Endothelin-A -Mediated Vasoconstriction During Exercise With Advancing Age

Barrett-O’Keefe, Zachary; Ives, Stephen J.; Trinity, Joel D.; Morgan, Garrett; Rossman, Matthew J.; Donato, Anthony J.; Runnels, Sean; Morgan, David E.; Gmelch, Benjamin S.; Bledsoe, Amber D.; Richardson, Russell S.; Wray, D. Walter

doi:10.1093/gerona/glu065

Cited by 43Cardiovascular and exercise physiologyNitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Endothelin-A -Mediated Vasoconstriction During Exercise With Advancing Age

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Barrett-O’Keefe, Zachary, Ives, Stephen J., Trinity, Joel D., Morgan, Garrett, Rossman, Matthew J., Donato, Anthony J., Runnels, Sean, Morgan, David E. +4 more·2015·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/glu065PMC PMC4400393

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Abstract

The endothelin-1 vasoconstrictor pathway contributes to age-related elevations in resting peripheral vascular tone primarily through activation of the endothelin subtype A (ET(A)) receptor. However, the regulatory influence of ET(A)-mediated vasoconstriction during exercise in the elderly is unknown. Thus, in 17 healthy volunteers (n = 8 young, 24±2 years; n = 9 old, 70±2 years), we examined leg blood flow, mean arterial pressure, leg arterial-venous oxygen (O2) difference, and leg O2 consumption (VO2) at rest and during knee-extensor exercise before and after intra-arterial administration of the ET(A) antagonist BQ-123. During exercise, BQ-123 administration increased leg blood flow to a greater degree in the old (+29±5 mL/min/W) compared with the young (+16±3 mL/min/W). The increase in leg blood flow with BQ-123 was accompanied by an increase in leg VO2 in both groups, suggesting a reduced efficiency following ET(A) receptor blockade. Together, these findings have identified an age-related increase in ET(A)-mediated vasoconstrictor activity that persists during exercise, suggesting an important role of this pathway in the regulation of exercising skeletal muscle blood flow and maintenance of arterial blood pressure in the elderly.

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Sympathetic vascular transduction is likely affected by circulating vasoconstrictors and vasodilators such as endothelin-1 and nitric oxide.
“In addition, sympathetic vascular transduction is likely influenced by circulating vasoconstrictors and vasodilators such as endothlin-138 and nitric oxide.39”
From Reducing Dietary Sodium to 1000 mg per Day Reduces Neurovascular Transduction Without Stimulating Sympathetic Outflow (2019) · cites this paper as [38]
The Perspectives (p. 9) report that endothelin-A signaling constrains blood flow during exercise in older adults, supporting endothelin-1’s role in vascular tone. The paper does not establish that endothelin-1 alters sympathetic vascular transduction specifically. Nitric oxide has a separate citation in the citing sentence and is not assessed here. (LLM, conf=0.82)
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A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y. I., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,716 · see citing works
Cloning and expression of a cDNA encoding an endothelin receptor
Arai, H., Hori, S., Aramori, I., Ohkubo, H., & Nakanishi, S. (1990) · Nature · doi:10.1038/348730a0 · Cited by 2,575 · see citing works
Exercise Standards for Testing and Training: A Statement for Healthcare Professionals From the American Heart Association
Fletcher, G. F., Balady, G. J., Amsterdam, E. A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V. F., Leon, A. S., Piña, I. L., Rodney, R., et al. (2001) · Circulation · doi:10.1161/hc3901.095960 · Cited by 1,923 · see citing works
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.
