Cited by 69Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

Senescence-Related Truncation and Multimerization of Apolipoprotein A-I in High-Density Lipoprotein With an Elevated Level of Advanced Glycated End Products and Cholesteryl Ester Transfer Activity

Park, K. H., Shin, D. G., Kim, J. R., Cho, K. H.·2010·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Abstract

To compare the change in lipoprotein metabolism with aging, we analyzed the lipid and protein compositions of individual lipoprotein fractions. Healthy and nonobese elderly participants (elderly group, n = 26) had a serum lipid profile within the normal range, although slightly higher than in young participants (control group, n = 18). However, the elderly group had a twofold higher serum uric acid level and triglyceride (TG):high-density lipoprotein cholesterol ratio. The elderly group had less antioxidant ability and elevated TG content in high-density lipoprotein (HDL) with enhanced cholesteryl ester transfer activity. An elevated level of advanced glycated end products in lipoproteins and fragmentation of apoA-I were present in the elderly group, with detected lower apoA-I level and more multimerized apoA-I in HDL. The protein levels of apoA-I, apoC-III, and serum amyloid A in lipoprotein-deficient serum were increased in the elderly group.

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Crossref · 10.1093/gerona/glq034

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  • In humans, a comparative study on 26 elderly participants and 18 controls reported a 2-fold reduction in serum UA levels in aged individuals compared to controls, in line with diminished antioxidant defences.

    “In humans, results from a comparative study conducted on 26 elderly participants and 18 controls reported a 2-fold reduction in serum UA levels in aged individuals compared to controls, and this pattern was in line with diminished antioxidant defences [225].”

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Authors
Park, K. H., Shin, D. G., Kim, J. R., & Cho, K. H.
Affiliations
  • Yeungnam University (KR)
  • Yeungnam University Medical Center (KR)
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Published
2010-04-26
Volume
65A
Issue
6
Pages
600-610
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
OpenAlex
W2149780434
Cited by
69
References
41
Citations by year
2025: 2 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 1 · 2019: 8 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 4
FWCI
6.74
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
apolipoprotein A-I, high-density lipoprotein, advanced glycation end products, aging, lipoprotein metabolism, uric acid, triglyceride to HDL cholesterol ratio, antioxidant capacity, apolipoprotein C-III, serum amyloid A, older adults
MeSH terms
Aged, Aging, Serum Amyloid A Protein, Antioxidants, Humans, Lipids, Lipoproteins, Lipoproteins, HDL, Cholesterol, HDL, Male, Particle Size, Reference Values, Triglycerides, Uric Acid, Apolipoprotein A-I, Glycation End Products, Advanced, Protein Isoforms, Aryldialkylphosphatase, Apolipoprotein C-III, Cholesterol Ester Transfer Proteins, Young Adult

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