The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Aerobic fitness reduces brain tissue loss in aging humans.
Abstract
BACKGROUND: The human brain gradually loses tissue from the third decade of life onward, with concomitant declines in cognitive performance. Given the projected rapid growth in aged populations, and the staggering costs associated with geriatric care, identifying mechanisms that may reduce or reverse cerebral deterioration is rapidly emerging as an important public health goal. Previous research has demonstrated that aerobic fitness training improves cognitive function in older adults and can improve brain health in aging laboratory animals, suggesting that aerobic fitness may provide a mechanism to improve cerebral health in aging humans. We examined the relationship between aerobic fitness and in vivo brain tissue density in an older adult population, using voxel-based morphometric techniques. METHODS: We acquired high-resolution magnetic resonance imaging scans from 55 older adults. These images were segmented into gray and white matter maps, registered into stereotaxic space, and examined for systematic variation in tissue density as a function of age, aerobic fitness, and a number of other health markers. RESULTS: Consistent with previous studies of aging and brain volume, we found robust declines in tissue densities as a function of age in the frontal, parietal, and temporal cortices. More importantly, we found that losses in these areas were substantially reduced as a function of cardiovascular fitness, even when we statistically controlled for other moderator variables. CONCLUSIONS: These findings extend the scope of beneficial effects of aerobic exercise beyond cardiovascular health, and they suggest a strong solid biological basis for the benefits of exercise on the brain health of older adults.
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“(iii) favorable structural brain changes in older adults (Colcombe et al., 2003; Erickson et al., 2009; Szabo et al., 2011; Bugg et al., 2012) and individuals with Alzheimer’s disease (Burns et al., 2008; Honea et al., 2009; Vidoni et al., 2012).”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Colcombe et al., 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation (Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“The clinical benefits of aerobic exercise on preventing brain tissue loss have been reported in older adults via crosssectional and longitudinal studies (Colcombe et al, 2003;Colcombe et al, 2006).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
In the citing paper
“Clinical and animal reports show that aerobic exercise (right) in humans and voluntary running in rodents is associated with enhanced neurogenesis, improved learning and memory, increased hippocampal BDNF, and dampened inflammatory response to immune challenge and microglia proliferation(Barrientos et al, 2011;Colcombe et al, 2003;Gebara et al, 2013).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Colcombe et al, 2003
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Zhang, Y., Brady, M., & Smith, S. M. (2001) · IEEE Transactions on Medical Imaging · doi:10.1109/42.906424 · Cited by 7,628
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study
Colcombe, S., & Kramer, A. F. (2003) · Psychological Science · doi:10.1111/1467-9280.t01-1-01430 · Cited by 3,782
Self-citationExercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739
An application of prefrontal cortex function theory to cognitive aging.
West, R. L. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.120.2.272 · Cited by 2,157
The handbook of aging and cognition
Craik, F. I. M., & Salthouse, T. A. (1992) · doi:10.4324/9781410601988 · Cited by 2,064
Flagged first, then by citations
Research works printed but not linked: 4
- 1995, Psychological bulletin, 120, 272
- 1987, Medicine and Science in Sports and Exercise, 19, 353
- 1995, Human brain mapping, 2, 198
- 1994, Human brain mapping, 1, 214
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Items 101–200 of 1,000
Halperin, J. M., & Healey, D. M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.006 · Cited by 237
Exercise moderates age-related atrophy of the medial temporal lobe
Bugg, J. M., & Head, D. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.008 · Cited by 248
Gait in ageing and associated dementias; its relationship with cognition
Scherder, E., Eggermont, L. H. P., Swaab, D. F., van Heuvelen, M. J. G., Kamsma, Y. P. T., de Greef, M., van Wijck, R., & Mulder, T. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.007 · Cited by 235
Fitness, aging and neurocognitive function
Kramer, A. F., Colcombe, S. J., McAuley, E., Scalf, P. E., & Erickson, K. I. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.009 · Cited by 233
Self-citationAerobic endurance exercise benefits memory and affect in young adults.