Nucci, G. D., Thomas, R., D’Orléans-Juste, P., Antunes, E., Walder, C. E., Warner, T. D., & Vane, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9797 · Cited by 1,400 · see citing works
Aging, Habitual Exercise, and Dynamic Arterial Compliance
Tanaka, H., Dinenno, F. A., Monahan, K. D., Clevenger, C. M., DeSouza, C. A., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.11.1270 · Cited by 1,116 · see citing works
Human Cardiovascular Control
Rowell, L. B. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199312000-00021 · Cited by 1,099 · see citing works
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor
Ihara, M., Noguchi, K., Saeki, T., Fukuroda, T., Tsuchida, S., Kimura, S., Fukami, T., Ishikawa, K., Nishikibe, M., & Yano, M. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90331-i · Cited by 870 · see citing works
Exercise : regulation and integration of multiple systems
Rowell, L. B., & Shepherd, J. T. (1996) · Medical Entomology and Zoology · Cited by 810 · see citing works
Aging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension
Taddei, S., Virdis, A., Mattei, P., Ghiadoni, L., Gennari, A., Fasolo, C. B., Sudano, I., & Salvetti, A. (1995) · Circulation · doi:10.1161/01.cir.91.7.1981 · Cited by 710 · see citing works
Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age
Sundlöf, G., & Wallin, B. G. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012170 · Cited by 601 · see citing works
Contribution of endogenous generation of endothelin-1 to basal vascular tone
Haynes, W. G. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92827-4 · Cited by 595 · see citing works
Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.
Ishikawa, K., Ihara, M., Noguchi, K., Mase, T., Mino, N., Saeki, T., Fukuroda, T., Fukami, T., Ozaki, S., & Nagase, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4892 · Cited by 571 · see citing works
The Effect of an Endothelin-Receptor Antagonist, Bosentan, on Blood Pressure in Patients with Essential Hypertension
Krum, H., Viskoper, R. J., Lacourcière, Y., Budde, M., & Charlon, V. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803193381202 · Cited by 567 · see citing works
Physical Activity Prevents Age-Related Impairment in Nitric Oxide Availability in Elderly Athletes
Taddei, S., Galetta, F., Virdis, A., Ghiadoni, L., Salvetti, G., Franzoni, F., Giusti, C., & Salvetti, A. (2000) · Circulation · doi:10.1161/01.cir.101.25.2896 · Cited by 460 · see citing works
Endothelin-A Receptor Antagonist–Mediated Vasodilatation Is Attenuated by Inhibition of Nitric Oxide Synthesis and by Endothelin-B Receptor Blockade
Verhaar, M. C., Strachan, F. E., Newby, D. E., Cruden, N. L. M., Koomans, H. A., Rabelink, T. J., & Webb, D. J. (1998) · Circulation · doi:10.1161/01.cir.97.8.752 · Cited by 452 · see citing works
Human Cardiovascular Control
Rowell, L. B. (1993) · doi:10.1093/oso/9780195073621.001.0001 · Cited by 443 · see citing works
Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults.
Jones, P. R., & PEARSON, J. S. (1969) · PubMed · Cited by 429 · see citing works
Dynamic knee extension as model for study of isolated exercising muscle in humans
Andersen, P., Adams, R. P., Sjøgaard, G., Thorboe, A., & Saltin, B. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.5.1647 · Cited by 385 · see citing works
Systemic Endothelin Receptor Blockade Decreases Peripheral Vascular Resistance and Blood Pressure in Humans
Haynes, W. G., Ferro, C. J., O’Kane, K. P. J., Somerville, D., Lomax, C. C., & Webb, D. J. (1996) · Circulation · doi:10.1161/01.cir.93.10.1860 · Cited by 318 · see citing works
Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase
Donato, A. J., Gano, L. B., Eskurza, I., Silver, A., Gates, P. E., Jablonski, K., & Seals, D. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00689.2008 · Cited by 318 · see citing works
Self-citation
Limb Blood Flow and Vascular Conductance Are Reduced With Age in Healthy Humans
Dinenno, F. A., Jones, P. P., Seals, D. R., & Tanaka, H. (1999) · Circulation · doi:10.1161/01.cir.100.2.164 · Cited by 309 · see citing works
Endothelin ET A and ET B Receptors Cause Vasoconstriction of Human Resistance and Capacitance Vessels In Vivo
Haynes, W. G., Strachan, F. E., & Webb, D. J. (1995) · Circulation · doi:10.1161/01.cir.92.3.357 · Cited by 279 · see citing works
Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men
Dinenno, F. A., Tanaka, H., Monahan, K. D., Clevenger, C. M., Eskurza, I., DeSouza, C. A., & Seals, D. R. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00287.x · Cited by 262 · see citing works
Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial cells. Receptor coupling to nitric oxide synthase.
