Association of IGF-I levels with muscle strength and mobility in older women
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The functional consequences of the age-associated decline in IGF-I are unknown. We hypothesized that low IGF-I levels in older women would be associated with poor muscle strength and mobility. We assessed this question in a population representative of the full spectrum of health in the community, obtaining serum IGF-I levels from women aged 70-79 yr, enrolled in the Women's Health and Aging Study I or II. Cross-sectional analyses were performed using 617 women with IGF-I levels drawn within 90 d of measurement of outcomes. After adjustment for age, there was an association between IGF-I and knee extensor strength (P = 0.004), but not anthropometry or other strength measures. We found a positive relationship between IGF-I levels and walking speed for IGF-I levels below 50 microg/liter (P < 0.001), but no relationship above this threshold. A decline in IGF-I level was associated with self-reported difficulty in mobility tasks. All findings were attenuated after multivariate adjustment. In summary, in a study population including frail and healthy older women, low IGF-I levels were associated with poor knee extensor muscle strength, slow walking speed, and self-reported difficulty with mobility tasks. These findings suggest a role for IGF-I in disability as well as a potential target population for interventions to raise IGF-I levels.
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The weak observational association between low circulating IGF-1 and some measures of weak muscle strength and limited mobility among older women may reflect general age-associated debility rather than specific hormonal effects.
“The weak observational association between low circulating IGF-1 and some, but not other, measures of weak muscle strength and limited mobility among older women may reflect general age-associated debility rather than any specific hormonal effects (173).”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [173]
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- Authors
- Cappola, A. R., Bandeen-Roche, K., Wand, G. S., Volpato, S., & Fried, L. P.
- Affiliations
- Johns Hopkins University (US)
- Department of Biostatistics, Johns Hopkins School of Hygiene and Public Health (K.B.-R.), Baltimore, Maryland 21205
- National Institutes of Health (US)
- Corresponding author
- Cappola, Anne R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2001-09-01
- Volume
- 86
- Issue
- 9
- Pages
- 4139-4146
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2082560483
- Cited by
- 205
- References
- 28
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 13
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- Johns Hopkins University
- Quest Diagnostics
- National Institute on Aging (N01AG12112, R01 AG11703, R01AG011703)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- insulin-like growth factor I, muscle strength, quadriceps strength, mobility (physical function), walking speed, older women, functional disability, aging, Women's Health and Aging Study
- MeSH terms
- Activities of Daily Living, Aged, Aging, Body Composition, Body Weight, Cross-Sectional Studies, Female, Humans, Insulin-Like Growth Factor I, Psychomotor Performance, Muscle, Skeletal, Hand Strength, Phlebotomy, Human Growth Hormone
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