Cited by 172Frailty in Older AdultsNutrition and Health in AgingBalance, Gait, and Falls Prevention

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Functional Outcomes for Clinical Trials in Frail Older Persons: Time To Be Moving: Working Group on Functional Outcome Measures for Clinical Trials

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·2008·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/63.2.160PMC PMC2645663

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Physical performance measures in the clinical setting
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“They have also realized that taking this approach would effectively exclude from clinical trials the truly frail elderly who are most in need of these new treatments (46).”
Background
Leg extensor power and functional performance in very old men and women.
Bassey, E. J., Fiatarone, M. A., O'neill, E. F., Kelly, M., Evans, W. J., & Lipsitz, L. A. (1992) · Clinical Science · doi:10.1042/cs0820321 · Cited by 943
Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>
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1994, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 49A, M85
2000, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 55A, M221
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2005, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 60A, 1304
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Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2008-02-01
Volume: 63
Issue: 2
Pages: 160-164
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/63.2.160
PMC: PMC2645663
OpenAlex: W2622205469
Cited by: 172
References: 46
Citations by year: 2025: 9 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 6 · 2019: 13 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 8 · 2014: 13 · 2013: 10 · 2012: 13
FWCI: 4.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z99 AG999999)
National Institute on Aging (K24AG021507)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
Keywords: functional outcome measures, frail elderly, clinical trials, functional status, aging, geriatric research, outcome measurement
MeSH terms: Activities of Daily Living, Aged, Chronic Disease, Geriatrics, Persons with Disabilities, Disabled Persons, Health Priorities, Humans, Research Design, Geriatric Assessment, Randomized Controlled Trials as Topic, Frail Elderly, Disease Progression

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