Tsukahara, H., Ende, H., Magazine, H. I., Bahou, W. F., & Goligorsky, M. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31872-0 · Cited by 248 · see citing works
Endothelin: Potential Role in Hypertension and Vascular Hypertrophy
Schiffrin, E. L. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1135 · Cited by 241 · see citing works
Aerobic Exercise Training Can Reverse Age-Related Peripheral Circulatory Changes in Healthy Older Men
Beere, P. A., Russell, S. D., Morey, M. C., Kitzman, D. W., & Higginbotham, M. B. (1999) · Circulation · doi:10.1161/01.cir.100.10.1085 · Cited by 240 · see citing works
Reduced leg blood flow during dynamic exercise in older endurance-trained men
Proctor, D. N., Shen, P. H., Dietz, N. M., Eickhoff, T. J., Lawler, L. A., Ebersold, E. J., Loeffler, D. L., & Joyner, M. J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.68 · Cited by 232 · see citing works
Nitric oxide in the regulation of vasomotor tone in human skeletal muscle
Rådegran, G., & Saltin, B. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.6.h1951 · Cited by 210 · see citing works
Aerobic exercise training reduces plasma endothelin-1 concentration in older women
Maeda, S., Tanabe, T., Miyauchi, T., Otsuki, T., Sugawara, J., Iemitsu, M., Kuno, S., Ajisaka, R., Yamaguchi, I., & Matsuda, M. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01016.2002 · Cited by 203 · see citing works
Control of Blood Flow to Cardiac and Skeletal Muscle During Exercise
Laughlin, M. H., Korthuis, R. J., Duncker, D. J., & Bache, R. J. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120116 · Cited by 189 · see citing works
Termination of endothelin signaling: Role of nitric oxide
Goligorsky, M. S., Tsukahara, H., Magazine, H. I., Andersen, T. T., Malik, A. B., & Bahou, W. F. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041580313 · Cited by 185 · see citing works
Vascular and metabolic response to isolated small muscle mass exercise: effect of age
Lawrenson, L., Poole, J. G., Kim, J. H., Brown, C., Patel, P. M., & Richardson, R. S. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00135.2003 · Cited by 174 · see citing works
Self-citation
Differential effects of aging on limb blood flow in humans
Donato, A. J., Uberoi, A., Wray, D. W., Nishiyama, S. K., Lawrenson, L., & Richardson, R. S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00405.2005 · Cited by 169 · see citing works
Self-citation
Endothelin-1 Vasoconstrictor Tone Increases With Age in Healthy Men But Can Be Reduced by Regular Aerobic Exercise
Guilder, G. P. V., Westby, C. M., Greiner, J. J., Stauffer, B. L., & DeSouza, C. A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.088294 · Cited by 167 · see citing works
Regional vascular resistance vs. conductance: which index for baroreflex responses?
O’Leary, D. S. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.260.2.h632 · Cited by 164 · see citing works
Enhanced Vascular Activity of Endogenous Endothelin-1 in Obese Hypertensive Patients
Cardillo, C., Campia, U., Iantorno, M., & Panza, J. A. (2003) · Hypertension · doi:10.1161/01.hyp.0000103868.45064.81 · Cited by 162 · see citing works
On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans
Amann, M., Runnels, S., MORGAN, D. E., Trinity, J. D., Fjeldstad, A. S., Wray, D. W., Reese, V. R., & Richardson, R. S. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.209353 · Cited by 160 · see citing works
Self-citation
Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans.
