.001 · Cited by 14
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Gow, A. J., Bielak, A. A. M., & Gerstorf, D. (2012) · Journal of Aging Research · doi:10.1155/2012/143595 · Cited by 14
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Liu, Y., Zhu, L., Cai, K., Dong, X., Xiong, X., Liu, Z., & Chen, A. (2022) · Brain Sciences · doi:10.3390/brainsci12111441 · Cited by 13
Reed, K. S., Frescoln, A. M., Keleher, Q., Brellenthin, A. G., Kohut, M. L., & Lefferts, W. K. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00689.2023 · Cited by 13
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Graßhoff, J., Beller, J., Kuhlmann, B. G., & Geyer, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254038 · Cited by 13
Tari, A. R., Berg, H. H., Videm, V., Bråthen, G., White, L. R., Røsbjørgen, R. N., Scheffler, K., Dalen, H., Holte, E., Haberg, A. K., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-056964 · Cited by 14
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Metadata
- Authors
- Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Wayne State University (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-01
- Volume
- 58
- Issue
- 2
- Pages
- M176-M180
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2145870733
- Cited by
- 1,017
- References
- 26
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 30 · 2023: 39 · 2022: 30 · 2021: 47 · 2020: 39 · 2019: 63 · 2018: 64 · 2017: 58 · 2016: 54 · 2015: 58 · 2014: 57 · 2013: 53 · 2012: 72
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Keywords
- cardiorespiratory fitness, brain tissue density, brain aging, gray matter loss, white matter, older adults, aerobic exercise, cognitive decline
- MeSH terms
- Aged, Aged, 80 and over, Aging, Brain, Brain Mapping, Cerebral Cortex, Cognition Disorders, Female, Humans, Life Style, Magnetic Resonance Imaging, Male, Middle Aged, Periaqueductal Gray, Physical Fitness, Probability, Cohort Studies, Geriatric Assessment, Neuroaxonal Dystrophies
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