Stroth, S., Hille, K., Spitzer, M., & Reinhardt, R. (2009) · Neuropsychological Rehabilitation · doi:10.1080/09602010802091183 · Cited by 232
Vascular Effects of Exercise: Endothelial Adaptations Beyond Active Muscle Beds
Padilla, J., Simmons, G. H., Bender, S. B., Arce‐Esquivel, A. A., Whyte, J. J., & Laughlin, M. H. (2011) · Physiology · doi:10.1152/physiol.00052.2010 · Cited by 241
Cruise, K. E., Bucks, R. S., Loftus, A. M., Newton, R. U., Pegoraro, R., & Thomas, M. G. (2011) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01338.x · Cited by 229
Brown, B. M., Peiffer, J. J., & Martins, R. N. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.162 · Cited by 239
Jonasson, L. S., Nyberg, L. H., Kramer, A. F., Lundquist, A., Riklund, K., & Boraxbekk, C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00336 · Cited by 245
Self-citationPhysical activity attenuates age-related biomarker alterations in preclinical AD
Okonkwo, O. C., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D. F., Cook, D. B., Koscik, R. L., Gallagher, C. L., Dowling, N. M., Carlsson, C. M., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000964 · Cited by 235
Increased heart rate variability and executive performance after aerobic training in the elderly
Albinet, C. T., Boucard, G., Bouquet, C. A., & Audiffren, M. F. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1393-y · Cited by 222
Benefits of physical exercise on executive functions in older people with Parkinson's disease
Tanaka, K., Quadros, A. C. D., Santos, R. F., Stella, F., Gobbi, L. T. B., & Gobbi, S. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2008.09.008 · Cited by 221
Chang, Y.-K., & Etnier, J. L. (2009) · Journal of Sport and Exercise Psychology · doi:10.1123/jsep.31.5.640 · Cited by 219
Cognitive Dysfunction in ICU Patients: Risk Factors, Predictors, and Rehabilitation Interventions
Wilcox, M. E., Brummel, N. E., Archer, K., Ely, E. W., Jackson, J. C., & Hopkins, R. O. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182a16946 · Cited by 215
Neurocognitive aging and cardiovascular fitness: recent findings and future directions
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Self-citationKennedy, K. M., Erickson, K. I., Rodrigue, K. M., Voss, M. W., Colcombe, S. J., Kramer, A. F., Acker, J. D., & Raz, N. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.020 · Cited by 214
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Self-citationSuo, C., Singh, M. F., Gates, N., Wen, W., Sachdev, P., Brodaty, H., Saigal, N., Wilson, G. C., Meiklejohn, J., Singh, N., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.19 · Cited by 212
Prakash, R. S., Snook, E. M., Motl, R. W., & Kramer, A. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.063 · Cited by 212
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Ung, H., Brown, J. E., Johnson, K. A., Younger, J., Hush, J. M., & Mackey, S. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs378 · Cited by 219
Chang, M., Jónsson, P. V., Snædal, J., Björnsson, S., Saczynski, J. S., Aspelund, T., Eiríksdóttir, G., Jónsdóttir, M. K., López, O. L., Harris, T. B., et al. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq152 · Cited by 212
The effect of midlife physical activity on structural brain changes in the elderly
Rovio, S., Spulber, G., Nieminen, L. J., Niskanen, E. I., Winblad, B. G., Tuomilehto, J., Nissinen, A. M., Soininen, H. S., & Kivipelto, M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.007 · Cited by 211
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Honea, R. A., Thomas, G., Harsha, A., Anderson, H. S., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819cb8a2 · Cited by 217
Lazarou, I., Parastatidis, T., Tsolaki, A., Γκιόκα, Μ., Καρακώστας, Α., Douka, S., & Tsolaki, M. (2017) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317517725813 · Cited by 221
Age-related changes in processing speed: unique contributions of cerebellar and prefrontal cortex
Eckert (2010) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.010.2010 · Cited by 239
Murrell, C. J., Cotter, J. D., Thomas, K. N., Lucas, S. J. E., Williams, M. J. A., & Ainslie, P. N. (2013) · AGE · doi:10.1007/s11357-012-9414-x · Cited by 207
Dupuy, O., Gauthier, C. J., Fraser, S., Desjardins-Crépeau, L., Desjardins, M., Mekary, S., Lesage, F., Hoge, R. D., Pouliot, P., & Bherer, L. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00066 · Cited by 224
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Antoniou, M., Gunasekera, G. M., & Wong, P. C. M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.004 · Cited by 211
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Hillman, C. H., Belopolsky, A. V., Snook, E. M., Kramer, A. F., & McAuley, E. (2004) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2004.10609149 · Cited by 202
Self-citationda Silva, F. C., Iop, R. D. R., de Oliveira, L. C., Boll, A. M., de Alvarenga, J. G. S., Gutierres Filho, P. J. B., de Melo, L. M. A. B., Xavier, A. J., & da Silva, R. (2018) · PLOS ONE · doi:10.1371/journal.pone.0193113 · Cited by 189
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Kennedy, G., Hardman, R. J., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160665 · Cited by 199
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Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155
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Self-citation
Metadata
- Authors
- Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Wayne State University (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-01
- Volume
- 58
- Issue
- 2
- Pages
- M176-M180
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2145870733
- Cited by
- 1,017
- References
- 26
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 30 · 2023: 39 · 2022: 30 · 2021: 47 · 2020: 39 · 2019: 63 · 2018: 64 · 2017: 58 · 2016: 54 · 2015: 58 · 2014: 57 · 2013: 53 · 2012: 72
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Keywords
- cardiorespiratory fitness, brain tissue density, brain aging, gray matter loss, white matter, older adults, aerobic exercise, cognitive decline
- MeSH terms
- Aged, Aged, 80 and over, Aging, Brain, Brain Mapping, Cerebral Cortex, Cognition Disorders, Female, Humans, Life Style, Magnetic Resonance Imaging, Male, Middle Aged, Periaqueductal Gray, Physical Fitness, Probability, Cohort Studies, Geriatric Assessment, Neuroaxonal Dystrophies
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