Sarcopenia in the elderly: basic and clinical issues

Sarcopenia: European consensus on definition and diagnosis

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Epidemiology of Sarcopenia among the Elderly in New Mexico

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Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia

Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256 · see citing works

Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability

Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · see citing works

The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · see citing works

Physical Activity and Public Health in Older Adults: Recommendation from the American College of Sports Medicine and the American Heart Association

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What is the cause of the ageing atrophy?

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Biochemical Adaptations in Muscle

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Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women

Janssen, I. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh058 · Cited by 1,190 · see citing works

Sarcopenia: alternative definitions and associations with lower extremity function

Newman, A. B., Kupelian, V., Visser, M., Simonsick, E., Goodpaster, B., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51534.x · Cited by 981 · see citing works

Sarcopenia != Dynapenia

Clark, B. C., & Manini, T. M. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.8.829 · Cited by 876 · see citing works

Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women

Delmonico, M. J., Harris, T. B., Lee, J., Visser, M., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Newman, A. B., & for the Health, A. A. B. C. S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01140.x · Cited by 819 · see citing works

Effects of Resistance Training on Older Adults

Hunter, G. R., McCarthy, J. P., & Bamman, M. M. (2004) · Sports Medicine · doi:10.2165/00007256-200434050-00005 · Cited by 764 · see citing works

Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men

Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740 · see citing works

Nutritional recommendations for the management of sarcopenia

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Impaired growth hormone secretion in the adult population: relation to age and adiposity.

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Oxidative Stress, Molecular Inflammation and Sarcopenia

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The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*

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Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections

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Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds

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Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability

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Chronic Administration of Ghrelin Improves Left Ventricular Dysfunction and Attenuates Development of Cardiac Cachexia in Rats With Heart Failure

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Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle

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Once‐Weekly Resistance Exercise Improves Muscle Strength and Neuromuscular Performance in Older Adults

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Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans

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The vitamin D deficiency pandemic and consequences for nonskeletal health: Mechanisms of action

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Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men

Fry, C. S., Glynn, E. L., Drummond, M. J., Timmerman, K. L., Fujita, S., Abe, T., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01266.2009 · Cited by 402 · see citing works

Sarcopenia: Diagnosis and treatment

Morley, J. E. (2008) · The journal of nutrition health & aging · doi:10.1007/bf02982705 · Cited by 398 · see citing works

Changes in skeletal muscle with aging: effects of exercise training.

Rogers, M. A., & Evans, W. J. (1993) · PubMed · Cited by 396 · see citing works

Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women

Zoico, E., Di Francesco, V, Guralnik, J. M., Mazzali, G., Bortolani, A., Guariento, S., Sergi, G., Bosello, O., & Zamboni, M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802552 · Cited by 392 · see citing works

Trends in aging--United States and worldwide.

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Interventions for sarcopenia and muscle weakness in older people

Borst, S. E. (2004) · Age and Ageing · doi:10.1093/ageing/afh201 · Cited by 349 · see citing works

Compartmental body composition based on total-body nitrogen, potassium, and calcium

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Exercise is medicine and physicians need to prescribe it!

Sallis, R. E. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.054825 · Cited by 338 · see citing works

Strength Training in the Elderly

Hurley, B. F., & Roth, S. M. (2000) · Sports Medicine · doi:10.2165/00007256-200030040-00002 · Cited by 327 · see citing works

Decreased muscle mass and increased central adiposity are independently related to mortality in older men

Wannamethee, S. G., Shaper, A. G., Lennon, L., & Whincup, P. H. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1339 · Cited by 307 · see citing works

Mortality associated with body fat, fat-free mass and body mass index among 60-year-old Swedish men—a 22-year follow-up. The study of men born in 1913

Heitmann, B. L., Eriksson, H., Ellsinger, B. M., Mikkelsen, K. L., & Larsson, B. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801082 · Cited by 298 · see citing works

Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men–the MINOS study

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Departures From Linearity in the Relationship Between Measures of Muscular Strength and Physical Performance of the Lower Extremities: The Women's Health and Aging Study

Ferrucci, L., Guralnik, J. M., Büchner, D. M., Kasper, J. D., Lamb, S. E., Simonsick, E. M., Corti, M. C., Bandeen‐Roche, K., & Fried, L. P. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.5.m275 · Cited by 280 · see citing works

A Mechanistic Approach to Blood Flow Occlusion

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Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men

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Minireview: A Hypothalamic Role in Energy Balance with Special Emphasis on Leptin

