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Cited by 49Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsAdrenal Hormones and Disorders

DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I

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Cappola, A. R., Xue, Q.-L., Walston, J. D., Leng, S. X., Ferrucci, L., Guralnik, J., Fried, L. P.·2006·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/61.9.957PMC PMC2645634
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Abstract

BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects. Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined. METHODS: The relationship between serum DHEAS level and 5-year mortality was analyzed in a cohort of 539 disabled women aged 65-100 years enrolled in the Women's Health and Aging Study I (WHAS I). Using Cox proportional hazard models, we calculated multivariate-adjusted mortality risks by DHEAS quartiles and by DHEAS continuously, allowing for a nonlinear relationship. We also examined cause-specific mortality. RESULTS: We found a U-shaped relationship between DHEAS level and mortality. After adjusting for multiple covariates, women in the top and bottom DHEAS quartiles had a more than 2-fold higher 5-year mortality than did those in the middle quartiles (hazard ratio, 2.15; 95% confidence interval [CI], 1.17-3.98 for the top quartile and 2.05; 95% CI, 1.27-3.32 for the bottom quartile, each compared to the third quartile). Women with higher DHEAS levels tended to have greater cancer mortality, whereas those with lower DHEAS tended to have greater cardiovascular mortality. CONCLUSION: Disabled older women with either low or high levels of DHEAS are at greater risk for death than are those with intermediate levels. More research is needed to determine if targeted dehydroepiandrosterone supplementation would provide clinical benefit to disabled older women.

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  • In disabled older women, DHEAS has been reported to have a U-shaped relationship with mortality.

    “A U-shaped association between DHEAS and mortality has been reported in disabled older women (47).”

    From Frailty in elderly people (2013) · cites this paper as [47]

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Authors
Cappola, A. R., Xue, Q.-L., Walston, J. D., Leng, S. X., Ferrucci, L., Guralnik, J., & Fried, L. P.
Affiliations
University of Pennsylvania (US)
Corresponding author
Cappola, A. R.
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2006-09-01
Volume
61
Issue
9
Pages
957-962
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/61.9.957
PMC
PMC2645634
OpenAlex
W2168012425
Cited by
49
References
44
Citations by year
2026: 1 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 3 · 2014: 3 · 2013: 6 · 2012: 4
FWCI
1.81
Type
journal article
Language
en
Open access
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r37ag019905-10, Z99 AG999999)
  • National Institute on Aging (R37-AG019905, R37-AG19905, N01AG12112, K23AG19161, R01 AG11703, R01AG011703, K23AG019161)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
dehydroepiandrosterone sulfate, mortality, sex steroids, U-shaped relationship, cancer mortality, cardiovascular mortality, aging
MeSH terms
Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Persons with Disabilities, Humans, Neoplasms, Surveys and Questionnaires, United States, Cohort Studies, Multivariate Analysis, Proportional Hazards Models, Dehydroepiandrosterone Sulfate

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