Dyke, C. K., Proctor, D. N., Dietz, N. M., & Joyner, M. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020964 · Cited by 157 · see citing works
Different vasodilator responses of human arms and legs
Newcomer, S. C., Leuenberger, U. A., Hogeman, C. S., Handly, B., & Proctor, D. N. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.059717 · Cited by 155 · see citing works
Vascular and metabolic response to cycle exercise in sedentary humans: effect of age
Poole, J. G., Lawrenson, L., Kim, J. H., Brown, C., & Richardson, R. S. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00790.2002 · Cited by 155 · see citing works
Self-citation
Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented α‐adrenergic vasoconstriction
Dinenno, F. A., Tanaka, H., Stauffer, B. L., & Seals, D. R. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00977.x · Cited by 153 · see citing works
Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men
Tanaka, H., Seals, D. R., Monahan, K. D., Clevenger, C. M., DeSouza, C. A., & Dinenno, F. A. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00824.2001 · Cited by 153 · see citing works
Systemic Blockade of the Endothelin-B Receptor Increases Peripheral Vascular Resistance in Healthy Men
Strachan, F. E., Spratt, J., Wilkinson, I. B., Johnston, N. R., Gray, G. A., & Webb, D. J. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.581 · Cited by 151 · see citing works
Age- and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects
Miyauchi, T., Yanagisawa, M., Iida, K., Ajisaka, R., Suzuki, N., Fujino, M., Goto, K., Masaki, T., & Sugishita, Y. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90734-d · Cited by 147 · see citing works
Angiogenic growth factor response to acute systemic exercise in human skeletal muscle
Gavin, T. P., Robinson, C. B., Yeager, R. C., England, J. A., Nifong, L. W., & Hickner, R. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00748.2003 · Cited by 136 · see citing works
Ageing reduces nitric‐oxide‐ and prostaglandin‐mediated vasodilatation in exercising humans
Schrage, W. G., Eisenach, J. H., & Joyner, M. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.124313 · Cited by 132 · see citing works
Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia
Lind, L., & Lithell, H. (1993) · American Heart Journal · doi:10.1016/0002-8703(93)90446-g · Cited by 132 · see citing works
Metabolic and Vascular Limb Differences Affected by Exercise, Gender, Age, and Disease
Richardson, R. S., Secher, N. H., Tschakovsky, M. E., Proctor, D. N., & Wray, D. W. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000229568.17284.ab · Cited by 127 · see citing works
Self-citation
Age‐related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects
Dinenno, F. A., Seals, D. R., DeSouza, C. A., & Tanaka, H. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0573i.x · Cited by 122 · see citing works
How reproducible is bilateral forearm plethysmography?
Petrie, J. R., Ueda, S., Morris, A. D., Murray, L. S., Elliott, H. L., & Connell, J. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00656.x · Cited by 110 · see citing works
Progressive handgrip exercise: evidence of nitric oxide-dependent vasodilation and blood flow regulation in humans
Wray, D. W., Witman, M. A., Ives, S. J., McDaniel, J., Fjeldstad, A. S., Trinity, J. D., Conklin, J. D., Supiano, M. A., & Richardson, R. S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01115.2010 · Cited by 109 · see citing works
Self-citation
Sex-specific influence of aging on exercising leg blood flow
Parker, B. A., Smithmyer, S. L., Pelberg, J. A., Mishkin, A. D., & Proctor, D. N. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01150.2007 · Cited by 102 · see citing works
Increased Expression of Endothelin-1 and Inducible Nitric Oxide Synthase Isoform II in Aging Arteries in Vivo: Implications for Atherosclerosis
Göettsch, W., Lattmann, T., Amann, K., Szibor, M., Morawietz, H., Münter, K., Müller, S. P., Shaw, S., & Barton, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4180 · Cited by 97 · see citing works
Heterogeneous limb vascular responsiveness to shear stimuli during dynamic exercise in humans
Wray, D. W., Uberoi, A., Lawrenson, L., & Richardson, R. S. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01285.2004 · Cited by 97 · see citing works
Self-citation
The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles
Donato, A. J., Lesniewski, L. A., & Delp, M. D. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.023 · Cited by 94 · see citing works
Self-citation
Enhanced endothelin-1-mediated leg vascular tone in healthy older subjects
Thijssen, D. H. J., Rongen, G. A. P. J. M., van Dijk, A. P. J., Smits, P., & Hopman, M. T. E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00357.2007 · Cited by 93 · see citing works
Systemic ETA receptor antagonism with BQ‐123 blocks ET‐1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men
Spratt, J., Goddard, J. G., Patel, N., Strachan, F. E., Rankin, A. J., & Webb, D. J. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704304 · Cited by 87 · see citing works
Ageing and leg postjunctional α‐adrenergic vasoconstrictor responsiveness in healthy men
Smith, E. G., Voyles, W. F., Kirby, B. S., Markwald, R. R., & Dinenno, F. A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.130591 · Cited by 82 · see citing works