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TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation

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The Functional Effects of Physical Exercise Training in Frail Older People

Chinapaw, M. J. M., van Uffelen, J. G. Z., Riphagen, I. I., & van Mechelen, W. (2008) · Sports Medicine · doi:10.2165/00007256-200838090-00006 · Cited by 256 · see citing works

Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men

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Aerobic exercise training improves whole muscle and single myofiber size and function in older women

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A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency

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Physiopathological Mechanism of Sarcopenia

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Changes in Skeletal Muscle with Aging

Rogers, M. A., & EVANS, W. J. (1993) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199301000-00003 · Cited by 232 · see citing works

Myostatin Inhibits Myogenesis and Promotes Adipogenesis in C3H 10T(1/2) Mesenchymal Multipotent Cells

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In vivo human muscle structure and function: adaptations to resistance training in old age

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Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease

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The Epidemiology of Sarcopenia

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Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients

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Factors contributing to neuromuscular impairment and sarcopenia during aging

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The Role of Cytokines in Regulating Protein Metabolism and Muscle Function

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Functional Outcomes for Clinical Trials in Frail Older Persons: Time To Be Moving: Working Group on Functional Outcome Measures for Clinical Trials

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Testosterone and leptin in older African-American men: Relationship to age, strength, function, and season

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Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men

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Muscle mitochondrial changes with aging and exercise

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Reexamining the Sarcopenia Hypothesis: Muscle Mass versus Muscle Strength

VISSER, M., NEWMAN, A. B., NEVITT, M. C., KRITCHEVSKY, S. B., STAMM, E. B., GOODPASTER, B. H., HARRIS, T. B., & FOR THE HEALTH, A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06500.x · Cited by 141 · see citing works

Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

Sáinz, N., Rodríguez, A., Catalán, V., Becerril, S., Ramírez, B., Gómez-Ambrosi, J., & Frühbeck, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006808 · Cited by 135 · see citing works

Effect on Body Weight and Safety of RC-1291, a Novel, Orally Available Ghrelin Mimetic and Growth Hormone Secretagogue: Results of a Phase I, Randomized, Placebo-Controlled, Multiple-Dose Study in Healthy Volunteers

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Corrected Arm Muscle Area: An Independent Predictor of Long‐Term Mortality in Community‐Dwelling Older Adults?

Miller, M., Crotty, M., Giles, L. C., Bannerman, E., Whitehead, C., Cobiac, L., Daniels, L., & Andrews, G. R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50316.x · Cited by 127 · see citing works

Effects of Human Growth Hormone, Insulin-Like Growth Factor I, and Diet and Exercise on Body Composition of Obese Postmenopausal Women1

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Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle

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The effect of age on protein metabolism

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Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity

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Effect of Inflammation on the Aging Microcirculation: Impact on Skeletal Muscle Blood Flow Control

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Bioimpedance vector analysis as a measure of muscle function

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Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function

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Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events

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Physical Activity and Sarcopenia

Pillard, F., Laoudj‐Chenivesse, D., Carnac, G., Mercier, J. G., RAMI, J., Rivière, D., & Rolland, Y. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.009 · Cited by 74 · see citing works

Postmenopausal HRT and tibolone in relation to muscle strength and body composition

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Untitled work

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Vitamin D Deficiency/Insufficiency Practice Patterns in a Veterans Health Administration Long-Term Care Population: A Retrospective Analysis

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Adverse Events Associated with Testosterone Administration

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Effects of Human Growth Hormone, Insulin-Like Growth Factor I, and Diet and Exercise on Body Composition of Obese Postmenopausal Women

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The Application of Blood Flow Measurements to the Study of Aging Muscle

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Age-Related Changes in Muscle

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Impact of short-term aerobic interval training on maximal exercise in sedentary aged subjects

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Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure

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mTOR function in skeletal muscle: a focal point for overnutrition and exercise

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Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia

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Advances in understanding and treating cardiac cachexia: Highlights from the 5th Cachexia Conference

von Haehling, S., Stepney, R., & Anker, S. D. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.05.042 · Cited by 36 · see citing works

The Effect of Tibolone on Fat Mass, Fat-Free Mass, and Total Body Water in Postmenopausal Women

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Short-term effects of leptin on skeletal muscle protein metabolism in the rat

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Simultaneously Significant Hepatic and Mild Splenic Uptake of Tc-99m MDP Resulting From Waldenstrom Macroglobulinemia

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The neurology of old age

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