The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Initial Manifestations of Frailty Criteria and the Development of Frailty Phenotype in the Women's Health and Aging Study II
Open accessAbstract
BACKGROUND: Understanding points of onset of the frailty syndrome is vital to early identification of at-risk individuals and to targeting intervention efforts to those components that are first affected, when reversal may be most possible. This study aims to characterize natural history by which commonly used frailty criteria manifest and to assess whether the rate of progression to frailty depends on initial manifestations. METHODS: The investigation was based on a 7.5-year observational study of 420 community-dwelling women aged 70-79 years who were not frail at baseline, with frailty defined as meeting>or=3 of 5 criteria: weight loss, slow walking speed, weakness, exhaustion, and low physical activity level. RESULTS: The 7.5-year incidence of frailty was 9% among women who were nonfrail at baseline. Despite significant heterogeneity, weakness was the most common first manifestation, and occurrence of weakness, slowness, and low physical activity preceded exhaustion and weight loss in 76% of the women who were nonfrail at baseline. Women with exhaustion or weight loss as initial presenting symptoms were 3-5 times more likely to become frail than were women without any criterion (p<.05). CONCLUSIONS: Our findings suggest that weakness may serve as a warning sign of increasing vulnerability in early frailty development, and weight loss and exhaustion may help to identify women most at risk for rapid adverse progression.
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Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Self-citationAccumulation of Deficits as a Proxy Measure of Aging
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Physical performance measures in the clinical setting
Studenski, S., Perera, S., Wallace, D., Chandler, J. M., Duncan, P. W., Rooney, E., Fox, M., & Guralnik, J. M. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51104.x · Cited by 1,218
Reverse engineering of biological complexity
Csete, M. E., & Doyle, J. C. (2002) · Science · doi:10.1126/science.1069981 · Cited by 1,215
Evidence for a non-linear relationship between leg strength and gait speed
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Review Article: Sarcopenia: Causes, Consequences, and Preventions
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Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle
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Frailty: implications for clinical practice and public health
Hoogendijk, E. O., Afilalo, J., Ensrud, K. E., Kowal, P., Onder, G., & Fried, L. P. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31786-6 · Cited by 3,282
Self-citationThe Frailty Syndrome: Definition and Natural History
Xue, Q.-L. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.08.009 · Cited by 2,061
Self-citationPhysical activity and exercise: Strategies to manage frailty
Angulo, J., El Assar, M., Álvarez-Bustos, A., & Rodríguez-Mañas, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101513 · Cited by 771
Association of frailty with survival: A systematic literature review
Shamliyan, T., Talley, K. M. C., Ramakrishnan, R., & Kane, R. L. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.001 · Cited by 666
The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty
Dent, E., Lien, C., Lim, W. S., Wong, W. C., Wong, C. H., Ng, T. P., Woo, J., Dong, B., de la Vega, S., Hua Poi, P. J., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.04.018 · Cited by 631
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Metadata
- Authors
- Xue, Q.-L., Bandeen-Roche, K., Varadhan, R., Zhou, J., & Fried, L. P.
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09
- Volume
- 63
- Issue
- 9
- Pages
- 984-990
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2142000545
- Cited by
- 484
- References
- 8
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xue, Q.-L., Bandeen-Roche, K., Varadhan, R., Zhou, J., & Fried, L. P. (2008). Initial Manifestations of Frailty Criteria and the Development of Frailty Phenotype in the Women's Health and Aging Study II. The Journals of Gerontology: Series A. https://doi.org/10.1093/gerona/63.9.984
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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