Reproducibility of blood flow and post-occlusive reactive hyperaemia as measured by venous occlusion plethysmography
Thijssen, D. H. J., Bleeker, M. W. P., Smits, P., & Hopman, M. T. E. (2005) · Clinical Science · doi:10.1042/cs20040177 · Cited by 82 · see citing works
Nitric oxide and muscle blood flow in exercise
Tschakovsky, M. E., & Joyner, M. J. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-148 · Cited by 75 · see citing works
Physical Activity and Prevention of Cardiovascular Disease in Older Adults
Büchner, D. M. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.08.002 · Cited by 70 · see citing works
Venous cuff pressures from 30 mmHg to diastolic pressure are recommended to measure arterial inflow by plethysmography
Groothuis, J. T., van Vliet, L., Kooijman, M., & Hopman, M. T. E. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00022.2003 · Cited by 64 · see citing works
Aging attenuates vascular and metabolic plasticity but does not limit improvement in muscle V o 2 max
Lawrenson, L., Hoff, J., & Richardson, R. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01070.2003 · Cited by 62 · see citing works
Self-citation
The Importance of Doppler Angle of Insonation on Differentiation Between 50–69% and 70–99% Carotid Artery Stenosis
Logason, K., Bärlin, T., Jonsson, M.-L., Boström, A., Hårdemark, H., & Karacagil, S. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2001.1331 · Cited by 58 · see citing works
Effects of endothelin on regional hemodynamics in conscious rats
Han, S. P., Trapani, A. J., Fok, K. F., Westfall, T. C., & Knuepfer, M. M. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90162-3 · Cited by 54 · see citing works
Endothelin: Systemic Arterial and Pulmonary Effects of a New Peptide with Potent Biologic Properties
Lüscher, T. F. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_2.s56 · Cited by 54 · see citing works
Human muscle blood flow and metabolism studied in the isolated quadriceps muscles
Richardson, R. S., & Saltin, B. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199801000-00005 · Cited by 52 · see citing works
Self-citation
Preserved α-Adrenergic Tone in the Leg Vascular Bed of Spinal Cord–Injured Individuals
Kooijman, M., Rongen, G. A. P. J. M., Smits, P., & Hopman, M. T. E. (2003) · Circulation · doi:10.1161/01.cir.0000096480.55857.3c · Cited by 46 · see citing works
Angiotensin II in the Elderly
Wray, D. W., Nishiyama, S. K., Harris, R. A., & Richardson, R. S. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111294 · Cited by 43 · see citing works
Self-citation
Taming the “sleeping giant”: the role of endothelin-1 in the regulation of skeletal muscle blood flow and arterial blood pressure during exercise
Barrett‐O’Keefe, Z., Ives, S. J., Trinity, J. D., Morgan, G., Rossman, M. J., Donato, A. J., Runnels, S., MORGAN, D. E., Gmelch, B. S., Bledsoe, A. D., et al. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00603.2012 · Cited by 42 · see citing works
Self-citation
Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and the role of nitric oxide
Helmy, A., Newby, D. E., Jalan, R., Hayes, P. C., & Webb, D. J. (2003) · Gut · doi:10.1136/gut.52.3.410 · Cited by 41 · see citing works
Endogenous Endothelin-1 Limits Exercise-Induced Vasodilation in Hypertensive Humans
McEniery, C. M., Wilkinson, I. B., Jenkins, D. G., & Webb, D. J. (2002) · Hypertension · doi:10.1161/01.hyp.0000024218.04872.f3 · Cited by 41 · see citing works
An Experimental Multiple-Organ Model for the Study of Regional Net Release/Uptake Rates of Tissue-type Plasminogen Activator in the Intact Pig
Jern, C., Seeman‐Lodding, H., Biber, B., Winsö, O., & Jern, S. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657702 · Cited by 39 · see citing works
Effects of chronic nitric oxide synthase inhibition on responses to acute exercise in swine
McAllister, R. M., Newcomer, S. C., Pope, E. R., Turk, J. R., & Laughlin, M. H. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00731.2007 · Cited by 34 · see citing works
Muscle Blood Flow and Mitochondrial Function: Influence of Aging
Terjung, R. L., Zarzeczny, R., & Yang, H. (2002) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.12.3.368 · Cited by 31 · see citing works
Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and α1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes
Bender, S. B., & Klabunde, R. E. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00566.2007 · Cited by 31 · see citing works
Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: Role of protein kinase C
Korzick, D. H., Muller‐Delp, J. M., Dougherty, P. M., Heaps, C. L., Bowles, D. K., & KRICK, K. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.015 · Cited by 31 · see citing works
Influence of aging on the contractile response to endothelin of rat thoracic aorta
Ishihata, A., Katano, Y., Morinobu, S., & Endoh, M. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90689-n · Cited by 30 · see citing works
Limitations to vasodilatory capacity and V o 2 maxin trained human skeletal muscle
Barden, J., Lawrenson, L., Poole, J. G., Kim, J., Wray, D. W., Bailey, D. M., & Richardson, R. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01396.2006 · Cited by 26 · see citing works
Self-citation
Exercise testing and training of the elderly patient.
Landin, R. J., Linnemeier, T. J., ROTHBAUM, D. A., Chappelear, J., & Noble, R. J. (1985) · PubMed · Cited by 23 · see citing works
Physical inactivity as a risk factor for cardiovascular disease
Fletcher, G. F. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00136-9 · Cited by 22 · see citing works
Endothelin Antagonists and Hypertension: A Question of Dose?
Goddard, J. G., & Webb, D. J. (2002) · Hypertension · doi:10.1161/01.hyp.0000028980.24709.68 · Cited by 18 · see citing works
Paradoxically Enhanced Endothelin-B Receptor–Mediated Vasoconstriction in Conscious Old Monkeys
Asai, K., Kudej, R. K., Takagi, G., Kudej, A. B., Natividad, F. F., Shen, Y., Vatner, D. E., & Vatner, S. F. (2001) · Circulation · doi:10.1161/01.cir.103.19.2382 · Cited by 18 · see citing works
Forearm plethysmography: does the right arm know what the left is doing?
Petrie, J. R., Perry, C. G., Cleland, S. J., Murray, L. S., Elliott, H. L., & Connell, J. (2000) · Clinical Science · doi:10.1042/cs0980209 · Cited by 14 · see citing works
[Variation in the plasma endothelin levels in relation to age].
Battistelli, S., Gori, S., Borgogni, T., & Manasse, G. (1996) · PubMed · Cited by 12 · see citing works
Flow ratios to express results obtained with the human in vivo‘perfused forearm technique’
Rongen, G. A. P. J. M., Lambrou, G. Ι., & Smits, P. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00003.x · Cited by 7 · see citing works
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Barbero (2014) · doi:10.1016/j · Cited by 1 · see citing works

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Authors: Barrett-O’Keefe, Z., Ives, S. J., Trinity, J. D., Morgan, G., Rossman, M. J., Donato, A. J., Runnels, S., Morgan, D. E., Gmelch, B. S., Bledsoe, A. D., Richardson, R. S., & Wray, D. W.
Affiliations: University of Utah (US)
VA Salt Lake City Healthcare System (US)
ORCID: Ives, Stephen J.
Trinity, Joel D.
Rossman, Matthew J.
Donato, Anthony J.
Runnels, Sean
Morgan, David E.
Bledsoe, Amber D.
Richardson, Russell S.
Wray, D. Walter
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2014-05-12
Volume: 70
Issue: 5
Pages: 554-565
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/glu065
PMC: PMC4400393
OpenAlex: W2150525772
Semantic Scholar: 0f2e50e56360e8de7277899f473b6faddbeb6342
Cited by: 43
References: 86
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 1
FWCI: 12.20
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journals of Gerontology Series A (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Creative Matter (Skidmore College) (submittedVersion)
Funders: National Institute on Aging (R21AG043952, K02AG045339, R01AG040297)
National Heart, Lung, and Blood Institute (R01HL118313, P01HL091830)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: endothelin-1, ETA receptor, vasoconstriction, aging, physical activity, leg blood flow, BQ-123, skeletal muscle oxygen consumption, arterial blood pressure, peripheral vascular tone, knee extension exercise, older adults
MeSH terms: Aged, Aging, Female, Humans, Leg, Lipids, Male, Oxygen Consumption, Peptides, Cyclic, Vasoconstriction, Exercise, Young Adult, Arterial Pressure, Healthy Volunteers, Endothelin Receptor Antagonists

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Endothelin-A -Mediated Vasoconstriction During Exercise With Advancing Age

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